Clinical significance of epithelial peptide antibiotics

BioDrugs

Volumn 11, Issue 5, 1999, Pages 293-300

  Schröder, Jens Michael ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DEFENSIN; MAGAININ DERIVATIVE; PEXIGANAN ACETATE; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG;

CATTLE; CHANNEL GATING; CLINICAL PHARMACOLOGY; DRUG EFFECT; EPITHELIUM CELL; FROG; HUMAN; IMMUNITY; INFECTION RESISTANCE; INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; REVIEW; SKIN EPITHELIUM;

EID: 0032930228     PISSN: 11738804     EISSN: None     Source Type: Journal    
DOI: 10.2165/00063030-199911050-00001     Document Type: Review

References (27)

1. Brockaert WF, Cammue BPA, De Bolle MFC, et al. Antimicrobial peptides from plants. Crit Rev Plant Sci 1997; 16: 297-323
2. Hoffmann JA, Reichhart JM, Hetru C. Iunate immunity in higher insects. Curr Opin Immunol 1996; 8: 8-13
3. Ferrandon D, Jung AC, Criqui M, et al. A drosomycin-GFP reporter transgene reveals a local immune response in Drosophila that is not dependent on the Toll pathway. EMBO J 1998; 17: 1217-27
4. Zasloff M. Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. Proc Natl Acad Sci U S A 1987; 84: 5449-53
5. Barra D, Simmaco M. Amphibian skin: a promising resource for antimicrobial peptides. Trends Biotechnol 1995; 13: 205-9
6. Schonwetter BS, Stolzenberg ED, Zasloff MA. Epithelial antibiotics induced at sites of inflammation. Science 1995; 267: 1645-8
7. Diamond G, Zasloff M, Eck H, et al. Tracheal antimicrobial peptide, a cystein-rich peptide from mammalian tracheal mucosa: peptide isolation and cloning of a cDNA. Proc Natl Acad Sci U S A 1991; 88: 3952-6
8. Russell JP, Diamond G, Tarver AP, et al. Coordinate induction of two antibiotic genes in tracheal epithelial cells exposed to the inflammatory mediators lipopolysaccharide and tumor necrosis factor alpha. Infect Immun 1996; 64: 1565-8
9. Stolzenberg ED, Anderson GM, Ackermann MR, et al. Epithelial antibiotic induced in states of disease. Proc Natl Acad Sci U S A 1997; 94: 8686-90
10. Tarver AP, Clark DP, Diamond G, et al. Enteric beta-defensin: molecular cloning and characterization of a gene with inducible intestinal epithelial cell expression associated with Cryptosporidium parvum infection. Infect Immun 1998; 66: 1045-56
11. Fleming A. On a remarkable bacteriolytic element found in tissues and secretions. Proc R Soc London 1922; 93: 306-17
12. Selsted ME, Ouellette AJ. Defensins in granules of phagocytic and non-phagocytic cells. Trends Cell Biol 1995; 5: 114-9
13. Martin E, Ganz T, Lehrer RI. Defensins and other endogenous peptide antibiotics of vertebrates. J Leukocyte Biol 1995; 58: 128-36
14. Ouellette AJ. Paneth cells and innate immunity in the crypt microenvironment. Gastroenterology 1997; 113: 1779-84
15. Harder J, Bartels J, Christophers E, et al. A peptide antibiotic from human skin. Nature 1997; 387: 861
16. Valore EV, Park CH, Quayle AJ, et al. Human β-defensin-1: an antimicrobial peptide of urogenital tissues. J Clin Invest 1998; 101: 1633-42
17. PK Singh, Jia HP, Wiles, K, et al. Production of b -defesins by human airway epithelia. Proc natl Acad U S A 1998; 95: 1461-6
18. Schröder J-M. Epithelial peptide antibiotics. Biochem Pharmacol 1999; 57: 121-34
19. Harder J, Siebert R, Zhang Y, et al. Mapping of the gene encoding human β-defensin-2 (DEFB2) to chromosome region 8p22-p23.1. Genomics 1997; 46: 472-5
20. Lemaitre B, Reichhart JM, Hoffmann JA. Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms. Proc Natl Acad Sci USA 1997; 94: 14614-9
21. Fujii G, Selsted ME, Eisenberg D. Defensin promote fusion and lysis of negatively charged membranes. Protein Sci 1993; 2: 1301-12
22. Smith JJ, Travis SM, Greenberg EP, et al. Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid. Cell 1996; 85: 229-36
23. Hancock RE. Peptide antibiotics. Lancet 1997; 349: 418-22
24. Lamb HM, Wiseman LR. Pexiganan acetate. Drugs 1998 Dec; 56 (6): 1047-52
25. Nos-Barbera S, Portoles M, Mortilla A, et al. Effect of hybrid peptides of cecropin A and melittia in an experimental model of bacterial keratitis. Cornea 1997; 16: 101-6
26. Hancock REW, Lehrer R. Cationic peptides: a new source of antibiotics. Trends Biotechnol 1998; 16: 82-8
27. Guo L, Lim KB, Poduje CM, et al. Lipid A acylation and bacterial resistance against vertebrate antimicrobial peptides. Cell 1998; 95: 189-98