Urokinase is a positive regulator of epidermal proliferation in vivo

Journal of Investigative Dermatology

Volumn 112, Issue 2, 1999, Pages 240-244

  Jensen, Pamela J ^a   Lavker, Robert M ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

UROKINASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; ENZYME ACTIVITY; ENZYME ASSAY; EPIDERMIS; GROWTH RATE; GROWTH REGULATION; KERATINIZATION; KERATINOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0032917127     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.1999.00494.x     Document Type: Article

References (32)

1. Ando Y, Jensen PJ: Protein kinase C mediates up-regulation of urokinase and its receptor in the migrating keratinocytes of wounded cultures, but urokinase is not required for movement across a substratum in vitro. J Cell Physiol 167:500- 511, 1996
2. Auber L: The anatomy of follicles producing wool-fibers, with special reference to keratinization. Trans Roy Soc Edin 62:191-254, 1950-1
3. Bugge TH, Kombrinck KW, Flick MJ, Daugherty CC, Danton MJS, Degen JL: Loss of fibrinogen rescues mice from the pleiotrophic effects of plasminogen deficiency. Cell 87:709-719, 1996
4. Carmeliet P, Collen D: Gene targeting and gene transfer studies of the biological role of the plaminogen/plasmin system. Thromb Haemo 74:429-436, 1995
5. Carmeliet P, Schoonjans L, Kieckens L, et al: Physiological consequences of loss of plasminogen activator gene function in mice. Nature 368:419-424, 1994
6. Cotsarelis G, Sun TT, Lavker RM: Label-retaining cells reside in the bulge of the pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis. Cell 61:1329-1337, 1990
7. Dano K, Andreasen PA, Grondal-Hansen J, Kristensen P, Nielsen LS, Skriver L: Plasminogen activators, tissue degradation and cancer. Adv Cancer Res 44:139- 266, 1985
8. Dear AE, Medcalf RL: The urokinase-type-plasminogen-activator receptor (CD87) is a pleiotropic molecule. Eur J Biochem 252:185-193, 1998
9. De Petro G, Copeta A, Barlati S: Urokinase-type and tissue-type plasminogen activators as growth factors of human fibroblasts. Exp Cell Res 213:286- 294, 1994
10. Eckert RL: Structure, function, and differentiation of the keratinocyte. Physiol Rev 69:1316-1246, 1989
11. Grøndahl-Hansen J, Lund LR, Ralfkiaer E, Ottevanger V, Danø K: Urokinase- and tissue-type plasminogen activators in keratinocytes during wound re- epithelialization In Vivo J Invest Dermatol 90:790-795, 1988
12. Jensen PJ, Lavker RM: Modulation of the plasminogen activator cascade during enhanced epidermal proliferation in vivo. Cell Growth Diff 7:1793-1804, 1996
13. Kamimura J, Lee D, Baden H, Brissette J, Dotto P: Primary mouse keratinocyte cultures contain hair follicle progenitor cells with multiple differentiation potential. J Invest Dermatol 109:534-540, 1997
14. Kan M, Zhang G, Zarnegar R, Michalopoulos G, Myoken Y, McKeehan WL, Stevens JI: Hepatocyte growth factor/hepatopoietin A stimulates the growth of rat kidney proximal tubule epithelial cells (RTPE), rat nonparenchymal liver cells, human melanoma cells, mouse keratinocytes, and stimulates anchorage- independent growth of SV-40 transformed RTPE. Biochem Biophys Res Commun 174:331-337, 1991
15. Kirchheimer JC, Wojta J, Christ G, Heinert G, Binder BR: Mitogenic effect of urokinase on malignant and unaffected adjacent human renal cells. Carcinogenesis 9:2121-2123, 1988
16. Kirchheimer JC, Christ G, Binder BR: Growth stimulation of human epidermal cells by urokinase is restricted to the intact active enzyme. Eur J Biochem 181:103-107, 1989
17. Konakova M, Hucho F, Schleuning W-D: Downstream targets of urokinase-type plasminogen-activator-mediated signal transduction. Eur J Biochem 253:421- 429, 1998
18. Kramer MD, Schaefer B, Reinartz J: Plasminogen activation by human keratinocytes: Molecular pathways and cell-biological consequences. Biol Chem Hoppe-Seyler 376:131-141, 1995
19. Lavker RM, Sun TT: Heterogeneity in epidermal basal cell keratinocytes: morphological and functional correlations. Science 215:1239-1241, 1982
20. Li M, Karakji EG, Xing R, Fryer JN, Carnegie JA, Rabbani SA, Tsang BK: Expression of urokinase-type plasminogen activator and its receptor during ovarian follicular development. Endocrinology 138:2790-2799, 1997
21. Mars WM, Kim T-H, Stolz DB, Lin M-L, Michalopoulos GK: Presence of urokinase in serum-free primary rat hepatocyte cultures and its role in activating hepatocyte growth factor. Can Res 56:2837-2843, 1996
22. Matsumoto K, Hashimoto K, Yoshikawa K, Nakamura T: Marked stimulation of growth and motility of human keratinocytes by hepatocyte growth factor. Exp Cell Res 196:114-120, 1991
23. Naldini L, Tamagnone L, Vigna E, et al: Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor. EMBO J 11:4825-4833, 1992
24. Plow EF, Herren T, Redlitz A, Miles LA, Hoover-Plow JL: The cell biology of the plasminogen system. FASEB J 9:939-945, 1995
25. Potten CS, Hendry JH: Clonogenic cells and stem cells in epidermis. Int J Radiat Biol 24:537-540, 1973
26. Reidy MA, Irvin C, Lindner V: Migration of arterial wall cells. Expression of plasminogen activators and inhibitors in injured rat arteries. Cir Res 78:405- 414, 1996
27. Rømer J, Lund LR, Eriksen J, et al: Differential expression of urokinase-type plasminogen activator and its type-1 inhibitor during healing of mouse skin wounds. J Invest Dermatol 97:803-811, 1991
28. Rømer J, Lund LR, Eriksen J, Pyke C, Kristensen P, Danø K: The receptor for urokinase-type plaminogen activator is expressed by keratinocytes at the leading edge during re-epithelialization of mouse skin wounds. J Invest Dermatol 102:519-522, 1994
29. Rømer J, Bugge TH, Pyke C, Lund LR, Flick MJ, Degen JL, Danø K: Impaired wound healing in mice with a disrupted plasminogen gene. Nature Med 2:287- 292, 1996
30. Rubin JS, Chan AM-L, Bottaro DP, et al: A broad-spectrum human lung fibroblast-derived mitogen is a varient of hepatocyte growth factor. Proc Natl Acad Sci 92:9151-9155, 1991
31. Sengal P: Pattern formation in skin development. Int J Dev Biol 34:33-50, 1990
32. Wilson C, Cotsarelis G, Wei ZG, et al: Cells within the bulge region of mouse hair follicle transiently proliferate during early anagen: heterogeneity and functional differences of various hair cycles. Differentiation 55:127-136, 1994