Apoptosis of colon cancer: Comparison with Ki-67 proliferative activity and expression of p53

Journal of Cancer Research and Clinical Oncology

Volumn 122, Issue 3, 1996, Pages 166-170

  Takano, Yasuo ^a   Saegusa, Makoto ^a   Ikenaga, Makoto ^a   Mitomi, Hiroyuki ^a   Okayasu, Isao ^a  

^a KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Apoptosis; bcl 2; Colon cancer; In situ nick ended DNA labeling; p53

Indexed keywords

MONOCLONAL ANTIBODY KI 67; PROTEIN BCL 2; PROTEIN P53;

APOPTOSIS; ARTICLE; COLON CARCINOMA; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL;

APOPTOSIS; CELL DIVISION; CELL NUCLEUS; COLONIC NEOPLASMS; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; NEOPLASM PROTEINS; NUCLEAR PROTEINS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0029922310     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01366957     Document Type: Article

References (25)

1. Arends MJ, Wyllie AH (1991) Apoptosis: mechanisms and roles in pathology. Int Rev Exp Pathol 32: 223-254
2. Arends MJ, McGregor AH, Wyllie AH (1994) Apoptosis is inversely related to necrosis and determines net growth in tumors bearing constitutively expressed myc, ras, and HPV oncogenes. Am J Pathol 144: 1045-1057
3. Gavriel Y, Sherman Y, Ben-Sasson SA (1992) Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 119: 493-501
4. Gerdes J, Lemke H, Baisch H, et at (1984) Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol 133: 1710-1716
5. Hockenbery DM, Zutter M, Hickey W, et al (1991) BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc Natl Acad Sci USA 88: 6961-6965
6. Hutter RVP, Sobin LH (1986) A universal staging system for cancer of the colon and rectum. Arch Pathol Lab Med 110: 367-368
7. Ito N, Yonehara S, Ishii A, et al (1991) The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell 66: 233-243
8. Kerr JFR, Harmon BV (1991) Definition and incidence of apoptosis: An historical perspective. In: Tomei LD, Cope FO (eds) Apoptosis: the molecular basis of cell death. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, pp 1-29
9. Kerr JFR, Searle J (1972) A suggested explanation for the paradoxically slow growth rate of basal-cell carcinoma that contain numerous mitotic figures. J Pathol 107: 41-44
10. Kerr JFR, Winterford CM, Harmon BV (1994) Apoptosis: its significance in cancer and cancer therapy. Cancer 73: 2013-2026
11. Krammer PH, Behrmann I, Bier V, et al (1991) Apoptosis in the APO-1 system. In: Tomei LD, Cope FO (eds) Apoptosis: the molecular basis of cell death. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, pp 87-99
12. Lane DP (1993) A death in the life of p53. Nature 362: 786-787
13. Leoncini L, Del Vecchio MT, Megha T, et al (1993) Correlations between apoptotic and proliferative indices in malignant non-Hodgkin's lymphomas. Am J Pathol 142: 755-763
14. Moller P, Koretz K, Leithauser F, et al (1994) Expression of Apo-1 (CD95), a member of the NGF/TNF receptor superfamily, in normal and neoplastic colon epithelium. Int J Cancer 57: 371-377
15. Orem M (1992) p53: the ultimate tumor suppressor gene? FASEB J 6: 3169-3176
16. Raff MC (1992) Social controls on cell survival and cell death. Nature 356: 397-400
17. Saegusa M, Takano Y, Okayasu I (1995) Bcl-2 expression and its correlation with apoptosis, p53 immunoreactivity and cell proliferation in human gastric carcinomas. J Cancer Res Clin Oncol 121: 357-363
18. Schiffer D, Cavalla P, Chio A, et al (1994) Tumor cell proliferation and apoptosis in medulloblastoma. Acta Neuropathol 87: 362-370
19. Shaw P, Bovey R, Tardy S, et al (1992) Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line. Proc Natl Acad Sci USA 89: 4495-4499
20. Shepherd NA, Richman PI, England J (1988) Ki-67 derived proliferative activity in colorectal adenocarcinoma with prognostic correlations. J Pathol 155: 213-219
21. Shi Y, Glynn JM, Guilbert LJ, et al (1992) Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas. Science 257: 212-214
22. Symonds H, Krall L, Remington L et al (1994) p53-dependent apoptosis suppresses tumor growth and progression in vivo. Cell 78: 703-711
23. Takano YS, Harmon BV, Winterford CM, et al (1991) Apoptosis induced by mild hyperthermia in human and murine cell lines: a study using electron microscopy and DNA gel electrophoresis. J Pathol 163: 329-326
24. Trauth BC, Klas C, Peters AMJ, et al (1989) Monoclonal antibody-mediated tumor regression by induction of apoptosis. Science 345: 301-305
25. Yonish-Rouach E, Resnitzky D, Lotem J, et al (1991) Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6. Nature 352: 345-347