Inhibition of hSP-B promoter in respiratory epithelial cells by a dominant negative retinoic acid receptor

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 276, Issue 3 20-3, 1999, Pages

  Ghaffari, Manely ^a   Whitsett, Jeffrey A ^a   Yan, Cong ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Human surfactant protein B; Lung development; Nuclear receptors

Indexed keywords

MUTANT PROTEIN; RETINOIC ACID RECEPTOR; RETINOID X RECEPTOR; SURFACTANT PROTEIN B; ZINC FINGER PROTEIN;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DIMERIZATION; DNA BINDING; ELECTROPHORETIC MOBILITY; FETUS; GENE EXPRESSION REGULATION; GENE MUTATION; GENE REPRESSION; GENE SEQUENCE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYDROPHOBICITY; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LUNG DEVELOPMENT; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN INDUCTION; PROTEIN PROCESSING; RECEPTOR INTRINSIC ACTIVITY; RESPIRATORY EPITHELIUM; TRANSACTIVATION; TRANSCRIPTION REGULATION;

EID: 0032926213     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.1999.276.3.l398     Document Type: Article

References (48)

1. Ballard, P. L., R. Ertsey, L. W. Gonzales, and J. Gonzales. Transcriptional regulation of human pulmonary surfactant proteins SP-B and SP-C by glucocorticoids. Am. J. Respir. Cell Mol. Biol. 14: 599-607, 1996.
2. Beers, M. F., H. Shuman, H. G. Liley, J. Floros, L. W. Gonzales, N. Yue, and P. L. Ballard. Surfactant protein B in human fetal lung: developmental and glucocorticoid regulation. Pediatr. Res. 38: 668-675, 1995.
3. Bogue, C. W., H. C. Jacobs, D. W. Dynia, C. M. Wilson, and I. Gross. Retinoic acid increases surfactant protein mRNA in fetal rat lung in culture. Am. J. Physiol. 271 (Lung Cell. Mol. Physiol. 15): L862-L868, 1996.
4. Bohinski, R., R. Di Lauro, and J. A. Whitsett. The lung-specific surfactant protein B gene promoter is a target for thyroid transcription factor 1 and hepatocyte nuclear factor 3, indicating common factors for organ-specific gene expression along the foregut axis. Mol. Cell. Biol. 14: 5671-5681, 1994.
5. Bourguet, W., M. Ruff, P. Chambon, H. Cronemeyer, and D. Moras. Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha. Nature 375: 377-382, 1995.
6. Cardoso, W. V., M. C. Williams, S. A. Mitsialis, M. Joyce-Brady, A. K. Rishi, and J. J. Brady. Retinoic acid induces changes in the pattern of airway branching and alters epithelial cell differentiation in the developing lung in vivo. Am. J. Respir. Cell Mol. Biol. 12: 464-467, 1995.
7. Chen, H. W., R. J. Lin, R. L. Schiltz, D. Chakravarti, A. Nash, L. Nagy, M. L. Privalsky, Y. Nakatani, and R. M. Evans. Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. Cell 90: 569-580, 1997.
8. Clark, J. C., S. E. Wert, C. J. Bachurski, M. T. Stahlman, B. R. Stripp, T. E. Weaver, and J. A. Whitsett. Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice. Proc. Natl. Acad. Sci. USA 92: 7794-7798, 1995.
9. Damm, K., R. A. Heyman, K. Umesono, and R. M. Evans. Functional inhibition of retinoic acid response by dominant negative retinoic acid receptor mutants. Proc. Natl. Acad. Sci. USA 90: 2989-2993, 1993.
10. Dolle, P., E. Ruberte, P. Leroy, G. Morriss-Kay, and P. Chambon. Retinoic acid receptors and cellular retinoid binding proteins I. A systematic study of their differential pattern of transcription during mouse organogenesis. Development 110: 1133-1151, 1990.
11. Durand, B., M. Saunders, C. Gaudon, B. Roy, R. Losson, and P. Chambon. Activation function 2 (AF-2) of retinoic acid receptor and 9-cis retinoic acid receptor: presence of a conserved autonomous constitutive activating domain and influence of the nature of the response element on AF-2 activity. EMBO J. 13: 5370-5382, 1994.
12. George, T. N., O. L. Miakotina, K. L. Goss, and J. M. Snyder. Mechanism of all trans-retinoic acid and glucocorticoid regulation of surfactant protein mRNA. Am. J. Physiol. 274 (Lung Cell. Mol. Physiol. 18): L560-L566, 1998.
13. George, T. N., and J. M. Snyder. Regulation of surfactant protein gene expression by retinoic acid metabolites. Pediatr. Res. 41: 693-701, 1997.
14. Ghaffari, M., X. Zeng, J. A. Whitsett, and C. Yan. Nuclear localization domain of thyroid transcription factor-1 in respiratory epithelial cells. Biochem. J. 328: 757-761, 1997.
15. Hong, H., K. Kohli, A. Trivedi, D. L. Johnson, and M. R. Stallcup. GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors. Proc. Natl. Acad. Sci. USA 93: 4948-4952, 1996.
16. Hui, L., P. J. Gomes, and J. D. Chen. RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2. Proc. Natl. Acad. Sci. USA 94: 8479-8484, 1997.
17. Imakado, S., J. R. Bickenbach, D. S. Bundman, J. A. Rothnagel, P. S. Attar, X. J. Wang, V. R. Walczak, S. Wisniewski, J. Pote, J. S. Gordon, R. A. Heyman, R. M. Evans, and D. R. Roop. Targeting expression of a dominant-negative retinoic acid receptor mutant in the epidermis of transgenic mice results in loss of barrier function. Genes Dev. 9: 317-329, 1995.
18. Kamei, Y., L. Xu, T. Heinzel, J. Torchia, R. Kurokawa, B. Gloss, S. C. Lin, R. A. Heyman, D. W. Rose, C. K. Glass, and M. G. Rosenfeld. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell 85: 403-414, 1996.
19. Kastner, P., M. Mark, and P. Chambon. Nonsteroid nuclear receptors: what are genetic studies telling us about their role in real life? Cell 83: 859-869, 1995.
20. Kumar, A. S., V. C. Venkatesh, B. C. Planer, S. I. Feinstein, and P. L. Ballard. Phorbol ester down-regulation of lung surfactant protein B gene expression by cytoplasmic trapping of thyroid transcription factor-1 and hepatocyte nuclear factor 3. J. Biol. Chem. 272: 20764-20773, 1997.
21. Mangelsdorf, D. J., and R. M. Evans. The RXR heterodimers and orphan receptors. Cell 83: 841-850, 1995.
22. Mangelsdorf, D. J., C. Thummel, M. Beato, P. Herrlich, G. Schutz, K. Umesono, B. Blumberg, P. Kastner, M. Mark, P. Chambon, and R. M. Evans. The nuclear receptor superfamily: the second decade. Cell 83: 835-839, 1995.
23. Massaro, G. D., and D. Massaro. Postnatal treatment with retinoic acid increases the number of pulmonary alveoli in rats. Am. J. Physiol. 270 (Lung Cell. Mol. Physiol. 14): L305-L310, 1996.
24. Massaro, G. D., and D. Massaro. Retinoic acid treatment abrogates elastase-induced pulmonary emphysema in rats. Nat. Med. 3: 675-677, 1997.
25. Masuyama, H., Y. Hiramatsu., and T. Kudo. Effect of retinoids on fetal lung development in the rat. Biol. Neonate 67: 264-273, 1995.
26. Mendelsohn, C., D. Lohnes, D. Decimo, T. Lufkin, M. LeMeur, and P. Chambon. Function of the retinoic acid receptors (RARs) during development (II). Multiple abnormalities at various stages of organogenesis in RAR double mutants. Development 120: 2749-2771, 1994.
27. II135 potentiates transcriptional activation by the AF-2s of the retinoic acid, vitamin D3, and thyroid hormone receptors in mammalian cells. Genes Dev. 11: 1381-1395, 1997.
28. Metzler, M., and J. M. Snyder. Retinoic acid differentially regulates expression of surfactant-associated proteins in human fetal lung. Endocrinology 133: 1990-1998, 1993.
29. Nogee, L. M., D. E. DeMello, L. P. Dehner, and H. R. Colten. Brief report: deficiency of pulmonary surfactant protein B in congenital alveolar proteinosis. N. Engl. J. Med. 328: 406-410, 1993.
30. Nogee, L. M., G. Garnier, H. C. Dietz, L. Singer, A. M. Murphy, D. E. DeMello, and H. R. Colter. A mutation in the surfactant protein B gene responsible for fatal neonatal respiratory disease in multiple kindreds. J. Clin. Invest. 93: 1860-1863, 1994.
31. Onate, S. A., S. Y. Tsai, M. J. Tsai, and B. W. O'Malley. Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. Science 270: 1354-1357, 1995.
32. O'Reilly, M. A., J. C. Clark, and J. A. Whitsett. Glucocorticoids enhance pulmonary surfactant protein B gene transcription. Am. J. Physiol. 260 (Lung Cell. Mol. Physiol. 4): L37-L43, 1991.
33. Pryhuber, G. S., S. L. Church, T. Kroft, A. Panchal, and J. A. Whitsett. 3′-Untranslated region of SP-B mRNA mediates inhibitory effects of TPA and TNF-α on SP-B expression. Am. J. Physiol. 267 (Lung Cell. Mol. Physiol. 11): L16-L24, 1994.
34. Pryhuber, G. S., M. A. O'Reilly, J. C. Clark, W. M. Hull, I. Fink, and J. A. Whitsett. Phorbol ester inhibits surfactant protein SP-A and SP-B expression. J. Biol. Chem. 265: 20822-20828, 1990.
35. Salbert, G., A. Fanjul, F. J. Piedrafita, X. P. Lu, S. J. Kim, P. Tran, and M. Pfahl. Retinoic acid receptors and retinoid X receptor a regulate the transforming growth factor-Β1 promoter by antagonizing AP-1 activity. Mol. Endocrinol. 10: 1347-1356, 1993.
36. Shenai, J. P., F. Chytil, A. Jhaveri, and M. T. Stahlman. Plasma vitamin A and retinol-binding protein in premature and term neonates. J. Pediatr. 99: 302-305, 1981.
37. Shenai, J. P., F. Chytil, and M. T. Stahlman. Vitamin A status of neonates with bronchopulmonary dysplasia. Pediatr. Rev. 19: 185-188, 1985.
38. Shenai, J. P., K. A. Kennedy, F. Chytil, and M. T. Stahlman. Clinical trial of vitamin A supplementation in infants susceptible to bronchopulmonary dysplasia. J. Pediatr. 111: 269-277, 1987.
39. Torchia, J., D. W. Rose, J. Inostroza, Y. Kamei, S. Westin, C. K. Glass, and M. G. Rosenfeld. The transcriptional coactivator p/CIP binds CBP and mediates nuclear-receptor function. Nature 387: 677-684, 1997.
40. Venkatesh, V. C., D. M. Iannuzzi, R. Ertsey, and P. L. Ballard. Differential glucocorticoid regulation of the pulmonary hydrophobic surfactant proteins SP-B and SP-C. Am. J. Respir. Cell Mol. Biol. 8: 222-228, 1993.
41. Venkatesh, V. C., B. C. Planer, M. Schwartz, J. N. Vanderbilt, R. T. White, and P. L. Ballard. Characterization of the promoter of human pulmonary surfactant protein B gene. Am. J. Physiol. 268 (Lung Cell. Mol. Physiol. 12): L674-L682, 1995.
42. Voegel, J. J., M. J. S. Heine, C. Zechel, P. Chambon, and H. Gronemeyer. TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors. EMBO J. 15: 3667-3675, 1996.
43. Whitsett, J. A., L. M. Nogee, T. E. Weaver, and A. D. Horowitz. Human surfactant protein B: structure, function, regulation and genetic disease. Physiol. Rev. 75: 749-757, 1995.
44. Wispe, J. R., J. C. Clark, B. B. Warner, D. Fajardo, W. E. Hull, R. B. Holtzman, and J. A. Whitsett. Tumor necrosis factor-alpha inhibits expression of pulmonary surfactant protein. J. Clin. Invest. 86: 1954-1960, 1990.
45. Yan, C., M. Ghaffari, J. A. Whitsett, X. Zeng, Z. Sever, and S. Lin. Retinoic acid receptor activation of SP-B gene transcription in respiratory epithelial cells. Am. J. Physiol. 275 (Lung Cell. Mol. Physiol. 19): L239-L246, 1998.
46. Yan, C., Z. Sever, and J. A. Whitsett. Upstream enhancer activity in the human surfactant protein B gene is mediated by thyroid transcription factor 1. J. Biol. Chem. 270: 24852-24857, 1995.
47. Yan, C., and I. Tamm. Molecular cloning and characterization of additional factors that bind to the interferon-α/Β response element B of the murine (2′-5′)oligoadenylate synthetase ME-12 gene. Proc. Natl. Acad. Sci. USA 89: 8859-8863, 1992.
48. Yan, C., and J. A. Whitsett. Protein kinase A activation of the surfactant protein B gene is mediated by phosphorylation of thyroid transcription factor 1. J. Biol. Chem. 272: 17327-17332, 1997.