An overview of animal toxicology studies with bicalutamide (ICI 176,334)

Journal of Toxicological Sciences

Volumn 22, Issue 2, 1997, Pages 75-88

  Iswaran, T J ^a  

^a Zeneca KK Pharmaceuticals   (Japan)

Author keywords

Anti androgen; Bicalutamide; ICI176,334; Toxicity

Indexed keywords

ANTIANDROGEN; BICALUTAMIDE; MIXED FUNCTION OXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENICITY; CARDIOTOXICITY; CONTROLLED STUDY; DOG; DOSE RESPONSE; DRUG STRUCTURE; ENZYME INDUCTION; HEPATOMEGALY; INTRAPERITONEAL DRUG ADMINISTRATION; LIVER CELL CARCINOMA; MALE; MOUSE; MUTAGENICITY; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; REPRODUCTIVE TOXICITY; THYROID ADENOMA; THYROID HYPERPLASIA; TOXICITY TESTING;

ANIMALIA; CANIS FAMILIARIS; RODENTIA;

EID: 0030977329     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.22.2_75     Document Type: Article

References (2)

1. Ashby, J. and Tennant, R. W. (1991): Definitive relationships among chemical structure, carcinogenicity and mutagenicity for 301 chemicals tested by US NTP. Mut. Res., 257, 229-306.
2. Barrass, N. C., Stewart, M., Warburton, S., Aitchison, J., Jackson, D. G., Wadsworth, P. F., Marsden, A. M. and Orton, T. C. (1993): Cell proliferation in the liver and thyroid of the C57BL/10J mouse following dietary administration of the non-genotoxic hepatocarcinogen chlordane. Environment. Health Perspect., 101, 219-224.