메뉴 건너뛰기




Volumn 18, Issue 1, 1999, Pages 5-11

Expression of p53, MDM2, and p21 proteins in high-grade cervical intraepithelial neoplasia and relationship to human papillomavirus infection

Author keywords

CIN; HPV; Immunoreactivity; MDM2; p21; p53

Indexed keywords

MONOCLONAL ANTIBODY; PROTEIN MDM2; PROTEIN P21; PROTEIN P53; VIRUS DNA;

EID: 0032909051     PISSN: 02771691     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004347-199901000-00002     Document Type: Article
Times cited : (25)

References (42)
  • 2
    • 0030941458 scopus 로고    scopus 로고
    • p53, the cellular gatekeeper for growth and division
    • Levine AJ. p53, the cellular gatekeeper for growth and division. Cell 1997;88:323-31.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 3
    • 0029315510 scopus 로고
    • Tumour suppressors, kinases and clamps: How p53 regulates the cell cycle in response to DNA damage
    • Cox LS, Lane DP. Tumour suppressors, kinases and clamps: how p53 regulates the cell cycle in response to DNA damage. Bioessays 1995;17:501-8.
    • (1995) Bioessays , vol.17 , pp. 501-508
    • Cox, L.S.1    Lane, D.P.2
  • 4
    • 0028299342 scopus 로고
    • p53 in tumor pathology: Can we trust immunohistochemistry?
    • Hall PA, Lane DP. p53 in tumor pathology: can we trust immunohistochemistry? J Pathol 1994;172:1-4.
    • (1994) J Pathol , vol.172 , pp. 1-4
    • Hall, P.A.1    Lane, D.P.2
  • 5
    • 0028348414 scopus 로고
    • Molecular pathogenesis of cancer of the cervix and its causation by specific human papillomavirus types
    • zur Hausen H. Molecular pathogenesis of cancer of the cervix and its causation by specific human papillomavirus types. Curr Top Microbiol Immunol 1994;186:131-56.
    • (1994) Curr Top Microbiol Immunol , vol.186 , pp. 131-156
    • Zur Hausen, H.1
  • 6
    • 0025271203 scopus 로고
    • Association of human papillomavirus types 16 and 18 E6 proteins with p53
    • Werness BA, Levine AJ, Howley PM. Association of human papillomavirus types 16 and 18 E6 proteins with p53. Science 1990; 248:76-9.
    • (1990) Science , vol.248 , pp. 76-79
    • Werness, B.A.1    Levine, A.J.2    Howley, P.M.3
  • 7
    • 0025639158 scopus 로고
    • The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
    • Scheffner M, Werness BA, Huibregtse JM, Levine AJ, Howley PM. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 1990;63:1129-36.
    • (1990) Cell , vol.63 , pp. 1129-1136
    • Scheffner, M.1    Werness, B.A.2    Huibregtse, J.M.3    Levine, A.J.4    Howley, P.M.5
  • 8
    • 0026649648 scopus 로고
    • The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
    • Momand J, Zambetti GP, Olson DC, George D, Levine AJ. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 1992;69:1237-45.
    • (1992) Cell , vol.69 , pp. 1237-1245
    • Momand, J.1    Zambetti, G.P.2    Olson, D.C.3    George, D.4    Levine, A.J.5
  • 9
    • 0027179604 scopus 로고
    • Identification and characterization of multiple mdm-2 proteins and mdm-2-p53 protein complexes
    • Olson DC, Marechal V, Momand J, Chen J, Romocki C, Levine AJ. Identification and characterization of multiple mdm-2 proteins and mdm-2-p53 protein complexes. Oncogene 1993;8:2353-60.
    • (1993) Oncogene , vol.8 , pp. 2353-2360
    • Olson, D.C.1    Marechal, V.2    Momand, J.3    Chen, J.4    Romocki, C.5    Levine, A.J.6
  • 10
    • 0027244853 scopus 로고
    • The p53-mdm-2 autoregulatory feedback loop
    • Wu X, Bayle JH, Olson D, Levine AJ. The p53-mdm-2 autoregulatory feedback loop. Genes Dev. 1993;7:1126-32.
    • (1993) Genes Dev. , vol.7 , pp. 1126-1132
    • Wu, X.1    Bayle, J.H.2    Olson, D.3    Levine, A.J.4
  • 11
    • 0030905284 scopus 로고    scopus 로고
    • Mdm2 promotes the rapid degradation of p53
    • Haupt Y, Maya R, Kazaz A, Oren M. Mdm2 promotes the rapid degradation of p53. Nature 1997;387:296-9.
    • (1997) Nature , vol.387 , pp. 296-299
    • Haupt, Y.1    Maya, R.2    Kazaz, A.3    Oren, M.4
  • 12
    • 0030825813 scopus 로고    scopus 로고
    • p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding
    • Midgley CA, Lane DP. p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding. Oncogene 1997;15:1179-89.
    • (1997) Oncogene , vol.15 , pp. 1179-1189
    • Midgley, C.A.1    Lane, D.P.2
  • 13
    • 0028294605 scopus 로고
    • WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis
    • el Deiry WS, Harper JW, O'Connor PM, et al. WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res 1994;54:1169-74.
    • (1994) Cancer Res , vol.54 , pp. 1169-1174
    • El Deiry, W.S.1    Harper, J.W.2    O'Connor, P.M.3
  • 15
    • 0028973586 scopus 로고
    • Increased levels of p21WAF1/ Cip1 in human brain tumors
    • Jung JM, Bruner JM, Ruan S, et al. Increased levels of p21WAF1/ Cip1 in human brain tumors. Oncogene 1995;11:2021-8.
    • (1995) Oncogene , vol.11 , pp. 2021-2028
    • Jung, J.M.1    Bruner, J.M.2    Ruan, S.3
  • 16
    • 0030943490 scopus 로고    scopus 로고
    • Expression of p53, mdm2, p21/waf1 and bcl-2 proteins in thymomas
    • Stefanaki K, Rontogianni D, Kouvidou CH, et al. Expression of p53, mdm2, p21/waf1 and bcl-2 proteins in thymomas. Histopathology 1997;30:549-55.
    • (1997) Histopathology , vol.30 , pp. 549-555
    • Stefanaki, K.1    Rontogianni, D.2    Kouvidou, C.H.3
  • 17
    • 0030812191 scopus 로고    scopus 로고
    • p53 protein expression in breast carcinomas. Comparative study with the wild type p53 induced proteins mdm2 and p21/waf1
    • Giannikaki E, Kouvidou C, Tzardi M, et al. p53 protein expression in breast carcinomas. Comparative study with the wild type p53 induced proteins mdm2 and p21/waf1. Anticancer Res 1997;17: 2123-7.
    • (1997) Anticancer Res , vol.17 , pp. 2123-2127
    • Giannikaki, E.1    Kouvidou, C.2    Tzardi, M.3
  • 18
    • 0030877712 scopus 로고    scopus 로고
    • Immunohistochemical expression of p53, bcl-2, mdm2 and waf1/p21 proteins in colorectal adenocarcinomas
    • Valassiadou KE, Stefanaki K, Tzardi M, et al. Immunohistochemical expression of p53, bcl-2, mdm2 and waf1/p21 proteins in colorectal adenocarcinomas. Anticancer Res 1997;17:2571-6.
    • (1997) Anticancer Res , vol.17 , pp. 2571-2576
    • Valassiadou, K.E.1    Stefanaki, K.2    Tzardi, M.3
  • 19
    • 0030958766 scopus 로고    scopus 로고
    • Overexpression of the cyclin-dependent kinase inhibitor p21/WAF1/CIP1 in human cutaneous malignant melanoma
    • Trotter MJ, Tang L, Tron VA. Overexpression of the cyclin-dependent kinase inhibitor p21/WAF1/CIP1 in human cutaneous malignant melanoma. J Cutan Pathol 1997;24:265-71.
    • (1997) J Cutan Pathol , vol.24 , pp. 265-271
    • Trotter, M.J.1    Tang, L.2    Tron, V.A.3
  • 20
    • 0031018178 scopus 로고    scopus 로고
    • TP53 protein accumulation and gene mutation in relation to overexpression of MDM2 protein in ovarian borderline tumours and stage I carcinomas
    • Skomedal H, Kristensen GB, Abeler VM, Borresen-Dale AL, Tropé C, Holm R. TP53 protein accumulation and gene mutation in relation to overexpression of MDM2 protein in ovarian borderline tumours and stage I carcinomas. J Pathol 1997;181:158-65.
    • (1997) J Pathol , vol.181 , pp. 158-165
    • Skomedal, H.1    Kristensen, G.B.2    Abeler, V.M.3    Borresen-Dale, A.L.4    Tropé, C.5    Holm, R.6
  • 21
    • 0028807737 scopus 로고
    • Occurrence of human papillomavirus infection in cervical intraepithelial neoplasia. A retrospective histopathological study of 317 cases treated by laser conization
    • Lie AK, Skjeldestad FE, Hagen B, Haugen OA. Occurrence of human papillomavirus infection in cervical intraepithelial neoplasia. A retrospective histopathological study of 317 cases treated by laser conization. APMIS 1995;103:693-8.
    • (1995) APMIS , vol.103 , pp. 693-698
    • Lie, A.K.1    Skjeldestad, F.E.2    Hagen, B.3    Haugen, O.A.4
  • 22
    • 0030929781 scopus 로고    scopus 로고
    • Comparision of light microscopy, in situ hybridization and polymerase chain reaction for detection of human papillomavirus in histological tissue of cervical intraepithelial neoplasia
    • Lie AK, Skjeldestad FE, Hagen B, Johannessen E, Skarsvåg S, Haugen OA. Comparision of light microscopy, in situ hybridization and polymerase chain reaction for detection of human papillomavirus in histological tissue of cervical intraepithelial neoplasia. APMIS 1997;105:115-20.
    • (1997) APMIS , vol.105 , pp. 115-120
    • Lie, A.K.1    Skjeldestad, F.E.2    Hagen, B.3    Johannessen, E.4    Skarsvåg, S.5    Haugen, O.A.6
  • 23
    • 0004060908 scopus 로고
    • Lyon: IARC
    • IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Human papillomaviruses. Lyon: IARC, 1995;1-409.
    • (1995) Human Papillomaviruses , pp. 1-409
  • 24
    • 0029882709 scopus 로고    scopus 로고
    • Detection of human papillomavirus in cervical intra-epithelial neoplasia, using in situ hybridization and various polymerase chain reaction techniques
    • Zehbe I, Rylander E, Edlund K, Wadell G, Wilander E. Detection of human papillomavirus in cervical intra-epithelial neoplasia, using in situ hybridization and various polymerase chain reaction techniques. Virchows Arch 1996;428:151-7.
    • (1996) Virchows Arch , vol.428 , pp. 151-157
    • Zehbe, I.1    Rylander, E.2    Edlund, K.3    Wadell, G.4    Wilander, E.5
  • 25
    • 0027393143 scopus 로고
    • Immunohistochemical analysis of p53 protein over-expression in normal, premalignant, and malignant tissues of the cervix uteri
    • Holm R, Skomedal H, Helland A, Kristensen G, Borresen AL, Nesland JM. Immunohistochemical analysis of p53 protein over-expression in normal, premalignant, and malignant tissues of the cervix uteri. J Pathol 1993;169:21-6.
    • (1993) J Pathol , vol.169 , pp. 21-26
    • Holm, R.1    Skomedal, H.2    Helland, A.3    Kristensen, G.4    Borresen, A.L.5    Nesland, J.M.6
  • 26
    • 0028643580 scopus 로고
    • p53 immunoreactivity in cervical intraepithelial neoplasia and non-neoplastic cervical squamous epithelium
    • Jeffers MD, Richmond J, Farquharson M, McNicol AM. p53 immunoreactivity in cervical intraepithelial neoplasia and non-neoplastic cervical squamous epithelium. J Clin Pathol 1994;47: 1073-6.
    • (1994) J Clin Pathol , vol.47 , pp. 1073-1076
    • Jeffers, M.D.1    Richmond, J.2    Farquharson, M.3    McNicol, A.M.4
  • 27
    • 0029155315 scopus 로고
    • Cervica squamous dysplasias and carcinomas with immunodetectable p53 frequently contain HPV
    • Mittal KR, Lin O, Chan W, Goswami S, Demopoulos RI. Cervica squamous dysplasias and carcinomas with immunodetectable p53 frequently contain HPV. Gynecol Oncol 1995;58:289-94.
    • (1995) Gynecol Oncol , vol.58 , pp. 289-294
    • Mittal, K.R.1    Lin, O.2    Chan, W.3    Goswami, S.4    Demopoulos, R.I.5
  • 29
    • 0028922786 scopus 로고
    • p53 and human papilloma virus type 16 in cervical intraepithelial neoplasia and carcinoma
    • Ter Harmsel B, van Belkum A, Quint W, et al. p53 and human papilloma virus type 16 in cervical intraepithelial neoplasia and carcinoma. Int J Gynecol Pathol 1995;14:125-33.
    • (1995) Int J Gynecol Pathol , vol.14 , pp. 125-133
    • Ter Harmsel, B.1    Van Belkum, A.2    Quint, W.3
  • 30
    • 0028652316 scopus 로고
    • p53 expression and genetic evidence for viral infection in intraepithelial neoplasi of the uterine cervix
    • Vecchione A, Cermele C, Giovagnoli MR, et al. p53 expression and genetic evidence for viral infection in intraepithelial neoplasi of the uterine cervix. Gynecol Oncol 1994;55:343-8.
    • (1994) Gynecol Oncol , vol.55 , pp. 343-348
    • Vecchione, A.1    Cermele, C.2    Giovagnoli, M.R.3
  • 31
    • 0027365651 scopus 로고
    • p5 antigen in cervical condylomata, intraepithelial neoplasia, and carcinoma: Relationship to HPV infection and integration
    • Cooper K, Herrington CS, Evans MF, Gatter KC, McGee JO. p5 antigen in cervical condylomata, intraepithelial neoplasia, and carcinoma: relationship to HPV infection and integration. J Pathol 1993;171:27-34.
    • (1993) J Pathol , vol.171 , pp. 27-34
    • Cooper, K.1    Herrington, C.S.2    Evans, M.F.3    Gatter, K.C.4    McGee, J.O.5
  • 32
    • 0031050140 scopus 로고    scopus 로고
    • p53 immunostainin and HPV DNA detection by PCR in cervical intraepithelial neoplasia: Clinical implications of a combinated evaluation
    • Garzetti GG, Ciavattini A, Lucarini G, et al. p53 immunostainin and HPV DNA detection by PCR in cervical intraepithelial neoplasia: clinical implications of a combinated evaluation. Antica cer Res 1997;17:555-60.
    • (1997) Antica Cer Res , vol.17 , pp. 555-560
    • Garzetti, G.G.1    Ciavattini, A.2    Lucarini, G.3
  • 33
    • 0028884967 scopus 로고
    • Presence and persistence of HPV infection and p mutation in cancer of the cervix uteri and the vulva
    • Milde Langosch K, Albrecht K, Joram S, Schlechte H, Giessing I, Loning T. Presence and persistence of HPV infection and p mutation in cancer of the cervix uteri and the vulva. Int J Cancer 1995;63:639-45.
    • (1995) Int J Cancer , vol.63 , pp. 639-645
    • Milde Langosch, K.1    Albrecht, K.2    Joram, S.3    Schlechte, H.4    Giessing, I.5    Loning, T.6
  • 34
    • 0027232336 scopus 로고
    • p53 immunoreactivity in inflammatory and neoplastic diseases of the uterine cervix
    • Bosari S, Roncalli M, Viale G, Bossi P, Coggi G. p53 immunoreactivity in inflammatory and neoplastic diseases of the uterine cervix. J Pathol 1993;169:425-30.
    • (1993) J Pathol , vol.169 , pp. 425-430
    • Bosari, S.1    Roncalli, M.2    Viale, G.3    Bossi, P.4    Coggi, G.5
  • 35
    • 0344732168 scopus 로고    scopus 로고
    • Aberrent expression of the cell cycle associated proteins TP53, MDM2, p21, p27, cdk4, cyclinD1, RB and EGFR in cervical carcinoma
    • in press
    • Skomedal H, Kristensen GB, Lie AK, Holm R. Aberrent expression of the cell cycle associated proteins TP53, MDM2, p21, p27, cdk4, cyclinD1, RB and EGFR in cervical carcinoma. Gynecol Oncol 1998; in press.
    • (1998) Gynecol Oncol
    • Skomedal, H.1    Kristensen, G.B.2    Lie, A.K.3    Holm, R.4
  • 36
    • 0030800922 scopus 로고    scopus 로고
    • Mdm2: Keeping p53 under control
    • Piette J, Neel H, Maréchal V. Mdm2: keeping p53 under control. Oncogene 1997;15:1001-10.
    • (1997) Oncogene , vol.15 , pp. 1001-1010
    • Piette, J.1    Neel, H.2    Maréchal, V.3
  • 37
    • 0029074268 scopus 로고
    • p53 mutation and MDM2 amplification are rare even in human papillomavirus-negative cervical carcinomas
    • Ikenberg H, Matthay K, Schmitt B, et al. p53 mutation and MDM2 amplification are rare even in human papillomavirus-negative cervical carcinomas. Cancer 1995;76:57-66.
    • (1995) Cancer , vol.76 , pp. 57-66
    • Ikenberg, H.1    Matthay, K.2    Schmitt, B.3
  • 38
    • 0030827303 scopus 로고    scopus 로고
    • Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein
    • Funk JO, Waga S, Harry JB, Espling E, Stillman B, Galloway DA. Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein. Genes Dev 1997;11:2090-100.
    • (1997) Genes Dev , vol.11 , pp. 2090-2100
    • Funk, J.O.1    Waga, S.2    Harry, J.B.3    Espling, E.4    Stillman, B.5    Galloway, D.A.6
  • 39
    • 0030756473 scopus 로고    scopus 로고
    • The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21 Cip1-mediated inhibition of cdk2
    • Jones DL, Alani RM, Munger K. The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21 Cip1-mediated inhibition of cdk2. Genes Dev 1997;11:2101-11.
    • (1997) Genes Dev , vol.11 , pp. 2101-2111
    • Jones, D.L.1    Alani, R.M.2    Munger, K.3
  • 40
    • 0028169236 scopus 로고
    • p21-containing cyclin kinases exist in both active and inactive states
    • Zhang H, Hannon GJ. Beach D. p21-containing cyclin kinases exist in both active and inactive states. Genes Dev 1994;8:1750-8.
    • (1994) Genes Dev , vol.8 , pp. 1750-1758
    • Zhang, H.1    Hannon, G.J.2    Beach, D.3
  • 41
    • 0027265041 scopus 로고
    • Detection of cutaneous and genital HPV types in clinical samples by PCR using consensus primers
    • Tieben LM, ter Schegget J, Minnaar RP, et al. Detection of cutaneous and genital HPV types in clinical samples by PCR using consensus primers. J Virol Methods 1993;42:265-79.
    • (1993) J Virol Methods , vol.42 , pp. 265-279
    • Tieben, L.M.1    Ter Schegget, J.2    Minnaar, R.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.