5-HT2A receptors mediate the effect of antidepressants in the elevated plus-maze test but have a partial role in the forced swimming test

Medical Science Research

Volumn 27, Issue 4, 1999, Pages 277-280

  Skrebuhhova, Tatjana ^a   Allikmets, Lembit ^a   Matto, Vallo ^a  

^a UNIVERSITY OF TARTU   (Estonia)

Author keywords

5 ht2a antagonists; Citalopram; Desipramine; Elevated plus maze test; Forced swimming test

Indexed keywords

ANTIDEPRESSANT AGENT; CITALOPRAM; DESIPRAMINE; KETANSERIN; RITANSERIN; SEROTONIN 2A ANTAGONIST; SEROTONIN 2A RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; FORCED SWIMMING TEST; MALE; MAZE TEST; NONHUMAN; RAT;

EID: 0032902965     PISSN: 02698951     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. De Jonghe F, Swinkels J, Selective serotonin reuptake inhibitors. Relevance of differences in their pharmacological and clinical profiles. CNS Drugs 1997: 7:452-467.
2. Schweizer E, Rickeis K, Uhlenhuth EH. Issues in the long term treatment of anxiety disorders. In: Bloom FE. Kupfer DJ (editors), Psychopharmacology. The Fourth Generation of Progress. New York: Raven Press; 1995. pp. 1349-1360.
3. Leonard BA, The comparative pharmacological properties of selective serotonin reuptake inhibitors in animals. In: Feigner JP, Boyer WF (editors). Selective Serotonin Reuptake Inhibitors. 2nd ed. Chichester: John Wiley & Sons; 1996. pp. 35-62.
4. Hyttel J, Arnt J, Sanchez C, The pharmacology of citalopram. Rev Contemp Pharmacother 1995; 6:271-285.
5. Aghajanian GK, Central 5-HT receptor subtypes: Physiological responses and signal transduction mechanisms. In: Marsden CA, Heal DJ (editors). Central Serotonin Receptors and Psychotropic Drugs. Oxford: Blackwell Scientific Publications; 1992. pp. 39-55.
6. Chopin P, Briley M, Animal models of anxiety: The effect of compounds that modify 5-HT neurotransmission. Trends Pharmacol Sei 1987; 8: 383-388.
7. Borsini F, Role of the serotoninergic system in the forced swimming test. Neumsci Biobehav Rev 1995; 19:377-395.
8. Sanchez C, Hyttel J, Isolation-induced aggression in mice: effects of 5hydroxytryptamine uptake inhibitors and involvement of postsynaptic 5-HT|A receptors. Eur J Pharmacol 1994; 264:241-247.
9. Handley SL, McBlane JW. 5-HT drugs in animal models of anxiety. Psychopharmacology 1993; 112:13-20.
10. Rodgers RJ, Cole JC, The elevated plus-maze: pharmacology, methodology, and ethology. In: Cooper SJ, Hendrie CA (editors), Ethology ami Psychopharmacology. Chichester: Wiley Press; 1994. pp. 9-44.
11. Lister RG, Ethologically-based animals models of anxiety disorders. Pharmac Ther 1990; 46:321-340.
12. Fellow S, Chopin P. File SE, Briley M. Validation of openxlosed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neiiraxci Mfth 1985; 14:149-167.
13. Porsolt RD, Bertin A, Blavet N, Deniel M, Jalf're M. Immobility induced by forced swimming in rats: Effects of agents which modify central catecholamine and serotonin activity. Eur J Phurmacol 1979; 57: 201-210.
14. Harro J, Oreland L, Vasar E. Bradwejn J. Impaired exploratory behaviour after DSP-4 treatment in rats: implications for the increased anxiety alter noradrenergic denervation. Eur Neuropsychopharmacol 1995:5: 447-455.
15. Ohno M, Yamamoto T, Kobayashi M. Watunabe S. Impairment of working memory induced by scopolaniine in rats with noradrenergic DSP-4 lesions. Enr J Phtirmacol 1993: 238:117-120.
16. Redrobe JP, Bourin M, Partial role of 5HT, and 5-HT, receptors in the activity of antidepressants in the mouse forced swimming test. Kit r J Phannacol 1997; 325:129-135.