Infection with an unenveloped DNA virus (TTV) in patients with acute or chronic liver disease of unknown etiology and in those positive for hepatitis C virus RNA

Journal of Hepatology

Volumn 30, Issue 2, 1999, Pages 205-212

  Ikeda, Hiroki ^a   Takasu, Masashi ^a   Inoue, Kyoichi ^a   Okamoto, Hiroaki ^b   Miyakawa, Yuzo ^b   Mayumi, Makoto ^a  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

^b JICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

Acute hepatitis; Chronic hepatitis; Hepatitis viruses; Hepatocellular carcinoma; Liver cirrhosis

Indexed keywords

ACUTE DISEASE; ADULT; AGED; ARTICLE; CHRONIC LIVER DISEASE; FEMALE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; IDIOPATHIC DISEASE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; VIRUS DETECTION; VIRUS INFECTION;

EID: 0032912359     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(99)80063-4     Document Type: Article

References (36)

1. Choo QL, Kuo G, Weiner AJ, Overby LR, Bradley DW, Houghton M. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science. 244:1989;359-362.
2. Kuo G, Choo QL, Alter HJ, Gitnick GL, Redeker AG, Purcell RH, et al. An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. Science. 244:1989;362-364.
3. Alter HJ, Purcell RH, Shih JW, Melpolder JC, Houghton M, Choo QL, et al. Detection of antibody to hepatitis C virus in prospectively followed transfusion recipients with acute and chronic non-A, non-B hepatitis. N Engl J Med. 321:1989;1494-1500.
4. Alter HJ, Bradley DW. Non-A, non-B hepatitis unrelated to the hepatitis C virus (non-ABC). Semin Liver Dis. 15:1995;110-120.
5. Feray C, Gigou M, Samuel D, Reyes G, Bernuau J, Reynes M, et al. Hepatitis C virus RNA and hepatitis B virus DNA in serum and liver of patients with fulminant hepatitis. Gastroenterology. 104:1993;549-555.
6. Kodali VP, Gordon SC, Silverman AL, McCray DG. Cryptogenic liver disease in the United States: further evidence for non-A, non-B, and non-C hepatitis. Am J Gastroenterol. 89:1994;1836-1839.
7. Simons JN, Leary TP, Dawson GJ, Pilot-Matias TJ, Muerhoff AS, Schlauder GG, et al. Isolation of novel virus-like sequences associated with human hepatitis. Nat Med. 1:1995;564-569.
8. Linnen J, Wages J, Zhang-Keck ZY, Fry KE, Krawczynski KZ, Alter H, et al. Molecular cloning and disease association of hepatitis G virus: a transfusion-transmissible agent. Science. 271:1996;505-508.
9. Leary TP, Muerhoff AS, Simons JN, Pilot-Matias TJ, Erker JC, Chalmers ML, et al. Sequence and genomic organization of GBV-C: a novel member of the Flaviviridae associated with human non-A-E hepatitis. J Med Virol. 48:1996;60-67.
10. Alter HJ. G-pers creepers, where'd you get those papers? A reassessment of the literature on the hepatitis G virus. Transfusion. 37:1997;569-572.
11. Miyakawa Y, Mayumi M. Hepatitis G virus - a true hepatitis virus or an accidental tourist? N Engl J Med. 336:1997;786-787.
12. Pessoa MG, Terrault NA, Detmer J, Kolberg J, Collins M, Hassoba HM, et al. Quantitation of hepatitis G and C viruses in the liver: evidence that hepatitis G virus is not hepatotropic. Hepatology. 27:1998;877-880.
13. Nishizawa T, Okamoto H, Konishi K, Yoshizawa H, Miyakawa Y, Mayumi M. A novel DNA virus (TTV) associated with elevated transaminase levels in posttransfusion hepatitis of unknown etiology. Biochem Biophys Res Commun. 241:1997;92-97.
14. Okamoto H, Nishizawa T, Kato N, Ukita M, Ikeda H, Iizuka H, et al. Molecular cloning and characterization of a novel DNA virus (TTV) associated with posttransfusion hepatitis of unknown etiology. Hepatol Res. 10:1998;1-16.
15. Iizuka H, Ohmura K, Ishijima A, Satoh K, Tanaka T, Tsuda F, et al. Correlation between anti-HBc titers and HBV DNA in blood units without detectable HBsAg. Vox Sang. 63:1992;107-111.
16. Okamoto H, Mishiro S, Tokita H, Tsuda F, Miyakawa Y, Mayumi M. Superinfection of chimpanzees carrying hepatitis C virus of genotype II/1b with that of genotype III/2a or I/1a. Hepatology. 20:1994;1131-1136.
17. Shimizu M, Osada K, Okamoto H. Transfusion-transmitted hepatitis G virus following open heart surgery (letter). Transfusion. 36:1996;937.
18. Okamoto H, Yotsumoto S, Akahane Y, Yamanaka T, Miyazaki Y, Sugai Y, et al. Hepatitis B viruses with precore region defects prevail in persistently infected hosts along with seroconversion to the antibody against e antigen. J Virol. 64:1990;1298-1303.
19. Okamoto H, Akahane Y, Ukita M, Fukuda M, Tsuda F, Miyakawa Y, et al. Fecal excretion of a nonenveloped DNA virus (TTV) associated with posttransfusion non-A- G hepatitis. J Med Virol. 56:1998;128-132.
20. Okamoto H, Okada S, Sugiyama Y, Kurai K, Iizuka H, Machida A, et al. Nucleotide sequence of the genomic RNA of hepatitis C virus isolated from a human carrier: comparison with reported isolates for conserved and divergent regions. J Gen Virol. 72:1991;2697-2704.
21. Gojobori T, Ishii K, Nei M. Estimation of average number of nucleotide substitutions when the rate of substitution varies with nucleotide. J Mol Evol. 18:1982;414-423.
22. Nei M. Phylogenetic trees. Nei M, . Molecular Evolutionary Genetics. 1987;287-326 Columbia University Press, New York.
23. Shimizu YK, Feinstone SM, Purcell RH, Alter HJ, London WT. Non-A, non-B hepatitis: ultrastructural evidence for two agents in experimentally infected chimpanzees. Science. 205:1979;197-200.
24. Bradley DW, Maynard JE, Popper H, Cook EH, Ebert JW, McCaustland KA, et al. Posttransfusion non-A, non-B hepatitis: physicochemical properties of two distinct agents. J Infect Dis. 148:1983;254-265.
25. Bradley DW, Krawczynski K, Ebert JW, McCaustland KA, Choo QL, Houghton MA, et al. Parenterally transmitted non-A, non-B hepatitis: virus-specific antibody response patterns in hepatitis C virus-infected chimpanzees. Gastroenterology. 99:1990;1054-1060.
26. Murphy FA. Virus Taxonomy. Fields BN, Knipe DM, Howley PM, Chanock RM, Melnick JL, Monath TP, Roizman B, Straus SE, . Fields Virology, 3rd ed. 1996;15-57 Lippincott-Raven, Philadelphia.
27. Pattison JR. Parvoviruses. Medical and biological aspects. Fields BN, Knipe DM, Chanock RM, Hirsch MS, Melnick JL, Monath TP, Roizman B, . Fields Virology, 2nd ed. 1990;1765-1784 Raven Press, New York.
28. Berns KI. Parvoviridae: the viruses and their replication. Fields BN, Knipe DM, Howley PM, Chanock RM, Melnick JL, Monath TP, Roizman B, Straus SE, . Fields Virology, 3rd ed. 1996;2173-2199 Lippincott-Raven, Philadelphia.
29. Paver WK, Caul EO, Clarke SK. Parvovirus-like particles in human faeces. [letter] Lancet. 1975; i: 691.
30. Paver WK, Caul EO, Clarke SK. Comparison of 22 nm virus from human faeces with animal parvoviruses. J Gen Virol. 22:1974;447-450.
31. Okamoto H,Kato N,Iizuka H,Tsuda F,Miyakawa Y,Mayumi M.Distinct genotypes of a non-enveloped DNA virus associated with posttransfusion non-A to G hepatitis (TTV) in plasma and peripheral blood mononuclear cells.J Med Virol, in press.
32. Simmonds P, Holmes EC, Cha TA, Chan SW, McOmish F, Irvine B, et al. Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region. J Gen Virol. 74:1993;2391-2399.
33. Tokita H, Okamoto H, Iizuka H, Kishimoto J, Tsuda F, Lesmana LA, et al. Hepatitis C virus variants from Jakarta, Indonesia classifiable into novel genotypes in the second (2e and 2f), tenth (10a) and eleventh (11a) genetic groups. J Gen Virol. 77:1996;293-301.
34. Bukh J, Miller RH, Purcell RH. Genetic heterogeneity of hepatitis C virus: quasispecies and genotypes. Semin Liver Dis. 15:1995;41-63.
35. Miyakawa Y, Okamoto H, Mayumi M. Classifying hepatitis C virus genotypes. Mol Med Today. 1:1995;20-25.
36. Simmonds P. Variability of hepatitis C virus. Hepatology. 21:1995;570-583.