AMPA/kainate-related mechanisms contribute to convulsant and proconvulsant effects of 3-nitropropionic acid

European Journal of Pharmacology

Volumn 370, Issue 3, 1999, Pages 251-256

  Urbanska, Ewa M ^a,b   Blaszczak, Piotr ^a   Saran, Tomasz ^a   Kleinrok, Zdzislaw ^a   Turski, Waldemar A ^a,b  

^a MEDICAL UNIVERSITY OF LUBLIN   (Poland)

^b INSTITUTE OF AGRICULTURAL MEDICINE   (Poland)

Author keywords

3 Nitropropionic acid; Excitatory amino acid receptor agonist; Excitatory amino acid receptor antagonist; Mitochondrial toxin; NMDA receptor; Non NMDA receptor; Seizure

Indexed keywords

1 (4 AMINOPHENYL) 4 METHYL 7,8 METHYLENEDIOXY 5H 2,3 BENZODIAZEPINE; 3 NITROPROPIONIC ACID; 6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMINO ACID RECEPTOR BLOCKING AGENT; AMINO ACID RECEPTOR STIMULATING AGENT; AMPA RECEPTOR ANTAGONIST; KAINIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLONIC SEIZURE; CONTROLLED STUDY; CONVULSION; DRUG MECHANISM; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTICONVULSANTS; BEHAVIOR, ANIMAL; DRUG INTERACTIONS; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; INJECTIONS, INTRAVENTRICULAR; MALE; MICE; MITOCHONDRIA; N-METHYLASPARTATE; NITRO COMPOUNDS; PROPIONIC ACIDS; QUINOXALINES; RECEPTORS, AMPA;

EID: 0032908498     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00147-8     Document Type: Article

References (26)

1. Alston T.A., Mela L., Bright H.J. 3-Nitropropionate, the toxic substance of Indigofera, is a suicide inactivator of succinate dehydrogenase. Proc. Natl. Acad. Sci. U.S.A. 74:1977;3767-3771.
2. Beal M.F., Brouillet E., Jenkins B.G., Ferrante R.J., Kowall N.W., Miller J.M., Storey E., Srivastava R., Rosen B.R., Hyman B.T. Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid. J. Neurosci. 13:1993;4181-4192.
3. Clineschmidt B.V., Martin G.E., Bunting P.R., Papp M.L. Central sympathomimetic activity of (±)-5-methyl-10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5,10-imine (MK-801), a substance with potent anticonvulsant, central sympathomimetic, and apparent anxiolytic properties. Drug Dev. Res. 2:1982;135-146.
4. Fink S.L., Ho D.Y., Sapolsky R.M. Energy and glutamate dependency of 3-nitropropionic acid neurotoxicity in culture. Exp. Neurol. 138:1996;298-304.
5. Fragoso-Veloz J., Tapia R. NMDA receptor antagonists protect against seizures and wet-dog shakes induced by 4-aminopyridine. Eur. J. Pharmacol. 221:1992;275-280.
6. Geddes J.W., Pang Z., Wiley D.H. Hippocampal damage and cytoskeletal disruption resulting from impaired energy metabolism. Implications for Alzheimer disease. Mol. Chem. Neuropathol. 28:1996;65-74.
7. Gould D.H., Gustine D.L. Basal ganglia degeneration, myelin alterations, and enzyme inhibition induced in mice by the plant toxin 3-nitropropionic acid. Neuropathol. Appl. Neurobiol. 8:1982;377-393.
8. Henneberry R.C., Novelli A., Cox J.A., Lysko P.G. Neurotoxicity at the N-methyl-D-aspartate receptor in energy-compromised neurons: An hypothesis for cell death in aging and disease. Ann. NY Acad. Sci. 568:1989;225-233.
9. Litchfield J.T., Wilcoxon F. A simplified method of evaluating dose-effect experiments. J. Pharmacol. Exp. Ther. 96:1949;99-111.
10. Löscher W., Honack D. The behavioural effects of MK-801 in rats: involvement of dopaminergic, serotonergic and noradrenergic systems. Eur. J. Pharmacol. 215:1992;199-208.
11. Ludolph A.C., He F., Spencer P.S., Hammerstad J., Sabri M. 3-Nitropropionic acid - exogenous animal neurotoxin and possible human striatal toxin. Can. J. Neurol. Sci. 18:1991;492-498.
12. Ludolph A.C., Seelig M., Ludolph A., Novitt P., Allen C.N., Spencer P.S., Sabri M.I. 3-Nitropropionic acid decreases cellular energy levels and causes neuronal degeneration in cortical explants. Neurodegeneration. 1:1992;155-161.
13. Meldrum B.S. The role of glutamate in epilepsy and other CNS disorders. Neurology. 44(suppl. 8):1994;S14-S23.
14. Pang Z., Geddes J.W. Mechanisms of cell death induced by mitochondrial toxin 3-nitropropionic acid: acute excitotoxic necrosis and delayed apoptosis. J. Neurosci. 17:1997;3064-3073.
15. Riepe M., Hori N., Ludolph A.C., Carpenter D.O., Spencer P.S., Allen C.N. Inhibition of energy metabolism by 3-nitropropionic acid activates ATP-sensitive potassium channels. Brain Res. 586:1992;61-66.
16. Riepe M., Ludolph A., Seelig M., Spencer P.S., Ludolph A.C. Increase of ATP levels by glutamate antagonists is unrelated to neuroprotection. Neuroreport. 5:1994;2130-2132.
17. Riepe M.W., Hori N., Ludolph A.C., Carpenter D.O. Failure of neuronal ion exchange, not potentiated excitation, causes excitotoxicity after inhibition of oxidative phosphorylation. Neuroscience. 64:1995;91-97.
18. Simpson J.R., Isacson O. Mitochondrial impairment reduces the threshold for in vivo NMDA-mediated neuronal death in the striatum. Exp. Neurol. 121:1993;57-64.
19. Turski W.A., Dziki M., Urbanska E., Calderazzo-Filho L.S., Cavalheiro E.A. Seizures induced by aminooxyacetic acid in mice: pharmacological characteristics. Synapse. 7:1991;173-180.
20. Urbanska E., Dziki M., Kleinrok Z., Czuczwar S.J., Turski W.A. Influence of MK-801 on the anticonvulsant activity of antiepileptics. Eur. J. Pharmacol. 200:1991;277-282.
21. Urbanska E., Blaszczak P., Saran T., Kleinrok Z., Turski W.A. Mitochondrial toxin 3-nitropropionic acid evokes seizures in mice. Eur. J. Pharmacol. 359:1998;55-58.
22. Urbanska E.M., Czuczwar S.J., Kleinrok Z., Turski W.A. Excitatory amino acids in epilepsy. Rest. Neurol. Neurosci. 13:1998;25-39.
23. Weller M., Paul S.M. 3-Nitropropionic acid is an indirect excitotoxin to cultured cerebellar granule neurons. Eur. J. Pharmacol. 248:1993;223-228.
24. Wenk G.L., Danysz W., Roice D.D. The effect of mitochondrial failure upon cholinergic toxicity in the nucleus basalis. Neuroreport. 7:1996;1453-1456.
25. Zeevalk G.D., Nicklas W.J. Mechanisms underlying initiation of excitotoxicity associated with metabolic inhibition. J. Pharmacol. Exp. Ther. 257:1991;870-878.
26. Zeevalk G.D., Derr-Yellin E., Nicklas W.J. NMDA receptor involvement in toxicity to dopamine neurons in vitro caused by the succinate dehydrogenase inhibitor 3-nitropropionic acid. J. Neurochem. 64:1995;455-458.