Induction and differential regulation of bee venom phospholipase A2-specific human IgE and IgG4 antibodies in vitro requires allergen-specific and nonspecific activation of T and B cells

Journal of Allergy and Clinical Immunology

Volumn 99, Issue 3, 1997, Pages 345-353

  Akdis, Cezmi A ^a   Blesken, Thorsten ^a   Akdis, Mübeccel ^a   Alkan, Sefik S ^b   Wüthrich, Brunello ^c   Heusser, Christoph H ^b   Blaser, Kurt ^a  

^a SWISS INSTITUTE OF ALLERGY AND ASTHMA RESEARCH SIAF   (Switzerland)

^b CIBA GEIGY LTD   (Switzerland)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Allergen specific IgE; Bee venom phospholipase A2; IgE antibody; IgG4 antibody; Isotype regulation

Indexed keywords

ALLERGEN; BEE VENOM; CD2 ANTIGEN; CD40 ANTIGEN; GAMMA INTERFERON; IMMUNOGLOBULIN E ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G4; INTERLEUKIN 2; INTERLEUKIN 4; LIGAND; MONOCLONAL ANTIBODY; PHOSPHOLIPASE A2;

ADULT; ANTIBODY PRODUCTION; ARTICLE; B LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IMMUNOASSAY; IMMUNOGLOBULIN PRODUCTION; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0030944340     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-6749(97)70052-6     Document Type: Article

References (56)

1. Hussain R, Poindexter RW, Ottesen EA. Control of allergic reactivity in human filariasis. Predominant localisation of blocking antibody to the IgG4 subclass. J Immunol 1992;148:2731-9.
2. Carballido JM, Carballido-Perrig N, Kägi MK, Meloen RH, Wüthrich B, Heusser CH, et al. T cell epitope specificity in human allergic and non-allergic subjects to bee venom phospholipase A2. J Immunol 1993;150:3582-91.
3. 2 in vitro. J Allergy Clin Immunol 1994;93:758-67.
4. Werner-Favre C, Matthes T, Barnet M, Zubler RH. High IgE secretion capacity of human plasma cells. Eur J Immunol 1993;23:2038-40.
5. 2. Proc Natl Acad Sci USA 1988;85:6880-4.
6. Romagnani S, Del Prete G, Maggi G, Ricci M. Activation through CD3 molecule leads a number of human T cell clones to induce IgE synthesis in vitro by B cells from allergic and non allergic individuals. J Immunol 1987;138:1744-9.
7. Del Prete G, Maggi E, Parronchi P, Chrétian I, Tiri A, et al. IL-4 is an essential factor for the IgE synthesis induced in vitro by human T cell clones and their supernatants. J Immunol 1988;140:4193-8.
8. Gascan H, Gauchat J-F, Aversa G, Van Vlasselaer P, De Vries JE. Anti-CD40 monoclonal antibodies or CD4+ T cell clones and IL-4 induce IgG4 and IgE switching in purified B cells via different signaling pathways. J Immunol 1991;147:8-13.
9. Shinomiya N, Kumai M, Marsh DG, Huang S-K. Detection of specific IgE-secreting cells with an enzyme-linked immunospot assay. J Allergy Clin Immunol 1993;92:479-87.
10. Kuchler K, Gmachl M, Sippl MJ, Kreil G. Analysis of the cDNA for phospholipase A2 from honey bee venom glands. Eur J Biochem 1989;1184:249-54.
11. Kagey-Sobotka A, Franklin RM, Adkinson NF Jr, Valentine M, Bauer H, Lichtenstein LM. Allergy to insect sting. II. Phospholipase A: the major allergen in honey bee venom. J Allergy Clin Immunol 1976;57:29-40.
12. 2 from honeybee venom is similar. J Allergy Clin Immunol 1995;96:395-402.
13. Aalberse RC, van der Gaag R, van Leuwen J. Serologic aspects of IgG4 antibodies. I. Prolonged immunisation results in an IgG4-restricted response. J Immunol 1983;130:722-6.
14. Lucas AH. IgG subclass restricted immune responses to allergens. Semin Immunopathol 1990;12:385-400.
15. Graft DF. Venom immunotherapy for stinging insect allergy. Clin Rev Allergy 1987;5:149-59.
16. Randolph CC, Reisman RE. Evaluation of decline in serum venom specific IgE as a criterion for stopping venom immunotherapy. J Allergy Clin Immunol 1986;77:823-7.
17. Wyss M, Scheitlin T, Stadler BM. Wüthrich B. Immunotherapy with aluminum hydroxide adsorbed insect venom extracts (Alutard SQ): immunologic and clinical results of a prospective study over 3 years. Allergy 1993;48:81-6.
18. Spiegelberg HL. The role of interleukin-4 in IgE and IgG subclass formation. Springer Semin Immunopathol 1990;12:365-83.
19. Vercelli D, Jabara HH, Arai K-I, Geha RS. Induction of human IgE synthesis requires interleukin-4 and T/B cell interactions involving the T cell receptor and MHC class II antigens. J Exp Med 1989;169:1295-307.
20. Gascan H, Aversa G, Gauchat JF, Van Vlasselaer P, Roncarolo M-G, Yssel H, et al. Membranes of activated CD4+ T cells expressing T cell receptor (TcR) αβ or TcR γδ induce IgE synthesis by human B cells in the presence of interleukin-4. Eur J Immunol 1992;22:1133-41.
21. Werner-Favre C, Gauchat J-F, Mazzei G, Aubry J-P, Zubler RH. Similar CD40L expression on EL-4 thymoma cell lines with widely different helper activity for B lymphocytes. Immunology 1994;81:111-4.
22. Van der Pouw-Kraan T, Van Kooten C, Rensink I, Aarden L. Interleukin (IL)-4 production by human cells: differential regulation of IL-4 vs. IL-2 production. Eur J Immunol 1992;22:1237-41.
23. Lane P, Brocker T, Hubele S, Padovan E, Lanzavecchia A, McConnell F. Soluble CD40 ligand can replace the normal T cell derived CD40 ligand signal to B cells in T cell-dependent activation. J Exp Med 1993;177:1209-13.
24. Miltenyi S, Müller W, Weichel W, Radbruch A. High gradient magnetic cell separation with MACS. Cytometry 1990;11:231-8.
25. Alkan S, Akdis C, Towbin H. Chemiluminescent and enzyme-linked immuno assays for sensitive detection of human IFN-γ. J Immunoassay 1994;15:217-38.
26. Gillis S, Ferm MM, Ou W, Smith KA. T cell growth factor: parameters of production and a quantitative microassay for activity. J Immunol 1978;120:2027-32.
27. Held W, Stucki M, Heusser CH, Blaser K. Production of human antibodies to bee venom phospholipase A2 In vitro. Scand J Immunol 1989;29:203-9.
28. Rieben R, Blaser K. Quantification of IgG and IgG4 antibodies to bee venom phospholipase A2 by inhibition ELISA. J Immunol Methods 1989;119:1-8.
29. 2. J Allergy Clin Immunol 1994;94:61-70.
30. Noelle RJ, Roy M, Shepherd DM, Stamenkovic I, Ledbetter JA, Aruffo A. A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells. Proc Natl Acad Sci USA 1992;89:6550-4.
31. Splawski JB, Fu SM, Lipsky PE. Immunoregulatory role of CD40 in human B cell differentiation. J Immunol 1993;150:1276-85.
32. Punnonen J, Aversa G, Cocks BG, McKenzie AN, Menon S, Zurawaski G, et al. Interleukin-13 induces interleukin-4 independent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc Natl Acad Sci USA 1993;90:3730-4.
33. Lane P, Traunecker A, Hubele S, Inui S, Lanzavecchia A, Gray D. Activated T cells express a ligand for the human B cell associated antigen CD40 which participates in T cell dependent activation of B lymphocytes. Eur J Immunol 1992;22:2573-8.
34. Armitage RJ, Fanslow WC, Strockbine L, et al. Molecular and biological characterisation of a murine ligand for CD40. Nature 1992;357:80-2.
35. Knox KA, Gordon J. Protein thyrosine phosphorilation is mandatory for CD40-mediated rescue of germinal center B cells from apoptosis. Eur J Immunol 1993;23:2578-84.
36. Jabara HH, Fu SM, Geha RS, Vercelli D. CD40 and IgE: synergism between anti-CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B cells. J Exp Med 1990;172:1861-4.
37. Zhang K, Clark EA, Saxon A. CD40 stimulation provides an IFN-γ-independent and IL-4-dependent differentiation signal directly to human B cells for IgE production. J Immunol 1991;146:1836-42.
38. Rousset F, Garcia E, Banchereau J. Cytokine-induced proliferation and immunoglobulin production of human B lymphocytes triggered through their CD40 antigen. J Exp Med 1991;173:705-10.
39. Banchereau J, De Paoli P, Vall A, Garcia E, Rousset F. Long-term human B cell lines dependent on interleukin-4 and antibody to CD40. Science 1991;251:70-2.
40. Tsubata T, Honjo W-JT. B cell apoptosis induced by antigen receptor crosslinking is blocked by a T cell signal through CD40. Nature 1993;364:645-8.
41. Sutherland M, Blaser K, Pene J. Effects of interleukin-4 and interferon-γ on the secretion of IgG4 from human peripheral blood mononuclear cells. Allergy 1993;48:504-10.
42. Aubry J-P, Pochon S, Graber P, Jansen KU, Bonnefoy J-Y. CD21 is a ligand for CD23 and regulates IgE production. Nature 1992;358:505-7.
43. Aversa G. Punnonen J, De Vries JE. The 26-kD transmembrane form of tumor necrosis factor-α on activated CD4+ T cell clones provides a co-stimulatory signal for human B cell activation. J Exp Med 1993;177:1575-85.
44. Costello R, Cerdan C, Pavon C, Brailly H, Hurpin C, Mawas C, et al. The CD2 and CD28 adhesion molecules induce long-term autokrine proliferation of CD4+ T cells. Eur J Immunol 1993;23:608-13.
45. Van Lier RAW, Brouwer M, Aarden LA. Signals involved in T cell activation. T cell proliferation induced through the synergistic action of anti-CD28 and anti-CD2 monoclonal antibodies. Eur J Immunol 1988;18:167-72.
46. Yang SY, Denning ST, Mizuno S, Dupont B, Haynes BF. A novel activation pathway for mature thymocytes. J Exp Med 1988;168:1457-68.
47. Schwarz M, Bohuslav J, Majdic O, Stockinger H, Knapp W, Holter W. Identification of the TS2/18-recognized epitope on the CD2 molecule as a target for suppression of T cell cytokine synthesis. J Immunol 1995;154:5813-20.
48. Vercelli D, Jabara HH, Lauener RP, Geha RS. IL-4 inhibits the synthesis of IFN-γ and induces the synthesis of IgE in human mixed lymphocyte cultures. J Immunol 1990;144:570-3.
49. Vernino L, McNally LM, Ramberg J, Lipsky PE. Generation of nondividing high rate Ig-secreting plasma cells in cultures of human B cells stimulated with anti-CD3-activated T cells. J Immunol 1992;148:404-10.
50. Quint DJ, Bolton EJ, McNamee EA, Solari R, Hissey PH, Cham-pion B. Functional and phenotypic analysis of human T cell clones which stimulate IgE in vitro. Immunology 1989;67:68-74.
51. Carballido JM, Carballido-Perrig N, Terres G, Heusser CH, Blaser K. Bee venom phospholipase A2 specific-T-cell clones from human allergic and non allergic individuals: cytokine patterns change in response to antigen concentration. Eur J Immunol 1992;22:1357-63.
52. Carballido JM, Carballido-Perrig N, Heusser CH, Blaser K. Regulation of the cytokine production of allergen-specific human T-cell clones by the allergen. Int Arch Allergy Immunol 1992;99:366-9.
53. Casten LA, Lakey EK, Jelachich ML, Margoliash H, Pierce SK. Anti-immunoglobulin augments the B-cell antigen-presentation function independently of internalization of receptor-antigen complex. Proc Natl Acad Sci USA 1985;82:5890-4.
54. Faassen AE, Dalke DP, Berton MT, Warren WD, Pierce SK. CD40-CD40 ligand interactions stimulate B cell antigen processing. Eur J Immunol 1995;25:3249-55.
55. Coutinho A, Gronowicz E, Bullock WW, Möller G. Mechanism of thymus-independent irnmunocyte triggering. Mitogenic activation of B cells results in specific immune responses. J Exp Med 1974;139:74-92.
56. Coutinho A, Gronowicz E, Möller G. Mechanism of B-cell activation and paralysis by thymus-independent antigens. Additive effects between NNP-LPS and LPS in the specific response to hapten. Scand J Immunol 1975;4:89-94.