-
1
-
-
0014128388
-
Plasma levels of monomethylated tricyclic antidepressants during treatment wich imipramine-like compounds
-
Hammer W, Sjöqvist F. Plasma levels of monomethylated tricyclic antidepressants during treatment wich imipramine-like compounds. Life Sci 1967; 6: 1895-903
-
(1967)
Life Sci
, vol.6
, pp. 1895-1903
-
-
Hammer, W.1
Sjöqvist, F.2
-
2
-
-
0022621321
-
Plasma level monitoring of antipsychotic drugs
-
Dahl SG. Plasma level monitoring of antipsychotic drugs. Clin Pharmacokinet 1986; 11: 36-61
-
(1986)
Clin Pharmacokinet
, vol.11
, pp. 36-61
-
-
Dahl, S.G.1
-
4
-
-
0026651273
-
Human cytochromes P450: Problems and prospects
-
Gonzalez FJ. Human cytochromes P450: problems and prospects. Trends Pharmacol Sci 1992; 13: 346-52
-
(1992)
Trends Pharmacol Sci
, vol.13
, pp. 346-352
-
-
Gonzalez, F.J.1
-
5
-
-
0017695082
-
Polymorphic hydroxylation of debrisoquine in man
-
Mahgoub A, Idle JR, Dring DG, et al. Polymorphic hydroxylation of debrisoquine in man. Lancet 1977; 2: 584-6
-
(1977)
Lancet
, vol.2
, pp. 584-586
-
-
Mahgoub, A.1
Idle, J.R.2
Dring, D.G.3
-
6
-
-
0017667456
-
Polymorphic hydroxylation of debrisoquine in man
-
Tucker GT, Silas JH, Iyun AO, et al. Polymorphic hydroxylation of debrisoquine in man [letter]. Lancet 1977; 2: 718
-
(1977)
Lancet
, vol.2
, pp. 718
-
-
Tucker, G.T.1
Silas, J.H.2
Iyun, A.O.3
-
7
-
-
0018615011
-
Defective N-oxidation of sparteine in man: A new pharmacogenetic defect
-
Eichelbaum M, Spannbrucker N, Steinke B, et al. Defective N-oxidation of sparteine in man: a new pharmacogenetic defect. Eur J Clin Pharmacol 1979; 16: 183-7
-
(1979)
Eur J Clin Pharmacol
, vol.16
, pp. 183-187
-
-
Eichelbaum, M.1
Spannbrucker, N.2
Steinke, B.3
-
8
-
-
0020068049
-
Polymorphic oxidation of sparteine and debrisoquine: Related pharmacogenetic entities
-
Eichelbaum M, Bertilsson L, Säwe J, et al. Polymorphic oxidation of sparteine and debrisoquine: related pharmacogenetic entities. Clin Pharmacol Ther 1982; 31: 184-6
-
(1982)
Clin Pharmacol Ther
, vol.31
, pp. 184-186
-
-
Eichelbaum, M.1
Bertilsson, L.2
Säwe, J.3
-
10
-
-
0027445449
-
Isolation and characterization of human liver cytochrome P4502C19: Correlation between 2C19 and S-mephenytoin 4′-hydroxylation
-
Wrighton SA, Stevens JC, Becker GW, et al. Isolation and characterization of human liver cytochrome P4502C19: correlation between 2C19 and S-mephenytoin 4′-hydroxylation. Arch Biochem Biophys 1993; 306: 240-5
-
(1993)
Arch Biochem Biophys
, vol.306
, pp. 240-245
-
-
Wrighton, S.A.1
Stevens, J.C.2
Becker, G.W.3
-
11
-
-
0028279041
-
Evidence that CYP2C19 is the major (S)-mephenytoin 4′-hydroxylase in humans
-
Goldstein JA, Faletto MB, Romkes-Sparks M, et al. Evidence that CYP2C19 is the major (S)-mephenytoin 4′-hydroxylase in humans. Biochemistry 1994; 33: 1743-52
-
(1994)
Biochemistry
, vol.33
, pp. 1743-1752
-
-
Goldstein, J.A.1
Faletto, M.B.2
Romkes-Sparks, M.3
-
12
-
-
0018900001
-
A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population
-
Evans DA, Mahgoub A, Sloan TP, et al. A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population. J Med Genet 1980; 17: 102-5
-
(1980)
J Med Genet
, vol.17
, pp. 102-105
-
-
Evans, D.A.1
Mahgoub, A.2
Sloan, T.P.3
-
13
-
-
0025572192
-
Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations
-
Alván G, Bechtel P, Iselius L, et al. Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations. Eur J Clin Pharmacol 1990; 39: 533-7
-
(1990)
Eur J Clin Pharmacol
, vol.39
, pp. 533-537
-
-
Alván, G.1
Bechtel, P.2
Iselius, L.3
-
14
-
-
0026506140
-
Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquine and S-mephenytoin
-
Bertilsson L, Lou YQ, Du YL, et al. Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquine and S-mephenytoin. Clin Pharmacol Ther 1992; 51: 388-97
-
(1992)
Clin Pharmacol Ther
, vol.51
, pp. 388-397
-
-
Bertilsson, L.1
Lou, Y.Q.2
Du, Y.L.3
-
16
-
-
0029055448
-
Phenotyping and genotyping of S-mephenytoin hydroxylase (cytochrome P450 2C19) in a Shona population of Zimbabwe
-
Masimirembwa C, Bertilsson L, Johansson I, et al. Phenotyping and genotyping of S-mephenytoin hydroxylase (cytochrome P450 2C19) in a Shona population of Zimbabwe. Clin Pharmacol Ther 1995; 37: 656-61
-
(1995)
Clin Pharmacol Ther
, vol.37
, pp. 656-661
-
-
Masimirembwa, C.1
Bertilsson, L.2
Johansson, I.3
-
17
-
-
0023154962
-
Debrisoquine 4-hydroxylase: Characterization of anew P450 gene family, regulation, chromosomal mapping and molecular analysis of the DA rat polymorphism
-
Gonzalez FJ, Matsunaga T, Nagata K, et al. Debrisoquine 4-hydroxylase: characterization of anew P450 gene family, regulation, chromosomal mapping and molecular analysis of the DA rat polymorphism. DNA 1987; 6: 149-61
-
(1987)
DNA
, vol.6
, pp. 149-161
-
-
Gonzalez, F.J.1
Matsunaga, T.2
Nagata, K.3
-
18
-
-
0023684586
-
Absence of hepatic cytochrome P450bufI causes genetically deficient debrisoquine oxidation in man
-
Zanger UM, Vilbois F, Hardwick JP, et al. Absence of hepatic cytochrome P450bufI causes genetically deficient debrisoquine oxidation in man. Biochemistry 1988; 27: 5447-54
-
(1988)
Biochemistry
, vol.27
, pp. 5447-5454
-
-
Zanger, U.M.1
Vilbois, F.2
Hardwick, J.P.3
-
19
-
-
0025036544
-
Multiple mutations of the human cytochrome P450IID6 gene (CYP2D6) in poor metabolisers of debrisoquine
-
Kagimoto M, Heim M, Kagimoto K, et al. Multiple mutations of the human cytochrome P450IID6 gene (CYP2D6) in poor metabolisers of debrisoquine. J Biol Chem 1990; 265: 17209-14
-
(1990)
J Biol Chem
, vol.265
, pp. 17209-17214
-
-
Kagimoto, M.1
Heim, M.2
Kagimoto, K.3
-
20
-
-
0025080352
-
Genotyping of poor metabolisers of debrisoquine by allele-specific PCR amplification
-
Heim M, Meyer UA. Genotyping of poor metabolisers of debrisoquine by allele-specific PCR amplification. Lancet 1990; 336: 529-32
-
(1990)
Lancet
, vol.336
, pp. 529-532
-
-
Heim, M.1
Meyer, U.A.2
-
21
-
-
0025114258
-
Identification of the primary gene defect at the cytochrome P450 CYP2D locus
-
Gough AC, Miles JS, Spurr NK, et al. Identification of the primary gene defect at the cytochrome P450 CYP2D locus. Nature 1990; 347: 773-6
-
(1990)
Nature
, vol.347
, pp. 773-776
-
-
Gough, A.C.1
Miles, J.S.2
Spurr, N.K.3
-
22
-
-
0025805934
-
Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism
-
Gaedigk A, Blum M, Gaedigk R, et al. Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism. Am J Hum Genet 1991; 48: 943-50
-
(1991)
Am J Hum Genet
, vol.48
, pp. 943-950
-
-
Gaedigk, A.1
Blum, M.2
Gaedigk, R.3
-
23
-
-
0025950370
-
Debrisoquine/sparteine hydroxylation genotype and phenotype: Analysis of common mutations and alleles of CYP2D6 in a European population
-
Broly F, Gaedigk A, Heim M, et al. Debrisoquine/sparteine hydroxylation genotype and phenotype: analysis of common mutations and alleles of CYP2D6 in a European population. DNA Cell Biol 1991; 10: 545-58
-
(1991)
DNA Cell Biol
, vol.10
, pp. 545-558
-
-
Broly, F.1
Gaedigk, A.2
Heim, M.3
-
24
-
-
0026610576
-
Analysis of the CYP2D6 gene in relation to debrisoquin and desipramine hydroxylation in a Swedish population
-
Dahl M-L, Johansson I, Porsmyr Palmertz M, et al. Analysis of the CYP2D6 gene in relation to debrisoquin and desipramine hydroxylation in a Swedish population. Clin Pharmacol Ther 1992; 51: 12-7
-
(1992)
Clin Pharmacol Ther
, vol.51
, pp. 12-17
-
-
Dahl, M.-L.1
Johansson, I.2
Porsmyr Palmertz, M.3
-
25
-
-
0027965620
-
Genetic analysis of the Chinese CYP2D6 locus: Characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation
-
Johansson I, Oscarsson M, Yue QY, et al. Genetic analysis of the Chinese CYP2D6 locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation. Mol Pharmacol 1994; 46: 452-9
-
(1994)
Mol Pharmacol
, vol.46
, pp. 452-459
-
-
Johansson, I.1
Oscarsson, M.2
Yue, Q.Y.3
-
26
-
-
0027763168
-
Genetic polymorphism of cytochrome P450 2D6 in Zimbabwean population
-
Masimirembwa CM, Johansson I, Hasler JA, et al. Genetic polymorphism of cytochrome P450 2D6 in Zimbabwean population. Pharmacogenetics 1993; 3: 275-80
-
(1993)
Pharmacogenetics
, vol.3
, pp. 275-280
-
-
Masimirembwa, C.M.1
Johansson, I.2
Hasler, J.A.3
-
27
-
-
0027276869
-
Genetic basis for a lower prevalence of deficient CYP2D6 oxidative drug metabolism phenotypes in black Americans
-
Evans WE, Relling MV, Rahman A, et al. Genetic basis for a lower prevalence of deficient CYP2D6 oxidative drug metabolism phenotypes in black Americans. J Clin Invest 1993; 91: 2150-4
-
(1993)
J Clin Invest
, vol.91
, pp. 2150-2154
-
-
Evans, W.E.1
Relling, M.V.2
Rahman, A.3
-
28
-
-
0027136288
-
Inherited amplification of an active gene in the cytochrome P450 CYP2D-locus as a cause of ultrarapid metabolism of debrisoquine
-
Johansson I, Lundqvist E, Bertilsson L, et al. Inherited amplification of an active gene in the cytochrome P450 CYP2D-locus as a cause of ultrarapid metabolism of debrisoquine. Proc Natl Acad Sci USA 1993; 90: 11825-9
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 11825-11829
-
-
Johansson, I.1
Lundqvist, E.2
Bertilsson, L.3
-
29
-
-
0001935587
-
Interindividual and interethnic differences in polymorphic drug oxidation: Implication for drug therapy with focus on psychoactive drugs
-
Pacifici GM, Fracchia GN, editors. Brussels: European Commission
-
Bertilsson L, Dahl M-L, Ingelman-Sundberg M, et al. Interindividual and interethnic differences in polymorphic drug oxidation: implication for drug therapy with focus on psychoactive drugs. In: Pacifici GM, Fracchia GN, editors. Advances in drug metabolism in man. Brussels: European Commission, 1995: 85-136
-
(1995)
Advances in Drug Metabolism in Man
, pp. 85-136
-
-
Bertilsson, L.1
Dahl, M.-L.2
Ingelman-Sundberg, M.3
-
30
-
-
0026240145
-
Identification of a new variant CYP2D6 allele lacking the codon encoding Lys-281: Possible association with the poor metabolizer phenotype
-
Tyndale R, Aoyama T, Broly F, et al. Identification of a new variant CYP2D6 allele lacking the codon encoding Lys-281: possible association with the poor metabolizer phenotype. Pharmacogenetics 1991; 1: 26-32
-
(1991)
Pharmacogenetics
, vol.1
, pp. 26-32
-
-
Tyndale, R.1
Aoyama, T.2
Broly, F.3
-
31
-
-
0027273757
-
Debrisoquine oxidation polymorphism: Phenotypic consequences of a 3-base-pair deletion in exon 5 of the CYP2D6 gene
-
Broly F, Meyer UA. Debrisoquine oxidation polymorphism: phenotypic consequences of a 3-base-pair deletion in exon 5 of the CYP2D6 gene. Pharmacogenetics 1993; 3: 123-30
-
(1993)
Pharmacogenetics
, vol.3
, pp. 123-130
-
-
Broly, F.1
Meyer, U.A.2
-
32
-
-
0027534276
-
Molecular basis for rational megaprescribing in ultrarapid hydroxylators of debrisoquine
-
Bertilsson L, Dahl M-L, Sjöqvist F, et al. Molecular basis for rational megaprescribing in ultrarapid hydroxylators of debrisoquine [letter]. Lancet 1993; 341: 63
-
(1993)
Lancet
, vol.341
, pp. 63
-
-
Bertilsson, L.1
Dahl, M.-L.2
Sjöqvist, F.3
-
33
-
-
0029064096
-
Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis
-
Dahl M-L, Johansson I, Bertilsson L, et al. Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis. J Pharmacol Exp Ther 1995; 274: 516-20
-
(1995)
J Pharmacol Exp Ther
, vol.274
, pp. 516-520
-
-
Dahl, M.-L.1
Johansson, I.2
Bertilsson, L.3
-
34
-
-
0022178173
-
Interethnic differences in genetic polymorphism of debrisoquine and mephenyloin hydroxylation between Japanese and Caucasian populations
-
Nakamura K, Goto F, Ray WA, et al. Interethnic differences in genetic polymorphism of debrisoquine and mephenyloin hydroxylation between Japanese and Caucasian populations. Clin Pharmacol Ther 1985; 38: 402-8
-
(1985)
Clin Pharmacol Ther
, vol.38
, pp. 402-408
-
-
Nakamura, K.1
Goto, F.2
Ray, W.A.3
-
35
-
-
0026091975
-
Metoprolol oxidation polymorphism in a Korean population: Comparison with native Japanese and Chinese populations
-
Sohn D-R, Shin S-G, Park C-W, et al. Metoprolol oxidation polymorphism in a Korean population: comparison with native Japanese and Chinese populations. Br J Clin Pharmacol 1991; 32: 504-7
-
(1991)
Br J Clin Pharmacol
, vol.32
, pp. 504-507
-
-
Sohn, D.-R.1
Shin, S.-G.2
Park, C.-W.3
-
36
-
-
0025890423
-
Genetic analysis of the interethnic difference between Chinese and Caucasians in the polymorphic metabolism of debrisoquine and codeine
-
Johansson I, Yue QY, Dahl M-L, et al. Genetic analysis of the interethnic difference between Chinese and Caucasians in the polymorphic metabolism of debrisoquine and codeine. Eur J Clin Pharmacol 1991; 40: 553-6
-
(1991)
Eur J Clin Pharmacol
, vol.40
, pp. 553-556
-
-
Johansson, I.1
Yue, Q.Y.2
Dahl, M.-L.3
-
37
-
-
0027527966
-
Evidence for a new variant CYP2D6 allele CYP2D6J in a Japanese population associated with lower in vitro rates of sparteine metabolism
-
Yokota H, Tamura S, Furuya H, et al. Evidence for a new variant CYP2D6 allele CYP2D6J in a Japanese population associated with lower in vitro rates of sparteine metabolism. Pharmacogenetics 1993; 3: 256-63
-
(1993)
Pharmacogenetics
, vol.3
, pp. 256-263
-
-
Yokota, H.1
Tamura, S.2
Furuya, H.3
-
38
-
-
0029053644
-
Genetic analysis of the CYP2D locus in relation to debrisoquine hydroxylation capacity in Korean, Japanese and Chinese subjects
-
Dahl M-L, Yue Q-Y, Roh H-K, et al. Genetic analysis of the CYP2D locus in relation to debrisoquine hydroxylation capacity in Korean, Japanese and Chinese subjects. Pharmacogenetics 1995; 5: 159-64
-
(1995)
Pharmacogenetics
, vol.5
, pp. 159-164
-
-
Dahl, M.-L.1
Yue, Q.-Y.2
Roh, H.-K.3
-
39
-
-
0026031652
-
Interethnic variation of drug metabolism
-
Kalow W. Interethnic variation of drug metabolism. Trends Pharmacol Sci 1991; 12: 102-7
-
(1991)
Trends Pharmacol Sci
, vol.12
, pp. 102-107
-
-
Kalow, W.1
-
40
-
-
0028260641
-
The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans
-
de Morais SMF, Wilkinson GR, Blaisdell J, et al. The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans. J Biol Chem 1994; 269: 15419-22
-
(1994)
J Biol Chem
, vol.269
, pp. 15419-15422
-
-
De Morais, S.M.F.1
Wilkinson, G.R.2
Blaisdell, J.3
-
41
-
-
0022511288
-
Genetic relationship of human populations and ethnic differences in reactions to drugs and food
-
Kalow W, Goedde HW, Agarwal DP, editors. New York: Alan R Liss
-
Nei M, Saitou N. Genetic relationship of human populations and ethnic differences in reactions to drugs and food. In: Kalow W, Goedde HW, Agarwal DP, editors. Ethnic differences in reactions to drugs and xenobiotics. New York: Alan R Liss, 1986: 21-37
-
(1986)
Ethnic Differences in Reactions to Drugs and Xenobiotics
, pp. 21-37
-
-
Nei, M.1
Saitou, N.2
-
42
-
-
0028044085
-
Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese
-
de Morais SMF, Wilkinson GR, Blaisdell J, et al. Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese. Mol Pharmacol 1994; 46: 594-8
-
(1994)
Mol Pharmacol
, vol.46
, pp. 594-598
-
-
De Morais, S.M.F.1
Wilkinson, G.R.2
Blaisdell, J.3
-
43
-
-
0029587180
-
Use of omeprazole as a probe drug for CYP2C19 phenotype in Swedish Caucasians. Comparison with S-mephenytoin hydroxylation phenotype and CYP2C19 genotype
-
Chang M, Duhl M-L, Tybring G, et al. Use of omeprazole as a probe drug for CYP2C19 phenotype in Swedish Caucasians. Comparison with S-mephenytoin hydroxylation phenotype and CYP2C19 genotype. Pharmacogenetics 1995; 5: 358-63
-
(1995)
Pharmacogenetics
, vol.5
, pp. 358-363
-
-
Chang, M.1
Duhl, M.-L.2
Tybring, G.3
-
44
-
-
0021684926
-
Mephenytoin hydroxylation deficiency in Caucasians: Frequency of a new oxidative drug metabolism polymorphism
-
Wedlund PJ, Aslanian WS, McAllister CB, et al. Mephenytoin hydroxylation deficiency in Caucasians: frequency of a new oxidative drug metabolism polymorphism. Clin Pharmacol Ther 1984; 36: 773-80
-
(1984)
Clin Pharmacol Ther
, vol.36
, pp. 773-780
-
-
Wedlund, P.J.1
Aslanian, W.S.2
McAllister, C.B.3
-
45
-
-
0024336503
-
S-mephenytoin hydroxylation phenotype in a Swedish population determined after co-administration with debrisoquin
-
Sanz EJ, Villen T, Alm C, et al. S-mephenytoin hydroxylation phenotype in a Swedish population determined after co-administration with debrisoquin. Clin Pharmacol Ther 1989; 45: 495-9
-
(1989)
Clin Pharmacol Ther
, vol.45
, pp. 495-499
-
-
Sanz, E.J.1
Villen, T.2
Alm, C.3
-
46
-
-
0022220338
-
Genetic polymorphism of mephenyloin p(4′)-hydroxylation: Difference between Orientals and Caucasians
-
Jurima M, Inaba T, Kadar D, et al. Genetic polymorphism of mephenyloin p(4′)-hydroxylation: difference between Orientals and Caucasians. Br J Clin Pharmacol 1985; 19: 483-7
-
(1985)
Br J Clin Pharmacol
, vol.19
, pp. 483-487
-
-
Jurima, M.1
Inaba, T.2
Kadar, D.3
-
47
-
-
0024442372
-
Metoprolol and mephenytoin oxidation polymorphisms in Far Eastern Oriental subjects: Japanese versus mainland Chinese
-
Horai Y, Nakano M, Ishizaki T, et al. Metoprolol and mephenytoin oxidation polymorphisms in Far Eastern Oriental subjects: Japanese versus mainland Chinese. Clin Pharmacol Ther 1989; 46: 198-207
-
(1989)
Clin Pharmacol Ther
, vol.46
, pp. 198-207
-
-
Horai, Y.1
Nakano, M.2
Ishizaki, T.3
-
48
-
-
0026705708
-
Incidence of S-mephenytoin hydroxylation deficiency in a Korean population and the interphenotypic differences in diazepam pharmacokinetics
-
Sohn DR, Kusaka M, Ishizaki T, et al. Incidence of S-mephenytoin hydroxylation deficiency in a Korean population and the interphenotypic differences in diazepam pharmacokinetics. Clin Pharmacol Ther 1992; 52: 160-9
-
(1992)
Clin Pharmacol Ther
, vol.52
, pp. 160-169
-
-
Sohn, D.R.1
Kusaka, M.2
Ishizaki, T.3
-
49
-
-
0025964524
-
The mephenytoin oxidation polymorphism is partially responsible for the N-demethylalion of imipramine
-
Skjelbo E, Brøsen K, Hallas J, et al. The mephenytoin oxidation polymorphism is partially responsible for the N-demethylalion of imipramine. Clin Pharmacol Ther 1991; 49: 18-23
-
(1991)
Clin Pharmacol Ther
, vol.49
, pp. 18-23
-
-
Skjelbo, E.1
Brøsen, K.2
Hallas, J.3
-
50
-
-
0025735576
-
The activation of the biguanide antimalarial proguanil co-segregates with the mephenytoin oxidation polymorphism - A panel study
-
Ward SA, Helsby NA, Skjelbo E, et al. The activation of the biguanide antimalarial proguanil co-segregates with the mephenytoin oxidation polymorphism - a panel study. Br J Clin Pharmacol 1991; 31: 689-92
-
(1991)
Br J Clin Pharmacol
, vol.31
, pp. 689-692
-
-
Ward, S.A.1
Helsby, N.A.2
Skjelbo, E.3
-
52
-
-
0028813788
-
Active hydroxymetabolites of antidepressants: Emphasis on E-10-hydroxy-nortriptyline
-
Nordin C, Bertilsson L. Active hydroxymetabolites of antidepressants: emphasis on E-10-hydroxy-nortriptyline. Clin Pharmacokinet 1995; 28: 26-40
-
(1995)
Clin Pharmacokinet
, vol.28
, pp. 26-40
-
-
Nordin, C.1
Bertilsson, L.2
-
53
-
-
0014693146
-
Steady-state plasma levels of nortriplyline in twins: Influence of genetic factors and drug therapy
-
Alexanderson B, Evans DAP, Sjöqvist F. Steady-state plasma levels of nortriplyline in twins: influence of genetic factors and drug therapy. BMJ 1969; 2: 764-8
-
(1969)
BMJ
, vol.2
, pp. 764-768
-
-
Alexanderson, B.1
Evans, D.A.P.2
Sjöqvist, F.3
-
54
-
-
0015077582
-
Genetic control of nortriptyline kinetics in man: A study of relatives of propositi with high plasma concentrations
-
Åsberg M, Evans DAP, Sjöqvist F. Genetic control of nortriptyline kinetics in man: a study of relatives of propositi with high plasma concentrations. J Med Genet 1971; 8: 129-35
-
(1971)
J Med Genet
, vol.8
, pp. 129-135
-
-
Åsberg, M.1
Evans, D.A.P.2
Sjöqvist, F.3
-
55
-
-
0014446905
-
Comparative studies of the metabolism of desmethylimipramine, nortriptyline and oxphenylbutazone in man
-
Hammer W, Mårtens S, Sjöqvist F. Comparative studies of the metabolism of desmethylimipramine, nortriptyline and oxphenylbutazone in man. Clin Pharmacol Ther 1969; 10: 44-6
-
(1969)
Clin Pharmacol Ther
, vol.10
, pp. 44-46
-
-
Hammer, W.1
Mårtens, S.2
Sjöqvist, F.3
-
56
-
-
34250454918
-
Pharmacokinetics of desmethylimipramine and nortriptyline in man after single and oral doses - A crossover study
-
Alexanderson B. Pharmacokinetics of desmethylimipramine and nortriptyline in man after single and oral doses - a crossover study. Eur J Clin Pharmacol 1972; 5: 7-10
-
(1972)
Eur J Clin Pharmacol
, vol.5
, pp. 7-10
-
-
Alexanderson, B.1
-
57
-
-
0018643637
-
Intraindividual similarity in the metabolism of amitriptyline and chlorimipramine in depressed patients
-
Mellström B, Bertilsson L, Träskman L, et al. Intraindividual similarity in the metabolism of amitriptyline and chlorimipramine in depressed patients. Pharmacology 1979; 19: 282-7
-
(1979)
Pharmacology
, vol.19
, pp. 282-287
-
-
Mellström, B.1
Bertilsson, L.2
Träskman, L.3
-
58
-
-
0000165070
-
Urinary excretion of nortriptyline and five of its metabolites in man after single and multiple oral doses
-
Alexanderson B, Borgå O. Urinary excretion of nortriptyline and five of its metabolites in man after single and multiple oral doses. Eur J Clin Pharmacol 1973; 5: 174-80
-
(1973)
Eur J Clin Pharmacol
, vol.5
, pp. 174-180
-
-
Alexanderson, B.1
Borgå, O.2
-
59
-
-
0001140482
-
Stereospecific hydroxylation of nortriptyline in man in relation to interindividual differences in its steady-state plasma level
-
Bertilsson L, Alexanderson B. Stereospecific hydroxylation of nortriptyline in man in relation to interindividual differences in its steady-state plasma level. Eur J Clin Pharmacol 1972: 4: 201-5
-
(1972)
Eur J Clin Pharmacol
, vol.4
, pp. 201-205
-
-
Bertilsson, L.1
Alexanderson, B.2
-
60
-
-
0019199097
-
Nortriptyline and antipyrine clearance in relation to debrisoquine hydroxylation in man
-
Bertilsson L, Eichelbaum M, Mellström B, et al. Nortriptyline and antipyrine clearance in relation to debrisoquine hydroxylation in man. Life Sci 1980; 27: 1673-7
-
(1980)
Life Sci
, vol.27
, pp. 1673-1677
-
-
Bertilsson, L.1
Eichelbaum, M.2
Mellström, B.3
-
61
-
-
0019449455
-
E- and Z-10-hydroxylation of nortriptyline: Relationship to polymorphic debrisoquine hydroxylation
-
Mellström B, Bertilsson L, Säwe J, et al. E- and Z-10-hydroxylation of nortriptyline: relationship to polymorphic debrisoquine hydroxylation. Clin Pharmacol Ther 1981; 30: 189-93
-
(1981)
Clin Pharmacol Ther
, vol.30
, pp. 189-193
-
-
Mellström, B.1
Bertilsson, L.2
Säwe, J.3
-
62
-
-
0020541470
-
E- And Z-10-hydroxylation of nortriptyline by human liver microsomes - methods and characterisation
-
Mellström B, Bertilsson L, Birgersson C, et al. E- and Z-10-hydroxylation of nortriptyline by human liver microsomes - methods and characterisation. Drug Metab Disp 1983; 11: 115-9
-
(1983)
Drug Metab Disp
, vol.11
, pp. 115-119
-
-
Mellström, B.1
Bertilsson, L.2
Birgersson, C.3
-
63
-
-
0021933958
-
Plasma concentrations of nortriptyline and its 10-hydroxy metabolite in depressed patients - Relationship to the debrisoquine metabolic ratio
-
Nordin C, Siwers B, Benitez J, et al. Plasma concentrations of nortriptyline and its 10-hydroxy metabolite in depressed patients - relationship to the debrisoquine metabolic ratio. Br J Clin Pharmacol 1985; 19: 832-5
-
(1985)
Br J Clin Pharmacol
, vol.19
, pp. 832-835
-
-
Nordin, C.1
Siwers, B.2
Benitez, J.3
-
64
-
-
0024465177
-
Steady state plasma levels of E- And Z-10-OH-nortriptyline in nortriplyline treated patients: Significance of concurrent medication and the sparteine oxidation phenotype
-
Gram LF, Brøsen K, Kragh-Sørensen P, et al. Steady state plasma levels of E- and Z-10-OH-nortriptyline in nortriplyline treated patients: significance of concurrent medication and the sparteine oxidation phenotype. Ther Drug Monit 1989; 11: 508-14
-
(1989)
Ther Drug Monit
, vol.11
, pp. 508-514
-
-
Gram, L.F.1
Brøsen, K.2
Kragh-Sørensen, P.3
-
65
-
-
0023214623
-
Clinical and biochemical effects during treatment of depression with nortriptyline: The role of 10-hydroxy-nortriptyline
-
Nordin C, Bertilsson L, Siwers B. Clinical and biochemical effects during treatment of depression with nortriptyline: the role of 10-hydroxy-nortriptyline. Clin Pharmacol Ther 1987; 42: 10-9
-
(1987)
Clin Pharmacol Ther
, vol.42
, pp. 10-19
-
-
Nordin, C.1
Bertilsson, L.2
Siwers, B.3
-
66
-
-
9044224348
-
Clinical pharmacokinetics of psychotropic drugs - Fundamental and practical aspects
-
van Praag HM, Lader MH, Rafaelson OJ, et al., editors. New York: Marcel Dekker Inc.
-
Potter WZ, Bertilsson L, Sjöqvist F. Clinical pharmacokinetics of psychotropic drugs - fundamental and practical aspects. In: van Praag HM, Lader MH, Rafaelson OJ, et al., editors. Handbook of biological psychiatry: part VI. New York: Marcel Dekker Inc., 1981: 71-134
-
(1981)
Handbook of Biological Psychiatry: Part VI
, pp. 71-134
-
-
Potter, W.Z.1
Bertilsson, L.2
Sjöqvist, F.3
-
67
-
-
0020662811
-
The debrisoquine hydroxylation test predicts steady-state plasma levels of desipramine
-
Bertilsson L, Åberg-Wistedt A. The debrisoquine hydroxylation test predicts steady-state plasma levels of desipramine. Br J Clin Pharmacol 1983; 15: 388-90
-
(1983)
Br J Clin Pharmacol
, vol.15
, pp. 388-390
-
-
Bertilsson, L.1
Åberg-Wistedt, A.2
-
68
-
-
0021747581
-
Phenotypic consistency in hydroxylation of desmethylimipramine and debrisoquine in healthy subjects and in human liver microxomes
-
Spina E, Birgersson C, von Bahr C, et al. Phenotypic consistency in hydroxylation of desmethylimipramine and debrisoquine in healthy subjects and in human liver microxomes. Clin Pharmacol Ther 1984; 36: 677-82
-
(1984)
Clin Pharmacol Ther
, vol.36
, pp. 677-682
-
-
Spina, E.1
Birgersson, C.2
Von Bahr, C.3
-
69
-
-
0023139103
-
Hydroxylation of desmethylimipramine: Dependence on the debrisoquin hydroxylation phenotype
-
Spina E, Steiner E, Ericsson O, et al. Hydroxylation of desmethylimipramine: dependence on the debrisoquin hydroxylation phenotype. Clin Pharmacol Ther 1987; 41: 314-9
-
(1987)
Clin Pharmacol Ther
, vol.41
, pp. 314-319
-
-
Spina, E.1
Steiner, E.2
Ericsson, O.3
-
70
-
-
0027167806
-
Polymorphic 2-hydroxylation of desipramine: A population and family study
-
Dahl M-L, Iselius L, Alm C, et al. Polymorphic 2-hydroxylation of desipramine: a population and family study. Eur J Clin Pharmacol 1993; 44: 445-50
-
(1993)
Eur J Clin Pharmacol
, vol.44
, pp. 445-450
-
-
Dahl, M.-L.1
Iselius, L.2
Alm, C.3
-
71
-
-
0020444627
-
Role of oxidation polymorphism on blood and urine concentrations of amitriptyline and its metabolites in man
-
Balant-Gorgia AE, Schultz P, Dayer P, et al. Role of oxidation polymorphism on blood and urine concentrations of amitriptyline and its metabolites in man. Arch Psychiatr Nervenkr 1982; 232: 215-22
-
(1982)
Arch Psychiatr Nervenkr
, vol.232
, pp. 215-222
-
-
Balant-Gorgia, A.E.1
Schultz, P.2
Dayer, P.3
-
72
-
-
0022898438
-
Importance of oxidative polymorphism and levomepromazine treatment on the steady-state blood concentrations of clomipramine and its major metabolites
-
Balant-Gorgia AE, Balant LP, Genet Ch, et al. Importance of oxidative polymorphism and levomepromazine treatment on the steady-state blood concentrations of clomipramine and its major metabolites. Eur J Clin Pharmacol 1986; 31: 449-55
-
(1986)
Eur J Clin Pharmacol
, vol.31
, pp. 449-455
-
-
Balant-Gorgia, A.E.1
Balant, L.P.2
Genet, Ch.3
-
73
-
-
0020592679
-
Amitriptyline metabolism: Relationship to polymorphic debrisoquine hydroxylation
-
Mellström B, Bertilsson L, Lou Y-C, et al. Amitriptyline metabolism: relationship to polymorphic debrisoquine hydroxylation. Clin Pharmacol Ther 1983; 34: 516-20
-
(1983)
Clin Pharmacol Ther
, vol.34
, pp. 516-520
-
-
Mellström, B.1
Bertilsson, L.2
Lou, Y.-C.3
-
74
-
-
0022481136
-
Amitriptyline metabolism: Association with debrisoquin hydroxylation in nonsmokers
-
Mellström B, Säwe J, Bertilsson L, et al. Amitriptyline metabolism: association with debrisoquin hydroxylation in nonsmokers. Clin Pharmacol Ther 1986; 39: 369-71
-
(1986)
Clin Pharmacol Ther
, vol.39
, pp. 369-371
-
-
Mellström, B.1
Säwe, J.2
Bertilsson, L.3
-
75
-
-
0028059720
-
Involvement of CYP2D6, CYP3A4, and other cytochrome P-450 isozymes in N-dealkylation reactions
-
Coutts RT, Su P, Baker GB. Involvement of CYP2D6, CYP3A4, and other cytochrome P-450 isozymes in N-dealkylation reactions. J Pharmacol Toxicol Methods 1994; 31: 177-86
-
(1994)
J Pharmacol Toxicol Methods
, vol.31
, pp. 177-186
-
-
Coutts, R.T.1
Su, P.2
Baker, G.B.3
-
76
-
-
0027980392
-
Stereoselective disposition of mianserin is related to debrisoquine hydroxylation polymorphism
-
Dahl M-L, Tybring G, Elwin C-E, et al. Stereoselective disposition of mianserin is related to debrisoquine hydroxylation polymorphism. Clin Pharmacol Ther 1994; 56: 176-83
-
(1994)
Clin Pharmacol Ther
, vol.56
, pp. 176-183
-
-
Dahl, M.-L.1
Tybring, G.2
Elwin, C.-E.3
-
77
-
-
0028282613
-
Maprotiline metabolism appears to cosegregate with the genetically-determined CYP2D6 polymorphic hydroxylation of debrisoquine
-
Firkusny L, Gleiter H. Maprotiline metabolism appears to cosegregate with the genetically-determined CYP2D6 polymorphic hydroxylation of debrisoquine. Br J Clin Pharmacol 1994; 37: 383-8
-
(1994)
Br J Clin Pharmacol
, vol.37
, pp. 383-388
-
-
Firkusny, L.1
Gleiter, H.2
-
78
-
-
0026606822
-
The relationship between paroxetine and the sparteine oxidation polymorphism
-
Sindrup SH, Brøsen K, Gram LF, et al. The relationship between paroxetine and the sparteine oxidation polymorphism. Clin Pharmacol Ther 1992; 51: 278-87
-
(1992)
Clin Pharmacol Ther
, vol.51
, pp. 278-287
-
-
Sindrup, S.H.1
Brøsen, K.2
Gram, L.F.3
-
79
-
-
0027472058
-
Pharmacokinetics of citalopram in relation to the sparteine and the mephenytoin oxidation polymorphisms
-
Sindrup SH, Brøsen K, Hansen MGJ, et al. Pharmacokinetics of citalopram in relation to the sparteine and the mephenytoin oxidation polymorphisms. Ther Drug Monit 1993; 15: 11-7
-
(1993)
Ther Drug Monit
, vol.15
, pp. 11-17
-
-
Sindrup, S.H.1
Brøsen, K.2
Hansen, M.G.J.3
-
80
-
-
0027383271
-
The pharmacogenetics of the selective serotonin reuptake inhibitors
-
Brøsen K. The pharmacogenetics of the selective serotonin reuptake inhibitors. Clin Invest 1993; 71: 1002-9
-
(1993)
Clin Invest
, vol.71
, pp. 1002-1009
-
-
Brøsen, K.1
-
81
-
-
0029016328
-
Moclobemide, a substrate of CYP2C19 and an inhibitor of CYP2C19, CYP2D6 and CYP1A2: A panel study
-
Gram LF, Guentert TW, Grange S, et al. Moclobemide, a substrate of CYP2C19 and an inhibitor of CYP2C19, CYP2D6 and CYP1A2: a panel study. Clin Pharmacol Ther 1995; 57: 670-7
-
(1995)
Clin Pharmacol Ther
, vol.57
, pp. 670-677
-
-
Gram, L.F.1
Guentert, T.W.2
Grange, S.3
-
83
-
-
0017641799
-
Plasma level monitoring of tricyclic antidepressant therapy
-
Gram LF. Plasma level monitoring of tricyclic antidepressant therapy. Clin Pharmacokinet 1977; 2: 237-51
-
(1977)
Clin Pharmacokinet
, vol.2
, pp. 237-251
-
-
Gram, L.F.1
-
84
-
-
0023881612
-
Therapeutic drug monitoring of tricyclic antidepressants
-
Preskorn SH, Dorey RC, Jerkovich GS. Therapeutic drug monitoring of tricyclic antidepressants. Clin Chem 1988; 34: 822-8
-
(1988)
Clin Chem
, vol.34
, pp. 822-828
-
-
Preskorn, S.H.1
Dorey, R.C.2
Jerkovich, G.S.3
-
85
-
-
0015214158
-
Relationship between plasma level and therapeutic effect of nortriptyline
-
Åsberg M, Cronholm B, Sjöqvist F, et al. Relationship between plasma level and therapeutic effect of nortriptyline. BMJ 1971; 3: 331-4
-
(1971)
BMJ
, vol.3
, pp. 331-334
-
-
Åsberg, M.1
Cronholm, B.2
Sjöqvist, F.3
-
86
-
-
0019450472
-
Slow hydroxylation of nortriptyline and concomitant poor debrisoquine hydroxylation: Clinical implication
-
Bertilsson L, Mellström B, Sjöqvist F, et al. Slow hydroxylation of nortriptyline and concomitant poor debrisoquine hydroxylation: clinical implication. Lancet 1981; 1: 560-1
-
(1981)
Lancet
, vol.1
, pp. 560-561
-
-
Bertilsson, L.1
Mellström, B.2
Sjöqvist, F.3
-
87
-
-
0021119533
-
Clinical pharmacology of antidepressant drugs: Pharmacogenetics
-
Usdin E, Åsberg M, Bertilsson L, et al., editors. New York: Raven Press
-
Sjöqvist F, Bertilsson L. Clinical pharmacology of antidepressant drugs: pharmacogenetics. In: Usdin E, Åsberg M, Bertilsson L, et al., editors. Frontiers in biochemical and pharmacological research in depression. New York: Raven Press, 1984: 359-72
-
(1984)
Frontiers in Biochemical and Pharmacological Research in Depression
, pp. 359-372
-
-
Sjöqvist, F.1
Bertilsson, L.2
-
88
-
-
0022482555
-
Slow hydroxylation of tricyclic antidepressants - Relationship to polymorphic drug oxidation
-
Kalow W, Goedde HW, Agarwal DP, editors. New York: Alan R Liss Inc.
-
Sjöqvist F, Bertilsson L. Slow hydroxylation of tricyclic antidepressants - relationship to polymorphic drug oxidation. In: Kalow W, Goedde HW, Agarwal DP, editors. Ethnic differences in reactions to drugs and xenobiotics. New York: Alan R Liss Inc., 1986: 169-88
-
(1986)
Ethnic Differences in Reactions to Drugs and Xenobiotics
, pp. 169-188
-
-
Sjöqvist, F.1
Bertilsson, L.2
-
89
-
-
0024308013
-
High blood concentrations of imipramine or clomipramine and therapeutic failure: A case report study using drug monitoring data
-
Balant-Gorgia AE, Balant LP, Garrone G. High blood concentrations of imipramine or clomipramine and therapeutic failure: a case report study using drug monitoring data. Ther Drug Monit 1989; 11: 415-20
-
(1989)
Ther Drug Monit
, vol.11
, pp. 415-420
-
-
Balant-Gorgia, A.E.1
Balant, L.P.2
Garrone, G.3
-
90
-
-
0022510805
-
Steady-stale levels of imipramine and its metabolites in relation to the sparteine/debrisoquine polymorphism
-
Brøsen K, Klysner R, Gram LF, et al. Steady-stale levels of imipramine and its metabolites in relation to the sparteine/debrisoquine polymorphism. Eur J Clin Pharmacol 1986; 30: 679-84
-
(1986)
Eur J Clin Pharmacol
, vol.30
, pp. 679-684
-
-
Brøsen, K.1
Klysner, R.2
Gram, L.F.3
-
91
-
-
0022337949
-
Extremely rapid hydroxylation of debrisoquine: A case report with implication for treatment with nortriptyline and other tricyclic antidepressants
-
Bertilsson L, Åberg-Wistedl A, Gustafsson LL, et al. Extremely rapid hydroxylation of debrisoquine: a case report with implication for treatment with nortriptyline and other tricyclic antidepressants. Ther Drug Monit 1985; 7: 478-80
-
(1985)
Ther Drug Monit
, vol.7
, pp. 478-480
-
-
Bertilsson, L.1
Åberg-Wistedl, A.2
Gustafsson, L.L.3
-
92
-
-
0021165503
-
Desipramine pharmacokinetics in Chinese and Caucasian volunteers
-
Rudorfer MV, Lane EA, Chang WH, et al. Desipramine pharmacokinetics in Chinese and Caucasian volunteers. Br J Clin Pharmacol 1984; 17: 433-40
-
(1984)
Br J Clin Pharmacol
, vol.17
, pp. 433-440
-
-
Rudorfer, M.V.1
Lane, E.A.2
Chang, W.H.3
-
93
-
-
85046111154
-
Estimating plasma concentrations of desipramine in Chinese depressed patients using the repeated one-point method
-
Chan K, Chiun H, Lee S, et al. Estimating plasma concentrations of desipramine in Chinese depressed patients using the repeated one-point method. Br J Clin Pharmacol 1988; 26: 638-9P
-
(1988)
Br J Clin Pharmacol
, vol.26
-
-
Chan, K.1
Chiun, H.2
Lee, S.3
-
94
-
-
0026320147
-
Pharmacokinetic and other related factors affecting psychotropic responses in Asians
-
Lin KM, Poland RE, Smith MW, et al. Pharmacokinetic and other related factors affecting psychotropic responses in Asians. Psychopharmacol Bull 1991; 27: 427-39
-
(1991)
Psychopharmacol Bull
, vol.27
, pp. 427-439
-
-
Lin, K.M.1
Poland, R.E.2
Smith, M.W.3
-
95
-
-
0024359574
-
Clinical significance of the sparteine/debrisoquine oxidation polymorphism
-
Brøsen K, Gram LF. Clinical significance of the sparteine/debrisoquine oxidation polymorphism. Eur J Clin Pharmacol 1989; 36: 537-47
-
(1989)
Eur J Clin Pharmacol
, vol.36
, pp. 537-547
-
-
Brøsen, K.1
Gram, L.F.2
-
96
-
-
0021130892
-
The nonlinear kinetics of desipramine and 2-hydroxydesipramine in plasma
-
Cooke RG, Warsh JJ, Stancer HC, et al. The nonlinear kinetics of desipramine and 2-hydroxydesipramine in plasma. Clin Pharmacol Ther 1984; 36: 343-9
-
(1984)
Clin Pharmacol Ther
, vol.36
, pp. 343-349
-
-
Cooke, R.G.1
Warsh, J.J.2
Stancer, H.C.3
-
97
-
-
0022647723
-
Steady-state levels of imipramine and its metabolites: Significance of dose-dependent kinetics
-
Brøsen K, Gram LF, Klysner R, et al. Steady-state levels of imipramine and its metabolites: significance of dose-dependent kinetics. Eur J Clin Pharmacol 1986; 30: 43-9
-
(1986)
Eur J Clin Pharmacol
, vol.30
, pp. 43-49
-
-
Brøsen, K.1
Gram, L.F.2
Klysner, R.3
-
98
-
-
0025076711
-
Nonlinear kinetics of imipramine in low and medium plasma level ranges
-
Sindrup SH, Brøsen K, Gram LF. Nonlinear kinetics of imipramine in low and medium plasma level ranges. Ther Drug Monit 1990; 12: 445-9
-
(1990)
Ther Drug Monit
, vol.12
, pp. 445-449
-
-
Sindrup, S.H.1
Brøsen, K.2
Gram, L.F.3
-
99
-
-
0023905440
-
First-pass metabolism of imipramine and desipramine: Impact of the sparteine oxidation phenotype
-
Brøsen K, Gram LF. First-pass metabolism of imipramine and desipramine: impact of the sparteine oxidation phenotype. Clin Pharmacol Ther 1988; 43: 400-6
-
(1988)
Clin Pharmacol Ther
, vol.43
, pp. 400-406
-
-
Brøsen, K.1
Gram, L.F.2
-
100
-
-
0021825307
-
Inhibition of desmethylimipramine 2-hydroxylation by drugs in human liver microsomes
-
von Bahr C, Spina E, Birgersson C, et al. Inhibition of desmethylimipramine 2-hydroxylation by drugs in human liver microsomes. Biochem Pharmacol 1985; 34: 2501-5
-
(1985)
Biochem Pharmacol
, vol.34
, pp. 2501-2505
-
-
Von Bahr, C.1
Spina, E.2
Birgersson, C.3
-
102
-
-
0022390883
-
In vitro inhibition studies of two isozymes of human liver cytochrome P-450. Mephenytoin p-hydroxylase and sparteine monooxygenase
-
Inaba T, Jurima M, Mahon WA, et al. In vitro inhibition studies of two isozymes of human liver cytochrome P-450. Mephenytoin p-hydroxylase and sparteine monooxygenase. Drug Metab Dispos 1985; 13: 443-8
-
(1985)
Drug Metab Dispos
, vol.13
, pp. 443-448
-
-
Inaba, T.1
Jurima, M.2
Mahon, W.A.3
-
103
-
-
0015515625
-
Drug interaction: Inhibitory effect of neuroleptics on metabolism of tricyclic antidepressants in man
-
Gram LF, Fredricson-Overø K. Drug interaction: inhibitory effect of neuroleptics on metabolism of tricyclic antidepressants in man. BMJ 1972; 1: 463-5
-
(1972)
BMJ
, vol.1
, pp. 463-465
-
-
Gram, L.F.1
Fredricson-Overø, K.2
-
105
-
-
0028115901
-
The use of therapeutic drug monitoring data to document kinetic drug interactions: An example with amitriptyline and nortriptyline
-
Jerling M, Bertilsson L, Sjöqvist F. The use of therapeutic drug monitoring data to document kinetic drug interactions: an example with amitriptyline and nortriptyline. Ther Drug Monit 1994; 16: 1-12
-
(1994)
Ther Drug Monit
, vol.16
, pp. 1-12
-
-
Jerling, M.1
Bertilsson, L.2
Sjöqvist, F.3
-
106
-
-
0026787192
-
The effect of selective serotonin re-uptake inhibitors on cytochrome P4502D6 (CYP2D6) activity in human liver microsomes
-
Crewe HR, Lennard MS, Tucker GT, et al. The effect of selective serotonin re-uptake inhibitors on cytochrome P4502D6 (CYP2D6) activity in human liver microsomes. Br J Clin Pharmacol 1992; 34: 262-5
-
(1992)
Br J Clin Pharmacol
, vol.34
, pp. 262-265
-
-
Crewe, H.R.1
Lennard, M.S.2
Tucker, G.T.3
-
107
-
-
0027406654
-
Fluvoxamine is a potent inhibitor of cytochrome P4501A2
-
Brøsen K, Skjelbo E, Rasmussen BB, et al. Fluvoxamine is a potent inhibitor of cytochrome P4501A2. Biochem Pharmacol 1993; 45: 1211-4
-
(1993)
Biochem Pharmacol
, vol.45
, pp. 1211-1214
-
-
Brøsen, K.1
Skjelbo, E.2
Rasmussen, B.B.3
-
108
-
-
0026019728
-
Fluvoxamine tricyclic antidepressant interaction: An accidental finding
-
Bertschy G, Vandel S, Vandel R, et al. Fluvoxamine tricyclic antidepressant interaction: an accidental finding. Eur J Clin Pharmacol 1991; 40: 119-20
-
(1991)
Eur J Clin Pharmacol
, vol.40
, pp. 119-120
-
-
Bertschy, G.1
Vandel, S.2
Vandel, R.3
-
109
-
-
0026725007
-
Interaction between fluvoxamine und imipramine/desipramine in four patients
-
Spina E, Campo GM, Avenso A, et al. Interaction between fluvoxamine und imipramine/desipramine in four patients. Ther Drug Monit 1992; 14: 194-6
-
(1992)
Ther Drug Monit
, vol.14
, pp. 194-196
-
-
Spina, E.1
Campo, G.M.2
Avenso, A.3
-
110
-
-
0027254118
-
Effect of fluvoxamine on the pharmacokinetics of imipramine and desipramine in healthy subjects
-
Spina E, Pollicino AM, Avenso A, et al. Effect of fluvoxamine on the pharmacokinetics of imipramine and desipramine in healthy subjects. Ther Drug Monit 1993; 15: 243-6
-
(1993)
Ther Drug Monit
, vol.15
, pp. 243-246
-
-
Spina, E.1
Pollicino, A.M.2
Avenso, A.3
-
111
-
-
0023873890
-
Significance of neuroleptic dose and plasma level in the pharmacological treatment of psychoses
-
Baldessarini RJ, Cohen BM, Teicher MH. Significance of neuroleptic dose and plasma level in the pharmacological treatment of psychoses. Arch Gen Psychiatry 1988; 45: 79-91
-
(1988)
Arch Gen Psychiatry
, vol.45
, pp. 79-91
-
-
Baldessarini, R.J.1
Cohen, B.M.2
Teicher, M.H.3
-
112
-
-
0027483214
-
Genetically variable metabolism of antidepressants and neuroleptic drugs in man
-
Dahl ML, Bertilsson L. Genetically variable metabolism of antidepressants and neuroleptic drugs in man. Pharmacogenetics 1993; 3: 61-70
-
(1993)
Pharmacogenetics
, vol.3
, pp. 61-70
-
-
Dahl, M.L.1
Bertilsson, L.2
-
113
-
-
0022979770
-
Inhibitory effects of neuroleptics on debrisoquine oxidation in man
-
Syvälahti EKG, Lindberg R, Kallio J, et al. Inhibitory effects of neuroleptics on debrisoquine oxidation in man. Br J Clin Pharmacol 1986; 22: 89-92
-
(1986)
Br J Clin Pharmacol
, vol.22
, pp. 89-92
-
-
Syvälahti, E.K.G.1
Lindberg, R.2
Kallio, J.3
-
114
-
-
0024333471
-
Disposition of perphenazine is related to polymorphic debrisoquin hydroxylation in human beings
-
Dahl-Puustinen M-L, Lidén A, Alm C, et al. Disposition of perphenazine is related to polymorphic debrisoquin hydroxylation in human beings. Clin Pharmacol Ther 1989; 46: 78-81
-
(1989)
Clin Pharmacol Ther
, vol.46
, pp. 78-81
-
-
Dahl-Puustinen, M.-L.1
Lidén, A.2
Alm, C.3
-
115
-
-
0025824216
-
Disposition of the neuroleptic zuclopenthixol cosegregates with the polymorphic hydroxylation of debrisoquine in humans
-
Dahl M-L, Ekqvist B, Widén J, et al. Disposition of the neuroleptic zuclopenthixol cosegregates with the polymorphic hydroxylation of debrisoquine in humans. Acta Psychiatr Scand 1991; 84: 99-102
-
(1991)
Acta Psychiatr Scand
, vol.84
, pp. 99-102
-
-
Dahl, M.-L.1
Ekqvist, B.2
Widén, J.3
-
117
-
-
0024336061
-
Interconversion between haloperidol and reduced haloperidol in healthy volunteers
-
Chakraborty BS, Hubbard JW, Hawes EM, et al. Interconversion between haloperidol and reduced haloperidol in healthy volunteers. Eur J Clin Pharmacol 1989; 37: 45-8
-
(1989)
Eur J Clin Pharmacol
, vol.37
, pp. 45-48
-
-
Chakraborty, B.S.1
Hubbard, J.W.2
Hawes, E.M.3
-
118
-
-
0025782876
-
Oxidation of reduced haloperidol to haloperidol: Involvement of human P450IID6 (sparteine/debrisoquine monooxygenase)
-
Tyndale RF, Kalow W, Inaba T. Oxidation of reduced haloperidol to haloperidol: involvement of human P450IID6 (sparteine/debrisoquine monooxygenase). Br J Clin Pharmacol 1991; 31: 655-60
-
(1991)
Br J Clin Pharmacol
, vol.31
, pp. 655-660
-
-
Tyndale, R.F.1
Kalow, W.2
Inaba, T.3
-
119
-
-
0026692983
-
Haloperidol disposition is dependent on debrisoquine hydroxylation phenotype
-
LLerena A, Alm C, Dahl M-L, et al. Haloperidol disposition is dependent on debrisoquine hydroxylation phenotype. Ther Drug Monit 1992; 14: 92-7
-
(1992)
Ther Drug Monit
, vol.14
, pp. 92-97
-
-
Llerena, A.1
Alm, C.2
Dahl, M.-L.3
-
120
-
-
0026780430
-
Haloperidol disposition is dependent on the debrisoquine hydroxylation phenotype: Increased plasma levels of the reduced metabolite in poor metabolizers
-
LLerena A, Dahl M-L, Ekqvist B, et al. Haloperidol disposition is dependent on the debrisoquine hydroxylation phenotype: increased plasma levels of the reduced metabolite in poor metabolizers. Ther Drug Monit 1992; 14: 261-4
-
(1992)
Ther Drug Monit
, vol.14
, pp. 261-264
-
-
Llerena, A.1
Dahl, M.-L.2
Ekqvist, B.3
-
121
-
-
0028982509
-
2 Dopamine receptor occupancy during low-dose treatment with haloperidol decanoate
-
2 Dopamine receptor occupancy during low-dose treatment with haloperidol decanoate. Am J Psychiatry 1995; 152: 173-8
-
(1995)
Am J Psychiatry
, vol.152
, pp. 173-178
-
-
Nyberg, S.1
Farde, L.2
Halldin, C.3
-
122
-
-
0021268309
-
Haloperidol concentrations elevated in Chinese patients
-
Potkin SG, Shen Y, Pardes H, et al. Haloperidol concentrations elevated in Chinese patients. Psychiatry Res 1984; 12: 167-72
-
(1984)
Psychiatry Res
, vol.12
, pp. 167-172
-
-
Potkin, S.G.1
Shen, Y.2
Pardes, H.3
-
123
-
-
0023935333
-
Haloperidol and prolactin concentrations in Asians and Caucasians
-
Lin KM, Poland RE, Lau JK, et al. Haloperidol and prolactin concentrations in Asians and Caucasians. J Clin Psychopharmacol 1988; 8: 195-201
-
(1988)
J Clin Psychopharmacol
, vol.8
, pp. 195-201
-
-
Lin, K.M.1
Poland, R.E.2
Lau, J.K.3
-
124
-
-
0020597567
-
Neuroleptic dosage for Asians
-
Lin KM, Finder E. Neuroleptic dosage for Asians. Am J Psychiatry 1983; 140: 490-1
-
(1983)
Am J Psychiatry
, vol.140
, pp. 490-491
-
-
Lin, K.M.1
Finder, E.2
-
125
-
-
0025758615
-
Ethnic differences in drug disposition and responsiveness
-
Wood AJJ, Zhou H. Ethnic differences in drug disposition and responsiveness. Clin Pharmacokinet 1991; 20: 350-73
-
(1991)
Clin Pharmacokinet
, vol.20
, pp. 350-373
-
-
Wood, A.J.J.1
Zhou, H.2
-
127
-
-
0028307888
-
Disposition of clozapine in man: Lack of association with debrisoquine and S-mephenytoin hydroxylation polymorphisms
-
Dahl M-L, LLerena A, Bondesson U, et al. Disposition of clozapine in man: lack of association with debrisoquine and S-mephenytoin hydroxylation polymorphisms. Br J Clin Pharmacol 1994; 37: 71-4
-
(1994)
Br J Clin Pharmacol
, vol.37
, pp. 71-74
-
-
Dahl, M.-L.1
Llerena, A.2
Bondesson, U.3
-
128
-
-
0026666976
-
The antipsychotic clozapine is metabolized by the polymorphic human microsomal recombinant cytochrome P4502D6
-
Fischer B, Vogels G, Maurer G, et al. The antipsychotic clozapine is metabolized by the polymorphic human microsomal recombinant cytochrome P4502D6. J Pharmacol Exp Ther 1992; 260: 1355-60
-
(1992)
J Pharmacol Exp Ther
, vol.260
, pp. 1355-1360
-
-
Fischer, B.1
Vogels, G.2
Maurer, G.3
-
129
-
-
0028318482
-
Fluvoxamine inhibition and carbamazepine induction of the metabolism of clozapine: Evidence from a therapeutic drug monitoring service
-
Jerling M, Lindström L, Bondesson U, et al. Fluvoxamine inhibition and carbamazepine induction of the metabolism of clozapine: evidence from a therapeutic drug monitoring service. Ther Drug Monit 1994; 16: 368-74
-
(1994)
Ther Drug Monit
, vol.16
, pp. 368-374
-
-
Jerling, M.1
Lindström, L.2
Bondesson, U.3
-
130
-
-
0027197152
-
The use of caffeine for enzyme assays: A critical appraisal
-
Kalow W, Tang B-K. The use of caffeine for enzyme assays: a critical appraisal. Clin Pharmacol Ther 1943; 53: 503-14
-
(1943)
Clin Pharmacol Ther
, vol.53
, pp. 503-514
-
-
Kalow, W.1
Tang, B.-K.2
-
131
-
-
0028298784
-
Caffeine metabolism in a healthy Spanish population: N-acetylator phenotype and oxidation pathways
-
Carrillo JA, Benitez J. Caffeine metabolism in a healthy Spanish population: N-acetylator phenotype and oxidation pathways. Clin Pharmacol Ther 1994; 55: 293-304
-
(1994)
Clin Pharmacol Ther
, vol.55
, pp. 293-304
-
-
Carrillo, J.A.1
Benitez, J.2
-
132
-
-
0027985726
-
Clozapine disposition covaries with CYP1A2 activity determined by a caffeine test
-
Bertilsson L, Carrillo JA, Dahl M-L, et al. Clozapine disposition covaries with CYP1A2 activity determined by a caffeine test. Br J Clin Pharmacol 1994; 38: 471-3
-
(1994)
Br J Clin Pharmacol
, vol.38
, pp. 471-473
-
-
Bertilsson, L.1
Carrillo, J.A.2
Dahl, M.-L.3
-
133
-
-
0024468418
-
Dose related plasma levels of clozapine: Influence of smoking behaviour, sex and age
-
Haring C, Meise U, Humpel C, et al. Dose related plasma levels of clozapine: influence of smoking behaviour, sex and age. Psychopharmacol 1989; 99: 538-40
-
(1989)
Psychopharmacol
, vol.99
, pp. 538-540
-
-
Haring, C.1
Meise, U.2
Humpel, C.3
-
136
-
-
0026086815
-
Plasma levels of thioridazine and metabolites are influenced by the debrisoquine hydroxylation phenotype
-
von Bahr C, Movin G, Nordin C, et al. Plasma levels of thioridazine and metabolites are influenced by the debrisoquine hydroxylation phenotype. Clin Pharmacol Ther 1991; 49: 234-40
-
(1991)
Clin Pharmacol Ther
, vol.49
, pp. 234-240
-
-
Von Bahr, C.1
Movin, G.2
Nordin, C.3
-
138
-
-
0027436269
-
Pharmacokinetics of the novel antipsychotic agent risperidone and the prolactin response in healthy subjects
-
Huang M-L, van Peer A, Woestenborghs R, et al. Pharmacokinetics of the novel antipsychotic agent risperidone and the prolactin response in healthy subjects. Clin Pharmacol Ther 1993; 54: 257-68
-
(1993)
Clin Pharmacol Ther
, vol.54
, pp. 257-268
-
-
Huang, M.-L.1
Van Peer, A.2
Woestenborghs, R.3
-
139
-
-
0023568113
-
MPTP, the neurotoxin inducing Parkinson's disease, is a potent competitive inhibitor of human and rat cytochrome P450 isozymes (P450 bufI.P450db1) catalyzing debrisoquine 4-hydroxylation
-
Fonne-Pfister R, Bargetzi MJ, Meyer UA. MPTP, the neurotoxin inducing Parkinson's disease, is a potent competitive inhibitor of human and rat cytochrome P450 isozymes (P450 bufI.P450db1) catalyzing debrisoquine 4-hydroxylation. Biochem Biophys Res Commun 1987; 148: 1144-50
-
(1987)
Biochem Biophys Res Commun
, vol.148
, pp. 1144-1150
-
-
Fonne-Pfister, R.1
Bargetzi, M.J.2
Meyer, U.A.3
-
140
-
-
0025055586
-
The dopamine transporter and cytochrome P450IID1 (debrisoquine 4-hydroxylase) in brain: Resolution and identification of two distinct [3H] GBR-12935 binding proteins
-
Niznik HB, Tyndale RF, Sallee RF, et al. The dopamine transporter and cytochrome P450IID1 (debrisoquine 4-hydroxylase) in brain: resolution and identification of two distinct [3H] GBR-12935 binding proteins. Arch Biochem Biophys 1990; 276: 424-32
-
(1990)
Arch Biochem Biophys
, vol.276
, pp. 424-432
-
-
Niznik, H.B.1
Tyndale, R.F.2
Sallee, R.F.3
-
141
-
-
0002255855
-
Debrisoquine/sparteine monooxygenase and other P450s in brain
-
Kalow W, editor. New York: Pergamon Press, Inc.
-
Kalow W, Tyndale RF. Debrisoquine/sparteine monooxygenase and other P450s in brain. In: Kalow W, editor. Pharmacogenetics of drug metabolism. New York: Pergamon Press, Inc., 1992: 649-56
-
(1992)
Pharmacogenetics of Drug Metabolism
, pp. 649-656
-
-
Kalow, W.1
Tyndale, R.F.2
-
142
-
-
0011578981
-
Debrisoquine hydroxylation polymorphism and personality
-
Bertilsson L, Alm C, de las Carreras C, et al. Debrisoquine hydroxylation polymorphism and personality [letter]. Lancet 1989; 1: 555
-
(1989)
Lancet
, vol.1
, pp. 555
-
-
Bertilsson, L.1
Alm, C.2
De Las Carreras, C.3
-
143
-
-
0027464041
-
Relationship between personality and debrisoquine hydroxylation capacity - Suggestion of an endogenous neuroactive substrate or product of the cytochrome P4502D6
-
LLerena A, Edman G, Cobaleda J, et al. Relationship between personality and debrisoquine hydroxylation capacity - suggestion of an endogenous neuroactive substrate or product of the cytochrome P4502D6. Acta Psychiatr Scand 1993; 87: 23-8
-
(1993)
Acta Psychiatr Scand
, vol.87
, pp. 23-28
-
-
Llerena, A.1
Edman, G.2
Cobaleda, J.3
-
144
-
-
0027484793
-
Role of genetic polymorphism in psychopharmacology - An update
-
Gram LF, Balant LP, Meltzer HY, et al., editors. Berlin, Heidelberg: Springer Verlag
-
Brøsen K, Sindrup SH, Skjelbo E, et al. Role of genetic polymorphism in psychopharmacology - an update. In: Gram LF, Balant LP, Meltzer HY, et al., editors. Clinical pharmacology in psychiatry. Berlin, Heidelberg: Springer Verlag, 1993: 199-211
-
(1993)
Clinical Pharmacology in Psychiatry
, pp. 199-211
-
-
Brøsen, K.1
Sindrup, S.H.2
Skjelbo, E.3
-
145
-
-
0024580554
-
Importance of genetic factors in the regulation of diazepam metabolism: Relationship to S-mephenytoin, but not debrisoquine hydroxylation phenotype
-
Bertilsson L, Henthorn TK, Santz E, et al. Importance of genetic factors in the regulation of diazepam metabolism: relationship to S-mephenytoin, but not debrisoquine hydroxylation phenotype. Clin Pharmacol Ther 1989; 45: 348-55
-
(1989)
Clin Pharmacol Ther
, vol.45
, pp. 348-355
-
-
Bertilsson, L.1
Henthorn, T.K.2
Santz, E.3
-
146
-
-
0025223056
-
Diazepam metabolism in native Chinese poor and extensive hydroxylators of S-mephenytoin: Interethnic differences in comparison with white subjects
-
Zhang Y, Reviriego J, Lou YQ, et al. Diazepam metabolism in native Chinese poor and extensive hydroxylators of S-mephenytoin: interethnic differences in comparison with white subjects. Clin Pharmacol Ther 1990; 48: 496-502
-
(1990)
Clin Pharmacol Ther
, vol.48
, pp. 496-502
-
-
Zhang, Y.1
Reviriego, J.2
Lou, Y.Q.3
-
147
-
-
0027208084
-
Why are diazepam metabolism and polymorphic S-mephenytoin hydroxylation associated with each other in white and Korean populations, but not in Chinese populations?
-
Bertilsson L, Kalow W. Why are diazepam metabolism and polymorphic S-mephenytoin hydroxylation associated with each other in white and Korean populations, but not in Chinese populations? Clin Pharmacol Ther 1993; 53: 608-10
-
(1993)
Clin Pharmacol Ther
, vol.53
, pp. 608-610
-
-
Bertilsson, L.1
Kalow, W.2
-
148
-
-
0028348860
-
Interethnic factors affecting drug activity
-
Testa B, Meyer UA, editors. London: Academic Press
-
Kalow W, Bertilsson L. Interethnic factors affecting drug activity. In: Testa B, Meyer UA, editors. Advances in drug research. Vol. 25. London: Academic Press, 1994: 1-53
-
(1994)
Advances in Drug Research
, vol.25
, pp. 1-53
-
-
Kalow, W.1
Bertilsson, L.2
-
149
-
-
0019373990
-
Diazepam effect and kinetics in Caucasians and Orientals
-
Ghoneim MM, Korttila K, Chiang CK, et al. Diazepam effect and kinetics in Caucasians and Orientals. Clin Pharmacol Ther 1981; 29: 749-56
-
(1981)
Clin Pharmacol Ther
, vol.29
, pp. 749-756
-
-
Ghoneim, M.M.1
Korttila, K.2
Chiang, C.K.3
-
150
-
-
0023113714
-
Differences in diazepam pharmacokinetics in Chinese and white Caucasians - Relation to body lipid stores
-
Kumana CR, Lauder IJ, Chan M, et al. Differences in diazepam pharmacokinetics in Chinese and white Caucasians - relation to body lipid stores. Eur J Clin Pharmacol 1987; 32: 211-5
-
(1987)
Eur J Clin Pharmacol
, vol.32
, pp. 211-215
-
-
Kumana, C.R.1
Lauder, I.J.2
Chan, M.3
-
151
-
-
0027935778
-
Diazepam metabolism by human liver microsomes is mediated by both S-mephenytoin hydroxylase and CYP3A isoforms
-
Andersson T, Miners JO, Veronese ME, et al. Diazepam metabolism by human liver microsomes is mediated by both S-mephenytoin hydroxylase and CYP3A isoforms. Br J Clin Pharmacol 1994; 38: 131-7
-
(1994)
Br J Clin Pharmacol
, vol.38
, pp. 131-137
-
-
Andersson, T.1
Miners, J.O.2
Veronese, M.E.3
-
152
-
-
0028080304
-
Inhibition of diazepam metabolism by fluvoxamine: A pharmacokinetic study in normal volunteers
-
Perucca E, Gatti G, Cipolla G, et al. Inhibition of diazepam metabolism by fluvoxamine: a pharmacokinetic study in normal volunteers. Clin Pharmacol Ther 1994; 56: 471-6
-
(1994)
Clin Pharmacol Ther
, vol.56
, pp. 471-476
-
-
Perucca, E.1
Gatti, G.2
Cipolla, G.3
|