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Volumn 69, Issue 2, 1999, Pages 88-94

Deregulation of apoptosis in colorectal carcinoma: Theoretical and therapeutic implications

Author keywords

Apoptosis; Bcl 2; Colorectal carcinoma; p53; Programmed cell death; Terminal deoxynucleotidyl transferase dUTP nick end labelling (TUNEL)

Indexed keywords

DNA NUCLEOTIDYLEXOTRANSFERASE; PROTEIN BCL 2; PROTEIN P53;

EID: 0032910650     PISSN: 00048682     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1622.1999.01498.x     Document Type: Review
Times cited : (43)

References (98)
  • 3
    • 0023099309 scopus 로고
    • Abnormal patterns of cell proliferation in the entire colonie mucosa of patients with colon adenoma or cancer
    • Terpstra OT, van-Blankstein M, Dees J, Eilers GA. Abnormal patterns of cell proliferation in the entire colonie mucosa of patients with colon adenoma or cancer. Gastroenterology 1987; 92: 704-8.
    • (1987) Gastroenterology , vol.92 , pp. 704-708
    • Terpstra, O.T.1    Van-Blankstein, M.2    Dees, J.3    Eilers, G.A.4
  • 4
    • 0030928527 scopus 로고    scopus 로고
    • Failure to detect colonie mucosal hyperproliferation in mutation positive members of a family with hereditary non-polyposis colorectal cancer
    • Jass JR, Ajikora Y, Radojkovic M et al. Failure to detect colonie mucosal hyperproliferation in mutation positive members of a family with hereditary non-polyposis colorectal cancer. Histopatli. 1997;30:201-7.
    • (1997) Histopatli. , vol.30 , pp. 201-207
    • Jass, J.R.1    Ajikora, Y.2    Radojkovic, M.3
  • 5
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990; 61: 759-67.
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 6
    • 0028350601 scopus 로고
    • Mutation of a miitL homolog in hereditary colon cancer
    • Papadopoulos N, Nicolaides NC, Wei Y-F et al. Mutation of a miitL homolog in hereditary colon cancer. Science 1994; 263: 1625-9.
    • (1994) Science , vol.263 , pp. 1625-1629
    • Papadopoulos, N.1    Nicolaides, N.C.2    Wei, Y.-F.3
  • 7
    • 0027742295 scopus 로고
    • The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer
    • Fishel R, Lescoe MK, Rao MRS et al. The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell 1993; 75: 1027-38.
    • (1993) Cell , vol.75 , pp. 1027-1038
    • Fishel, R.1    Lescoe, M.K.2    Mrs, R.3
  • 8
    • 0027145633 scopus 로고
    • Mutation of a mutS homolog in hereditary nonpolyposis colorectal cancer
    • Leach FS, Nicolaides NC, Papadopoulos N et al. Mutation of a mutS homolog in hereditary nonpolyposis colorectal cancer. Cell 1993; 75: 1215-25.
    • (1993) Cell , vol.75 , pp. 1215-1225
    • Leach, F.S.1    Nicolaides, N.C.2    Papadopoulos, N.3
  • 10
    • 0029941463 scopus 로고    scopus 로고
    • Apoptosis and chemotherapy resistance
    • Hickman JA. Apoptosis and chemotherapy resistance. Eur. J. Cancer 1996; 32A: 921-6.
    • (1996) Eur. J. Cancer , vol.32 , pp. 921-926
    • Hickman, J.A.1
  • 11
    • 0028945346 scopus 로고
    • Functional significance of two cytolytic pathways of cytotoxic T lymphocytes
    • Podack ER. Functional significance of two cytolytic pathways of cytotoxic T lymphocytes. J. Lenk. Biol. 1995; 57: 548-52.
    • (1995) J. Lenk. Biol. , vol.57 , pp. 548-552
    • Podack, E.R.1
  • 12
    • 0028329172 scopus 로고
    • Apoptosis: Its significance in cancer and cancer therapy
    • Kerr JFR, Winterford CM, Harmon BV. Apoptosis: Its significance in cancer and cancer therapy. Cancer 1994; 73: 2013-26.
    • (1994) Cancer , vol.73 , pp. 2013-2026
    • Kerr, J.F.1    Winterford, C.M.2    Harmon, B.V.3
  • 13
    • 0015383455 scopus 로고
    • Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
    • Kerr JFR, Wyllie AH, Currie AR. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 1972; 26: 239-57.
    • (1972) Br. J. Cancer , vol.26 , pp. 239-257
    • Kerr, J.F.1    Wyllie, A.H.2    Currie, A.R.3
  • 14
    • 0030033193 scopus 로고    scopus 로고
    • Transducers of life and death: TNF receptor superfamily and associated proteins
    • Baker SJ, Reddy EP. Transducers of life and death: TNF receptor superfamily and associated proteins. Oncogene 1996; 12: 1-9.
    • (1996) Oncogene , vol.12 , pp. 1-9
    • Baker, S.J.1    Reddy, E.P.2
  • 15
    • 0020674141 scopus 로고
    • Response of intestinal cells of differing topographical and hierarchical status to ten cytotoxic drugs and five sources of radiation
    • Ijiri K, Pötten CS. Response of intestinal cells of differing topographical and hierarchical status to ten cytotoxic drugs and five sources of radiation. Br. J. Cancer 1983; 47: 175-85.
    • (1983) Br. J. Cancer , vol.47 , pp. 175-185
    • Ijiri, K.1    Pötten, C.S.2
  • 17
    • 0023819818 scopus 로고
    • Activation of a Ca2+Mg2t-dependent endonuclease as an early event in castrationinduced prostatic cell death
    • Kyprianou N, English HF, Isaacs JT. Activation of a Ca2+Mg2t-dependent endonuclease as an early event in castrationinduced prostatic cell death. Prostate 1988; 13: 103-17.
    • (1988) Prostate , vol.13 , pp. 103-117
    • Kyprianou, N.1    English, H.F.2    Isaacs, J.T.3
  • 18
    • 0018830636 scopus 로고
    • Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation
    • Wyllie AH. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 1980; 284: 555-6-
    • (1980) Nature , vol.284
    • Wyllie, A.H.1
  • 22
    • 0028946358 scopus 로고
    • Calcium-mediated cell injury and cell death
    • Trump BF, Berezesky IK. Calcium-mediated cell injury and cell death. FASEB J. 1995; 9: 219-28.
    • (1995) FASEB J. , vol.9 , pp. 219-228
    • Trump, B.F.1    Berezesky, I.K.2
  • 23
    • 0028087585 scopus 로고
    • Tyrosine kinase activation provides an early and requisite signal for Fas-induced apoptosis
    • Eischen CM, Dick CJ, Leibson PJ. Tyrosine kinase activation provides an early and requisite signal for Fas-induced apoptosis. J. Immunol. 1994; 153: 1947-54.
    • (1994) J. Immunol. , vol.153 , pp. 1947-1954
    • Eischen, C.M.1    Dick, C.J.2    Leibson, P.J.3
  • 24
    • 0028846079 scopus 로고
    • Role of multiple cellular proteases in the execution of programmed cell death
    • Kumar S, Harvey NL. Role of multiple cellular proteases in the execution of programmed cell death. FEBS Lett. 1995; 375: 169-73.
    • (1995) FEBS Lett. , vol.375 , pp. 169-173
    • Kumar, S.1    Harvey, N.L.2
  • 25
    • 0029927422 scopus 로고    scopus 로고
    • The role of proteases during apoptosis
    • Patel T, Gores GJ, Kaufmann SH. The role of proteases during apoptosis. FASEB J. 1996; 10: 587-97.
    • (1996) FASEB J. , vol.10 , pp. 587-597
    • Patel, T.1    Gores, G.J.2    Kaufmann, S.H.3
  • 26
    • 0029101644 scopus 로고
    • Sequential reduction of mitochondria! transmembrane potential and generation of reactive oxygen species in early programmed cell death
    • Zamzami N, Marchetti P, Castedo M et al. Sequential reduction of mitochondria! transmembrane potential and generation of reactive oxygen species in early programmed cell death. J. Exp. Med. 1995; 182: 367-77.
    • (1995) J. Exp. Med. , vol.182 , pp. 367-377
    • Zamzami, N.1    Marchetti, P.2    Castedo, M.3
  • 27
    • 0028537064 scopus 로고
    • The sphingomyelin signal transduction pathway mediates apoptosis for tumor necrosis factor, Fas, and ionizing radiation
    • Kolesnick RN, Haimovitz-Friedman A, Fuks Z. The sphingomyelin signal transduction pathway mediates apoptosis for tumor necrosis factor, Fas, and ionizing radiation. Biochem. CcllBiol 1994; 72: 471-4.
    • (1994) Biochem. CcllBiol , vol.72 , pp. 471-474
    • Kolesnick, R.N.1    Haimovitz-Friedman, A.2    Fuks, Z.3
  • 28
    • 0029894529 scopus 로고    scopus 로고
    • ICE/CED-3 proteases in apoptosis
    • Whyte M. ICE/CED-3 proteases in apoptosis. Trends Cell Biol. 1996; 6: 245-8.
    • (1996) Trends Cell Biol. , vol.6 , pp. 245-248
    • Whyte, M.1
  • 30
    • 0027286802 scopus 로고
    • Bcl-2 expression in adult and embryonic non-haematopoietic tissues
    • Lu Q-L, Poulsom R, Wong L, Hanby AM. Bcl-2 expression in adult and embryonic non-haematopoietic tissues. J. Pathol. 1993:169:431-7.
    • (1993) J. Pathol. , vol.169 , pp. 431-437
    • Lu, Q.-L.1    Poulsom, R.2    Wong, L.3    Hanby, A.M.4
  • 31
    • 0026731996 scopus 로고
    • The significance of spontaneous and induced apoptosis in the gastrointestinal tract of mice
    • Pötten CS. The significance of spontaneous and induced apoptosis in the gastrointestinal tract of mice. Cancer Metastasis Rev. 1992; 11: 179-95.
    • (1992) Cancer Metastasis Rev. , vol.11 , pp. 179-195
    • Pötten, C.S.1
  • 33
    • 0028589378 scopus 로고
    • Regulation of cell number in the mammalian gastrointestinal tract: The importance of apoptosis
    • Hall PA, Coates PJ, Ansari B, Hopwood D. Regulation of cell number in the mammalian gastrointestinal tract: The importance of apoptosis. J. Cell Sei. 1994; 107: 3569-77.
    • (1994) J. Cell Sei. , vol.107 , pp. 3569-3577
    • Hall, P.A.1    Coates, P.J.2    Ansari, B.3    Hopwood, D.4
  • 34
    • 0028875431 scopus 로고
    • In situ detection of enterocytic apoptosis in normal colonie mucosa and in familial adenomatous polyposis
    • Strater J, Koretz K, Gunthert AR, Moller P. In situ detection of enterocytic apoptosis in normal colonie mucosa and in familial adenomatous polyposis. Cut 1995; 37: 819-25.
    • (1995) Cut , vol.37 , pp. 819-825
    • Strater, J.1    Koretz, K.2    Gunthert, A.R.3    Moller, P.4
  • 35
    • 0029940289 scopus 로고    scopus 로고
    • Rapid onset of apoptosis in vitro follows disruption of β1-integrin/matrix interactions in human colonie crypt cells
    • Strater J, Wedding U, Barth TFE, Koretz K, Elsing C, Moller P. Rapid onset of apoptosis in vitro follows disruption of β1-integrin/matrix interactions in human colonie crypt cells. Gastroenterology 1996; 110: 1776-84.
    • (1996) Gastroenterology , vol.110 , pp. 1776-1784
    • Strater, J.1    Wedding, U.2    Tfe, B.3    Koretz, K.4    Elsing, C.5    Moller, P.6
  • 36
    • 0028057613 scopus 로고
    • Disruption of epithelial cell-matrix interactions induces apoptosis
    • Frisch SM, Francis H. Disruption of epithelial cell-matrix interactions induces apoptosis. J. Cell Biol. 1994; 124: 619-26.
    • (1994) J. Cell Biol. , vol.124 , pp. 619-626
    • Frisch, S.M.1    Francis, H.2
  • 37
    • 0030953013 scopus 로고    scopus 로고
    • Cell-cell contact and specific cytokines inhibit apoptosis of colonie epithelial cells: Growth factors protect against c-/;ryc-independent apoptosis
    • Hague A, Hicks DJ, Bracey TS, Paraskeva C. Cell-cell contact and specific cytokines inhibit apoptosis of colonie epithelial cells: Growth factors protect against c-/;ryc-independent apoptosis. Br. J. Cancer 1997; 75: 960-8.
    • (1997) Br. J. Cancer , vol.75 , pp. 960-968
    • Hague, A.1    Hicks, D.J.2    Bracey, T.S.3    Paraskeva, C.4
  • 38
    • 0026504147 scopus 로고
    • Social controls on cell survival and cell death
    • Raff MC. Social controls on cell survival and cell death. Nature 1992; 356: 397-400.
    • (1992) Nature , vol.356 , pp. 397-400
    • Raff, M.C.1
  • 39
    • 0028941441 scopus 로고
    • Inhibition of apoptosis during development of colorectal cancer
    • Bedi A, Pasricha PJ, Akhtar AJ et al. Inhibition of apoptosis during development of colorectal cancer. Cancer Res. 1995; 55: 1811-16.
    • (1995) Cancer Res. , vol.55 , pp. 1811-1816
    • Bedi, A.1    Pasricha, P.J.2    Akhtar, A.J.3
  • 40
    • 0030443509 scopus 로고    scopus 로고
    • Cell adhesion molecules and colon cancer
    • Agrez MV. Cell adhesion molecules and colon cancer. Anst. N.Z. J.Surg. 1996:66:791-8.
    • (1996) Anst. N.Z. J.Surg. , vol.66 , pp. 791-798
    • Agrez, M.V.1
  • 41
    • 0023748414 scopus 로고
    • Genetic alterations during colorectal-tumor development. -N
    • Vogelstein B, Fearon ER, Hamilton SR el al. Genetic alterations during colorectal-tumor development. -N. Eng!. J. Med. 1988;319:525-32.
    • (1988) Eng!. J. Med. , vol.319 , pp. 525-532
    • Vogelstein, B.1    Fearon, E.R.2    Hamilton, S.R.3
  • 42
    • 0027738023 scopus 로고
    • Association of the APC gene product with -catenin
    • Rubinfeld B, Souza B, Albert I et al. Association of the APC gene product with -catenin. Science 1993; 262: 1731-4.
    • (1993) Science , vol.262 , pp. 1731-1734
    • Rubinfeld, B.1    Souza, B.2    Albert, I.3
  • 43
    • 0027756014 scopus 로고
    • Association of the APC tumor suppressor protein with catenins
    • Su L-K, Vogelstein B, Kinzler KW. Association of the APC tumor suppressor protein with catenins. Science 1993; 262: 1734-7.
    • (1993) Science , vol.262 , pp. 1734-1737
    • Su, L.-K.1    Vogelstein, B.2    Kinzler, K.W.3
  • 45
    • 0027763413 scopus 로고
    • Cell division versus cell death: A functional model of multistep neoplasia
    • McDonnell TJ. Cell division versus cell death: A functional model of multistep neoplasia. Mol. Carcinogen. 1993; 8: 209-13.
    • (1993) Mol. Carcinogen. , vol.8 , pp. 209-213
    • McDonnell, T.J.1
  • 46
    • 0029549426 scopus 로고
    • A cautionary note on the use of the TUNEL stain to determine apoptosis
    • Charriaut-Marlangue C, Ben-Ari Y. A cautionary note on the use of the TUNEL stain to determine apoptosis. Neuroreport 1995; 7: 61-4.
    • (1995) Neuroreport , vol.7 , pp. 61-64
    • Charriaut-Marlangue, C.1    Ben-Ari, Y.2
  • 47
    • 0029415421 scopus 로고
    • Is it suitable for the TUNEL staining? Pathol
    • Ichimura E, Fukuda T, Oyama T et al Formalin fixation by boiling: Is it suitable for the TUNEL staining? Pathol. Int. 1995:45:971-2.
    • (1995) Int. , vol.45 , pp. 971-972
    • Ichimura, E.1    Fukuda, T.2    Oyama, T.3
  • 50
    • 0029566202 scopus 로고
    • Histochem
    • fixation on the detection of apoptosis in human brain by in situ end-labelling of DNA. Histochem. J. 1995; 27: 983-8.
    • (1995) J. , vol.27 , pp. 983-988
    • Dhamendra, S.1
  • 51
    • 0029294613 scopus 로고
    • In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note
    • Grasl-Kraupp B, Ruttkay-Nedccky B, Koudelka H, Bukowska K, Bursch V, Schulte-Hermann R. In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note. Hepatol. 1995; 21: 1465-8.
    • (1995) Hepatol. , vol.21 , pp. 1465-1468
    • Grasl-Kraupp, B.1    Ruttkay-Nedccky, B.2    Koudelka, H.3    Bukowska, K.4    Schulte-Hermann, R.5
  • 52
    • 0030024253 scopus 로고    scopus 로고
    • Apoptosis and immunohistochemical bcl-2 expression in colorectal adenomas and carcinomas
    • Baretton GB, Diebold J, Christoforis G et al. Apoptosis and immunohistochemical bcl-2 expression in colorectal adenomas and carcinomas. Cancer 1996; 77: 255-64.
    • (1996) Cancer , vol.77 , pp. 255-264
    • Baretton, G.B.1    Diebold, J.2    Christoforis, G.3
  • 53
    • 0029825362 scopus 로고    scopus 로고
    • Abnormalities of epithelial apoptosis in multistep colorectal neoplasia demonstrated by terminal deoxyuridine nick end labeling
    • Moss SF, Scholes JV, Holt PR. Abnormalities of epithelial apoptosis in multistep colorectal neoplasia demonstrated by terminal deoxyuridine nick end labeling. Dig. Dis. Sei. 1996; 41: 2238-447.
    • (1996) Dig. Dis. Sei. , vol.41 , pp. 2238-2447
    • Moss, S.F.1    Scholes, J.V.2    Holt, P.R.3
  • 54
    • 0030070626 scopus 로고    scopus 로고
    • Apoptosis occurs more frequently in metastatic foci than in primary lesions of human colorectal carcinomas: Analysis by terminal-deoxynucleotidyl-transferase-mediateddUTP-biotin nick end labeling
    • Tatebe S, Ishida M, Kasagi N, Tsujitani S, Kaibara N, Ito H. Apoptosis occurs more frequently in metastatic foci than in primary lesions of human colorectal carcinomas: Analysis by terminal-deoxynucleotidyl-transferase-mediateddUTP-biotin nick end labeling. Int. J. Cancer 1996; 65: 173-7.
    • (1996) Int. J. Cancer , vol.65 , pp. 173-177
    • Tatebe, S.1    Ishida, M.2    Kasagi, N.3    Tsujitani, S.4    Kaibara, N.5    Ito, H.6
  • 55
    • 0030925132 scopus 로고    scopus 로고
    • Pathological and genetic correlates of apoptosis in the progression of colorectal neoplasia
    • Hawkins N, Lees J, Margrave R, O'ConnorT, Meagher A, Ward R. Pathological and genetic correlates of apoptosis in the progression of colorectal neoplasia. Tumor Biol. 1997; 18: 146-56.
    • (1997) Tumor Biol. , vol.18 , pp. 146-156
    • Hawkins, N.1    Lees, J.2    Margrave, R.3    O'ConnorT4    Meagher, A.5    Ward, R.6
  • 56
    • 0029898284 scopus 로고    scopus 로고
    • Apoptosis of colon cancers assessed by in situ DNA nick end-labeling method
    • Ikenaga M, Takano Y, Saegusa M et al. Apoptosis of colon cancers assessed by in situ DNA nick end-labeling method. Pathollnt. 1996; 46: 33-7.
    • (1996) Pathollnt. , vol.46 , pp. 33-37
    • Ikenaga, M.1    Takano, Y.2    Saegusa, M.3
  • 57
    • 0029993271 scopus 로고    scopus 로고
    • Significance of spontaneous apoptosis during colorectal tumorigenesis
    • Koike M. Significance of spontaneous apoptosis during colorectal tumorigenesis. J. Surg. Oncol. 1996; 62: 97-108.
    • (1996) J. Surg. Oncol. , vol.62 , pp. 97-108
    • Koike, M.1
  • 58
    • 0029848277 scopus 로고    scopus 로고
    • What is an apoptotic index measuring? a commentary
    • Pötten CS. What is an apoptotic index measuring? A commentary. Br. J. Cancer 1996; 74: 1743-8.
    • (1996) Br. J. Cancer , vol.74 , pp. 1743-1748
    • Pötten, C.S.1
  • 59
    • 0029922310 scopus 로고    scopus 로고
    • Apoptosis of colon cancer: Comparison with Ki-67 proliferative activity and expression of p53
    • Takano Y, Saegusa M, Ikenaga M, Mitomi H, Okayasu I. Apoptosis of colon cancer: Comparison with Ki-67 proliferative activity and expression of p53. J. Cancer Res. Clin. Oncol. 1996; 122: 166-70.
    • (1996) J. Cancer Res. Clin. Oncol. , vol.122 , pp. 166-170
    • Takano, Y.1    Saegusa, M.2    Ikenaga, M.3    Mitomi, H.4    Okayasu, I.5
  • 60
    • 0029074441 scopus 로고
    • Role of apoptosis in modulation of the growth of human colorectal tubular and villous adenomas
    • Arai T, Kino I. Role of apoptosis in modulation of the growth of human colorectal tubular and villous adenomas. J. Palhol. 1995; 176: 37-44.
    • (1995) J. Palhol. , vol.176 , pp. 37-44
    • Arai, T.1    Kino, I.2
  • 61
    • 0028877086 scopus 로고
    • Cell death in colorectal polyps as evaluated by in situ 3'-tailing reaction and its relationship to BCL-2 expression
    • Nakamura T, Sakai T, Nariya S. Cell death in colorectal polyps as evaluated by in situ 3'-tailing reaction and its relationship to BCL-2 expression. Pathol. Int. 1995; 45: 721-8.
    • (1995) Pathol. Int. , vol.45 , pp. 721-728
    • Nakamura, T.1    Sakai, T.2    Nariya, S.3
  • 62
    • 33847518133 scopus 로고
    • P53, guardian of the genome
    • Lane DP. p53, guardian of the genome. Nature 1995; 376: 37-43.
    • (1995) Nature , vol.376 , pp. 37-43
    • Lane, D.P.1
  • 64
    • 0027319521 scopus 로고    scopus 로고
    • P53 is required for radiation-induced apoptosis in mouse thymocytes
    • Lowe SW, Schmitt EM, Smith SW, Osborne BA, Jacks T. P53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 993n- 362: 847-9.
    • Nature , vol.993 , pp. 362-447
    • Lowe, S.W.1    Schmitt, E.M.2    Smith, S.W.3    Osborne, B.A.4    Jacks, T.5
  • 65
    • 0028072523 scopus 로고
    • DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2
    • Strasser A, Harris AW, Jacks T, Cory S. DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2. Cell 1994; 79: 329-39.
    • (1994) Cell , vol.79 , pp. 329-339
    • Strasser, A.1    Harris, A.W.2    Jacks, T.3    Cory, S.4
  • 66
    • 0031045270 scopus 로고    scopus 로고
    • Induction of p53independent apoptosis associated with G2M arrest following DNA damage in human colon cancer cell lines
    • Arita D, Kambe M, Ishioka C, Kanamaru R. Induction of p53independent apoptosis associated with G2M arrest following DNA damage in human colon cancer cell lines. Jpn. J. Cancer Res. 1997; 88: 39-43.
    • (1997) Jpn. J. Cancer Res. , vol.88 , pp. 39-43
    • Arita, D.1    Kambe, M.2    Ishioka, C.3    Kanamaru, R.4
  • 67
    • 0030055095 scopus 로고    scopus 로고
    • Comparative alterations in p53 expression and apoptosis in the irradiated rat small and large intestine
    • Arai T, Kida Y, Harmon BV, Gobe GC. Comparative alterations in p53 expression and apoptosis in the irradiated rat small and large intestine. Br. J. Cancer 1996; 74: 406-12.
    • (1996) Br. J. Cancer , vol.74 , pp. 406-412
    • Arai, T.1    Kida, Y.2    Harmon, B.V.3    Gobe, G.C.4
  • 68
    • 0029048596 scopus 로고
    • Differential expression of bcl-2 in intestinal epithelia
    • Merritt AJ, Potten CS, Watson AJM et al. Differential expression of bcl-2 in intestinal epithelia. J. Cell Set. 1995; 108: 2261-71.
    • (1995) J. Cell Set. , vol.108 , pp. 2261-2271
    • Merritt, A.J.1    Potten, C.S.2    Ajm, W.3
  • 69
    • 0027056098 scopus 로고
    • A possible explanation for the differential cancer incidence in the intestine, based on distribution of the cytotoxic effects of carcinogens in the murine large bowel
    • Potten CS, Li YQ, O'Connor PJ, Winton DJ. A possible explanation for the differential cancer incidence in the intestine, based on distribution of the cytotoxic effects of carcinogens in the murine large bowel. Carcinogen 1992; 13: 2305-12.
    • (1992) Carcinogen , vol.13 , pp. 2305-2312
    • Potten, C.S.1    Li, Y.Q.2    O'Connor, P.J.3    Winton, D.J.4
  • 70
    • 0027096262 scopus 로고
    • Dietary intake of fiber and decreased risk of cancers of the colon and rectum: Evidence from the combined analysis of 13 case-control studies
    • Howe GR, Benito E, Castelleto R et al. Dietary intake of fiber and decreased risk of cancers of the colon and rectum: evidence from the combined analysis of 13 case-control studies. J. Natl Cancer Inst. 1992; 84: 1887-96.
    • (1992) J. Natl Cancer Inst. , vol.84 , pp. 1887-1896
    • Howe, G.R.1    Benito, E.2    Castelleto, R.3
  • 71
    • 0019128183 scopus 로고
    • The role of anaerobic bacteria in the metabolic welfare of the colonie mucosa in man
    • Roediger WEW. The role of anaerobic bacteria in the metabolic welfare of the colonie mucosa in man. Gut 1980; 21: 793-8.
    • (1980) Gut , vol.21 , pp. 793-798
    • Wew, R.1
  • 72
    • 0027485599 scopus 로고
    • Sodium butyrate induces apoptosis in human colonie tumour cell lines in a p53-independent pathway: Implications for the possible role of dietary fibre in the prevention of large-bowel cancer. ///J
    • Hague A, Manning AM, Hanlon KA, Huschtscha LI, Hart D, Paraskeva C. Sodium butyrate induces apoptosis in human colonie tumour cell lines in a p53-independent pathway: Implications for the possible role of dietary fibre in the prevention of large-bowel cancer. ///J. J. Cancer 1993; 55: 498-505.
    • (1993) J. Cancer , vol.55 , pp. 498-505
    • Hague, A.1    Manning, A.M.2    Hanlon, K.A.3    Huschtscha, L.I.4    Hart, D.5    Paraskeva, C.6
  • 73
    • 0028859161 scopus 로고
    • Apoptosis in colorectal tumour cells: Induction by the short chain fatty acids butyrate, propionate and acetate and by the bile salt deoxycholate
    • Hague A; Elder DJE, Hicks DJ, Paraskeva C. Apoptosis in colorectal tumour cells: Induction by the short chain fatty acids butyrate, propionate and acetate and by the bile salt deoxycholate. Int. J. Cancer 1995; 60: 400-6.
    • (1995) Int. J. Cancer , vol.60 , pp. 400-406
    • Hague, A.1    Elder, D.J.2    Hicks, D.J.3    Paraskeva, C.4
  • 74
    • 0029874733 scopus 로고    scopus 로고
    • Butyrate and the colonocyte: Implications for neoplasia
    • Valazquez OC, Lederer HM, Rombeau JL. Butyrate and the colonocyte: Implications for neoplasia. Dig. Dis. Sei. 1996; 41: 727-39.
    • (1996) Dig. Dis. Sei. , vol.41 , pp. 727-739
    • Valazquez, O.C.1    Lederer, H.M.2    Rombeau, J.L.3
  • 75
    • 0025339274 scopus 로고
    • Hypotheses for the etiology of colorectal cancer: An overview
    • Cheah PY. Hypotheses for the etiology of colorectal cancer: An overview. Nutr. Cancer 1990; 14: 5-13.
    • (1990) Nutr. Cancer , vol.14 , pp. 5-13
    • Cheah, P.Y.1
  • 76
    • 0019500048 scopus 로고
    • Diet and excretion of bile acids
    • ReddyBS. Diet and excretion of bile acids. Cancer Res. 1981; 41: 3766-8.
    • (1981) Cancer Res. , vol.41 , pp. 3766-3768
    • Reddy, B.S.1
  • 77
    • 0026327144 scopus 로고
    • Bile salt/acid induction of DNA damage in bacterial and mammalian cells: Implications for colon cancer
    • Kandell RL, Bernstein C. Bile salt/acid induction of DNA damage in bacterial and mammalian cells: Implications for colon cancer. Nutr. Cancer 1991; 16: 227-38.
    • (1991) Nutr. Cancer , vol.16 , pp. 227-238
    • Kandell, R.L.1    Bernstein, C.2
  • 78
    • 0029094616 scopus 로고
    • Role of apoptosis in biology and pathology: Resistance to apoptosis in colon carcinogenesis
    • Payne CM, Bernstein H, Bernstein C, Garewal H. Role of apoptosis in biology and pathology: Resistance to apoptosis in colon carcinogenesis. Ultrastruct. Palhol. 1995; 19: 221-448.
    • (1995) Ultrastruct. Palhol. , vol.19 , pp. 221-448
    • Payne, C.M.1    Bernstein, H.2    Bernstein, C.3    Garewal, H.4
  • 79
    • 0030002903 scopus 로고    scopus 로고
    • Reduced bile acid-induced apoptosis in 'normal' colorectal mucosa: A potential biological marker for cancer risk
    • Garewal H, Bernstein H, Bernstein C, Sampliner R, Payne C. Reduced bile acid-induced apoptosis in 'normal' colorectal mucosa: A potential biological marker for cancer risk. Cancer Res. 1996; 56: 1480-3.
    • (1996) Cancer Res. , vol.56 , pp. 1480-1483
    • Garewal, H.1    Bernstein, H.2    Bernstein, C.3    Sampliner, R.4    Payne, C.5
  • 80
  • 81
    • 0024536654 scopus 로고
    • Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas
    • Baker SJ, Fearon ER, Nigro JM et al. Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas. Science 1989:244:217-21.
    • (1989) Science , vol.244 , pp. 217-221
    • Baker, S.J.1    Fearon, E.R.2    Nigro, J.M.3
  • 82
    • 0029780701 scopus 로고    scopus 로고
    • Genes mediating programmed cell death: An immunohistochemical study of bcI-2, c-myc and p53 expression in colorectal neoplasia
    • Scott N, Martin I, Jack AS, Dixon MF, Quirk P. Genes mediating programmed cell death: An immunohistochemical study of bcI-2, c-myc and p53 expression in colorectal neoplasia. J. Clin. Palhol. Mol. Palhol. 1996; 49: M151-8.
    • (1996) J. Clin. Palhol. Mol. Palhol. , vol.49
    • Scott, N.1    Martin, I.2    Jack, A.S.3    Dixon, M.F.4    Quirk, P.5
  • 83
    • 8944236536 scopus 로고    scopus 로고
    • An immunohistochemical study of the simultaneous expression of bcI-2 and p53 oncoproteins in epithelial tumors of the colon and rectum
    • Mosnier J-F, Perret AG, Vindimian M et al. An immunohistochemical study of the simultaneous expression of bcI-2 and p53 oncoproteins in epithelial tumors of the colon and rectum. Arch. Pathol. Lab. Med. 1996; 120: 654-9.
    • (1996) Arch. Pathol. Lab. Med. , vol.120 , pp. 654-659
    • Mosnier, J.-F.1    Perret, A.G.2    Vindimian, M.3
  • 85
    • 0029835823 scopus 로고    scopus 로고
    • Expression of bcl-2 and p53 in de novo and ex-adenoma colon carcinoma: A comparative immunohistochemical study
    • Meuller J, Meuller E, Hoepner I et al. Expression of bcl-2 and p53 in de novo and ex-adenoma colon carcinoma: A comparative immunohistochemical study. J. Pathol. 1996; 180: 259-65.
    • (1996) J. Pathol. , vol.180 , pp. 259-265
    • Meuller, J.1    Meuller, E.2    Hoepner, I.3
  • 88
    • 0028989844 scopus 로고
    • Bcl-2 oncoprotein in colorectal hyperplastic polyps, adenomas, and adenocarcinomas
    • Bosari S, Moneghini L, Graziani D et al. Bcl-2 oncoprotein in colorectal hyperplastic polyps, adenomas, and adenocarcinomas. Hum. Pathol. 1995; 26: 534-40.
    • (1995) Hum. Pathol. , vol.26 , pp. 534-540
    • Bosari, S.1    Moneghini, L.2    Graziani, D.3
  • 89
    • 0029868847 scopus 로고    scopus 로고
    • Expression of Bcl-2 protein in hyperplastic polyps, adenomas and carcinomas of the colon
    • Flohil CC, Janssen PA, Bosman FT. Expression of Bcl-2 protein in hyperplastic polyps, adenomas and carcinomas of the colon. J. Pathol. 1996; 178: 393-7.
    • (1996) J. Pathol. , vol.178 , pp. 393-397
    • Flohil, C.C.1    Janssen, P.A.2    Bosman, F.T.3
  • 90
    • 0028814213 scopus 로고
    • The bcl-2 protooncogene and the gastrointestinal epithelial tumor progression model
    • Bronner MP, Culin C, Reed JC, Furth EE. The bcl-2 protooncogene and the gastrointestinal epithelial tumor progression model. Am. J. Pathol. 1995; 146: 20-6.
    • (1995) Am. J. Pathol. , vol.146 , pp. 20-26
    • Bronner, M.P.1    Culin, C.2    Reed, J.C.3    Furth, E.E.4
  • 91
    • 0028357022 scopus 로고
    • Loss of heterozygosity at the bcl-2 gene locus and expression of bcl-2 in human gastric and colorectal carcinomas
    • Ayhan A, Yasui W, Yokozaki H, Seto M, Ueda R, Tahara E. Loss of heterozygosity at the bcl-2 gene locus and expression of bcl-2 in human gastric and colorectal carcinomas. Jpn J. Cancer Res. 1994; 85: 584-91.
    • (1994) Jpn J. Cancer Res. , vol.85 , pp. 584-591
    • Ayhan, A.1    Yasui, W.2    Yokozaki, H.3    Seto, M.4    Ueda, R.5    Tahara, E.6
  • 92
    • 0027166048 scopus 로고
    • Bcl-2 heterodimerises in vivo with a conserved homolog, Bax, that accelerates programed cell death
    • Oltvai ZN, Milliman CL, Korsmeyer SJ. Bcl-2 heterodimerises in vivo with a conserved homolog, Bax, that accelerates programed cell death. Cell 1993; 74: 609-19.
    • (1993) Cell , vol.74 , pp. 609-619
    • Oltvai, Z.N.1    Milliman, C.L.2    Korsmeyer, S.J.3
  • 93
    • 0028883179 scopus 로고
    • Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
    • Miyashita T, Reed JC. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 1995; 80: 293-9.
    • (1995) Cell , vol.80 , pp. 293-299
    • Miyashita, T.1    Reed, J.C.2
  • 94
    • 0031018674 scopus 로고
    • Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype
    • Rampino N, Yamamoto H, lonov Y et al. Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science 1994; 275: 967-9.
    • (1994) Science , vol.275 , pp. 967-969
    • Rampino, N.1    Yamamoto, H.2    Lonov, Y.3
  • 95
    • 0028276666 scopus 로고
    • Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences
    • Kim H, Jen J, Vogelstein B et al. Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences. Am. J. Pathol. 1994; 145: 148-56.
    • (1994) Am. J. Pathol. , vol.145 , pp. 148-156
    • Kim, H.1    Jen, J.2    Vogelstein, B.3
  • 96
    • 0027451668 scopus 로고
    • P53-dependent apoptosis modulates the cytotoxicity of anticancer agents
    • Lowe SW, Ruley HE, Jacks T, Housman DE. P53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 1993b; 74: 957-67.
    • (1993) Cell , vol.74 , pp. 957-967
    • Lowe, S.W.1    Ruley, H.E.2    Jacks, T.3    Housman, D.E.4
  • 97
    • 0027258466 scopus 로고
    • Thymocyte apoptosis induced by p53-dependent and independent pathways
    • Clarke AR, Purdie CA, Harrison DJ et al. Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature 1993:362:849-52.
    • (1993) Nature , vol.362 , pp. 849-852
    • Clarke, A.R.1    Purdie, C.A.2    Harrison, D.J.3
  • 98
    • 0027944206 scopus 로고
    • P53 status and the efficacy of cancer therapy in vivo
    • Lowe SW, Bodis S, McCIatchey A et al. P53 status and the efficacy of cancer therapy in vivo. Science 1994; 266: 807-10.
    • (1994) Science , vol.266 , pp. 807-810
    • Lowe, S.W.1    Bodis, S.2    McCiatchey, A.3


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