메뉴 건너뛰기




Volumn 19, Issue 3, 1999, Pages 373-409

Metabolism of tricyclic antidepressants

Author keywords

Antidepressants; Drug drug interactions; Hydroxy metabolites; Metabolism; Pharmacogenetics; Pharmacokinetics; Plasma concentrations; Toxicity; Tricyclic

Indexed keywords

10 HYDROXYNORTRIPTYLINE; ALCOHOL; AMITRIPTYLINE; AMOXAPINE; BARBITURIC ACID DERIVATIVE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CARBAMAZEPINE; CIMETIDINE; CLOMIPRAMINE; CYTOCHROME P450; DEBRISOQUINE; DESIPRAMINE; DEXFENFLURAMINE; DOSULEPIN; DOXEPIN; DRUG METABOLITE; FENFLURAMINE; FLUOXETINE; IMIPRAMINE; LOFEPRAMINE; NORTRIPTYLINE; ORAL CONTRACEPTIVE AGENT; PAROXETINE; RECEPTOR; SEROTONIN; SEROTONIN UPTAKE INHIBITOR; TRICYCLIC ANTIDEPRESSANT AGENT; UNINDEXED DRUG; VALPROIC ACID;

EID: 0032912604     PISSN: 02724340     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1006949816036     Document Type: Article
Times cited : (109)

References (204)
  • 1
    • 0030928338 scopus 로고    scopus 로고
    • Grapefruits and drugs: When is statistically significant clinically significant?
    • Abernethy, D. R. (1997). Grapefruits and drugs: When is statistically significant clinically significant? (Editorial). J. Clin. Invest. 99:2297-2298.
    • (1997) J. Clin. Invest. , vol.99 , pp. 2297-2298
    • Abernethy, D.R.1
  • 2
    • 0021152079 scopus 로고
    • Imipramine disposition in users of oral contraceptive steroids
    • Abernethy, D. R., Greenblatt, D. J., and Shader, R. I. (1984). Imipramine disposition in users of oral contraceptive steroids. Clin. Pharmacol. Ther. 35:792-797.
    • (1984) Clin. Pharmacol. Ther. , vol.35 , pp. 792-797
    • Abernethy, D.R.1    Greenblatt, D.J.2    Shader, R.I.3
  • 3
    • 0030044855 scopus 로고    scopus 로고
    • Pregnancy and psychotropic medication: Changes in blood levels
    • Altshuler, L. L., and Hendrick, V. C. (1996). Pregnancy and psychotropic medication: Changes in blood levels. J. Clin. Psychopharmacol. 16:78-80.
    • (1996) J. Clin. Psychopharmacol. , vol.16 , pp. 78-80
    • Altshuler, L.L.1    Hendrick, V.C.2
  • 6
    • 0021888499 scopus 로고
    • Desipramine and 2-hydroxydesipramine plasma levels in endogenous depressed patients: Lack of correlation with therapeutic response
    • Amsterdam, J. D., Brunswick, D. J., Potter, W. Z., Winokur, A., and Rickels, K. (1985). Desipramine and 2-hydroxydesipramine plasma levels in endogenous depressed patients: Lack of correlation with therapeutic response. Arch. Gen. Psychiatry 42:361-364.
    • (1985) Arch. Gen. Psychiatry , vol.42 , pp. 361-364
    • Amsterdam, J.D.1    Brunswick, D.J.2    Potter, W.Z.3    Winokur, A.4    Rickels, K.5
  • 7
    • 0029133833 scopus 로고
    • Grapefruit juice interactions with drugs
    • Anonymous (1995). Grapefruit juice interactions with drugs. Med. Lett. 37:73-74.
    • (1995) Med. Lett. , vol.37 , pp. 73-74
  • 8
    • 0025179793 scopus 로고
    • Amoxapine versus amitriptyline combined with perphenazine in the treatment of psychotic depression
    • Anton, R. F., Jr., and Burch, E. A., Jr. (1990). Amoxapine versus amitriptyline combined with perphenazine in the treatment of psychotic depression. Am. J. Psychiatry 147:1203-1208.
    • (1990) Am. J. Psychiatry , vol.147 , pp. 1203-1208
    • Anton R.F., Jr.1    Burch E.A., Jr.2
  • 9
    • 0015214158 scopus 로고
    • Relationship between plasma levels and therapeutic effect of nortriptyline
    • Asberg, M., Cronholm, B., Sjöqvist, F., and Tuck, D. (1971). Relationship between plasma levels and therapeutic effect of nortriptyline. Br. Med. J. 3:331-334.
    • (1971) Br. Med. J. , vol.3 , pp. 331-334
    • Asberg, M.1    Cronholm, B.2    Sjöqvist, F.3    Tuck, D.4
  • 11
    • 0022898438 scopus 로고
    • Importance of oxidative polymorphism and levomepromazine treatment on the steady-state blood concentrations of clomipramine and its major metabolites
    • Balant-Gorgia, A. E., Balant, L. P., Genet, C., Dayer, P., Aeschlimann, J. M., and Garrone, G. (1986). Importance of oxidative polymorphism and levomepromazine treatment on the steady-state blood concentrations of clomipramine and its major metabolites. Eur. J. Clin. Pharmacol. 31:449-455.
    • (1986) Eur. J. Clin. Pharmacol. , vol.31 , pp. 449-455
    • Balant-Gorgia, A.E.1    Balant, L.P.2    Genet, C.3    Dayer, P.4    Aeschlimann, J.M.5    Garrone, G.6
  • 13
    • 0029841944 scopus 로고    scopus 로고
    • A non-selective (amitriptyline), but not a selective (citalopram), serotonin reuptake inhibitor is effective in the prophylactic treatment of chronic tension-type headache
    • Bendtsen, L., Jensen, R., and Olesen, J. (1996). A non-selective (amitriptyline), but not a selective (citalopram), serotonin reuptake inhibitor is effective in the prophylactic treatment of chronic tension-type headache. J. Neurol. Neurosurg. Psychiatry 61:285-290.
    • (1996) J. Neurol. Neurosurg. Psychiatry , vol.61 , pp. 285-290
    • Bendtsen, L.1    Jensen, R.2    Olesen, J.3
  • 14
    • 0344156998 scopus 로고
    • Neonatal effects of maternal clomipramine therapy
    • Ben Musa, A., and Smith, C. S. (1979). Neonatal effects of maternal clomipramine therapy. Arch. Dis. Child. 54405.
    • (1979) Arch. Dis. Child. , pp. 54405
    • Ben Musa, A.1    Smith, C.S.2
  • 15
    • 0026552617 scopus 로고
    • Quantification and mechanism of the fluoxetine and tricyclic antidepressant interaction
    • Bergstrom, R. F., Peyton, A. L., and Lemberger, L. (1992). Quantification and mechanism of the fluoxetine and tricyclic antidepressant interaction. Clin. Pharmacol. Ther. 51:239-248.
    • (1992) Clin. Pharmacol. Ther. , vol.51 , pp. 239-248
    • Bergstrom, R.F.1    Peyton, A.L.2    Lemberger, L.3
  • 16
    • 0029979414 scopus 로고    scopus 로고
    • Polymorphic drug oxidation: Relevance to the treatment of psychiatric disorders
    • Bertilsson, L., and Dahl, M.-L. (1996). Polymorphic drug oxidation: Relevance to the treatment of psychiatric disorders. CNS Drugs 5:200-223.
    • (1996) CNS Drugs , vol.5 , pp. 200-223
    • Bertilsson, L.1    Dahl, M.-L.2
  • 17
    • 0022550959 scopus 로고
    • Disposition of single oral doses of E-10-hydroxynortriptyline in healthly subjects, with some observations on pharmacodynamic effects
    • Bertilsson, L., Nordin, C., Otani, K., Resul, B., Scheinin, M., Siwers, B., and Sjöqvist, F. (1986). Disposition of single oral doses of E-10-hydroxynortriptyline in healthly subjects, with some observations on pharmacodynamic effects. Clin. Pharmacol. Ther. 40:261-267.
    • (1986) Clin. Pharmacol. Ther. , vol.40 , pp. 261-267
    • Bertilsson, L.1    Nordin, C.2    Otani, K.3    Resul, B.4    Scheinin, M.5    Siwers, B.6    Sjöqvist, F.7
  • 18
    • 0018574466 scopus 로고
    • Pronounced inhibition of noradrenaline uptake by 10-hydroxy-metabolites of nortriptyline
    • Bertilsson, L., Mellström, B., and Sjöqvist, F. (1979). Pronounced inhibition of noradrenaline uptake by 10-hydroxy-metabolites of nortriptyline. Life Sci. 25:1285-1292.
    • (1979) Life Sci. , vol.25 , pp. 1285-1292
    • Bertilsson, L.1    Mellström, B.2    Sjöqvist, F.3
  • 19
    • 0022337949 scopus 로고
    • Extremely rapid hydroxylation of debrisoquine: A case report with implication for treatment with nortriptyline and other tricyclic antidepressants
    • Bertilsson, L., Aberg-Wistedt, A., Gustafsson, L. L., and Nordin, C. (1985). Extremely rapid hydroxylation of debrisoquine: A case report with implication for treatment with nortriptyline and other tricyclic antidepressants. Ther. Drug Monit. 7:478-480.
    • (1985) Ther. Drug Monit. , vol.7 , pp. 478-480
    • Bertilsson, L.1    Aberg-Wistedt, A.2    Gustafsson, L.L.3    Nordin, C.4
  • 20
    • 0024831588 scopus 로고
    • E-10-hydroxynortriptyline: Effects and disposition of a potential novel antidepressant
    • Dahl, S. G., and Gram, L. F. (eds.), Springer-Verlag, Berlin
    • Bertilsson, L., Dahl-Puustinen, M.-L., and Nordin, C. (1989). E-10-hydroxynortriptyline: Effects and disposition of a potential novel antidepressant. In Dahl, S. G., and Gram, L. F. (eds.), Clinical Pharmacology in Psychiatry, Springer-Verlag, Berlin, pp. 52-59.
    • (1989) Clinical Pharmacology in Psychiatry , pp. 52-59
    • Bertilsson, L.1    Dahl-Puustinen, M.-L.2    Nordin, C.3
  • 21
    • 0030222251 scopus 로고    scopus 로고
    • Cerebral metabolism of imipramine and a purified flavin-containing monooxygenase from human brain
    • Bhagwat, S. V., Bhamre, S., Boyd, M. R., and Ravindranath, V. (1996). Cerebral metabolism of imipramine and a purified flavin-containing monooxygenase from human brain. Neuropsychopharmacology 15:133-142.
    • (1996) Neuropsychopharmacology , vol.15 , pp. 133-142
    • Bhagwat, S.V.1    Bhamre, S.2    Boyd, M.R.3    Ravindranath, V.4
  • 22
    • 0027215257 scopus 로고
    • A naturalistic study of 24-hour electrocardiographic recording and echocardiographic findings in children and adolescents treated with desipramine
    • Biederman, J., Baldessarini, R. J., Goldblatt, A., Lapey, K. A., Doyle, A., and Hesslein, P. S. (1993). A naturalistic study of 24-hour electrocardiographic recording and echocardiographic findings in children and adolescents treated with desipramine. J. Am. Acad. Child Adolesc. Psychiatry 32: 805-813.
    • (1993) J. Am. Acad. Child Adolesc. Psychiatry , vol.32 , pp. 805-813
    • Biederman, J.1    Baldessarini, R.J.2    Goldblatt, A.3    Lapey, K.A.4    Doyle, A.5    Hesslein, P.S.6
  • 23
    • 0027471030 scopus 로고
    • Genetically determined drug-metabolizing activity and desipramine-associated cardiotoxicity: A case report
    • Bluhm, R. E., Wilkinson, G. R., Shelton, R., and Branch, R. A. (1993). Genetically determined drug-metabolizing activity and desipramine-associated cardiotoxicity: A case report. Clin. Pharmacol. Ther. 53:89-95.
    • (1993) Clin. Pharmacol. Ther. , vol.53 , pp. 89-95
    • Bluhm, R.E.1    Wilkinson, G.R.2    Shelton, R.3    Branch, R.A.4
  • 24
    • 0020309115 scopus 로고
    • Steady-state plasma concentrations of cis- and trans-10-H amitriptyline metabolites
    • Bock, J., Giller, E., Gray, S., and Jatlow, P. (1982). Steady-state plasma concentrations of cis- and trans-10-H amitriptyline metabolites. Clin. Pharmacol. Ther. 31:609-616.
    • (1982) Clin. Pharmacol. Ther. , vol.31 , pp. 609-616
    • Bock, J.1    Giller, E.2    Gray, S.3    Jatlow, P.4
  • 25
    • 0020596673 scopus 로고
    • Desipramine hydroxylation: Variability and effect of antipsychotic drugs
    • Bock, J. L., Nelson, J. C., Gray, S., and Jatlow, P. (1983). Desipramine hydroxylation: Variability and effect of antipsychotic drugs. Clin. Pharmacol. Ther. 33:322-328.
    • (1983) Clin. Pharmacol. Ther. , vol.33 , pp. 322-328
    • Bock, J.L.1    Nelson, J.C.2    Gray, S.3    Jatlow, P.4
  • 26
    • 0024536178 scopus 로고
    • Validation of a therapeutic plasma level range in amitriptyline treatment of depression
    • Breyer-Pfaff, U., Giedke, H., Gaertner, H. J., and Nill, K. (1989). Validation of a therapeutic plasma level range in amitriptyline treatment of depression. J. Clin. Psychopharmacol. 9:116-121.
    • (1989) J. Clin. Psychopharmacol. , vol.9 , pp. 116-121
    • Breyer-Pfaff, U.1    Giedke, H.2    Gaertner, H.J.3    Nill, K.4
  • 28
    • 0028902851 scopus 로고
    • Secretion of amitriptyline and metabolites into breast milk
    • Breyer-Pfaff, U., Entenmann, A., and Gaertner, H. J. (1995). Secretion of amitriptyline and metabolites into breast milk. Am. J. Psychiatry 152:812-813.
    • (1995) Am. J. Psychiatry , vol.152 , pp. 812-813
    • Breyer-Pfaff, U.1    Entenmann, A.2    Gaertner, H.J.3
  • 29
    • 0020043237 scopus 로고
    • Amitriptyline and nortriptyline excretion in human breast milk
    • Brixen-Rasmussen, L., Halgrener, J., and Jorgensen, A. (1982). Amitriptyline and nortriptyline excretion in human breast milk. Psychopharmacology 76:94-95.
    • (1982) Psychopharmacology , vol.76 , pp. 94-95
    • Brixen-Rasmussen, L.1    Halgrener, J.2    Jorgensen, A.3
  • 30
    • 0022647723 scopus 로고
    • Steady-state levels of imipramine and its metabolites: Significance of dose-dependent kinetics
    • Brosen, K., Gram, L. F., Klysner, R., and Bech, P. (1986). Steady-state levels of imipramine and its metabolites: Significance of dose-dependent kinetics. Eur. J. Pharmacol. 30:43-49.
    • (1986) Eur. J. Pharmacol. , vol.30 , pp. 43-49
    • Brosen, K.1    Gram, L.F.2    Klysner, R.3    Bech, P.4
  • 31
    • 0025011958 scopus 로고
    • Possible influences of carbamazepine on plasma imipramine concentrations in children with attention deficit hyperactivity disorder
    • Brown, C. S., Wells, B. G., Cold, J. A., Froemming, J. H., Self, T. H., and Jabbour, J. T. (1990). Possible influences of carbamazepine on plasma imipramine concentrations in children with attention deficit hyperactivity disorder. J. Clin. Psychopharmacol. 10:359-362.
    • (1990) J. Clin. Psychopharmacol. , vol.10 , pp. 359-362
    • Brown, C.S.1    Wells, B.G.2    Cold, J.A.3    Froemming, J.H.4    Self, T.H.5    Jabbour, J.T.6
  • 33
    • 0029553050 scopus 로고
    • Effect of exposure to dothiepin and northiaden in breast milk on child development
    • Buist, A., and Janson, H. (1995). Effect of exposure to dothiepin and northiaden in breast milk on child development. Br. J. Psychiatry 167:370-373.
    • (1995) Br. J. Psychiatry , vol.167 , pp. 370-373
    • Buist, A.1    Janson, H.2
  • 34
    • 0027050801 scopus 로고
    • Pharmacokinetic and pharmacodynamic significance of antidepressant drug metabolites
    • Caccia, S., and Garattini, S. (1992). Pharmacokinetic and pharmacodynamic significance of antidepressant drug metabolites. Pharmacol. Res. 26:317-329.
    • (1992) Pharmacol. Res. , vol.26 , pp. 317-329
    • Caccia, S.1    Garattini, S.2
  • 37
    • 0023275341 scopus 로고
    • Fatal toxicity of antidepressant drugs in overdose
    • Cassidy, S. L., and Henry, J. A. (1987). Fatal toxicity of antidepressant drugs in overdose. Br. Med. J. 295:1021-1024.
    • (1987) Br. Med. J. , vol.295 , pp. 1021-1024
    • Cassidy, S.L.1    Henry, J.A.2
  • 38
  • 39
    • 0021366268 scopus 로고
    • Effects of chronic desipramine on plasma norepinephrine concentrations and cardiovascular parameters in elderly depressed women: A preliminary report
    • Cutler, N. R., Zavadil, A., Linnoila, M., Scheinin, M., Rudorfer, M. V., and Potter, W. Z. (1984). Effects of chronic desipramine on plasma norepinephrine concentrations and cardiovascular parameters in elderly depressed women: A preliminary report. Biol. Psychiatry 19:549-556.
    • (1984) Biol. Psychiatry , vol.19 , pp. 549-556
    • Cutler, N.R.1    Zavadil, A.2    Linnoila, M.3    Scheinin, M.4    Rudorfer, M.V.5    Potter, W.Z.6
  • 43
    • 0026321869 scopus 로고
    • Gender differences in pharmacokinetics and pharmacodynamics of psychotropics: Focus on women
    • Dawkins, K., and Potter, W. Z. (1991). Gender differences in pharmacokinetics and pharmacodynamics of psychotropics: Focus on women. Psychopharmacol. Bull. 27:417-426.
    • (1991) Psychopharmacol. Bull. , vol.27 , pp. 417-426
    • Dawkins, K.1    Potter, W.Z.2
  • 44
    • 0020261462 scopus 로고
    • Nortriptyline metabolism in chronic renal failure: Metabolite elimination
    • Dawling, S., Lynn, K., Rosser, R., and Braithwaite, R. (1982). Nortriptyline metabolism in chronic renal failure: Metabolite elimination. Clin. Pharmacol. Ther. 32:322-329.
    • (1982) Clin. Pharmacol. Ther. , vol.32 , pp. 322-329
    • Dawling, S.1    Lynn, K.2    Rosser, R.3    Braithwaite, R.4
  • 45
    • 0345450694 scopus 로고    scopus 로고
    • Decision making in the use of antidepressants, part II: Choosing a medication
    • Delgado, P. L., and Gelenberg, A. J. (1997). Decision making in the use of antidepressants, part II: Choosing a medication. Essent. Psychopharmacol. 1:313-330.
    • (1997) Essent. Psychopharmacol. , vol.1 , pp. 313-330
    • Delgado, P.L.1    Gelenberg, A.J.2
  • 47
    • 0028603653 scopus 로고
    • Pharmacogenetics and drug metabolism of newer antidepressant agents
    • DeVane, C. L. (1994). Pharmacogenetics and drug metabolism of newer antidepressant agents. J. Clin. Psychiatry 55 (Suppl. 12):38-45.
    • (1994) J. Clin. Psychiatry , vol.55 , Issue.12 SUPPL. , pp. 38-45
    • Devane, C.L.1
  • 48
    • 0019481339 scopus 로고
    • Plasma concentration monitoring of hydroxylated metabolites of imipramine and desipramine
    • DeVane, C. L., and Jusko, W. (1981). Plasma concentration monitoring of hydroxylated metabolites of imipramine and desipramine. Drug Intell. Clin. Pharm. 15:263-266.
    • (1981) Drug Intell. Clin. Pharm. , vol.15 , pp. 263-266
    • DeVane, C.L.1    Jusko, W.2
  • 49
    • 0019349648 scopus 로고
    • Desipramine and 2-hydroxy-desipramine pharmacokinetics in normal volunteers
    • DeVane, C. L., Savett, M., and Jusko, W. J. (1981). Desipramine and 2-hydroxy-desipramine pharmacokinetics in normal volunteers. Eur. J. Clin. Pharmacol. 19:61-64.
    • (1981) Eur. J. Clin. Pharmacol. , vol.19 , pp. 61-64
    • DeVane, C.L.1    Savett, M.2    Jusko, W.J.3
  • 50
    • 0022652708 scopus 로고
    • Treatment of childhood hyperactivity with desipramine: Plasma drug concentration, cardiovascular effects, plasma and urinary catecholamine levels, and clinical response
    • Donnelly, M., Zametkin, A. J., Rapoport, J. L., Ismond, D. R., Weingartner, H., Lane, E., Oliver, J., Linnoila, M., and Potter, W. Z. (1986). Treatment of childhood hyperactivity with desipramine: Plasma drug concentration, cardiovascular effects, plasma and urinary catecholamine levels, and clinical response. Clin. Pharmacol. Ther. 39:72-81.
    • (1986) Clin. Pharmacol. Ther. , vol.39 , pp. 72-81
    • Donnelly, M.1    Zametkin, A.J.2    Rapoport, J.L.3    Ismond, D.R.4    Weingartner, H.5    Lane, E.6    Oliver, J.7    Linnoila, M.8    Potter, W.Z.9
  • 51
    • 0027363392 scopus 로고
    • Trough concentrations of cyclosporine in blood following administration with grapefruit juice
    • Ducharme, M. P., Provenzano, R., Dehoorne-Smith, M., and Edwards, D. J. (1993). Trough concentrations of cyclosporine in blood following administration with grapefruit juice. Br. J. Clin. Pharmacol. 36:457-459.
    • (1993) Br. J. Clin. Pharmacol. , vol.36 , pp. 457-459
    • Ducharme, M.P.1    Provenzano, R.2    Dehoorne-Smith, M.3    Edwards, D.J.4
  • 52
    • 0023250630 scopus 로고
    • Therapeutic drug monitoring of amitriptyline: Impact of age, smoking and contraceptives on drug and metabolite levels in bulimic women
    • Edelbroek, P. M., Zitman, F. G., Knoppert-van der Klein, E. A. M., van Putten, P. M., and de Wolff, F. A. (1987). Therapeutic drug monitoring of amitriptyline: Impact of age, smoking and contraceptives on drug and metabolite levels in bulimic women. Clin. Chim. Acta 165:177-187.
    • (1987) Clin. Chim. Acta , vol.165 , pp. 177-187
    • Edelbroek, P.M.1    Zitman, F.G.2    Knoppert-van Der Klein, E.A.M.3    Van Putten, P.M.4    De Wolff, F.A.5
  • 53
    • 0026544204 scopus 로고
    • Acute effects of drinking grapefruit juice on the pharmacokinetics and dynamics on felodipine - and its potential clinical relevance
    • Edgar, B., Bailey, D., Bergstrand, R., Johnsson, G., and Regårdh, C. G. (1992). Acute effects of drinking grapefruit juice on the pharmacokinetics and dynamics on felodipine - and its potential clinical relevance. Eur. J. Clin. Pharmacol. 42:313-317.
    • (1992) Eur. J. Clin. Pharmacol. , vol.42 , pp. 313-317
    • Edgar, B.1    Bailey, D.2    Bergstrand, R.3    Johnsson, G.4    Regårdh, C.G.5
  • 54
    • 0030482468 scopus 로고    scopus 로고
    • Identification of 6′,7′-dihydroxybergamottin, a cytochrome P450 inhibitor, in grapefruit juice
    • Edwards, D. J., Bellevue, F. H., III, and Woster, P. M. (1996). Identification of 6′,7′-dihydroxybergamottin, a cytochrome P450 inhibitor, in grapefruit juice. Drug Metab. Dispos. 24:1287-1290.
    • (1996) Drug Metab. Dispos. , vol.24 , pp. 1287-1290
    • Edwards, D.J.1    Bellevue F.H. III2    Woster, P.M.3
  • 55
    • 0020701396 scopus 로고
    • Antagonism by antidepressants of muscarinic acetylcholine receptors of human brain
    • El-Fakahany, E., and Richelson, E. (1983). Antagonism by antidepressants of muscarinic acetylcholine receptors of human brain. Br. J. Pharmacol. 78:97-102.
    • (1983) Br. J. Pharmacol. , vol.78 , pp. 97-102
    • El-Fakahany, E.1    Richelson, E.2
  • 56
    • 0344156993 scopus 로고    scopus 로고
    • Intravenous clomipramine for obsessive compulsive disorder
    • Goodman, W. K., Rudorfer, M. V., and Maser, J. D. (eds.), Lawrence Erlbaum Associates, Mahwah, NJ (in press)
    • Fallon, B. A., and Liebowitz, M. R. (1999). Intravenous clomipramine for obsessive compulsive disorder. In Goodman, W. K., Rudorfer, M. V., and Maser, J. D. (eds.), Treatment Challenges in Obsessive-Compulsive Disorder, Lawrence Erlbaum Associates, Mahwah, NJ (in press).
    • (1999) Treatment Challenges in Obsessive-Compulsive Disorder
    • Fallon, B.A.1    Liebowitz, M.R.2
  • 57
    • 0022450170 scopus 로고
    • Induction of cytochrome P-448 iso-enzymes and related glucuronyltransferases in the human liver by cigarette smoking
    • Fleischmann, R., Remmer, H., and Starz, U. (1986). Induction of cytochrome P-448 iso-enzymes and related glucuronyltransferases in the human liver by cigarette smoking. Eur. J. Clin. Pharmacol. 30:475-480.
    • (1986) Eur. J. Clin. Pharmacol. , vol.30 , pp. 475-480
    • Fleischmann, R.1    Remmer, H.2    Starz, U.3
  • 58
    • 0031025664 scopus 로고    scopus 로고
    • Fenfluramine and the cytochrome P450 system
    • Fogelson, D. L. (1997). Fenfluramine and the cytochrome P450 system. Am. J. Psychiatry 154:436-437.
    • (1997) Am. J. Psychiatry , vol.154 , pp. 436-437
    • Fogelson, D.L.1
  • 59
    • 0018664804 scopus 로고
    • Galactorrhea and hyperprolactinemia associated with amoxapine therapy: Report of a case
    • Gelenberg, A. J., Cooper, D. S., Doller, J. C., and Maloof, F. (1979). Galactorrhea and hyperprolactinemia associated with amoxapine therapy: Report of a case. JAMA 242:1900-1901.
    • (1979) JAMA , vol.242 , pp. 1900-1901
    • Gelenberg, A.J.1    Cooper, D.S.2    Doller, J.C.3    Maloof, F.4
  • 60
    • 0026328999 scopus 로고
    • Psychopharmacology of children and adolescents: Pharmacokinetics and relationships of plasma/serum levels to response
    • Geller, B. (1991). Psychopharmacology of children and adolescents: Pharmacokinetics and relationships of plasma/serum levels to response. Psychopharmacol. Bull. 27:401-409.
    • (1991) Psychopharmacol. Bull. , vol.27 , pp. 401-409
    • Geller, B.1
  • 61
    • 0026578099 scopus 로고
    • Pharmacokinetically designed double-blind placebo-controlled study of nortriptyline in 6-to-12-year olds with major depressive disorder
    • Geller, B., Cooper, T. B., Graham, D. L., Fetner, H. H., Marsteller, F. A., and Wells, J. M. (1992). Pharmacokinetically designed double-blind placebo-controlled study of nortriptyline in 6-to-12-year olds with major depressive disorder. J. Am. Acad. Child. Adolesc. Psychiatry 31:34-44.
    • (1992) J. Am. Acad. Child. Adolesc. Psychiatry , vol.31 , pp. 34-44
    • Geller, B.1    Cooper, T.B.2    Graham, D.L.3    Fetner, H.H.4    Marsteller, F.A.5    Wells, J.M.6
  • 62
    • 0025090955 scopus 로고
    • Clomipramine metabolism: Model-based analysis of variability factors from drug monitoring data
    • Gex-Fabry, M., Balant-Gorgia, A. E., Balant, L. P., and Garrone, G. (1990). Clomipramine metabolism: Model-based analysis of variability factors from drug monitoring data. Clin. Pharmacokinet. 19:241-255.
    • (1990) Clin. Pharmacokinet. , vol.19 , pp. 241-255
    • Gex-Fabry, M.1    Balant-Gorgia, A.E.2    Balant, L.P.3    Garrone, G.4
  • 63
    • 0027316235 scopus 로고
    • The safety of tricyclic antidepressants in cardiac patients: Risk-benefit reconsidered
    • Glassman, A. H., Roose, S. P., and Bigger, J. T., Jr. (1993). The safety of tricyclic antidepressants in cardiac patients: Risk-benefit reconsidered. JAMA 269:2673-2675.
    • (1993) JAMA , vol.269 , pp. 2673-2675
    • Glassman, A.H.1    Roose, S.P.2    Bigger J.T., Jr.3
  • 64
    • 0026324821 scopus 로고
    • Antidepressant challenge tests: The interface of pharmacokinetics and pharmacodynamics
    • Golden, R. N., Gilmore, J. H., and Carson, S. W. (1991). Antidepressant challenge tests: The interface of pharmacokinetics and pharmacodynamics. Psychopharmacol. Bull. 27:611-617.
    • (1991) Psychopharmacol. Bull. , vol.27 , pp. 611-617
    • Golden, R.N.1    Gilmore, J.H.2    Carson, S.W.3
  • 65
    • 0007453032 scopus 로고
    • Trazodone and other antidepressants
    • Schatzberg, A.F., and Nemeroff, C. B. (eds.), American Psychiatric Press, Washington, DC
    • Golden, R. N., Bebchuk, J. M., and Leatherman, M. E. (1995).Trazodone and other antidepressants. In Schatzberg, A.F., and Nemeroff, C. B. (eds.), The American Psychiatric Press Textbook of Psychopharmacology, American Psychiatric Press, Washington, DC, pp. 195- 213.
    • (1995) The American Psychiatric Press Textbook of Psychopharmacology , pp. 195-213
    • Golden, R.N.1    Bebchuk, J.M.2    Leatherman, M.E.3
  • 67
    • 0344156991 scopus 로고    scopus 로고
    • Distribution of pharmacokinetic parameter values for various drug classes
    • Greenberg, H. E., England, M. J., and Bjornsson, T. D. (1997). Distribution of pharmacokinetic parameter values for various drug classes. Clin. Pharmacol. Ther. 61:220.
    • (1997) Clin. Pharmacol. Ther. , vol.61 , pp. 220
    • Greenberg, H.E.1    England, M.J.2    Bjornsson, T.D.3
  • 68
    • 0030446631 scopus 로고    scopus 로고
    • The importance of presystemic extraction in clinical psychopharmacology
    • Greenblatt, D. J., VonMoltke, L. L., and Shader, R. I. (1996). The importance of presystemic extraction in clinical psychopharmacology. J. Clin. Psychopharmacol. 16: 417-419.
    • (1996) J. Clin. Psychopharmacol. , vol.16 , pp. 417-419
    • Greenblatt, D.J.1    Vonmoltke, L.L.2    Shader, R.I.3
  • 69
    • 0014128388 scopus 로고
    • Plasma levels of monomethylated tricyclic antidepressants during treatment with imipramine-like compounds
    • Hammer, W., and Sjöqvist, F. (1967). Plasma levels of monomethylated tricyclic antidepressants during treatment with imipramine-like compounds. Life Sci. 6:1895-1903.
    • (1967) Life Sci. , vol.6 , pp. 1895-1903
    • Hammer, W.1    Sjöqvist, F.2
  • 70
    • 0030016458 scopus 로고    scopus 로고
    • Cytochrome P450 enzymes: Interpretation of their interactions with selective serotonin reuptake inhibitors
    • Harvey, A. T., and Preskorn, S. H. (1996). Cytochrome P450 enzymes: Interpretation of their interactions with selective serotonin reuptake inhibitors. Part I. J. Clin. Psychopharmacol. 16:273-285.
    • (1996) Part I. J. Clin. Psychopharmacol. , vol.16 , pp. 273-285
    • Harvey, A.T.1    Preskorn, S.H.2
  • 71
    • 0028986262 scopus 로고
    • Efficacy of tricyclic drugs in treating child and adolescent depression: A meta-analysis
    • Hazell, P., O'Connell, D., and Heathcote, D. (1995). Efficacy of tricyclic drugs in treating child and adolescent depression: A meta-analysis. Br. Med. J. 310:897-901.
    • (1995) Br. Med. J. , vol.310 , pp. 897-901
    • Hazell, P.1    O'Connell, D.2    Heathcote, D.3
  • 72
    • 0022762896 scopus 로고
    • Persistent tardive dyskinesia associated with amoxapine therapy
    • Huang, C. C. (1986). Persistent tardive dyskinesia associated with amoxapine therapy. Am. J. Psychiatry 143:1069-1070.
    • (1986) Am. J. Psychiatry , vol.143 , pp. 1069-1070
    • Huang, C.C.1
  • 73
    • 0017601623 scopus 로고
    • Effects of several tricyclic antidepressants on the hemodynamics and myocardial contractility of anesthetized dogs
    • Jandhyala, B. S., Steenberg, M. L., Perel, J. M., Manian, A. A., and Buckley, J. (1977). Effects of several tricyclic antidepressants on the hemodynamics and myocardial contractility of anesthetized dogs. Eur. J. Pharmacol. 42:403-410.
    • (1977) Eur. J. Pharmacol. , vol.42 , pp. 403-410
    • Jandhyala, B.S.1    Steenberg, M.L.2    Perel, J.M.3    Manian, A.A.4    Buckley, J.5
  • 74
    • 0026349796 scopus 로고
    • Clinical pharmacokinetics of tricyclic antidepressant overdose
    • Jarvis, M. R. (1991). Clinical pharmacokinetics of tricyclic antidepressant overdose. Psychopharmacol. Bull. 27:541-550.
    • (1991) Psychopharmacol. Bull. , vol.27 , pp. 541-550
    • Jarvis, M.R.1
  • 75
    • 0018414674 scopus 로고
    • Inhibition of biogenic amine uptake by imipramine, desipramine, 2 OH-imipramine and 2 OH-desipramine in rat brain
    • Javaid, J. I., Perel, J. M., and Davis, J. M. (1979). Inhibition of biogenic amine uptake by imipramine, desipramine, 2 OH-imipramine and 2 OH-desipramine in rat brain. Life Sci. 24:21- 28.
    • (1979) Life Sci. , vol.24 , pp. 21-28
    • Javaid, J.I.1    Perel, J.M.2    Davis, J.M.3
  • 76
    • 0029018320 scopus 로고
    • Tamoxifen-associated reduction in tricyclic antidepressant levels in blood
    • Jefferson, J. W. (1995). Tamoxifen-associated reduction in tricyclic antidepressant levels in blood. J. Clin. Psychopharmacol. 15:223-224.
    • (1995) J. Clin. Psychopharmacol. , vol.15 , pp. 223-224
    • Jefferson, J.W.1
  • 77
    • 0027136288 scopus 로고
    • Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine
    • Johansson, I., Lundqvist, E., Bertilsson, L., Dahl, M.-L., Sjöqvist, F., and Ingelman-Sundberg, M. (1993). Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine. Proc. Natl. Acad. Sci. USA 90:11825-11829.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 11825-11829
    • Johansson, I.1    Lundqvist, E.2    Bertilsson, L.3    Dahl, M.-L.4    Sjöqvist, F.5    Ingelman-Sundberg, M.6
  • 78
    • 0024618510 scopus 로고
    • Transference and the beta adrenergic receptor: A case presentation
    • Kantor, S. J. (1989). Transference and the beta adrenergic receptor: A case presentation. Psychiatry 52:107-115.
    • (1989) Psychiatry , vol.52 , pp. 107-115
    • Kantor, S.J.1
  • 79
    • 0022348205 scopus 로고
    • Excretion of doxepin and N-desmethyldoxepin in human milk
    • Kemp, J., Ilett, K. F., and Booth, J. (1985). Excretion of doxepin and N-desmethyldoxepin in human milk. Br. J. Clin. Pharmacol. 20:479-484.
    • (1985) Br. J. Clin. Pharmacol. , vol.20 , pp. 479-484
    • Kemp, J.1    Ilett, K.F.2    Booth, J.3
  • 82
    • 0030055999 scopus 로고    scopus 로고
    • Steady-state plasma concentrations of imipramine and desipramine in relation to S-mephenytoin 4′-hydroxylation status in Japanese depressive patients
    • Koyama, E., Tanaka, T., Chiba, K., Kawakatsu, S., Morinobu, S., Totsuka, S., and Ishizaki, T. (1996). Steady-state plasma concentrations of imipramine and desipramine in relation to S-mephenytoin 4′-hydroxylation status in Japanese depressive patients. J. Clin. Psychopharmacol. 16:286-293.
    • (1996) J. Clin. Psychopharmacol. , vol.16 , pp. 286-293
    • Koyama, E.1    Tanaka, T.2    Chiba, K.3    Kawakatsu, S.4    Morinobu, S.5    Totsuka, S.6    Ishizaki, T.7
  • 84
    • 0022481211 scopus 로고
    • Electrocardiogram changes and therapeutic desipramine and 2-hydroxy-desipramine concentrations in elderly depressives
    • Kutcher, S. P., Reid, K., Dubbin, J. D., and Shulman, K. I. (1986a). Electrocardiogram changes and therapeutic desipramine and 2-hydroxy-desipramine concentrations in elderly depressives. Br. J. Psychiatry 148:676-679.
    • (1986) Br. J. Psychiatry , vol.148 , pp. 676-679
    • Kutcher, S.P.1    Reid, K.2    Dubbin, J.D.3    Shulman, K.I.4
  • 85
    • 0022968398 scopus 로고
    • Desipramine plasma concentration and therapeutic response in elderly depressives: A naturalistic pilot study
    • Kutcher, S. P., Shulman, K. I., and Reed, K. (1986b). Desipramine plasma concentration and therapeutic response in elderly depressives: A naturalistic pilot study. Can. J. Psychiatry 31:752- 754.
    • (1986) Can. J. Psychiatry , vol.31 , pp. 752-754
    • Kutcher, S.P.1    Shulman, K.I.2    Reed, K.3
  • 86
    • 0024323979 scopus 로고
    • Lofepramine: A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness
    • Lancaster, S. G., and Gonzalez, J. P. (1989a). Lofepramine: A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness. Drugs 37:123-140.
    • (1989) Drugs , vol.37 , pp. 123-140
    • Lancaster, S.G.1    Gonzalez, J.P.2
  • 87
    • 0024323979 scopus 로고
    • Dothiepin: A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness
    • Lancaster, S. G., and Gonzalez, J. P. (1989b). Dothiepin: A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness. Drugs 38:123-147.
    • (1989) Drugs , vol.38 , pp. 123-147
    • Lancaster, S.G.1    Gonzalez, J.P.2
  • 88
    • 0026329106 scopus 로고
    • Renal function and the disposition of antidepressants and their metabolites
    • Lane, E. A. (1991). Renal function and the disposition of antidepressants and their metabolites. Psychopharmacol. Bull. 27:533-540.
    • (1991) Psychopharmacol. Bull. , vol.27 , pp. 533-540
    • Lane, E.A.1
  • 90
    • 0002962585 scopus 로고
    • Ethnicity, culture, and psychopharmacology
    • Bloom, F. E., and Kupfer, D. J. (eds.), Raven Press, New York
    • Lin, K.-M., and Poland, R. E. (1995). Ethnicity, culture, and psychopharmacology. In Bloom, F. E., and Kupfer, D. J. (eds.), Psychopharmacology: The Fourth Generation of Progress, Raven Press, New York, pp. 1907-1917.
    • (1995) Psychopharmacology: the Fourth Generation of Progress , pp. 1907-1917
    • Lin, K.-M.1    Poland, R.E.2
  • 91
    • 0020305302 scopus 로고
    • Plasma steady-state concentrations of hydroxylated metabolites of clomipramine
    • Linnoila, M., Insel, T., Kilts, C., Potter, W. Z., and Murphy, D. L. (1982). Plasma steady-state concentrations of hydroxylated metabolites of clomipramine. Clin. Pharmacol. Ther. 32:208-211.
    • (1982) Clin. Pharmacol. Ther. , vol.32 , pp. 208-211
    • Linnoila, M.1    Insel, T.2    Kilts, C.3    Potter, W.Z.4    Murphy, D.L.5
  • 92
    • 0020603073 scopus 로고
    • Amoxapine overdose
    • Litovitz, T. L., and Troutman, W. G. (1983). Amoxapine overdose. JAMA 250:1069-1071.
    • (1983) JAMA , vol.250 , pp. 1069-1071
    • Litovitz, T.L.1    Troutman, W.G.2
  • 93
    • 0019719843 scopus 로고
    • Amoxapine: An antidepressant with some neuroleptic properties?
    • Lydiard, R. B., and Gelenberg, A. J. (1981). Amoxapine: An antidepressant with some neuroleptic properties? Pharmacotherapy 1:163-178.
    • (1981) Pharmacotherapy , vol.1 , pp. 163-178
    • Lydiard, R.B.1    Gelenberg, A.J.2
  • 94
    • 0023179676 scopus 로고
    • Serotonin uptake inhibition during treatment of depression with nortriptyline caused by parent drug and not by 10-hydroxymetabolites
    • Malmgren, R., Åberg-Wistedt, A., and Bertilsson, L. (1987). Serotonin uptake inhibition during treatment of depression with nortriptyline caused by parent drug and not by 10-hydroxymetabolites. Psychopharmacology 92:169-172.
    • (1987) Psychopharmacology , vol.92 , pp. 169-172
    • Malmgren, R.1    Åberg-Wistedt, A.2    Bertilsson, L.3
  • 95
    • 0022385811 scopus 로고
    • Respiratory depression caused by N-desmethyldoxepin in breast milk
    • Matheson, J., Pande, H., and Alersten, A. R. (1985). Respiratory depression caused by N-desmethyldoxepin in breast milk. Lancet 2:1124.
    • (1985) Lancet , vol.2 , pp. 1124
    • Matheson, J.1    Pande, H.2    Alersten, A.R.3
  • 96
    • 0024339393 scopus 로고
    • Plasma levels of nortriptyline and 10-hydroxynortriptyline and treatment-related electrocardiographic changes in the elderly depressed
    • McCue, R. E., Georgotas, A., Nagachandran, N., Basir, M. A., Go, E. A., Suckow, R. F., and Cooper, T. B. (1989). Plasma levels of nortriptyline and 10-hydroxynortriptyline and treatment-related electrocardiographic changes in the elderly depressed. J. Psychiatr. Res. 23:73-79.
    • (1989) J. Psychiatr. Res. , vol.23 , pp. 73-79
    • McCue, R.E.1    Georgotas, A.2    Nagachandran, N.3    Basir, M.A.4    Go, E.A.5    Suckow, R.F.6    Cooper, T.B.7
  • 97
    • 0019449455 scopus 로고
    • E- and Z-10-hydroxylation of nortriptyline: Relationship to polymorphic debrisoquine hydroxlylation
    • Mellström, B., Bertilsson, L., Säwe, J., Schulz, H.-U., and Sjöqvist, F. (1981). E- and Z-10-hydroxylation of nortriptyline: Relationship to polymorphic debrisoquine hydroxlylation. Clin. Pharmacol. Ther. 30:189-193.
    • (1981) Clin. Pharmacol. Ther. , vol.30 , pp. 189-193
    • Mellström, B.1    Bertilsson, L.2    Säwe, J.3    Schulz, H.-U.4    Sjöqvist, F.5
  • 99
    • 0022481136 scopus 로고
    • Amitriptyline metabolism: Association with debrisoquine hydroxylation in nonsmokers
    • Mellström, B., Säwe, J., Bertilsson, L., and Sjöqvist, F. (1986). Amitriptyline metabolism: Association with debrisoquine hydroxylation in nonsmokers. Clin. Pharmacol. Ther. 39:369-371.
    • (1986) Clin. Pharmacol. Ther. , vol.39 , pp. 369-371
    • Mellström, B.1    Säwe, J.2    Bertilsson, L.3    Sjöqvist, F.4
  • 100
    • 0024425090 scopus 로고
    • Nonlinear kinetics of trimipramine in depressed patients
    • Musa, M. N. (1989). Nonlinear kinetics of trimipramine in depressed patients. J. Clin. Pharmacol. 29:746-747.
    • (1989) J. Clin. Pharmacol. , vol.29 , pp. 746-747
    • Musa, M.N.1
  • 101
    • 0026739661 scopus 로고
    • Steady-state plasma levels of clomipramine and its metabolites: Impact of sparteine/debrisoquine oxidation polymorphism
    • Neilsen, K. K., and Gram, L. F. (1992). Steady-state plasma levels of clomipramine and its metabolites: Impact of sparteine/debrisoquine oxidation polymorphism. Eur. J. Pharmacol. 43:405-411.
    • (1992) Eur. J. Pharmacol. , vol.43 , pp. 405-411
    • Neilsen, K.K.1    Gram, L.F.2
  • 102
    • 0019996926 scopus 로고
    • Major adverse reactions during desipramine treatment: Relationship to drug plasma concentrations, concomitant antipsychotic treatment and patient characteristics
    • Nelson, J. C., Jatlow, P. I., and Bock, J. (1982). Major adverse reactions during desipramine treatment: Relationship to drug plasma concentrations, concomitant antipsychotic treatment and patient characteristics. Arch. Gen. Psychiatry 39:1055-1061.
    • (1982) Arch. Gen. Psychiatry , vol.39 , pp. 1055-1061
    • Nelson, J.C.1    Jatlow, P.I.2    Bock, J.3
  • 103
    • 0020575385 scopus 로고
    • Clinical implications of 2-hydroxydesipramine plasma concentrations
    • Nelson, J. C., Bock, J. L., and Jatlow, P. (1983). Clinical implications of 2-hydroxydesipramine plasma concentrations. Clin. Pharmacol. Ther. 33:183-189.
    • (1983) Clin. Pharmacol. Ther. , vol.33 , pp. 183-189
    • Nelson, J.C.1    Bock, J.L.2    Jatlow, P.3
  • 105
    • 0024076999 scopus 로고
    • Antidepressant activity of 2-hydroxydesipramine
    • Nelson, J. C., Mazure, C., and Jatlow, P. I. (1988b). Antidepressant activity of 2-hydroxydesipramine. Clin. Pharmacol. Ther. 88:283-288.
    • (1988) Clin. Pharmacol. Ther. , vol.88 , pp. 283-288
    • Nelson, J.C.1    Mazure, C.2    Jatlow, P.I.3
  • 106
    • 0024824048 scopus 로고
    • Clinical implications of the pharmacokinetics of tricyclic antidepressant
    • Dahl, S. G., and Gram, L. F. (eds.), Springer-Verlag, Berlin
    • Nelson, J. C., Mazure, C., and Jatlow, P. I. (1989). Clinical implications of the pharmacokinetics of tricyclic antidepressant. In Dahl, S. G., and Gram, L. F. (eds.), Clinical Pharmacology in Psychiatry, Springer-Verlag, Berlin, pp. 219-227.
    • (1989) Clinical Pharmacology in Psychiatry , pp. 219-227
    • Nelson, J.C.1    Mazure, C.2    Jatlow, P.I.3
  • 107
    • 8944262827 scopus 로고    scopus 로고
    • Clinical relevance of serum nortriptyline and 10-hydroxy-nortriptyline measurements in the depressed elderly: A multicenter pharmacokinetic and pharmacodynamic study
    • Ng Ying Kin, N. M. K., Klitgaard, N., Nair, N. P. V., Amin, M., Kragh-Sørensen, P., and Schwartz, G. (1996). Clinical relevance of serum nortriptyline and 10-hydroxy-nortriptyline measurements in the depressed elderly: A multicenter pharmacokinetic and pharmacodynamic study. Neuropsychpharmacology 15:1-6.
    • (1996) Neuropsychpharmacology , vol.15 , pp. 1-6
    • Ng Ying Kin, N.M.K.1    Klitgaard, N.2    Nair, N.P.V.3    Amin, M.4    Kragh-Sørensen, P.5    Schwartz, G.6
  • 108
    • 0025773565 scopus 로고
    • Antidepressant adverse drug reactions
    • Nierenberg, A. A., and Cole, J. O. (1991). Antidepressant adverse drug reactions. J. Clin. Psychiatry. 52 (Suppl. 6):40-47.
    • (1991) J. Clin. Psychiatry , vol.52 , Issue.6 SUPPL. , pp. 40-47
    • Nierenberg, A.A.1    Cole, J.O.2
  • 109
    • 0025962041 scopus 로고
    • Affinity of nortriptyline and its E-10-hydroxy metabolite for muscarinic receptors
    • Nilvebrant, L., and Nordin, C. (1991). Affinity of nortriptyline and its E-10-hydroxy metabolite for muscarinic receptors. Pharmacol. Toxicol. 68:64-67.
    • (1991) Pharmacol. Toxicol. , vol.68 , pp. 64-67
    • Nilvebrant, L.1    Nordin, C.2
  • 110
    • 0027143922 scopus 로고
    • CSF/plasma ratio of 10-hydroxynortriptyline is influenced by sex and body height
    • Nordin, C. (1993). CSF/plasma ratio of 10-hydroxynortriptyline is influenced by sex and body height. Psychopharmacology 113:222-224.
    • (1993) Psychopharmacology , vol.113 , pp. 222-224
    • Nordin, C.1
  • 111
    • 0028813788 scopus 로고
    • Active hydroxymetabolites of antidepressants: Emphasis on E-10-hydroxy-nortriptyline
    • Nordin, C., and Bertilsson, L. (1995). Active hydroxymetabolites of antidepressants: Emphasis on E-10-hydroxy-nortriptyline. Clin. Pharmacokinet. 28:26-40.
    • (1995) Clin. Pharmacokinet. , vol.28 , pp. 26-40
    • Nordin, C.1    Bertilsson, L.2
  • 112
    • 0022385112 scopus 로고
    • CSF and plasma levels of nortriptyline and its 10-hydroxy metabolite
    • Nordin, C., Bertilsson, L., and Siwers, B. (1985a). CSF and plasma levels of nortriptyline and its 10-hydroxy metabolite. Br. J. Pharmacol. 20:411-413.
    • (1985) Br. J. Pharmacol. , vol.20 , pp. 411-413
    • Nordin, C.1    Bertilsson, L.2    Siwers, B.3
  • 113
    • 0021933958 scopus 로고
    • Plasma concentrations of nortiptyline and its 10-hydroxy metabolite in depressed patients - Relationship to the debrisoquine hydroxylation metabolic ratio
    • Nordin, C., Siwers, B., Benitez, J., and Bertilsson, L. (1985b). Plasma concentrations of nortiptyline and its 10-hydroxy metabolite in depressed patients - Relationship to the debrisoquine hydroxylation metabolic ratio. Br. J. Clin. Pharmacol. 19::832-835.
    • (1985) Br. J. Clin. Pharmacol. , vol.19 , pp. 832-835
    • Nordin, C.1    Siwers, B.2    Benitez, J.3    Bertilsson, L.4
  • 114
    • 0023137711 scopus 로고
    • Little anticholinergic effect of E-10-hydroxynortriptyline compared with nortriptyline in healthy subjects
    • Nordin, C., Bertilsson, L., Otani, K., and Widmark, A. (1987a). Little anticholinergic effect of E-10-hydroxynortriptyline compared with nortriptyline in healthy subjects. Clin. Pharmacol. Ther. 41:97-102.
    • (1987) Clin. Pharmacol. Ther. , vol.41 , pp. 97-102
    • Nordin, C.1    Bertilsson, L.2    Otani, K.3    Widmark, A.4
  • 115
    • 0023214623 scopus 로고
    • Clinical and biochemical effects during treatment with nortriptyline: The role of 10-hydroxynortriptyline
    • Nordin, C., Bertilsson, L., and Siwers, B. (1987b). Clinical and biochemical effects during treatment with nortriptyline: The role of 10-hydroxynortriptyline. Clin. Pharmacol. Ther. 42:10-19.
    • (1987) Clin. Pharmacol. Ther. , vol.42 , pp. 10-19
    • Nordin, C.1    Bertilsson, L.2    Siwers, B.3
  • 116
    • 0026027245 scopus 로고
    • Treatment of depression with E-10-hydroxynortriptyline - Pilot study on biochemical effects and pharmacokinetics
    • Nordin, C., Bertilsson, L., Dahl-Puustinen, M.-L., Resul, B., Toresson, G., and Sjöqvist, F. (1991). Treatment of depression with E-10-hydroxynortriptyline - pilot study on biochemical effects and pharmacokinetics. Psychopharmacology 103:287-290.
    • (1991) Psychopharmacology , vol.103 , pp. 287-290
    • Nordin, C.1    Bertilsson, L.2    Dahl-Puustinen, M.-L.3    Resul, B.4    Toresson, G.5    Sjöqvist, F.6
  • 117
    • 0028856537 scopus 로고
    • Comparative neurotransmitter reuptake and anticholinergic potencies of the 8-hydroxy metabolites of clomipramine
    • Nunez, R., and Perel, J. M. (1995). Comparative neurotransmitter reuptake and anticholinergic potencies of the 8-hydroxy metabolites of clomipramine. Psychopharmacol. Bull. 31:217-221.
    • (1995) Psychopharmacol. Bull. , vol.31 , pp. 217-221
    • Nunez, R.1    Perel, J.M.2
  • 118
    • 0031033613 scopus 로고    scopus 로고
    • Grapefruit juice and clomipramine: Shifting metabolic ratios
    • Oesterheld, J., and Kallepalli, B. R. (1997). Grapefruit juice and clomipramine: Shifting metabolic ratios. J. Clin. Psychopharmacol. 17:62-63.
    • (1997) J. Clin. Psychopharmacol. , vol.17 , pp. 62-63
    • Oesterheld, J.1    Kallepalli, B.R.2
  • 119
    • 0022492224 scopus 로고
    • Effects of smoking on nortriptyline plasma concentrations in depressed patients
    • Perry, P. J., Browne, J. L., Prince, R. A., Alexander, B., and Tsuang, M. T. (1986). Effects of smoking on nortriptyline plasma concentrations in depressed patients. Ther. Drug. Monit. 8:279-284.
    • (1986) Ther. Drug. Monit. , vol.8 , pp. 279-284
    • Perry, P.J.1    Browne, J.L.2    Prince, R.A.3    Alexander, B.4    Tsuang, M.T.5
  • 121
    • 0028096880 scopus 로고
    • Recent developments in drug metabolism of relevance to psychiatrists
    • Pollock, B. G. (1994). Recent developments in drug metabolism of relevance to psychiatrists. Harv. Rev. Psychiatry. 2:204-213.
    • (1994) Harv. Rev. Psychiatry , vol.2 , pp. 204-213
    • Pollock, B.G.1
  • 122
    • 0030872675 scopus 로고    scopus 로고
    • Gender differences in psychotropic drug metabolism
    • Pollock, B. G. (1997). Gender differences in psychotropic drug metabolism. Psychopharmacol. Bull. 33:235-241.
    • (1997) Psychopharmacol. Bull. , vol.33 , pp. 235-241
    • Pollock, B.G.1
  • 123
    • 0024795334 scopus 로고
    • Hydroxy metabolites of tricyclic antidepressants: Evaluation of relative cardiotoxicity
    • Dahl, S. G., and Gram, L. F. (eds.), Springer-Verlag, Berlin
    • Pollock, B. G., and Perel, J. M. (1989). Hydroxy metabolites of tricyclic antidepressants: Evaluation of relative cardiotoxicity. In Dahl, S. G., and Gram, L. F. (eds.), Clinical Pharmacology in Psychiatry, Springer-Verlag, Berlin, pp. 232-236.
    • (1989) Clinical Pharmacology in Psychiatry , pp. 232-236
    • Pollock, B.G.1    Perel, J.M.2
  • 124
    • 0026501196 scopus 로고
    • Comparative cardiotoxicity of nortriptyline and its isomeric 10-hydroxymetabolites
    • Pollock, B. G., Everett, G., and Perel, J. M. (1992a). Comparative cardiotoxicity of nortriptyline and its isomeric 10-hydroxymetabolites. Neuropsychopharmacology 6:1-10.
    • (1992) Neuropsychopharmacology , vol.6 , pp. 1-10
    • Pollock, B.G.1    Everett, G.2    Perel, J.M.3
  • 127
    • 0344698287 scopus 로고
    • Metabolites of tricyclic antidepressants - Biological activity and clinical implications
    • Usdin, E. (ed.), Elsevier North-Holland, New York
    • Potter, W. Z., and Calil, H. M. (1981). Metabolites of tricyclic antidepressants - Biological activity and clinical implications. In Usdin, E. (ed.), Clinical Pharmacology in Psychiatry, Elsevier North-Holland, New York, pp. 311-324.
    • (1981) Clinical Pharmacology in Psychiatry , pp. 311-324
    • Potter, W.Z.1    Calil, H.M.2
  • 128
    • 0025282416 scopus 로고
    • Antidepressants, metabolites, and apparent drug resistance
    • Potter, W. Z., and Manji, H. K. (1990). Antidepressants, metabolites, and apparent drug resistance. Clin. Neuropharmacol. 13 (Suppl 1):S45-S53.
    • (1990) Clin. Neuropharmacol. , vol.13 , Issue.1 SUPPL.
    • Potter, W.Z.1    Manji, H.K.2
  • 130
    • 0018862365 scopus 로고
    • Steadystate concentrations of hydroxylated metabolites of tricyclic antidepressants in patients: Relationship to clinical effect
    • Potter, W. Z., Calil, H. M., Zavadil, A. P., Sutfin, T., Jusko, W. J., and Rapoport, J. (1980). Steadystate concentrations of hydroxylated metabolites of tricyclic antidepressants in patients: Relationship to clinical effect. Psychopharmacol. Bull. 16:32-34.
    • (1980) Psychopharmacol. Bull. , vol.16 , pp. 32-34
    • Potter, W.Z.1    Calil, H.M.2    Zavadil, A.P.3    Sutfin, T.4    Jusko, W.J.5    Rapoport, J.6
  • 132
    • 0344763778 scopus 로고
    • Hydroxy metabolite concentrations: Role of renal clearance
    • Gram, L. F., Usdin, E., Dahl, S. G., Kragh-Sørensen, P., Sjöqvist, F., and Morselli, P. L. (eds.), Macmillan Press, London
    • Potter, W. Z., Lane, E. A., and Rudorfer, M. V. (1983). Hydroxy metabolite concentrations: Role of renal clearance. In Gram, L. F., Usdin, E., Dahl, S. G., Kragh-Sørensen, P., Sjöqvist, F., and Morselli, P. L. (eds.), Clinical Pharmacology in Psychiatry. Bridging the Experimental-Therapeutic Gap, Macmillan Press, London, pp. 203-216.
    • (1983) Clinical Pharmacology in Psychiatry. Bridging the Experimental-Therapeutic Gap , pp. 203-216
    • Potter, W.Z.1    Lane, E.A.2    Rudorfer, M.V.3
  • 133
    • 0021194994 scopus 로고
    • Active metabolites of antidepressants: Pharmacodynamics and relevant pharmacokinetics
    • Usdin, E., Bertilsson, L., and Sjögvist, F. (eds.), Raven Press, New York
    • Potter, W. Z., Rudorfer, M. V., and Lane, E. A. (1984). Active metabolites of antidepressants: Pharmacodynamics and relevant pharmacokinetics. In Usdin, E., Bertilsson, L., and Sjögvist, F. (eds.), Frontiers in Biochemical and Pharmacological Research in Depression, Raven Press, New York, pp. 373-390.
    • (1984) Frontiers in Biochemical and Pharmacological Research in Depression , pp. 373-390
    • Potter, W.Z.1    Rudorfer, M.V.2    Lane, E.A.3
  • 135
    • 0004693377 scopus 로고
    • New clinical studies support a role of norepinephrine in antidepressant action
    • Barchas, J. D., and Bunney, W. E., Jr. (eds.), Alan R. Liss, New York
    • Potter, W. Z., Rudorfer, M. V., and Linnoila, M. (1988). New clinical studies support a role of norepinephrine in antidepressant action. In Barchas, J. D., and Bunney, W. E., Jr. (eds.), Perspectives in Psychopharmacology: A Collection of Papers in Honor of Earl Usdin. Alan R. Liss, New York, pp. 495-513.
    • (1988) Perspectives in Psychopharmacology: a Collection of Papers in Honor of Earl Usdin , pp. 495-513
    • Potter, W.Z.1    Rudorfer, M.V.2    Linnoila, M.3
  • 136
    • 0026433674 scopus 로고
    • The pharmacologic treatment of depression
    • Potter, W. Z., Rudorfer, M. V., and Manji, H. K. (1991). The pharmacologic treatment of depression. N. Engl. J. Med. 325:633-642.
    • (1991) N. Engl. J. Med. , vol.325 , pp. 633-642
    • Potter, W.Z.1    Rudorfer, M.V.2    Manji, H.K.3
  • 137
    • 0002900584 scopus 로고    scopus 로고
    • Tricyclics and tetracyclics
    • Schatzberg, A. F., and Nemeroff, C. B. (eds.), American Psychiatric Press, Washington, DC
    • Potter, W. Z., Manji, H. K., and Rudorfer, M. V. (1998). Tricyclics and tetracyclics. In Schatzberg, A. F., and Nemeroff, C. B. (eds.), The American Psychiatric Press Textbook of Psychopharmacology, American Psychiatric Press, Washington, DC, pp. 191-218.
    • (1998) The American Psychiatric Press Textbook of Psychopharmacology , pp. 191-218
    • Potter, W.Z.1    Manji, H.K.2    Rudorfer, M.V.3
  • 138
    • 0027375143 scopus 로고
    • Pharmacokinetics of antidepressants: Why and how they are relevant to treatment
    • Preskorn, S. H. (1993). Pharmacokinetics of antidepressants: Why and how they are relevant to treatment. J. Clin. Psychiatry 54 (Suppl 9):14-34.
    • (1993) J. Clin. Psychiatry , vol.54 , Issue.9 SUPPL. , pp. 14-34
    • Preskorn, S.H.1
  • 140
    • 0025779099 scopus 로고
    • Therapeutic drug monitoring for antidepressants: Efficacy, safety, and cost effectiveness
    • Preskorn, S. H., and Fast, G. A. (1991). Therapeutic drug monitoring for antidepressants: Efficacy, safety, and cost effectiveness. J. Clin. Psychiatry 52 (Suppl 6):23-33.
    • (1991) J. Clin. Psychiatry , vol.52 , Issue.6 SUPPL. , pp. 23-33
    • Preskorn, S.H.1    Fast, G.A.2
  • 141
    • 0020054272 scopus 로고
    • Toxicity of tricyclic antidepressants - Kinetics, mechanism, intervention: A review
    • Preskorn, S., and Irwin, H. (1982). Toxicity of tricyclic antidepressants - Kinetics, mechanism, intervention: A review. J. Clin. Psychiatry 43:151-156.
    • (1982) J. Clin. Psychiatry , vol.43 , pp. 151-156
    • Preskorn, S.1    Irwin, H.2
  • 144
    • 0345194262 scopus 로고    scopus 로고
    • Naturalistic study of the coadministration of psychostimulants and desipramine: Effects on serum desipramine levels
    • Prince, J., and Wilens, T. E. (1996). Naturalistic study of the coadministration of psychostimulants and desipramine: Effects on serum desipramine levels. Child Adolesc. Psychopharmacol. News 1(2):7.
    • (1996) Child Adolesc. Psychopharmacol. News , vol.1 , Issue.2 , pp. 7
    • Prince, J.1    Wilens, T.E.2
  • 145
    • 0021154649 scopus 로고
    • Antagonism by antidepressants of neurotransmitter receptors of normal human brain in vitro
    • Richelson, E., and Nelson, A. L. (1984). Antagonism by antidepressants of neurotransmitter receptors of normal human brain in vitro. J. Pharmacol. Toxicol. Methods 230:94-102.
    • (1984) J. Pharmacol. Toxicol. Methods , vol.230 , pp. 94-102
    • Richelson, E.1    Nelson, A.L.2
  • 147
    • 0027181359 scopus 로고
    • Challenges in medication clinical trials
    • Rudorfer, M. V. (1993a). Challenges in medication clinical trials. Psychopharmacol. Bull. 29:35-44.
    • (1993) Psychopharmacol. Bull. , vol.29 , pp. 35-44
    • Rudorfer, M.V.1
  • 148
    • 0027445286 scopus 로고
    • Pharmacokinetics of psychotropic drugs in special populations
    • Rudorfer, M. V. (1993b). Pharmacokinetics of psychotropic drugs in special populations. J. Clin. Psychiatry 54 (Suppl 9):50-54.
    • (1993) J. Clin. Psychiatry , vol.54 , Issue.9 SUPPL. , pp. 50-54
    • Rudorfer, M.V.1
  • 149
    • 0024337507 scopus 로고
    • Antidepressants: A comparative review of the clinical pharmacology and therapeutic use of the "newer" versus the "older" drugs
    • Rudorfer, M. V., and Potter, W. Z. (1989). Antidepressants: a comparative review of the clinical pharmacology and therapeutic use of the "newer" versus the "older" drugs. Drugs 37:713-738.
    • (1989) Drugs , vol.37 , pp. 713-738
    • Rudorfer, M.V.1    Potter, W.Z.2
  • 150
    • 0030949753 scopus 로고    scopus 로고
    • The role of metabolites of antidepressants in the treatment of depression
    • Rudorfer, M. V., and Potter, W. Z. (1997). The role of metabolites of antidepressants in the treatment of depression. CNS Drugs 7:273-312.
    • (1997) CNS Drugs , vol.7 , pp. 273-312
    • Rudorfer, M.V.1    Potter, W.Z.2
  • 151
    • 0018831877 scopus 로고
    • Desipramine: Cardiovascular effects and plasma levels
    • Rudorfer, M. V., and Young, R. C. (1980a). Desipramine: Cardiovascular effects and plasma levels. Am. J. Psychiatry 137:984-986.
    • (1980) Am. J. Psychiatry , vol.137 , pp. 984-986
    • Rudorfer, M.V.1    Young, R.C.2
  • 152
    • 0019146585 scopus 로고
    • Anticholinergic effects and plasma desipramine levels
    • Rudorfer, M. V., and Young, R. C. (1980b). Anticholinergic effects and plasma desipramine levels. Clin. Pharmacol. Ther. 28:703-706.
    • (1980) Clin. Pharmacol. Ther. , vol.28 , pp. 703-706
    • Rudorfer, M.V.1    Young, R.C.2
  • 157
    • 0028084777 scopus 로고
    • Comparative tolerability profiles of the newer versus older antidepressants
    • Rudorfer, M. V., Manji, H. K., and Potter, W. Z. (1994). Comparative tolerability profiles of the newer versus older antidepressants. Drug Saf. 10:18-46.
    • (1994) Drug Saf. , vol.10 , pp. 18-46
    • Rudorfer, M.V.1    Manji, H.K.2    Potter, W.Z.3
  • 158
  • 159
    • 0024263169 scopus 로고
    • Electrocardiographic changes with nortriptyline and 10-hydroxynortriptyline in elderly depressed outpatients
    • Schneider, L. S., Cooper, T. B., Severson, J. A., Zemplenyi, T., and Sloane, R.B . (1988). Electrocardiographic changes with nortriptyline and 10-hydroxynortriptyline in elderly depressed outpatients. J. Clin. Psychopharmacol. 8:402-408.
    • (1988) J. Clin. Psychopharmacol. , vol.8 , pp. 402-408
    • Schneider, L.S.1    Cooper, T.B.2    Severson, J.A.3    Zemplenyi, T.4    Sloane, R.B..5
  • 160
    • 0025000073 scopus 로고
    • Relationship of hydroxynortriptyline to nortriptyline concentration and creatinine clearance in depressed elderly outpatients
    • Schneider, L. S., Cooper, T. B., Suckow, R. F., Lyness, S. A., Haugen, C, Palmer, R., and Sloane, R. B. (1990). Relationship of hydroxynortriptyline to nortriptyline concentration and creatinine clearance in depressed elderly outpatients. J. Clin. Psychopharmacol. 10:333-337.
    • (1990) J. Clin. Psychopharmacol. , vol.10 , pp. 333-337
    • Schneider, L.S.1    Cooper, T.B.2    Suckow, R.F.3    Lyness, S.A.4    Haugen, C.5    Palmer, R.6    Sloane, R.B.7
  • 162
    • 0028832177 scopus 로고
    • Cytochrome P450 monooxygenases and interactions of psychotropic drugs: A five-year update
    • Shen, W. W. (1995). Cytochrome P450 monooxygenases and interactions of psychotropic drugs: A five-year update. Int. J. Psychiatry Med. 25:271-284.
    • (1995) Int. J. Psychiatry Med. , vol.25 , pp. 271-284
    • Shen, W.W.1
  • 163
    • 0030975675 scopus 로고    scopus 로고
    • The metabolism of psychoactive drugs: A review of enzymatic biotransformation and inhibition
    • Shen, W. W. (1997). The metabolism of psychoactive drugs: A review of enzymatic biotransformation and inhibition. Biol. Psychiatry 41:814-826.
    • (1997) Biol. Psychiatry , vol.41 , pp. 814-826
    • Shen, W.W.1
  • 164
    • 0025897328 scopus 로고
    • Cytochrome P450 monooxygenases and interactions of psychotropic drugs
    • Shen, W. W., and Lin, K.-M. (1991). Cytochrome P450 monooxygenases and interactions of psychotropic drugs. Int. J. Psychiatry Med. 21:47-56.
    • (1991) Int. J. Psychiatry Med. , vol.21 , pp. 47-56
    • Shen, W.W.1    Lin, K.-M.2
  • 165
    • 0029075613 scopus 로고
    • Interindividual variations of desmethylation and hydroxylation of amitriptyline in a Japanese psychi-atric population
    • Shimoda, K., Noguchi, T., Morita, S., Ozeki, Y., Shibasaki, M., Someya, T., and Takahashi, S. (1995a). Interindividual variations of desmethylation and hydroxylation of amitriptyline in a Japanese psychi-atric population. J. Clin. Psychopharmacol. 15:175-181.
    • (1995) J. Clin. Psychopharmacol. , vol.15 , pp. 175-181
    • Shimoda, K.1    Noguchi, T.2    Morita, S.3    Ozeki, Y.4    Shibasaki, M.5    Someya, T.6    Takahashi, S.7
  • 166
    • 0029092399 scopus 로고
    • Metabolism of clomipramine in a Japanese psychiatric population: Hydroxylation, desmethylation, and glucuronidation
    • Shimoda, K., Noguchi, T., Ozeki, Y., Morita, S., Shibasaki, M., and Someya, T., Takahashi, S. (1995b). Metabolism of clomipramine in a Japanese psychiatric population: Hydroxylation, desmethylation, and glucuronidation. Neurospychopharmacology 12:323-333.
    • (1995) Neurospychopharmacology , vol.12 , pp. 323-333
    • Shimoda, K.1    Noguchi, T.2    Ozeki, Y.3    Morita, S.4    Shibasaki, M.5    Someya, T.6    Takahashi, S.7
  • 167
    • 0026324564 scopus 로고
    • Interaction of ethanol and smoking on the pharmacokinetics and pharmacodynamics of psychotropic medications
    • Shoaf, S. E., and Linnoila, M. (1991). Interaction of ethanol and smoking on the pharmacokinetics and pharmacodynamics of psychotropic medications. Psychopharmacol. Bull. 27:577-594.
    • (1991) Psychopharmacol. Bull. , vol.27 , pp. 577-594
    • Shoaf, S.E.1    Linnoila, M.2
  • 168
    • 0024813498 scopus 로고
    • Pharmacogenetics of antidepressants
    • Dahl, S. G., and Gram, L. F. (eds.), Springer-Verlag, Berlin, 1989
    • Sjöqvist, F. (1989). Pharmacogenetics of antidepressants. In Dahl, S. G., and Gram, L. F. (eds.), Clinical Pharmacology in Psychiatry, Springer-Verlag, Berlin, 1989, pp. 181-191.
    • (1989) Clinical Pharmacology in Psychiatry , pp. 181-191
    • Sjöqvist, F.1
  • 169
    • 0025964524 scopus 로고
    • The mephenytoin oxidation polymorphism is partially responsible for the N-demethylation of imipramine
    • Skjelbo, E., Brosen, K., Hallas, J., and Gram, L. F. (1991). The mephenytoin oxidation polymorphism is partially responsible for the N-demethylation of imipramine. Clin. Pharmacol. Ther. 49:18-23.
    • (1991) Clin. Pharmacol. Ther. , vol.49 , pp. 18-23
    • Skjelbo, E.1    Brosen, K.2    Hallas, J.3    Gram, L.F.4
  • 170
    • 0017341989 scopus 로고
    • Antidepressants and the muscarinic acetylcholine receptor
    • Snyder, S. H., and Yamamura, H. I. (1977). Antidepressants and the muscarinic acetylcholine receptor. Arch. Gen .Psychiatry 34:236-239.
    • (1977) Arch. Gen .Psychiatry , vol.34 , pp. 236-239
    • Snyder, S.H.1    Yamamura, H.I.2
  • 172
    • 0030944304 scopus 로고    scopus 로고
    • Drug interactions with grapefruit: Whose responsibility is it to warn the public?
    • Spence, D. J. (1997). Drug interactions with grapefruit: Whose responsibility is it to warn the public? (Editorial). Clin. Pharmacol. Ther. 61:395-400.
    • (1997) Clin. Pharmacol. Ther. , vol.61 , pp. 395-400
    • Spence, D.J.1
  • 173
  • 174
    • 0001216806 scopus 로고
    • Newer and older antidepressants: A comparative review of drug interactions
    • Spina, E., and Perucca, E. (1994). Newer and older antidepressants: A comparative review of drug interactions. CNS Drugs 2:479-497.
    • (1994) CNS Drugs , vol.2 , pp. 479-497
    • Spina, E.1    Perucca, E.2
  • 175
    • 0027254118 scopus 로고
    • Effect of fluvoxamine on the pharmacokinetics of imipramine and desipramine in healthy subjects
    • Spina, E., Pollicino, A. M., Avenoso, A., Campo, G. M., Perucca, E., and Caputi, A. P. (1993a). Effect of fluvoxamine on the pharmacokinetics of imipramine and desipramine in healthy subjects. Ther. Drug Monit. 15:243-246.
    • (1993) Ther. Drug Monit. , vol.15 , pp. 243-246
    • Spina, E.1    Pollicino, A.M.2    Avenoso, A.3    Campo, G.M.4    Perucca, E.5    Caputi, A.P.6
  • 176
    • 0027342798 scopus 로고
    • Fluvoxamine-induced alterations in plasma concentrations of imipramine and desipramine in depressed patients
    • Spina, E., Pollicino, A. M., Avenoso, A., Campo, G. M., and Caputi, A. P. (1993b). Fluvoxamine-induced alterations in plasma concentrations of imipramine and desipramine in depressed patients. Int. J. Clin. Pharmacol. Res. 13:167-171.
    • (1993) Int. J. Clin. Pharmacol. Res. , vol.13 , pp. 167-171
    • Spina, E.1    Pollicino, A.M.2    Avenoso, A.3    Campo, G.M.4    Caputi, A.P.5
  • 177
    • 0026485291 scopus 로고
    • High-fiber diet and serum tricyclic antidepressant levels
    • Stewart, D. E. (1992). High-fiber diet and serum tricyclic antidepressant levels. J. Clin. Psychopharmacol. 12:438-440.
    • (1992) J. Clin. Psychopharmacol. , vol.12 , pp. 438-440
    • Stewart, D.E.1
  • 178
    • 0021318951 scopus 로고
    • The analysis and disposition of imipramine and its metabolites in man
    • Sutfin, T. A., DeVane, L. C., and Jusko, W. J. (1984). The analysis and disposition of imipramine and its metabolites in man. Psychopharmacology 82:310-317.
    • (1984) Psychopharmacology , vol.82 , pp. 310-317
    • Sutfin, T.A.1    DeVane, L.C.2    Jusko, W.J.3
  • 179
    • 0023854892 scopus 로고
    • Multiple-dose pharmacokinetics of imipramine and its major active and conjugated metabolites in depressed patients
    • Sutfin, T., Perini, G., Molnar, G., and Jusko, W. J. (1988). Multiple-dose pharmacokinetics of imipramine and its major active and conjugated metabolites in depressed patients. J. Clin. Psychopharmacol. 8:48-53.
    • (1988) J. Clin. Psychopharmacol. , vol.8 , pp. 48-53
    • Sutfin, T.1    Perini, G.2    Molnar, G.3    Jusko, W.J.4
  • 180
    • 0023926941 scopus 로고
    • Neuroleptic malignant syndrome following amoxapine overdose
    • Taylor, N. E., and Schwartz, H. I. (1988). Neuroleptic malignant syndrome following amoxapine overdose. J. Nerv. Ment. Dis. 176:249-251.
    • (1988) J. Nerv. Ment. Dis. , vol.176 , pp. 249-251
    • Taylor, N.E.1    Schwartz, H.I.2
  • 182
    • 0029126371 scopus 로고
    • Developmental perspectives in pediatric psychopharmacology
    • Vitiello, B., and Jensen, P. S. (1995). Developmental perspectives in pediatric psychopharmacology. Psychopharmacol. Bull. 31:75-81.
    • (1995) Psychopharmacol. Bull. , vol.31 , pp. 75-81
    • Vitiello, B.1    Jensen, P.S.2
  • 183
    • 0021267727 scopus 로고
    • Weak binding of 10-hydroxymetabolites of nortriptyline to rat brain muscarinic acetylcholine receptors
    • Wägner, A., Ekqvist, B., Bertilsson, L., and Sjöqvist, F. (1984). Weak binding of 10-hydroxymetabolites of nortriptyline to rat brain muscarinic acetylcholine receptors. Life Sci. 35:1379-1383.
    • (1984) Life Sci. , vol.35 , pp. 1379-1383
    • Wägner, A.1    Ekqvist, B.2    Bertilsson, L.3    Sjöqvist, F.4
  • 184
    • 0025688972 scopus 로고
    • Role of cytochromes P450 in drug metabolism and hepatotoxicity
    • Watkins, P. B. (1990). Role of cytochromes P450 in drug metabolism and hepatotoxicity. Semin. Liver Dis. 10:235-250.
    • (1990) Semin. Liver Dis. , vol.10 , pp. 235-250
    • Watkins, P.B.1
  • 185
    • 0026696674 scopus 로고
    • Developmental changes in serum concentrations of desipramine and 2-hydroxydesipramine during treatment with desipramine
    • Wilens, T. E., Biederman, J., Baldessarini, R. J., and Puopolo, P. R. (1992). Developmental changes in serum concentrations of desipramine and 2-hydroxydesipramine during treatment with desipramine. J. Am. Acad. Child Adolesc. Psychiatry 31:691-698.
    • (1992) J. Am. Acad. Child Adolesc. Psychiatry , vol.31 , pp. 691-698
    • Wilens, T.E.1    Biederman, J.2    Baldessarini, R.J.3    Puopolo, P.R.4
  • 186
    • 0027263389 scopus 로고
    • Electrocardiographic effects of desipramine and 2-hydroxydesipramine in children, adolescents, and adults treated with desipramine
    • Wilens, T. E., Biederman, J., Baldessarini, R. J., Puopolo, P. R., and Flood, J. G. (1993). Electrocardiographic effects of desipramine and 2-hydroxydesipramine in children, adolescents, and adults treated with desipramine. J. Am. Acad. Child Adolesc. Psychiatry 32:798-804.
    • (1993) J. Am. Acad. Child Adolesc. Psychiatry , vol.32 , pp. 798-804
    • Wilens, T.E.1    Biederman, J.2    Baldessarini, R.J.3    Puopolo, P.R.4    Flood, J.G.5
  • 187
    • 0031021117 scopus 로고    scopus 로고
    • Case study: Adverse effects of smoking marijuana while receiving tricyclic antidepressants
    • Wilens, T. E., Biederman, J., and Spencer, T. J. (1997). Case study: Adverse effects of smoking marijuana while receiving tricyclic antidepressants. J. Am. Acad. Child Adolesc. Psychiatry 36:45- 48.
    • (1997) J. Am. Acad. Child Adolesc. Psychiatry , vol.36 , pp. 45-48
    • Wilens, T.E.1    Biederman, J.2    Spencer, T.J.3
  • 188
    • 0017826454 scopus 로고
    • Antiarrhythmic effects of tricyclic antidepressant drugs in ouabain-induced arrhythmias in the dog
    • Wilkerson, R. D. (1978). Antiarrhythmic effects of tricyclic antidepressant drugs in ouabain-induced arrhythmias in the dog. J. Pharmacol. Exp. Ther. 206:666-674.
    • (1978) J. Pharmacol. Exp. Ther. , vol.206 , pp. 666-674
    • Wilkerson, R.D.1
  • 189
    • 0025739054 scopus 로고
    • Serum nortriptyline levels in nursing mothers and their infants
    • Wisner, K. L., and Perel, J. M. (1991). Serum nortriptyline levels in nursing mothers and their infants. Am. J. Psychiatry 148:1234-1236.
    • (1991) Am. J. Psychiatry , vol.148 , pp. 1234-1236
    • Wisner, K.L.1    Perel, J.M.2
  • 190
    • 0027521318 scopus 로고
    • Tricyclic dose requirements across pregnancy
    • Wisner, K. L., Perel, J. M., and Wheeler, S. B. (1993). Tricyclic dose requirements across pregnancy. Am. J. Psychiatry. 150:1541-1542.
    • (1993) Am. J. Psychiatry. , vol.150 , pp. 1541-1542
    • Wisner, K.L.1    Perel, J.M.2    Wheeler, S.B.3
  • 191
    • 0028815043 scopus 로고
    • Serum clomipramine and metabolite levels in four nursing mother-infant pairs
    • Wisner, K. L., Perel, J. M., and Foglia, J. P. (1995). Serum clomipramine and metabolite levels in four nursing mother-infant pairs. J. Clin. Psychiatry 56:17-20.
    • (1995) J. Clin. Psychiatry , vol.56 , pp. 17-20
    • Wisner, K.L.1    Perel, J.M.2    Foglia, J.P.3
  • 192
    • 0030795509 scopus 로고    scopus 로고
    • Nortriptyline and its hydroxymetabolites in breastfeeding mothers and newborns
    • Wisner, K. L., Perel, J. M., Findling, R. L., and Hinnes, R. L. (1997). Nortriptyline and its hydroxymetabolites in breastfeeding mothers and newborns. Psychopharmacol. Bull. 33:249- 251.
    • (1997) Psychopharmacol. Bull. , vol.33 , pp. 249-251
    • Wisner, K.L.1    Perel, J.M.2    Findling, R.L.3    Hinnes, R.L.4
  • 193
    • 0029757143 scopus 로고    scopus 로고
    • Effects of divalproes sodium on amitriptyline and nortriptyline pharmacokinetics
    • Wong, S. L., Cavanaugh, J., Shi, H., Awni, W. M., and Granneman, R. (1996). Effects of divalproes sodium on amitriptyline and nortriptyline pharmacokinetics. Clin. Pharmacol. Ther. 60:48-53.
    • (1996) Clin. Pharmacol. Ther. , vol.60 , pp. 48-53
    • Wong, S.L.1    Cavanaugh, J.2    Shi, H.3    Awni, W.M.4    Granneman, R.5
  • 194
    • 0026529727 scopus 로고
    • Gender differences in pharmacokinetics and pharmacodynamics of psychotropic medication
    • Yonkers, K. A., Kando, J. C., Cole, J. O., and Blumentahl, S. (1992). Gender differences in pharmacokinetics and pharmacodynamics of psychotropic medication. Am. J. Psychiatry 149:587- 595.
    • (1992) Am. J. Psychiatry , vol.149 , pp. 587-595
    • Yonkers, K.A.1    Kando, J.C.2    Cole, J.O.3    Blumentahl, S.4
  • 195
    • 0026357115 scopus 로고
    • Hydroxylated metabolites of antidepressants
    • Young, R. C. (1991). Hydroxylated metabolites of antidepressants. Psychopharmacol. Bull. 27:521-552.
    • (1991) Psychopharmacol. Bull. , vol.27 , pp. 521-552
    • Young, R.C.1
  • 196
    • 0021337318 scopus 로고
    • Heart failure associated with high plasma 10-hydroxynortriptyline levels
    • Young, R. C., Alexopoulos, G. S., Shamoian, C. A., Dhar, A. K., and Kutt, H. (1984a). Heart failure associated with high plasma 10-hydroxynortriptyline levels. Am. J. Psychiatry 141:432-433.
    • (1984) Am. J. Psychiatry , vol.141 , pp. 432-433
    • Young, R.C.1    Alexopoulos, G.S.2    Shamoian, C.A.3    Dhar, A.K.4    Kutt, H.5
  • 197
    • 0021241821 scopus 로고
    • Plasma 10-hydroxynortriptyline in elderly depressed patients
    • Young, R. C., Alexopoulos, G. S., and Shamoian, C. A. (1984b). Plasma 10-hydroxynortriptyline in elderly depressed patients. Clin. Pharmacol. Ther. 35:540-544.
    • (1984) Clin. Pharmacol. Ther. , vol.35 , pp. 540-544
    • Young, R.C.1    Alexopoulos, G.S.2    Shamoian, C.A.3
  • 199
    • 0023266675 scopus 로고
    • 10-hydroxynortriptyline and renal function in elderly depressives
    • Young, R. C., Alexopoulos, G. S., Dhar, A. K., and Kutt, H. (1987). 10-hydroxynortriptyline and renal function in elderly depressives. Biol. Psychiatry 22:1283-1287.
    • (1987) Biol. Psychiatry , vol.22 , pp. 1283-1287
    • Young, R.C.1    Alexopoulos, G.S.2    Dhar, A.K.3    Kutt, H.4
  • 202
    • 0017612046 scopus 로고
    • Tricyclic plasma levels: Effect of age, race, sex, and smoking
    • Ziegler, V. E., and Biggs, J. T. (1977). Tricyclic plasma levels: Effect of age, race, sex, and smoking. JAMA 238:2167-2169.
    • (1977) JAMA , vol.238 , pp. 2167-2169
    • Ziegler, V.E.1    Biggs, J.T.2
  • 203
    • 0017131067 scopus 로고
    • Nortriptyline and 10-hydroxynortriptyline plasma concentrations
    • Ziegler, V. E., Fuller, T. A., and Biggs, J. T. (1976). Nortriptyline and 10-hydroxynortriptyline plasma concentrations. J. Pharm. Pharmacol. 28:849-850.
    • (1976) J. Pharm. Pharmacol. , vol.28 , pp. 849-850
    • Ziegler, V.E.1    Fuller, T.A.2    Biggs, J.T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.