Acyloxymethyl acidic drug derivatives: In vitro hydrolytic reactivity

International Journal of Pharmaceutics

Volumn 180, Issue 2, 1999, Pages 151-160

  Redden, Peter R ^a   Melanson, Rhea L ^a   Douglas, Jo Anne E ^a   Dick, Arthur J ^a  

^a Scotia Research Institute   (Canada)

Author keywords

Acyloxymethyl derivatives; Enzymatic hydrolysis; Fatty acids; Human plasma; Porcine liver esterase; Prodrugs

Indexed keywords

ESTERASE; GAMMA LINOLENIC ACID; INDOMETACIN DERIVATIVE; PHENYTOIN DERIVATIVE; PRODRUG; THEOPHYLLINE DERIVATIVE; THIOCTIC ACID; THIOCTIC ACID DERIVATIVE; UNCLASSIFIED DRUG; VALERIC ACID;

ARTICLE; DRUG HYDROLYSIS; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; KINETICS; LIPOPHILICITY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PLASMA; PRIORITY JOURNAL; STEREOSPECIFICITY;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ESTERASES; GAMMA-LINOLENIC ACID; HUMANS; HYDROLYSIS; INDOMETHACIN; KINETICS; LIVER; PENTANOIC ACIDS; PHENYTOIN; PRODRUGS; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE; THEOPHYLLINE;

EID: 0032915257     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(98)00372-X     Document Type: Article

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