Prevention of age-related aneuploidies by polar body testing of oocytes

Journal of Assisted Reproduction and Genetics

Volumn 16, Issue 4, 1999, Pages 165-169

  Verlinsky, Y ^a   Cieslak, J ^a   Ivakhnenko, V ^a   Evsikov, S ^a   Wolf, G ^a   White, M ^a   Lifchez, A ^a   Kaplan, B ^a   Moise, J ^a   Valle, J ^a   Ginsberg, N ^a   Strom, C ^a   Kuliev, A ^a  

^a REPRODUCTIVE GENETICS INSTITUTE   (United States)

Author keywords

Chromosome 13, 18, and 21 aneuploidies; First and second polar bodies; FISH; IVF; Preimplantation diagnosis

Indexed keywords

ADULT; AGE; ANEUPLOIDY; CHROMOSOME 13; CHROMOSOME 18; CHROMOSOME 21; CONFERENCE PAPER; DIAGNOSTIC ACCURACY; EMBRYO TRANSFER; FEMALE; FERTILIZATION IN VITRO; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; MAJOR CLINICAL STUDY; OOCYTE; PRENATAL DIAGNOSIS; PRIORITY JOURNAL;

ADULT; ANEUPLOIDY; CHROMOSOMES, HUMAN, PAIR 13; CHROMOSOMES, HUMAN, PAIR 18; CHROMOSOMES, HUMAN, PAIR 21; FEMALE; FERTILIZATION IN VITRO; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; OOCYTES; PREGNANCY; PREIMPLANTATION DIAGNOSIS;

EID: 0032903719     PISSN: 10580468     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1020304621338     Document Type: Conference Paper

References (6)

1. Verlinsky Y, Rechitsky S, Cieslak, J, Ivakhnenko V, Wolf G, Lifchez A, Kaplan B, Moise J, Walle J, White M, Ginsberg N, Strom C, Kuliev A: Preimplantation diagnosis of single gene disorders by two-step oocyte genetic analysis using first and second polar body. Biochem Mol Med 1997;62:182-187
2. Verlinsky Y, Cieslak J, Ivakhnenko V, Lifchez A, Strom C, Kuliev A: Birth of healthy children after preimplantation diagnosis of common aneuploidies by polar body fluorescent in situ hybridization analysis. Fertil Steril 1996;66(1):126-129
3. Verlinsky Y, Cieslak J, Ivakhnenko V, Evsikov S, Wolf G, White M, Lifchez A, Kaplan B, Moise J, Valle J, Ginsberg N, Srom C, Kuliev A: Preimplantation diagnosis of common aneuploidies by first- and second-polar body FISH analysis. J Assist Reprod Genet 1998;15:285-289
4. Verlinsky Y, Cieslak J, Ivakhnenko V, et al.: Prepregnancy genetic testing for age-related aneuploidies by polar body analysis. Genet Test 1998;1(4):231-235
5. Nicolaides P, Petersen M: Origin and mechanisms of non-disjunction in human autosomal trisomies. Hum Reprod 1998;13(2):313-319
6. Battaglia DE, Goodwin P, Klein NA, Soules MR: Influence of maternal age on meiotic spindle assembly in oocytes from naturally cycling women. Hum Reprod 1996;11:2217-2222