Nickel enhances telomeric silencing in Saccharomyces cerevisiae

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 440, Issue 2, 1999, Pages 121-130

  Broday, Limor ^a   Cai, Jian ^a   Costa, Max ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Chromatin condensation; Gene position; Heavy metal; Inheritance

Indexed keywords

HEAVY METAL; NICKEL;

ANIMAL CELL; ARTICLE; CARCINOGENESIS; CHROMATIN CONDENSATION; CHROMOSOME 7; CONTROLLED STUDY; DROSOPHILA; GENE LOCATION; GENE SILENCING; INHERITANCE; MARKER GENE; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE; SACCHAROMYCES CEREVISIAE; SENESCENCE; YEAST;

CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION, FUNGAL; GENETIC MARKERS; MAGNESIUM; METALS; NICKEL; SACCHAROMYCES CEREVISIAE; TELOMERE; TIME FACTORS; TRANSCRIPTION, GENETIC;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS; SACCHAROMYCES CEREVISIAE;

EID: 0032923145     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(99)00018-2     Document Type: Article

References (44)

1. J. Spofford, Genetics and Biology of Drosophila 1c, Academic Press, London, 1976, pp. 955-1019.
2. Gottschling D.E., Aparicio O.M., Billington B.L., Zakian V.A. Position effect at S. cerevisiae telomeres: reversible repression of PolII transcription. Cell. 63:1990;751-762.
3. Aparicio O.M., Billington B.L., Gottschling D.E. Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae. Cell. 66:1991;1279-1287.
4. Hecht A., Laroche T., Strahl-Bolsinger S., Gasser S.M., Grunstein M. Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: a molecular model for the formation of heterochromatin in yeast. Cell. 80:1995;583-592.
5. Paro R. Mechanisms of heritable gene repression during development of Drosophila. Curr. Opin. Cell. Biol. 5:1993;999-1005.
6. Laurenson P., Rine J. Silencers, silencing, and heritable transcriptional states. Microbiol. Rev. 56:1992;543-560.
7. Migeon B. X-chromosome inactivation: molecular mechanisms and genetic consequences. Trends Genet. 10:1994;230-235.
8. Solter D. Differential imprinting and expression of maternal and paternal genomes. Annu. Rev. Genet. 22:1988;127-146.
9. Grunstein M. Molecular model for telomeric heterochromatin in yeast. Curr. Opin. Cell. Biol. 9:1997;383-387.
10. Grunstein M. Yeast heterochromatin: regulation of its assembly and inheritance by histones. Cell. 93:1998;325-328.
11. Ekwall K., Olsson T., Turner B.M., Cranston G., Allshire R.C. Transient inhibition of histone deacetylation alters the structural and functional imprint at fission yeast centromeres. Cell. 91:1997;1021-1032.
12. IARC Monographs on the Evaluation of Carcinogenic Risk to Humans: Chromium, Nickel and Welding, Vol. 49, Lyon, France, 1990.
13. Klein C.B., Conway K., Wang X.W., Bhamra R.K., Lin X., Cohen M.D., Annab L., Barrett J.C., Costa M. Senescence of nickel-transformed cells by an X chromosome: possible epigenetic control. Science. 251:1991;796-799.
14. Lee Y.W., Klein C.B., Kargacin B., Salnikow K., Kitahara J., Dowjat K., Zhitkovich A., Christie N.T., Costa M. Carcinogenic nickel silences gene expression by chromatin condensation and DNA methylation: a new model for epigenetic carcinogens. Mol. Cell. Biol. 15:1995;2255-2547.
15. Renauld H., Aparicio O.M., Zierath P.D., Billington B.I., Chhablani S.K., Gottschling D.E. Silent domains are assembled continuously from the telomere and are defined by promoter distance and strength, and by SIR3 dosage. Genes Dev. 7:1993;1133-1145.
16. Boeke J.D., Trueheart J., Natsoulis G., Fink G.R. 5-Fluoroorotic acid as a selective agent in yeast molecular genetics. Meth. Enzymol. 154:1987;164-175.
17. Aparicio O.M., Gottschling D.E. Overcoming telomeric silencing: a trans-activator competes to establish gene expression in a cell cycle-dependent way. Genes Dev. 8:1994;1133-1146.
18. Fuhrmann G., Rhothstein A. The transport of Zn, Co and Ni into yeast cells. Biochim. Biophys. Acta. 163:1968;325-330.
19. I.S. Ross, Membrane transport processes and response to exposure to heavy metals, in: D.H. Jennings (Ed.), Stress Tolerance of Fungi, Marcel Dekker, New York, 1993, pp. 97-125.
20. Joho M., Inouhe M., Tohoyama H., Murayama T. Nickel resistance mechanisms in yeasts and other fungi. J. Indust. Microbiol. 14:1995;164-168.
21. Coogan T.P., Latta D.M., Snow E.T., Costa M. Toxicity and carcinogenicity of nickel compounds. Crit. Rev. Toxicol. 19:1989;341-384.
22. Costa M. Molecular mechanisms of nickel carcinogenesis. Annu. Rev. Pharmacol. Toxicol. 31:1991;321-337.
23. Loo S., Rine J. Silencing and heritable domains of gene expression. Annu. Rev. Cell. Biol. Dev. 11:1995;519-548.
24. Hecht A., Strahl-Bolsinger S., Grunstein M. Spreading of transcriptional repressor SIR3 from telomeric heterochromatin. Nature. 383:1996;92-96.
25. De Rubertis F., Kadosh D., Henchoz S., Pauli D., Reuter G., Struhl K., Spierer P. The histone deacetylase RPD3 counteracts genomic silencing in Drosophila and yeast. Nature. 384:1996;589-591.
26. Clarkson T.W. Molecular and ionic mimicry of toxic metals. Annu. Rev. Pharmacol. Toxicol. 32:1993;545-571.
27. Borochov N., Ausio J., Eisenberg H. Interaction and conformational changes of chromatin with divalent ions. Nucleic Acids Res. 12:1984;3089-3096.
28. Howe L., Iskandar M., Ausio J. Folding of chromatin in the presence of heterogeneous histone H1 binding to nucleosomes. J. Biol. Chem. 273:1998;11625-11629.
29. K.S. Kasprzak, Cytotoxic, mutagenic and carcinogenic potential of heavy metals related to human environment, in: N.D. Hadjiliadis (Ed.), Kluwer Academic Publishers, The Netherlands, 1997, pp. 93-106.
30. Ross I.S. Reduced uptake of nickel by a nickel resistant strain of Candida utilis. Microbios. 83:1995;261-270.
31. Robison S.H., Cantoni O., Costa M. Strand breakage and decreased molecular weight of DNA induced by specific metal compounds. Carcinogenesis. 3:1982;657-662.
32. Beyersmann D., Hartwig A. The genetic toxicology of cobalt. Toxicol. Appl. Pharmacol. 115:1992;137-145.
33. E. Nieboer, G.G. Fletcher, Determinants of reactivity in metal toxicology, in: L.W. Chang (Ed.), Toxicology of Metals, CRC Press, US, 1996, pp. 113-132.
34. Grunstein M. Histone acetylation in chromatin structure and transcription. Nature. 389:1997;349-352.
35. Gregory P.D., Horz W. Chromatin and transcription. Eur. J. Biochem. 251:1998;9-18.
36. Struhl K. Histone acetylation and transcriptional regulatory mechanisms. Genes Dev. 12:1998;599-606.
37. Perego P., Howell S.B. Molecular mechanisms controlling sensitivity to toxic metal ions in yeast. Toxicol. Appl. Pharmacol. 147:1997;312-318.
38. Buchman C., Skroch P., Welch J., Fogel S., Karin M. The CUP2 gene product, regulator of yeast metallothionein expression, is a copper-activated DNA-binding protein. Mol. Cell. Biol. 9:1989;4091-4095.
39. Welch J., Fogel S., Buchman C., Karin M. The CUP2 gene product regulates the expression of the CUP1 gene, coding for yeast metallothionein. EMBO J. 8:1989;255-260.
40. Huibregtse J.M., Engelke D.R., Thiele D.J. Copper-induced binding of cellular factors to yeast metallothionein upstream activation sequences. Proc. Natl. Acad. Sci. U.S.A. 86:1989;65-69.
41. Utley R.T., Ikeda K., Grant P.A., Cote J., Steger D.J., Eberharter A., John S., Workman J.L. Transcriptional activators direct histone acetyltransferase complexes to nucleosomes. Nature. 394:1998;498-502.
42. Leman H., Balderes D., Shore D. Disturbance of normal cell cycle progression enhances the establishment of transcriptional silencing in Saccharomyces cerevisiae. Mol. Cell. Biol. 15:1995;3608-3617.
43. Fox C.A., Rine J. Influence of the cell cycle on silencing. Curr. Opin. Cell. Biol. 8:1996;354-357.
44. Sherman J.M., Pillus L. An uncertain silence. Trends Genet. 13:1997;308-313.