Effect of nucleoside analogs and non-nucleoside inhibitors of HIV-1 reverse transcriptase on cell-free virions

Archives of Virology

Volumn 144, Issue 3, 1999, Pages 513-523

  Ventura, M ^a,c   Tarrago Litvak, L ^a   Dolle V ^b   Nguyen, C H ^b   Legraverend, M ^b   Fleury, H J A ^a   Litvak, S ^a  

^a UNIVERSITÉ DE BORDEAUX   (France)

^b INSTITUT CURIE   (France)

^c EP 630 CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CURIE PYRIDINONE; ENZYME INHIBITOR; HUMAN IMMUNODEFICIENCY VIRUS TYPE 1; RETROVIRUS; RNA DIRECTED DNA POLYMERASE; VIRUS INFECTION;

ANTI-HIV AGENTS; CELL LINE, TRANSFORMED; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; NUCLEOSIDES; REVERSE TRANSCRIPTASE INHIBITORS; VIRION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; UNIDENTIFIED RETROVIRUS;

EID: 0032932831     PISSN: 03048608     EISSN: None     Source Type: Journal    
DOI: 10.1007/s007050050522     Document Type: Article

References (25)

1. 1. Aloia RC, Tian H, Jensen FC (1993) Lipid composition and fluidity of the human immunodeficiency virus envelope and host cell plasma membranes. Proc Natl Acad Sci USA 90: 5181-5185
2. 2. Arts EJ, Wainberg MA (1996) Human immunodeficiency virus type 1 reverse transcriptase and early events in reverse transcription. Adv Virus Res 46: 97-163
3. 3. Arts EJ, Wainberg MA (1996) Mechanisms of nucleoside analog antiviral activity and resistance during HIV reverse transcription. Antimicrob Agents Chemother 40: 527-540
4. 4. Barnard J, Borkow G, Parniak M (1997) The thiocarboxanilide nonnucleoside UC781 is a tight-binding inhibitor of HIV-1 reverse transcriptase. Biochemistry 36: 7786-7792
5. 5. Bordier B, Peräla-Heape M, Degols G, Lebleu B, Litvak S, Sarih-Cottin L, Hélène C (1995) Sequence-specific inhibition of HIV reverse transcription by antisense oligonucleotides: comparative study in cell-free assays and in HIV-infected cells. Proc Natl Acad Sci USA 92: 9383-9387
6. 6. Borkow G, Barnard J, Nguyen TM, Belmonte A, Wainberg MA, Parniak MA (1997) Chemical barriers to human immunodeficiency virus type 1 (HIV-1) infection: retrovirucidal activity of UC 781, a thiocarboxanilide nonnucleoside inhibitor of HIV-1 reverse transcriptase. J Virol 71: 3023-3030
7. 7. Charneau P, Mirambeau G, Roux P, Paulous S, Buc H, Clavel F (1994) HIV-1 reverse transcription. A termination step at the center of the genome. J Mol Biol 241: 651-662
8. 8. De Clercq E (1996) What can be expected from non-nucleoside reverse transcriptase inhibitors (NNRTI)s in the treatment of HIV-1 infections? Med Virol 6: 97-117
9. 9. Dollé V, Fan E, Nguyen CH, Aubertin AM, Kirn A, Andreola ML, Jamieson G, Tarrago-Litvak L, Bisagni E (1995) A new series of pyridinone derivatives as potent non-nucleoside HIV-1 specific reverse transcriptase inhibitors. J Med Chem 38: 4679-4686
10. Lys3 are strong inhibitors of HIV-1 reverse transcriptase and arrest viral replication in infected cells. Antimicrob Agents Chemother 41: 2141-2148
11. 11. Ho DD, Neumann AU, Perelson AS, Chen W, Leonard JM, Markowitz M (1995) Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 373: 123-126
12. 12. Lori F, Veronese FDM, De Vico AL, Lusso P, Reitz Jr MS, Gallo RC (1992) Viral DNA carried by human immunodeficiency virus type 1 virions. J Virol 66: 5067-5074
13. 13. Perelson AS, Neumann AU, Markowitz M, Leonard JM, Ho DD (1996) HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time. Science 271: 1582-1586
14. 14. Rocancourt D, Bonnerot C, Jouin H, Emerman M, Nicolas JF (1990) Activation of a beta-galactosidase recombinant provirus: application to titration of HIV and HIV-infected cells. J Virol 64: 2660-2668
15. 15. Sallafranque-Andreola ML, Robert D, Barr PJ, Fournier M, Litvak S, Sarih-Cottin L, Tarrago-Litvak L (1989) Human immunodeficiency virus reverse transcriptase expressed in transformed yeast cells. Eur J Biochem 184: 367-374
16. 16. Tarrago-Litvak L, Andreola ML, Nevinsky G, Sarih-Cottin L, Litvak S (1994) The reverse transcriptase of HIV-1: from enzymology to therapeutic intervention. FASEB J 8: 497-503
17. 17. Trono D (1992) Partial reverse transcripts in virions from human immunodeficiency and murine leukemia viruses. J Virol 66: 4893-4900
18. 18. Zhang H, Zhang Y, Spicer TP, Abbott LZ, Abbott M, Poiesz BJ (1993) Reverse transcription takes place within extracellular HIV-1 virions: potential biological significance. AIDS Res Hum Retroviruses 9: 1287-1296
19. 19. Zhang H, Bagasra O, Niikura M, Poiesz BJ, Pomerantz RJ (1994) Intravirion reverse transcripts in the peripheral blood plasma of HIV-1-infected individuals. J Virol 68: 7591-7597
20. 20. Zhang H, Duan LX, Dornadula G, Pomerantz RJ (1995) Increasing transduction efficiency of recombinant murine retrovirus vectors by initiation of endogenous reverse transcription: potential utility for genetic therapies. J Virol 69: 3929-3932
21. 21. Zhang H, Dornadula G, Wu Y, Havlir D, Richman DD, Pomerantz RJ (1996) Kinetic analysis of intravirion reverse transcription in the blood plasma of HIV-1 -infected individuals: direct assessment of resistance to reverse transcriptase inhibitors in vivo. J Virol 70: 628-634
22. 22. Zhang H, Dornadula G, Alur P, Laughlin MA, Pomerantz RJ (1996) Amphipatic domains in the C terminus of the transmembrane protein (gp41) permeabilize HIV-1 virions: a molecular mechanism underlying natural endogenous reverse transcription. Proc Natl Acad Sci USA 93: 12519-12524
23. 23. Zhang H, Dornadula G, Pomerantz RJ (1996) Endogenous reverse transcription of HIV-1 in physiological microenvironments: an important stage for viral infection of nondividing cells. J Virol 70: 2809-2824
24. 24. Miyasaka T, Tanaka H, Baba M, Hayakawa H, Walker RT, Balzarini J, De Clercq E (1989) A novel lead for specific anti-HIV-1 agents: 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine. J Med Chem 32: 2507-2509
25. 25. Goldman ME, Nunberg JH, O'Brien JA, Quintero JC, Schleif WA, Freund KF, Gaul SL, Saari WS, Wai JS, Hoffman JM, Anderson PS, Hupe DJ, Emini EA, Stern AM (1991) Pyridinone derivatives: specific HIV-1 reverse transcriptase inhibitors with antiviral activity. Proc Natl Acad Sci USA 88: 6863-6867