Homocyst(e)ine and heart disease: Pathophysiology of extracellular matrix

Clinical and Experimental Hypertension

Volumn 21, Issue 3, 1999, Pages 181-198

  Tyagi, Suresh C ^a  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

Cardiovascular disease; Collagen; Elastin; Extracellular matrix remodeling; Fibrosis; Heart failure; Hypertension; Matrix metalloproteinase; Redox receptor; Smooth muscle; Tissue inhibitor of metalloproteinase; Vascular tone; Vasoconstriction

Indexed keywords

HOMOCYSTEIC ACID;

ATHEROMA; ATHEROSCLEROSIS; BLOOD VESSEL COMPLIANCE; BLOOD VESSEL TONE; CORONARY RISK; DISEASE ASSOCIATION; FIBROSIS; HUMAN; HYPERHOMOCYSTEINEMIA; ISCHEMIC HEART DISEASE; REVIEW; RISK ASSESSMENT; RISK FACTOR;

EID: 0032928601     PISSN: 10641963     EISSN: None     Source Type: Journal    
DOI: 10.3109/10641969909068660     Document Type: Review

References (52)

1. McCully, K. S. Homocysteine and Vascular Disease. Nature Med. 1996; 2: 386-389.
2. Wilcken, D. E., Reddy, S. G., Gupta, V. J. Homocysteinemia, Ischemic Heart Disease and the Carrier State for Homocystinuria. Metabolism: Clinical & Experimental. 1983; 32: 363-370.
3. Genest, J. J. Jr., McNamara, J. R., Upson, B., Salem, D. N., Ordovas, J. M., Schaefer, E. J., Malinow, M. R. Prevalence of Familial Hyperhomocyst(e)inemia in Men With Premature Coronary Artery Disease. Arterioscler Thromb. 1991; 11: 1129-1136.
4. Harker, L. A., Ross, R., Slichter, S. J., Scott, C. R. Homocystine-induced Arteriosclerosis: The Role of Endothelial Cell Injury and Platelet Response in its Genesis. J Clin Invest. 1976; 58: 731-741.
5. Tsai, J.-C., Perrella, M. A., Yoshizumi, M., Hsieh, C.-M., Harber, E., Schlegel, R., Lee, M.-E. Promotion of Vascular Smooth Muscle Cell Growth by Homocysteine: A Link to Atherosclerosis. Proc Natl Acad Sci (USA). 1994; 91: 6369-6373.
6. Boers, G. H. J., Smals, A. G. H., Trijbels, F. J. M., Bakkeren, J. A. J. M., Schoonderwalt, H. C., Kloppenborg, P. W. C. Heterozygosity for Homocystinuria in Premature Peripheral and Cerebral Occlusive Arterial Disease. N Eng J Med. 1985; 313: 709-715.
7. Brattstrom, L. E., Hardebo, J. E., Hultberg, B. L. Moderate Homocysteinemia-a Possible Risk Factor for Arteriosclerotic Cerebrovascular Disease. Stroke. 1984; 15: 1012-1016.
8. Clarke, R., Daly, L., Robinson, K., Naughten, E., Cahalane, S., Fowler, B., Graham, I. Hyperhomocysteinemia: An Independent Risk Factor for Vascular Disease, N Eng J Med. 1991; 324: 1149-1155.
9. Coull, B. M., Malinow, M. R., Beamer, N., Sexton, G., Nordt, F., DeGarmo, P. Elevated Plasma Homocyst(e)ine Concentration as a Possible Independent Risk Factor for Stroke. Stroke. 1990; 21: 572-576.
10. Jalil, J. E., Doering, C. W., Janicki, J. S., Pick, R., Shroff, S. G., Weber, K. T. Fibrillar Collagen and Myocardial Stiffness in Intact Hypertrophied Rat LV. Circ Res. 1989; 64: 1041-1050.
11. Weber, K. T., Sun, Y., Tyagi, S. C., Cleutjens, J. Collagen Network of the Myocardium: Functional, Structural Remodeling and Regulatory Mechanisms. J Mol Cell Cardiol. 1994; 26: 279-292.
12. Tyagi, S. C., Meyer, L., Schmaltz, R. A., Reddy, H. K., Voelker, D. J. Proteinases and Restenosis in Human Coronary Artery: Extracellular Matrix Production Exceeds the Expression of Proteolytic Activity. Atherosclerosis. 1995; 116: 43-57.
13. Tyagi, S. C., Kumar, S. K., Parker, J. L. Regulation of Extracellular Matrix Components and Vascular Tone by Homocystine and Oxidative Mixed-Disulfide in Human Atherosclerotic Lesions. Circulation. 1996; 94:8, I-708.
14. Tyagi, S. C., Smiley, L. M., Mujumdar, V. S., Clonts, B., Parker, J. L. Reduction-Oxidation (Redox) and Vascular Tissue Level of Homocysteine in Human Coronary Atherosclerotic Lesions and Role in Extracellular Matrix Remodeling and Vascular Tone. Mol Cell Biochem. 1998; 181: 107-116.
15. Tyagi, S. C., Meyer, L., Schmaltz, R. A., Reddy, H. K., Voelker, D. J. Proteinases and Restenosis: Matrix Metalloproteinase and Their Inhibitor and Activator, in Cardiovascular Disease II: Cellular and molecular mechanisms, prevention, treatment (Gallo LL, editor), Plenum Publishing Corp, NY. 1995; 19-31.
16. Tyagi, S. C., Meyer, L., Kumar, S. G., Schmaltz, R. A., Reddy, H. K., Voelker, D. J. Induction of Tissue Inhibitor of Metalloproteinase and its Mitogenic Response to Endothelial Cells in Human Atherosclerotic and Restenotic Lesions. Can J Cardiol. 1996; 12: 353-362.
17. Johnson, D. E., Hinohara, T., Selmon, M. R., Braden, L. J., Simpson, J. B. Primary Peripheral Arterial Stenoses and Restenosis Excised by Transluminal Atherectomy: A Histopathologic Study. J Am Coll Cardiol. 1990; 15: 419-425.
18. Forrester, J. S., Fishbein, M., Helfant, R., Fagin, J. A Paradigm for Restenosis Based on Cell Biology: Clues for the Development of New Preventive Therapies. J Am Coll Cardiol. 1991; 17: 758-769.
19. Tyagi, S. C., Kumar, S. G., Banks, J., Fortson, W. Co-expression of Tissue Inhibitor and Matrix Metalloproteinase in Myocardium. J Mol Cell Cardiol. 1995; 27: 2177-2189.
20. Tyagi, S. C., Kumar, S., Katwa, L. Differential Regulation of Extracellular Matrix Metalloproteinase and Tissue Inhibitor by Heparin and Cholesterol in Fibroblast Cells. J Mol Cell Cardiol. 1997; 29: 391-404.
21. Pennington, J. A. T. Bowes and Church's "Food Values of Portions Commonly Used" 16th Edition, JB Lippincott Co, Philadelphia, PA. 1994; 325-377.
22. Woods, D. D., Foster, M. A., Guest, J. R. Cobalamin-Dependent and -Independent Methyl Transfer in Methionine Biosynthesis. in Transmethylation and Methionine Biosynthesis, Chicago and London (eds. Shapiro, S. K., Schlenk, F.) The University of Chicago Press, Chicago, IL. 1965. 138-156.
23. Borek, E., Srinivasan, P. R. Alteration of the Macromolecular Structure of Nucleic Acids by Transmethylation. in Transmethylation and Methionine Biosynthesis, Chicago and London (eds. Shapiro, S. K., Schlenk, F.) The University of Chicago Press, Chicago, IL. 1965. 115-137.
24. Bachmann, J., Tepel, M., Raidt, H., Riezler, R., Graefe, U., Langer, K., Zidek, W. Hyperhomocysteinemia and the Risk for Vascular Disease in Hemodialysis. J Am Soc Nephrol. 1995; 6: 121-125.
25. Malinow, M. R., Kang, S. S., Taylor, L. M., Wong, P. W. K., Coull, B., Inahara, T., Mukerkee, D., Sexton, G., Upson, B. Prevalence of hyperhomocyst(e)inemia in patients with peripheral arterial occlusive disease. Circulation. 1989; 79: 1180-1188.
26. Mathias, D., Becker, C. H., Riezler, R., Kindling, P. H. Homocysteine Induced Atherosclerosis-like Alterations of Aorta in Normotensive and Hypertensive Rats Following Application of High Doses of Methionine. Atherosclerosis. 1996; 122: 201-216.
27. Alfthan, G., Pekkanen, J., Jauhainen, M., Pitkaniemi, J., Karvonen, M., Tuomileto, J., Salonen, J. T., Enholm, C. Relation of Serum Homocysteine and Lipoprotein(a) Concentrations to Atherosclerotic Disease in a Prospective Finnish Population Based Study. Atherosclerosis. 1994; 106: 9-18.
28. Harker, L. A., Harlan, J. M., Ross, R. Effect of Sulfinpyrazone on Homocysteine-Induced Endothelial Injury and Arteriosclerosis in Baboons. Cir Res. 1983; 53: 731-739.
29. Ridker, P. M., Hennekens, C. H., Toitman-Johnson, B., Stampfer, M. J., Allen, J. Plasma Concentration of Soluble Intercellular Adhesion Molecule-1 and Risks of Future Myocardial Infarction in Apparently Healthy Men. Lancet. 1998; 351: 88-92.
30. Caulfield, J. B., Wolkowicz, P. E. Myocardial Connective Tissue Alterations. Toxicologic Pathology. 1990; 18: 488-496.
31. Stemerman, M. B., Ross, R. Experimental Arteriosclerosis. I Fibrous Plaque Formation in Primates, and Electron Microscopic Study. J Exp Med. 1972; 136: 769-789.
32. Hardin, N. J., Minick, C. R., Murphy, G. E. Experimental Induction of Athero-Arteriosclerosis by the Synergy of Allergic Injury to Arteries and Lipid-Rich Diet. III. The Role of Earlier Acquired Fibromuscular Intimal Thickening in the Pathogenesis of Later Developing Atherosclerosis. Am J Pathol. 1973; 73: 301-325.
33. Harker, L. A., Ross, R., Slichter, S. J., Scott, C. R. Homocystine-Induced Arteriosclerosis: the Role of Endothelial Cell Injury and Platelet Response in its Genesis. J Clin Invest. 1976; 58: 731-741.
34. Tyagi, S. C., Kumar, S. G., Borders, S. Reduction-Oxidation (Redox) State Regulation of Extracellular Matrix Metalloproteinases and Tissue Inhibitors in Cardiac Normal and Transformed Fibroblast Cells. J Cell Biochem. 1996; 61: 139-151.
35. Lee, A. M. E. Lipoprotein Patterns, Plaque, Homocysteine, and Hormones Among Ongoing Cardiology Studies. J Am Med Assoc. 1996; 276: 1122-1128.
36. Rolland, P. H., Friggi, A., Barlatier, A., Piquet, P., Latrille, V., Faye, M. M., Guillou, J., Charpiot, P, Bodard, H., Ghikinghelli, O. Hyperhomocysteinemia-Induced Vascular Damage in the Minipigs. Circulation. 1995; 91: 1161-1174.
37. Majino, G., Joris, I. Apoptosis, Oncosis and Necrosis: an Overview of Cell Death. Am J Pathol. 1995; 146: 3-15.
38. Berliner, J. A., Navab, M., Fogelman, A. M., Frank, J. S., Demer, L. L., Edwards, P. A., Watson, A. D., Lusis, A. J. Atherosclerosis: Basic Mechanisms Oxidation, Inflammation, and Genetics. Circulation. 1995; 91: 2488-2496.
39. Parthasarathy, S., Young, S. G., Witztum, J. L., Pittman, R. C., Steinberg, D. Probucol Inhibits Oxidative Modification of LDL. J Clin Invest. 1986; 77: 641-644.
40. Tyagi, S. C., Simon, S. R. Regulation of neutrophil elastase activity by elastin-derived peptide. J Biol Chem. 1993; 268: 16513-16518.
41. Hultberg, B., Andersson, A., Isaksson, A. Metabolism of Homocysteine, its Relation to the Other Cellular Thiols and its Mechanism of Cell Damage in a Cell Culture Line (Human Histiocytic Cell Line U-937). Biochim Biophys Acta. 1995; 1269: 6-12.
42. Dudman, N. P., Kicks, C., Wang, J., Wilcken, D. E. Human Arterial Endothelial Cell Detachment in Vitro: its Promotion by Homocysteine and Cysteine. Arteriosclerosis. 1991; 91: 77-83.
43. Gordon, P. B., Levitt, M. A., Jenkins, C. S., Hatcher, V. B. The Effect of the Extracellular Matrix on the Detachment of Human Endothelial Cells. J Cell Physiol. 1984; 121: 467-475.
44. Wang, H., Yoshizumi, M., Lai, K., Tsai, J.-C., Perrella, M. A., Haber, E., Lee, M.-E. Inhibition of Growth and p21ras Methylation in Vascular Endothelial Cells by Homocysteine but not Cysteine. J Biol Chem. 1997; 272: 25380-25385.
45. Tyagi, S. C. Homocysteine Reduction-Oxidation (Redox)-Receptor and Regulation of Extracellular Matrix Components in Human Vascular Smooth Muscle Cells. FASEB J. 1997; 11:3, A288.
46. Tyagi, S. C. Homocysteine Redox Receptor and Regulation of Extracellular Matrix in Vascular Cells. Am J Physiol. 1998; 274: C396-C405.
47. Nishinaga, M., Ozawa, T., Shimada, K. Homocysteine, a Thrombogenic Agent, Suppresses Anticoagulant Heparin Sulfate Expression in Cultured Porcine Aortic Endothelial Cells. J Clin Invest. 1993; 92: 1381-1386.
48. Hodgkin, D. D., Gilbert, R. D., Roos, P. J., Sandberg, L. B., Boucek, R. J. Dietary Lipid Modulation of Connective Tissue Matrix in Rat Abdominal Aorta. Am J Physiol. 1992; 262: R389-R394.
49. Stamler, J. S., Osborne, J. A., Jaraki, O., Rabbani, L. E., Mullins, M., Singel, D., Loscalzo, J. Adverse Vascular Effects of Homocystine are Modulated by Endothelial-Derived Relaxing Factor and Related Oxides of Nitrogen. J Clin Invest. 1993; 91: 308-318.
50. Kiowski, W., Sutch, G., Hunziker, P., Kim, J., Oechslin, E., Schmott, R., Jones, R., Bertel, O. Evidence for ET-1 Mediated Vasoconstriction in Severe Chronic Heart Failure. Lancet. 1995; 346: 732-736.
51. Lentz, S. R., Sobey C. G., Piegors D. J., Bhopatkar M. Y., Faraci, F. M., Malinow, M. R., Heistad, D. D. Vascular Dysfunction in Monkeys with Diet-Induced Hyperhomocysteinemia. J Clin Invest. 1996; 98: 24-29.
52. Demer, L. L., Watson, K. E., Bostrom, K. Mechanism of Calcification in Atherosclerosis. Trends Cardiovasc Med. 1994; 4: 45-49.