The effect of overdominance on characterizing deleterious mutations in large natural populations

Genetics

Volumn 151, Issue 2, 1999, Pages 895-913

  Li, Jin Long ^a   Li, Jian ^a   Deng, Hong Wen ^a  

^a CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; GENETIC SELECTION; GENETIC VARIABILITY; GENOME; HETEROSIS; INBREEDING; MUTATION; PRIORITY JOURNAL;

ANIMALS; GENES, DOMINANT; GENETICS, POPULATION; HUMANS; MODELS, GENETIC; MUTATION;

EID: 0032915512     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (63)

1. BARRETT, S. C. H., and D. CHARLESWORTH, 1991 Effects of a change in the level of inbreeding on the genetic load. Nature 352: 522-524.
2. BATEMAN, A. J., 1959 The viability of near-normal irradiated chromosomes. Int. J. Radiat. Biol. 1: 170-180.
3. BÜGER, R., and J. HOFBAUER, 1994 Mutation load and quantitative genetic traits. J. Math. Biol. 32: 193-218.
4. CABALLERO, A., and P. D. KEIGHTLEY, 1994 A pleiotropic nonadditive model of variation in quantitative traits. Genetics 138: 883-900.
5. CABALLERO, A., P. D. KEIGHTLEY and M. TURELLI, 1997 Average dominance for polygenes: Drawbacks of regression estimates. Genetics 147: 1487-1490.
6. CHARLESWORTH, B., 1990 Mutation-selection balance and the evolutionary advantage of sex and recombination. Genet. Res. 55: 199-221.
7. CHARLESWORTH, D., and B. CHARLESWORTH, 1987 Inbreeding depression and its evolutionary consequences. Annu. Rev. Ecol. Syst. 18 (Suppl.): 237-268.
8. CHARLESWORTH, B., and K. A. HUGHES, 1998 The maintenance of genetic variation in life-history traits, in Evolutionary Genetics from Molecules to Morphology, edited by R. S. SINGH and C. B. KRIMBAS. Cambridge University Press, Cambridge, UK (in press).
9. CHARLESWORTH, B., D. CHARLESWORTH and M. T. MORGAN, 1990 Genetic loads and estimates of imitation rates in highly inbred plain populations. Nature 347: 380-382.
10. CHARLESWORTH, B., M. T. MORGAN and D. CHARLESWORTH, 1993 The effects of deleterious mutations on neutral molecular variation. Genetics 134: 1289-1303.
11. CHARLESWORTH, D., E. E. LYONS and L. B. LITCHFIELD, 1994 Inbreeding depression in two highly inbreeding populations of Leavenworthia. Proc. R. Soc. Lond. Ser. B Biol. Sci. 258: 209-214.
12. CHARLESWORTH, D., B. CHARLESWORTH and M. T. MORGAN, 1995 The pattern of neutral molecular variation under the background selection model. Genetics 141: 1619-1632.
13. GRADDOCK, N., V. KHODEL, P. V. EERDEWEGH and T. REICH, 1995 Mathematical limits of multilocus models: the genetic transmission of bipolar disorder. Am. J. Hum. Genet. 57: 690-702.
14. CROW, J. F., 1952 Dominance and overdominance, pp. 282-297 in Heterosis, edited by J. W. GOWEN. Iowa State College Press, Ames, IA.
15. CROW, J. F., 1986 Basic Concepts in Population, Quantitative and Evolutionary Genetics. W. H. Freeman and Company, New York.
16. CROW, J. F., 1993 How much do we know about spontaneous human mutation rates? Environ. Mol. Mutagen. 21: 122-129.
17. CROW, J. F., and M. J. SIMMONS, 1983 The mutation load in Drosophila, pp. 1-35 in The Genetics and Biology of Drosophila, Vol. 3c, edited by M. ASHBURNER, H. L. CARSON and J. N. THOMPSON, Academic Press, London/NY.
18. DAVENPORT, C. B., 1908 Degeneration, albinism and inbreeding. Science 28: 454-455.
19. DENG, H.-W., 1998a Estimating (over)dominance coefficient and discriminating dominance vs. overdominance as the genetic cause of heterosis. Genetics 148: 2003-2014.
20. DENG, H.-W., 1998b Characterizing deleterious genomic mutations in outcrossing populations. Genetics 151: 945-956.
21. DENG, H.-W., and Y.-X. FU, 1998 On the three methods for estimating deleterious genomic mutation parameters., Genet. Res. 71: 223-236.
22. DENG, H.-W., and M. LYNCH, 1996 Estimation of the genomic mutation parameters in natural populations. Genetics 144: 349-360.
23. DENG, H.-W., and M. LYNCH, 1997 Inbreeding depression and inferred deleterious mutation parameters in Daphnia. Genetics 147: 147-155.
24. DENG, H.-W., Y.-X. FU and M. LYNCH, 1998a Inferring the major genomic mode of dominance and overdominance. Genetica 102/ 103: 559-567.
25. DENG, H.-W., J. LI and J. L. LI, 1998b On the experimental designs and data analyses of mutation-accumulation experiments. Genet. Res. (in press).
26. DRAKE, J. W., B. CHARLESWORTH, D. CHARLESWORTH and J. F. CROW, 1998 Rates of spontaneous mutations. Genetics 148: 1667-1686.
27. EAST, E. M., 1908 Inbreeding in corn. Rep. Conn. Agric. Exp. Stn. (1907) 419-428.
28. FU, Y.-B., and K. RITLAND, 1996 Marker-based inference about epistasis for gene influencing inbreeding depression. Genetics 144: 339-348.
29. GARCIA-DORADO, A., 1997 The rate and effects distribution of viability mutation in Drosophila: minimum distance estimation. Evolution 51: 1130-1139.
30. GREGORY, W. C., 1965 Mutation frequency, magnitude of change and the probability of improvement in adaptation. Radiat. Bot. 5 (Suppl.): 429-441.
31. HALDANE, J. B. S., 1937 The effects of variation on fitness. Am. Nat. 71: 337-349.
32. HOULE, D., 1989 Allozyme-associated heterosis in Drosophila melanogaster. Genetics 123: 789-801.
33. HOULE, D., 1994 Adaptive distance and the genetic basis of heterosis. Evolution 48: 1410-1417.
34. HOULE, D., B. MORIKAWA and M. LYNCH, 1996 Comparing mutational variabilities. Genetics 143: 1467-1483.
35. HUDSON, R., and N. L. KAPLAN, 1995 Deleterious background selection with recombination. Genetics 141: 1605-1617.
36. JOHNSTON, M., and D. J. SCHOEN, 1995 Mutation rates and dominance levels of genes affecting total fitness in two angiosperm species. Science 267: 226-229.
37. KACSER, H., and J. A. BURNS, 1981 The molecular basis of dominance. Genetics 97: 639-666.
38. KEIGHTLEY, P. D., 1994 The distribution of mutation effects on viability in Drosophila melanogaster. Genetics 138: 1315-1322.
39. KEIGHTLEY, P. D., 1996 Nature of deleterious mutation load in Drosophila. Genetics 144: 1993-1999.
40. KIMURA, M., T. MARUYAMA and J. F. CROW, 1963 The mutation load in small populations. Genetics 48: 1303-1312.
41. KIRKPATRICK, M., and M. J. RYAN, 1991 The evolution of mating preferences and the paradox of the lek. Nature 350: 33-38.
42. KONDRASHOV, A. S., 1985 Deleterious mutations as an evolutionary factor. II. Facultative apomixis and selfing. Genetics 111:635-653.
43. KONDRASHOV, A. S., 1988 Deleterious mutations and the evolution of sexual reproduction. Nature 336: 435-440.
44. KONDRASHOV, A. S., and J. F. CROW, 1991 Haploidy or diploidy: which is better? Nature 351: 314-315.
45. LANDE, R., 1994 Risk of population extinction from new deleterious mutations. Evolution 48: 1460-1469.
46. LYNCH, M., 1985 Spontaneous mutations for life-history characters in an obligate parthenogen. Evolution 39: 804-818.
47. LYNCH, M., 1988 The rate of polygenic mutation. Genet. Res. 51: 173-148.
48. LYNCH, M., J. CONERY and R. BURGER, 1995 Mutation accumulation and the extinction of small populations. Am. Nat. 146: 489-518.
49. LYNCH, M., J. CONERY and R. BURGER, 1996 Mutation meltdowns in sexual populations. Evolution 49: 1067-1080.
50. LYNCH, M., L. LATTA, J. HICKS and M. GIORGIANNI, 1998 Mutation, selection, and maintenance of life-history variation in a natural population. Evolution 52: 727-733.
51. MACKAY, T. F. C., R. F. LYMAN and M. S. JACKSON, 1992 Effects of P element insertions on quantitative traits in Drosophila melanogaster. Genetics 130: 315-322.
52. MITTON, J. B., 1993 Theory and data pertinent to the relationship between heterozygosity and fitness, pp. 17-41 in The History of Inbreeding and Outbreeding, edited by N. D. THORNHILL. The University of Chicago Press, Chicago.
53. MORTON, N. E., J. F. CROW and H. J. MULLER, 1956 An estimate of the mutational damage in man from data on consanguineous marriages. Proc. Natl. Acad. Sci. USA 42: 855-863.
54. MUKAI, T., 1964 Spontaneous mutation rate of polygenes controlling viability. Genetics 50: 1-19.
55. MUKAI, T., 1979 Polygenic mutations, pp. 177-196 in Quantitative Genetic Variation, edited by J. N. THOMPSON, JR., and J. M. THODAY. Academic Press, New York.
56. MUKAI, T., S. I. CHIGUSA, L. E. METTLER and J. F. CROW, 1972 Mutation rate and dominance of genes affecting viability in Drosophila melanogaster. Genetics 72: 335-355.
57. MULLER, H. J., 1964 The relation of recombination to mutational advance. Mutat. Res. 1: 1-9.
58. PECK J. R., and A. EYRE-WALKER, 1997 The muddle about mutations. Nature 387: 135-136.
59. SHULL, G. H., 1908 The composition of a field of maize. Rep. Am. Breed. Assoc. 4: 296-301.
60. SIMMONS, M. J., and J. F. CROW, 1977 Mutations affecting fitness in Drosophila populations. Annu. Rev. Genet. 11: 49-78.
61. SPRAGUE, G. F., 1983 Heterosis in maize: theory and practice, pp. 47-70 in Heterosis: Reappraisal of Theory and Practice, edited by R. FRANKEL. Springer-Verlag, Berlin.
62. STUBER, C. W., S. E. LINCOLN, D. W. WOLFF, T. HELENTIJARIS and E. S. LANDER, 1992 Identification of genetic factors in a hybrid from two elite maize inbred lines using molecular markers. Genetics 132: 823-839.
63. WALLACE, B., 1989 One selectionist's perspective. Q. Rev. Biol. 64: 127-145.