Hippocampal damage and cytoskeletal disruption resulting from impaired energy metabolism: Implications for Alzheimer disease

Molecular and Chemical Neuropathology

Volumn 28, Issue 1-3, 1996, Pages 65-74

  Geodes, James W ^a   Pang, Zhen ^a   Wiley, David H ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

3 nitropropionic acid; cytoskeleton; dizocilpine maleate; hippocampus; Malonate; microtubule associated proteins; mitochondria; MK 801; neurofibrillary tangles; succinate dehydrogenase; proteins

Indexed keywords

3 NITROPROPIONIC ACID; DIZOCILPINE MALEATE; MALONIC ACID; MICROTUBULE ASSOCIATED PROTEIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE; SUCCINATE DEHYDROGENASE;

AGING; ALZHEIMER DISEASE; CELL DEATH; CONFERENCE PAPER; CYTOSKELETON; ENERGY METABOLISM; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HUMAN TISSUE; HUNTINGTON CHOREA; NEUROFIBRILLARY TANGLE; NEUROTRANSMISSION; PRIORITY JOURNAL; TISSUE INJURY;

EID: 0029814577     PISSN: 10447393     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf02815206     Document Type: Conference Paper

References (18)

1. Beal M. F. (1992) Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses? Ann. Neurol. 31, 119-130.
2. Beal M. F., Brouillet E., Jenkins B., Henshaw R., Rosen B., and Hyman B. T. (1993a) Age-dependent striatal excitotoxic lesions produced by the endogenous mitochondrial inhibitor malonate. J. Neurochem. 61, 1147-1150.
3. Beal M. F., Brouillet E., Jenkins B. G., Ferrante R. J., Kowall N. W., Miller J. M., Storey E., Srivastava R., Rosen B. R., and Hyman B. T. (1993b) Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid. J. Neurosci. 13, 4181-4192.
4. Blass J. P. and Gibson, G. E. (1991) The role of oxidative abnormalities in the pathophysiology of Alzheimer's disease. Rev. Neurol. (Paris) 147, 513-525.
5. Bossi S. R., Simpson J. R., and Isacson O. (1993) Age dependence of striatal neuronal death caused by mitochondrial dysfunction. NeuroReport 4, 73-76.
6. Brouillet E., Jenkins B. G., Hyman B. T., Ferrante R. J., Kowall N. W., Srivastava R., Roy D. S., Rosen B. R., and Beal M. F. (1993) Age-dependent vulnerability of the striatum to the mitochondrial toxin 3-nitropropionic acid. J. Neurochem. 60, 356-359.
7. Greenamyre J. T. and Young A. B. (1989) Excitatory amino acids and Alzheimer's disease. Neurobiol. Aging 10, 593-602.
8. Greene J. G. and Greenamyre J. T. (1995) Characterization of the excitotoxic potential of the reversible succinate dehydrogenase inhibitor malonate. J. Neurochem. 64, 430-436.
9. Greene J. G., Porter R. H., Eller R. V., and Greenamyre J. T. (1993) Inhibition of succinate dehydrogenase by malonic acid produces an "excitotoxic" lesion in rat striatum. J. Neurochem. 61, 1144-1151.
10. Henshaw R., Jenkins B. G., Schulz J. B., Ferrante R. J., Kowall N. W., Rosen B. R., and Beal M. F. (1994) Malonate produces striatal lesions by indirect NMDA receptor activation. Brain Res. 647, 161-166.
11. Hoyer S. (1992) Oxidative-energy metabolism in Alzheimer brain. Studies in early-onset and late-onset cases. Mol. Chem. Neuropathol. 16, 207-224.
12. 3H]glutamate-binding sites in rat brain. J. Neurosci. 5, 2909-2919.
13. Novelli A., Reilly J. A., Lysko P. G., and Henneberry R. C. (1988) Glutamate becomes neurotoxic via the N-methyl-D-aspartate receptor when intracellular energy levels are reduced. Brain Res. 451, 205-212.
14. Pang Z., Umberger G. H., and Geddes J. W. (1996) Neuronal loss and cytoskeletal disruption following intrahippocampal administration of the metabolic inhibitor malonate: lack of protection by MK-801. J. Neurochem. 66, 474-484.
15. Roberts-Lewis J. M., Savage M. J., Marcy V. R., Pinsker L. R., and Siman R. (1994) Immunolocalization of calpain-I mediated spectrin degradation to vulnerable neurons in the ischemic gerbil brain. J. Neurosci. 14, 3934-3944.
16. Schurr A. and Rigor B. M. (1992) The mechanism of cerebral hypoxic-ischemic damage. Hippocampus 2, 221-228.
17. Simpson I. A., Koteswara K. R., Davies-Hill T., Honer W. G., and Davies P. (1994) Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer's disease. Ann. Neurol. 35, 546-551.
18. Turski L. and Turski W. A. (1993) Towards an understanding of the role of glutamate in neurodegenerative disorders: energy metabolism and neuropathology. Experientia. 49, 1064-1072.