The prothrombin G20210A mutation: A new high-prevalence congenital risk factor for thrombosis

Gastroenterology

Volumn 116, Issue 1, 1999, Pages 213-215

  Laposata, M ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C; BLOOD CLOTTING FACTOR 5 LEIDEN; CARDIOLIPIN ANTIBODY; HOMOCYSTEINE; LUPUS ANTICOAGULANT; PROTEIN C; PROTEIN S; PROTHROMBIN;

ACTIVATED PROTEIN C RESISTANCE; EDITORIAL; FAMILY HISTORY; GENE MUTATION; GENETIC DISORDER; HUMAN; HYPERCOAGULABILITY; PORTAL VEIN THROMBOSIS; PRIORITY JOURNAL; RISK FACTOR;

EID: 0032924386     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0016-5085(99)70247-7     Document Type: Editorial

References (7)

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2. EM Van Cott M. Laposata Laboratory evaluation of hypercoagulable states Hematol Oncol Clin North Am 12 1998 1141 1166
3. SR Poort FR Rosendaal PH Reitsma RM. Bertina A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis Blood 88 1996 3698 3703
4. TE Howard M Marusa J Boysza A Young A. Duncan The prothrombin gene 3'-untranslated region mutation shows ethnicity-specific variation in allele frequency and is frequently associated with factor V Leiden in thrombophilic patients (abstr) Am J Clin Pathol 109 1998 469
5. FR Rosendaal CJM Doggen A Zivelin VR Arruda M Aiach DS Siscovick A Hillarp HH Watzke F Bernardi AM Cumming FE Preston PH. Reitsma Geographic distribution of the 20210 G to A prothrombin variant Thromb Haemost 79 1998 706 708
6. I Martinelli H Sacchi G Landi E Taioli F Duca PM. Mannucci High risk of cerebral vein thrombosis in carriers of a prothrombin gene mutation and in users of oral contraceptives N Engl J Med 338 1998 1793 1797
7. V De Stefano P Chiusolo K Paciaroni I Casorelli E Rossi M Molinari S Servidei P Tonali G. Leone Prothrombin G20210A mutant genotype is a risk factor for cerebrovascular ischemic disease in young patients Blood 91 1998 3562 3565