In vitro hydrolysis of novel gamma-linolenoyloxyalkyl derivatives of theophylline

International Journal of Pharmaceutics

Volumn 157, Issue 1, 1997, Pages 81-91

  Burke, Michael ^a   Redden, Peter R ^a   Douglas, Jo Anne ^a   Dick, Arthur ^b   Horrobin, David F ^a  

^a Scotia Research Institute   (Canada)

^b ACADIA UNIVERSITY   (Canada)

Author keywords

Linolenic acid; Enzymatic hydrolysis; Human plasma; N Acyloxyalkyl theophylline derivatives; Prodrugs; Theophylline

Indexed keywords

ESTERASE; GAMMA LINOLENIC ACID; PRODRUG; THEOPHYLLINE DERIVATIVE;

ARTICLE; CHEMICAL MODIFICATION; CHIRALITY; DRUG DEGRADATION; DRUG HYDROLYSIS; DRUG SYNTHESIS; HUMAN; KINETICS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PLASMA; PRIORITY JOURNAL; STEREOSPECIFICITY;

EID: 0030818255     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(97)00220-2     Document Type: Article

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