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Volumn 14, Issue 1, 1999, Pages 3-11

The neuroendocrinology of chronic fatigue syndrome: Focus on the hypothalamic-pituitary-adrenal axis

Author keywords

Adrenocorticotropin (ACTH); Chronic fatigue syndrome (CFS); Cortisol; Hypothalamic pituitary adrenal axis (HPA); Serotonin (SHT)

Indexed keywords

CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; FLUOXETINE; GROWTH HORMONE; HYDROCORTISONE; OPIATE; PRASTERONE; PROLACTIN; SEROTONIN; VASOPRESSIN;

EID: 0032910667     PISSN: 03935264     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (42)

References (59)
  • 1
    • 0027973857 scopus 로고
    • The chronic fatigue syndrome: A comprehensive approach to its treatment and study
    • Fukuda K, Straus S, Hickie I et al. The chronic fatigue syndrome: a comprehensive approach to its treatment and study. Ann Intern Med 1994;121:253-259
    • (1994) Ann Intern Med , vol.121 , pp. 253-259
    • Fukuda, K.1    Straus, S.2    Hickie, I.3
  • 2
    • 0030770149 scopus 로고    scopus 로고
    • The epidemiology of chronic fatigue and chronic fatigue syndrome: A prospective primary care study
    • Wessely S, Chalder T, Hirsch S et al. The epidemiology of chronic fatigue and chronic fatigue syndrome: a prospective primary care study. Am J Public Health 1997;87:1449-1455
    • (1997) Am J Public Health , vol.87 , pp. 1449-1455
    • Wessely, S.1    Chalder, T.2    Hirsch, S.3
  • 5
    • 0020081582 scopus 로고
    • Prolonged atypical illness associated with serological evidence of persistent Epstein-Barr virus infection
    • Tobi M, Ravid Z, Feldman-Weiss V et al. Prolonged atypical illness associated with serological evidence of persistent Epstein-Barr virus infection. Ann Intern Med 1982;1:61-64
    • (1982) Ann Intern Med , vol.1 , pp. 61-64
    • Tobi, M.1    Ravid, Z.2    Feldman-Weiss, V.3
  • 6
    • 0000191719 scopus 로고
    • Chronic fatigue mononucleosis
    • Isaacs R. Chronic fatigue mononucleosis. Blood 1948;3:858-861
    • (1948) Blood , vol.3 , pp. 858-861
    • Isaacs, R.1
  • 8
    • 0023874790 scopus 로고
    • Chronic fatigue syndrome: A working case definition
    • Holmes GP, Kaplan J, Gantz N et al. Chronic fatigue syndrome: a working case definition. Ann Intern Med 1988;108:387-389
    • (1988) Ann Intern Med , vol.108 , pp. 387-389
    • Holmes, G.P.1    Kaplan, J.2    Gantz, N.3
  • 9
    • 0031015337 scopus 로고    scopus 로고
    • Immune responses associated with chronic fatigue syndrome: A case control study
    • Mawle AC, Nissenbaum R, Dobbins JG et al. Immune responses associated with chronic fatigue syndrome: a case control study. J Infect Dis 1997;175:136-141
    • (1997) J Infect Dis , vol.175 , pp. 136-141
    • Mawle, A.C.1    Nissenbaum, R.2    Dobbins, J.G.3
  • 10
    • 0025985435 scopus 로고
    • Mitochondrial abnormalities in the post-viral fatigue syndrome
    • Behan WMH. Mitochondrial abnormalities in the post-viral fatigue syndrome. Acta Neuropathol (Berl) 1991;83:61-65
    • (1991) Acta Neuropathol (Berl) , vol.83 , pp. 61-65
    • Behan, W.M.H.1
  • 11
    • 0024421944 scopus 로고
    • Fatigue syndromes: A comparison of chronic post-viral fatigue syndrome with neuromuscular and affective disorders
    • Wessely S, Powell R. Fatigue syndromes: a comparison of chronic post-viral fatigue syndrome with neuromuscular and affective disorders. J Neurol Neurosurg Psychiatry 1989;52:940-948
    • (1989) J Neurol Neurosurg Psychiatry , vol.52 , pp. 940-948
    • Wessely, S.1    Powell, R.2
  • 12
    • 85044495227 scopus 로고
    • The frequency of chronic fatigue syndrome in patients with symptoms of persisting fatigue
    • Manu P, Lane TJ, Matthews DA. The frequency of chronic fatigue syndrome in patients with symptoms of persisting fatigue. Ann Intern Med 1988;108:387-389
    • (1988) Ann Intern Med , vol.108 , pp. 387-389
    • Manu, P.1    Lane, T.J.2    Matthews, D.A.3
  • 13
    • 0023258956 scopus 로고
    • Depression in patients with neuromyasthenia (benign myalgic encephalomyelitis)
    • Taerk K, Toner B, Salit I et al. Depression in patients with neuromyasthenia (benign myalgic encephalomyelitis). Int J Psychiatry Med 1987; 17:49-56
    • (1987) Int J Psychiatry Med , vol.17 , pp. 49-56
    • Taerk, K.1    Toner, B.2    Salit, I.3
  • 14
    • 0026005988 scopus 로고
    • Chronic fatigue syndrome: The need for an integrative approach
    • Demitrack MA, Greden JF. Chronic fatigue syndrome: the need for an integrative approach. Biol Psychiatry 1991;30:747-752
    • (1991) Biol Psychiatry , vol.30 , pp. 747-752
    • Demitrack, Ma.1    Greden, J.F.2
  • 15
    • 0002590138 scopus 로고
    • The adrenal cortex
    • Felig P, Baxter J, Frohman L eds New York; McGraw-Hill Inc.
    • Baxter JD, Tyrell J. The adrenal cortex. In: Felig P, Baxter J, Frohman L eds Endocrinology and Metabolism. New York; McGraw-Hill Inc. 1981:385-510
    • (1981) Endocrinology and Metabolism , pp. 385-510
    • Baxter, J.D.1    Tyrell, J.2
  • 16
    • 0029037126 scopus 로고
    • The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation
    • Chrousos GP. The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. New Engl J Med 1995;332:1351-1362
    • (1995) New Engl J Med , vol.332 , pp. 1351-1362
    • Chrousos, G.P.1
  • 18
    • 0001256381 scopus 로고
    • Mediation of the stress response by the hypothalamic-pituitary-adrenal axis
    • Friedman M, Charney D, Deutch AY eds From Normal Adaptation to PTSD. Philadelphia, Lippincott Raven
    • Michelson D, Licinio J, Gold PW. Mediation of the stress response by the hypothalamic-pituitary-adrenal axis. In: Friedman M, Charney D, Deutch AY eds Neurobiological and Clinical Consequences of Stress. From Normal Adaptation to PTSD. Philadelphia, Lippincott Raven 1995:225-248
    • (1995) Neurobiological and Clinical Consequences of Stress , pp. 225-248
    • Michelson, D.1    Licinio, J.2    Gold, P.W.3
  • 19
    • 0025723445 scopus 로고
    • Evidence for impaired activation of the hypothalamic-pituitary-adrenal axis in chronic fatigue syndrome
    • Demitrack MA, Dale JK, Straus SE et al. Evidence for impaired activation of the hypothalamic-pituitary-adrenal axis in chronic fatigue syndrome. J Clin Endocrinol Metab 1991;73:1224-1234
    • (1991) J Clin Endocrinol Metab , vol.73 , pp. 1224-1234
    • Demitrack, M.A.1    Dale, J.K.2    Straus, S.E.3
  • 20
    • 0019433903 scopus 로고
    • Adrenocortical activity and some clinical findings in acute and chronic fatigue
    • Polietakhoff A. Adrenocortical activity and some clinical findings in acute and chronic fatigue. J Psychosom Res 1981;25:91-95
    • (1981) J Psychosom Res , vol.25 , pp. 91-95
    • Polietakhoff, A.1
  • 21
    • 0029128813 scopus 로고
    • Contrasting neuroendocrine responses in depression and chronic fatigue syndrome
    • Cleare AJ, Beam J, Allain T et al. Contrasting neuroendocrine responses in depression and chronic fatigue syndrome. J Affect Disord 1995;35:283-289
    • (1995) J Affect Disord , vol.35 , pp. 283-289
    • Cleare, A.J.1    Beam, J.2    Allain, T.3
  • 22
    • 0030786921 scopus 로고    scopus 로고
    • Blunted serotonergic-mediated prolactin release in chronic fatigue syndrome
    • Dinan T, Majeed T, Lavelle E et al. Blunted serotonergic-mediated prolactin release in chronic fatigue syndrome. Psychoneuroendocrinology 1997;22:261-267
    • (1997) Psychoneuroendocrinology , vol.22 , pp. 261-267
    • Dinan, T.1    Majeed, T.2    Lavelle, E.3
  • 23
    • 0031969736 scopus 로고    scopus 로고
    • Naloxone-mediated activation of the hypothalamic-pituitary-adrenal axis in chronic fatigue syndrome
    • Scott L, Burnett F, Medbak S, Dinan T. Naloxone-mediated activation of the hypothalamic-pituitary-adrenal axis in chronic fatigue syndrome. Psychol Med 1998;28:285-293
    • (1998) Psychol Med , vol.28 , pp. 285-293
    • Scott, L.1    Burnett, F.2    Medbak, S.3    Dinan, T.4
  • 24
    • 0031951617 scopus 로고    scopus 로고
    • Urinary free cortisol excretion in depression, in chronic fatigue syndrome and in health
    • Scott L, Dinan T. Urinary free cortisol excretion in depression, in chronic fatigue syndrome and in health. J Affect Disord 1998;47:49-54
    • (1998) J Affect Disord , vol.47 , pp. 49-54
    • Scott, L.1    Dinan, T.2
  • 25
    • 0031863525 scopus 로고    scopus 로고
    • The low-dose adrenocorticotropin test in chronic fatigue syndrome and in health
    • Scott L, Medbak S, Dinan T. The low-dose adrenocorticotropin test in chronic fatigue syndrome and in health. Clin Endocrinol (Oxf) 1998;48:733-737
    • (1998) Clin Endocrinol (Oxf) , vol.48 , pp. 733-737
    • Scott, L.1    Medbak, S.2    Dinan, T.3
  • 26
    • 0025756329 scopus 로고
    • Adrenocorticotropin stimulation tests: Effects of basal levels, time of day and sensitive new low dose test
    • Dickstein G, Schechner C, Nicholson W et al. Adrenocorticotropin stimulation tests: effects of basal levels, time of day and sensitive new low dose test. J Clin Endocrinol Metab 1991;72:773-778
    • (1991) J Clin Endocrinol Metab , vol.72 , pp. 773-778
    • Dickstein, G.1    Schechner, C.2    Nicholson, W.3
  • 27
    • 0344247497 scopus 로고    scopus 로고
    • Differing adrenal steroid profile in chronic fatigue syndrome, in depression and in health
    • in press
    • Scott L, Salahudin F, Cooney J, Svec F, Dinan T. Differing adrenal steroid profile in chronic fatigue syndrome, in depression and in health. J Affect Disord (in press)
    • J Affect Disord
    • Scott, L.1    Salahudin, F.2    Cooney, J.3    Svec, F.4    Dinan, T.5
  • 28
    • 0020061659 scopus 로고
    • Dexamethasone suppression test for melancholia
    • Carroll BJ. Dexamethasone suppression test for melancholia. Brit J Psychiatry 1982; 140:292-304
    • (1982) Brit J Psychiatry , vol.140 , pp. 292-304
    • Carroll, B.J.1
  • 29
    • 0031866106 scopus 로고    scopus 로고
    • Blunted adrenocorticotropin response to corticotropin-releasing hor-mone test in chronic fatigue syndrome
    • Scott L, Dinan T. Blunted adrenocorticotropin response to corticotropin-releasing hor-mone test in chronic fatigue syndrome. Acta Psychiatr Scand 1998;97:450-457
    • (1998) Acta Psychiatr Scand , vol.97 , pp. 450-457
    • Scott, L.1    Dinan, T.2
  • 30
    • 0029926722 scopus 로고    scopus 로고
    • Antidepressants and hypothalamic-pituitary-adrenocortical regulation
    • Holsboer F, Barden N. Antidepressants and hypothalamic-pituitary-adrenocortical regulation. Endocr Rev 1996;17:187-205
    • (1996) Endocr Rev , vol.17 , pp. 187-205
    • Holsboer, F.1    Barden, N.2
  • 31
    • 0017067876 scopus 로고
    • Urinary free cortisol excretion in depressives
    • Carroll BJ, Curtis G, Davies B et al. Urinary free cortisol excretion in depressives. Psychol Med 1976;6:43-47
    • (1976) Psychol Med , vol.6 , pp. 43-47
    • Carroll, B.J.1    Curtis, G.2    Davies, B.3
  • 32
    • 0020529501 scopus 로고
    • Cosyntropin (ACTH 1-24) stimulation test in depressed patients and healthy subjects
    • Amsterdam J, Winokur A, Abelman E et al. CoSyntropin (ACTH 1-24) stimulation test in depressed patients and healthy subjects. Am J Psychiatry 1983;140:907-909
    • (1983) Am J Psychiatry , vol.140 , pp. 907-909
    • Amsterdam, J.1    Winokur, A.2    Abelman, E.3
  • 33
    • 0027446733 scopus 로고
    • Adrenal gland volume in major depressives
    • Rubin R, Philips J. Adrenal gland volume in major depressives. Arch Gen Psychiatry 1993;50:833-834
    • (1993) Arch Gen Psychiatry , vol.50 , pp. 833-834
    • Rubin, R.1    Philips, J.2
  • 34
    • 0021714606 scopus 로고
    • Elevated concentrations of corticotropin releasing factor-like immunoreactivity in depressed patients
    • Nemeroff C, Widerlov E, Bissette G et al. Elevated concentrations of corticotropin releasing factor-like immunoreactivity in depressed patients. Science 1984;226:1342-1344
    • (1984) Science , vol.226 , pp. 1342-1344
    • Nemeroff, C.1    Widerlov, E.2    Bissette, G.3
  • 35
    • 0020409215 scopus 로고
    • Corticotropin-releasing factor produces beha-vioural activation in rats
    • Sutton R, Koob G, Le Maol M et al. Corticotropin-releasing factor produces beha-vioural activation in rats. Nature 1982;297: 331-333
    • (1982) Nature , vol.297 , pp. 331-333
    • Sutton, R.1    Koob, G.2    Le Maol, M.3
  • 36
    • 0021347816 scopus 로고
    • Arginine vasopressin potentiates adrenocorticotropin release induced by corticotropin releasing factor
    • DeBold C, Sheldon W, Cherney G et al. Arginine vasopressin potentiates adrenocorticotropin release induced by corticotropin releasing factor. J Clin Invest 1984;73:533-538
    • (1984) J Clin Invest , vol.73 , pp. 533-538
    • Debold, C.1    Sheldon, W.2    Cherney, G.3
  • 37
    • 0027413359 scopus 로고
    • Abnormal arginine-vasopressin secretion and water metabolism in patients with post-viral fatigue syndrome
    • Bakheit A, Behan P, Watson W, Morton J. Abnormal arginine-vasopressin secretion and water metabolism in patients with post-viral fatigue syndrome. Acta Neurol Scand 1993;87:234-238
    • (1993) Acta Neurol Scand , vol.87 , pp. 234-238
    • Bakheit, A.1    Behan, P.2    Watson, W.3    Morton, J.4
  • 38
    • 0029126836 scopus 로고    scopus 로고
    • The relationship between neurally-mediated hypotension and the chronic fatigue syndrome
    • Bou-Halaigah I, Rowe P, Kan J, Calkins H. The relationship between neurally-mediated hypotension and the chronic fatigue syndrome. JAMA 1996;274:961-967
    • (1996) JAMA , vol.274 , pp. 961-967
    • Bou-Halaigah, I.1    Rowe, P.2    Kan, J.3    Calkins, H.4
  • 39
    • 0030913940 scopus 로고    scopus 로고
    • Neuroendocrine correlates of chronic fatigue syndrome: A brief review
    • Demitrack MA. Neuroendocrine correlates of chronic fatigue syndrome: a brief review. J Psychiatr Res 1997;31:69-82
    • (1997) J Psychiatr Res , vol.31 , pp. 69-82
    • Demitrack, M.A.1
  • 40
    • 0030032350 scopus 로고    scopus 로고
    • Increased numbers of vasopressin- and oxytocin-containing neurons in the paraventricular nucleus of the hypothalamus of depressed patients
    • Purba J, Hoogendijk W, Stam F, Tilders F, Swaab D. Increased numbers of vasopressin- and oxytocin-containing neurons in the paraventricular nucleus of the hypothalamus of depressed patients. Arch Gen Psychiatry 1996;53:137-143
    • (1996) Arch Gen Psychiatry , vol.53 , pp. 137-143
    • Purba, J.1    Hoogendijk, W.2    Stam, F.3    Tilders, F.4    Swaab, D.5
  • 41
    • 0024314665 scopus 로고
    • Endocrine responses to 5HT1a receptor activation in humans
    • Lesch K, Rupprecht R, Poten B et al. Endocrine responses to 5HT1a receptor activation in humans. Biol Psychiatry 1989;28:203-205
    • (1989) Biol Psychiatry , vol.28 , pp. 203-205
    • Lesch, K.1    Rupprecht, R.2    Poten, B.3
  • 42
    • 0345541226 scopus 로고
    • 5HT1a receptor responsivity in unipolar major depression: Evaluation of ipsapironeinduced ACTH and cortisol secretion in patients and controls
    • Lesch K, Mayer S, Disselkamp-Tietze J et al. 5HT1a receptor responsivity in unipolar major depression: evaluation of ipsapironeinduced ACTH and cortisol secretion in patients and controls. Biol Psychiatry 1988; 28:203-205
    • (1988) Biol Psychiatry , vol.28 , pp. 203-205
    • Lesch, K.1    Mayer, S.2    Disselkamp-Tietze, J.3
  • 43
    • 0026611167 scopus 로고
    • Possible upregulation of hypothalamic 5-hydroxytryptamine receptors in patients with post-viral fatigue syndrome
    • Bakheit A, Behan P, Dinan T et al. Possible upregulation of hypothalamic 5-hydroxytryptamine receptors in patients with post-viral fatigue syndrome. BMJ 1992;304:1010-1012
    • (1992) BMJ , vol.304 , pp. 1010-1012
    • Bakheit, A.1    Behan, P.2    Dinan, T.3
  • 44
    • 0030569317 scopus 로고    scopus 로고
    • Increased prolactin response to buspirone in chronic fatigue syndrome
    • Sharpe M, Clements A, Hawton K et al. Increased prolactin response to buspirone in chronic fatigue syndrome. J Affect Disord 1996;41:71-76
    • (1996) J Affect Disord , vol.41 , pp. 71-76
    • Sharpe, M.1    Clements, A.2    Hawton, K.3
  • 45
    • 0030791841 scopus 로고    scopus 로고
    • Increased brain serotonin function in men with chronic fatigue syndrome
    • Sharpe K, Hawton K, Clements A, Cowen P. Increased brain serotonin function in men with chronic fatigue syndrome. BMJ 1997;315:164-165
    • (1997) BMJ , vol.315 , pp. 164-165
    • Sharpe, K.1    Hawton, K.2    Clements, A.3    Cowen, P.4
  • 46
    • 0028956529 scopus 로고
    • Neuroendocrine assessment of serotonin (5HT) function in chronic fatigue syndrome
    • Yatham L, Morehouse R, Chisholm B et al. Neuroendocrine assessment of serotonin (5HT) function in chronic fatigue syndrome. Can J Psychiatry 1995;40:93-96
    • (1995) Can J Psychiatry , vol.40 , pp. 93-96
    • Yatham, L.1    Morehouse, R.2    Chisholm, B.3
  • 47
    • 0025850790 scopus 로고
    • Prolactin and cortisol responses to d-fenfluraraine challenge in major depression; evidence for diminished responsivity of central serotonergic function
    • O'Keane V, Dinan T. Prolactin and cortisol responses to d-fenfluraraine challenge in major depression; evidence for diminished responsivity of central serotonergic function. Am J Psychiatry 1991;148:1009-1015
    • (1991) Am J Psychiatry , vol.148 , pp. 1009-1015
    • O'Keane, V.1    Dinan, T.2
  • 48
    • 0029917473 scopus 로고    scopus 로고
    • Serotonin and HPA function
    • Dinan TG. Serotonin and HPA function. Life Sci 1996;58:1683-1694
    • (1996) Life Sci , vol.58 , pp. 1683-1694
    • Dinan, T.G.1
  • 49
    • 85101728676 scopus 로고    scopus 로고
    • Randomised, placebo-controlled trial of fluoxetine in chronic fatigue syndrome
    • Vercoulen J, Swanink C, Zitman F et al. Randomised, placebo-controlled trial of fluoxetine in chronic fatigue syndrome. Lancet 1996;347;658-661
    • (1996) Lancet , vol.347 , pp. 658-661
    • Vercoulen, J.1    Swanink, C.2    Zitman, F.3
  • 50
    • 0025139104 scopus 로고
    • Acute administration of corticoids: A new and peculiar stimulus of growth hormone release in man
    • Casaneuva F, Burguera B, Murais C, Dieguez C. Acute administration of corticoids: a new and peculiar stimulus of growth hormone release in man. J Clin Endocrinol Metab 1990;70:234-237
    • (1990) J Clin Endocrinol Metab , vol.70 , pp. 234-237
    • Casaneuva, F.1    Burguera, B.2    Murais, C.3    Dieguez, C.4
  • 51
    • 0028861523 scopus 로고
    • Defective dexamethasone-induced growth hormone release in chronic fatigue syndrome: Evidence for glucocorticoid receptor resistance and lack of plasticity?
    • Majeed T, Dinan TG, Thakore J et al. Defective dexamethasone-induced growth hormone release in chronic fatigue syndrome: evidence for glucocorticoid receptor resistance and lack of plasticity? Journal of the Irish College of Physicians and Surgeons 1995;24:20-24
    • (1995) Journal of the Irish College of Physicians and Surgeons , vol.24 , pp. 20-24
    • Majeed, T.1    Dinan, T.G.2    Thakore, J.3
  • 53
    • 0028906426 scopus 로고
    • Neu-roendocrine response to d-fenflurarnine and insulin-induced hypoglycaemia in chronic fatigue syndrome
    • Beam J, Allain T, Coskeran P et al. Neu-roendocrine response to d-fenflurarnine and insulin-induced hypoglycaemia in chronic fatigue syndrome. Biol Psychiatry 1995;37: 245-252
    • (1995) Biol Psychiatry , vol.37 , pp. 245-252
    • Beam, J.1    Allain, T.2    Coskeran, P.3
  • 54
    • 0031104879 scopus 로고    scopus 로고
    • Changes in growth hormone, insulin, insulin-like growth factors (IGFs), and IGF-binding protein-1 in chronic fatigue syndrome
    • Allain T, Beam J, Coskeran P et al. Changes in growth hormone, insulin, insulin-like growth factors (IGFs), and IGF-binding protein-1 in chronic fatigue syndrome. Biol Psychiatry 1997;41:567-573
    • (1997) Biol Psychiatry , vol.41 , pp. 567-573
    • Allain, T.1    Beam, J.2    Coskeran, P.3
  • 55
    • 0019957895 scopus 로고
    • Opiates control ACTH release through a noradrenergic mechanism
    • Grossman A, Besser G. Opiates control ACTH release through a noradrenergic mechanism. Clin Endocrinol 1982; 17:287-290
    • (1982) Clin Endocrinol , vol.17 , pp. 287-290
    • Grossman, A.1    Besser, G.2
  • 56
    • 0026071205 scopus 로고    scopus 로고
    • Opioid peptides and depression
    • Ur E ed London; Balliere Tindall
    • Zis A, Garland J. Opioid peptides and depression. In: Ur E ed Clinical Endocrinology and Metabolism. London; Balliere Tindall 1991:97-117
    • Clinical Endocrinology and Metabolism , vol.1991 , pp. 97-117
    • Zis, A.1    Garland, J.2
  • 57
    • 0026536665 scopus 로고
    • The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis
    • Chrousos G, Gold P. The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. JAMA 1992;267:1244-1252
    • (1992) JAMA , vol.267 , pp. 1244-1252
    • Chrousos, G.1    Gold, P.2
  • 58
    • 0032581975 scopus 로고    scopus 로고
    • Low-dose hydrocortisone for treatment of chronic fatigue syndrome
    • McKenzie R, O'Fallon A, Dale J et al. Low-dose hydrocortisone for treatment of chronic fatigue syndrome. JAMA 1998;280:1061-1066
    • (1998) JAMA , vol.280 , pp. 1061-1066
    • McKenzie, R.1    O'Fallon, A.2    Dale, J.3
  • 59
    • 0031006994 scopus 로고    scopus 로고
    • A randomised controlled trial of graded exercise in chronic fatigue syndrome
    • Fulcher K, White P. A randomised controlled trial of graded exercise in chronic fatigue syndrome. BMJ 1997;313:1647-1652
    • (1997) BMJ , vol.313 , pp. 1647-1652
    • Fulcher, K.1    White, P.2


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