Plasma triglyceride reduction in mice after direct injections of muscle- specific lipoprotein lipase DNA

Diabetes

Volumn 48, Issue 1, 1999, Pages 223-227

  Schlaepfer, Isabel R ^a,b   Eckel, Robert H ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIPOPROTEIN LIPASE; MESSENGER RNA; TRIACYLGLYCEROL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME SPECIFICITY; GENE OVEREXPRESSION; IMMUNOGENICITY; IMMUNOMODULATION; IMMUNOTHERAPY; INTRAMUSCULAR DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUADRICEPS FEMORIS MUSCLE; SKELETAL MUSCLE; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; DNA; HUMANS; INJECTIONS, INTRAMUSCULAR; INJECTIONS, INTRAPERITONEAL; LIPOPROTEIN LIPASE; MALE; MICE; MICE, INBRED C57BL; MUSCLE, SKELETAL; TRANSGENES; TRIGLYCERIDES;

EID: 0032911025     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.48.1.223     Document Type: Article

References (22)

1. Eckel RH: Lipoprotein lipase: a multifunctional enzyme relevant to common metabolic diseases. N Engl J Med 320:1060-1068, 1989
2. Blanchette-Mackie EJ, Scow RO: Effects of the lipoprotein lipase on the structure of chylomicrons. J Cell Biol 58:689-708, 1973
3. Beisiegel U, Weber W, Bengtsson-Olivercrona G: Lipoprotein lipase enhances the binding of chylomicrons to low density lipoprotein receptor-related protein. Proc Natl Acad Sci U S A 88:8342-8346, 1991
4. Patemiti JR, Brown WV, Ginsberg HN, Artzt K: Combined lipase deficiency (cdl): a lethal mutation on chromosome 17 of the mouse. Science 221:167-169,1983
5. Weinstock PH, Bisgaier CL, Aalto-Setala K, Radner H, Ramakrishnan R, Levak-Frank S, Essenburg AD, Zechner Z, Breslow JL: Severe hypertriglyceridemia, reduced high density lipoprotein, and neonatal death in lipoprotein lipase knockout mice: mild hypertriglyceridemia with impaired very low density lipoprotein clearance in heterozygotes. J Clin Invest 96:2555-2568, 1996
6. Zsigmond E, Kobayashi K, Tzung KW, Li L, Fuke Y, Chan L: Adenovirus-mediated gene transfer of human lipoprotein lipase ameliorates the hyperlipidemias associated with apolipoprotein E and LDL receptor deficiencies in mice. Hum Gene Ther 8:1921-1933, 1997
7. Excoffon KJ, Liu G, Miao L, Wilson JE, McManus BM, Semenkovich CF, Coleman T, Benoit P, Duverger N, Branellec D, Denefle P, Hayden MR, Lewis ME: Correction of hypertriglyceridemia and impaired fat tolerance in lipoprotein lipase-deficient mice by adenovirus-mediated expression of human lipoprotein lipase. Arterioscler Thromb Vasc Biol 17:2532-2539, 1997
8. Kremer EJ, Perricaudet M: Adenovirus and adeno-associated virus mediated gene transfer. Br Med Bull 51:31-44, 1995
9. Acsadi G, Jiao SS, Jani A, Duke D, Williams P, Chong W, Wolff JA: Direct gene transfer and expression into rat heart in vivo. New Biol 3:71-81, 1991
10. Alila H, Coleman M, Nitta H, French M, Anwer K, Liu Q, Meyer T, Wang J, Mumper R, Oubari D, Long S, Nordstrom J, Rolland A: Expression of biologically active human insulin-like growth factor-I following intramuscular injection of a formulated plasmid in rats. Hum Gene Ther 8:1785-1795, 1997
11. Danko I, Williams P, Herweijer H, Zhang G, Latendresse JS, Bock I, Wolff JA: High expression of naked plasmid DNA in muscles of young rodents. Hum Mol Genet 6:1435-1443, 1997
12. Hickman MA, Malone RW, Lehmann-Bruinsma K, Sih TR, Knoell D, Szoka FC, Walzem R, Carlson DM, Powell JS: Gene expression following direct injection of DNA into liver. Hum Gene Ther 5:1477-1483, 1994
13. Levak-Frank S, Radner H, Walsh A, Stollberger R, Knipping G, Hoefler G, Sattler W, Weinstock PH, Breslow JL, Zechner R: Muscle-specific overexpression of lipoprotein lipase causes a severe myopathy characterized by proliferation of mitochondria and peroxisomes in transgenic mice. J Clin Invest 96:976-986, 1995
14. Jensen DR, Schlaepfer IR, Morin CL, Pennington DS, Marcell T, Ammon, SM, Gutierrez-Hartmann A, Eckel RH: Prevention of diet-induced obesity in transgenic mice overexpressing skeletal muscle lipoprotein lipase. Am J Physiol 273:R683-R689, 1997
15. Eckel RH, Kern PA, Sadur CN, Yost TJ: Methods for studying lipoprotein lipase in human adipose tissue. In Methods in Diabetic Research. Pohl S, Clarke W, Larner J, Eds. New York, Wiley, 1986, p. 259-273
16. Wolff JA, Malone RW, Williams P, Chong W, Acsadi G, Jani A, Felgner, PL: Direct gene transfer into mouse muscle in vivo. Science 247:1465-1468, 1990
17. Hansen E, Fernandes K, Goldspink G, Butterworth P, Umeda PK, Chang KC: Strong expression of foreign genes following direct injection into fish muscle. FEBS Lett 290:73-76, 1991
18. Levy MY, Barron LG, Meyer KB, Szoka FC Jr Characterization of plasmid DNA transfer into mouse skeletal muscle: evaluation of uptake mechanism, expression and secretion of gene products into blood. Gene Ther 3:201-211, 1996
19. Schwartz B, Benoist C, Abdallah B, Rangara R, Hassan A, Scherman D, Demeneix BA: Gene transfer by naked DNA into adult mouse brain. Gene Ther 3:405-411, 1996
20. Davis HL, Demeneix BA, Quantin B, Coulombe J, Whalen RG: Plasmid DNA is superior to viral vectors for direct gene transfer into adult mouse skeletal muscle. Hum Gene Ther 4:733-740, 1993
21. Konishi H, Ochiya T, Sakamoto H, Tsukamoto M, Saito I, Muto T, Sugimura T, Terada M: Effective prevention of thrombocytopenia in mice using adenovirus-mediated transfer of HST-1 (FGF-4) gene. J Clin Invest 96:1125-1130, 1995 (published erratum appears in J Clin Invest 96:2543, 1995)
22. Xing X, Liu V, Xia W, Stephens LC, Huang L, Lopez-Berestein G, Hung MC: Safety studies of the intraperitoneal injection of E1A-liposome complex in mice. Gene Ther 4:238-243, 1997