Ethologically-based animal models of anxiety disorders

Pharmacology and Therapeutics

Volumn 46, Issue 3, 1990, Pages 321-340

  Lister, Richard G ^a  

^a NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ANXIOLYTIC AGENT; BARBITURIC ACID DERIVATIVE; BENZODIAZEPINE DERIVATIVE; BUSPIRONE; CLONIDINE; IMIPRAMINE; MONOAMINE OXIDASE INHIBITOR; NICOTINE; PROPRANOLOL;

ANXIETY; DRUG THERAPY; ETIOLOGY; METHODOLOGY; NONHUMAN; PANIC; PRIORITY JOURNAL; PSYCHOLOGICAL ASPECT; REVIEW;

ANIMAL; ANXIETY DISORDERS; DISEASE MODELS, ANIMAL; ETHOLOGY; HUMAN; MODELS, PSYCHOLOGICAL;

EID: 0025321231     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/0163-7258(90)90021-S     Document Type: Review

References (208)

1. Tests for emotionality in rats and mice a review
2. Studies on the possible role of brain 5-HT systems and adrenocortical activity in behavioral responses to nicotine and diazepam in an elevated X-maze
3. Animal research psychiatric theory
4. Anxiogenic effects of methy-β-carboline-3 carboxylate in a light/dark choice situation
5. The benzodiazepine receptor inverse agonist β-CCM and Ro 15-3505 both reverse the anxiolytic effects of ethanol in mice
6. Benzodiazepine antagonist Ro 15-1788 partly reverses some anxiolytic effects of ethanol in the mouse
7. The arousal and satiation of perceptual curiosity in the rat
8. An etho-experimental approach to the study of fear
9. Ethanol changes patterns of defensive behavior in wild rats
10. An ethopharmacological approach to the biology of anxiety
11. Post-traumatic stress disorder following combat exposure: clinical features and psychopharmacological treatment
12. The Maudsley reactive and non-reactive strains a North American perspective
13. Further characterization of a simple, automated exploratory model for the anxiolytic effects of benzodiazepines
14. Dissociation de deux composantes dans le compartement d'investigation de la souris
15. L'utilisation d'une reaction particuliere de la souris (methode de la planche à trous) pour l'etude des medicaments psychotropes
16. New approaches to the study of anxiety and anxiolytic drugs in animal
17. A sensitive open field measure of anxiolytic drug activity
18. Experiments in psychogenetics
19. Abnormal animal behaviour
20. A note on further progress in a psychogenetic selection experiment
21. The Maudsley reactive and non-reactive strains of rats: a survey
22. The effects of caffeine on plasma MHPG, subjective anxiety, autonomic symptoms and blood pressure in healthy humans
23. Increased anxiogenic effects of caffeine in panic disorders
24. The effects of yohimbine on exploratory and locomotor behaviour are attributable to its effects at noradrenaline and not benzodiazepine receptors
25. A comparison of the effects of some benzodiazepines and other drugs on aggressive and exploratory behaviour in mice and rats
26. Nicotine and smoking: a perspective from animal studies
27. Preclinical procedures as predictors on antianxiety in man
28. Neurogenetic adaptive mechanisms in alcoholism
29. Normal responses to mother-infant separation in nonhuman primates
30. Maudsley reactive and non-reactive rat strains: differential performance in a conflict task
31. Observational conditioning of snake fear in unrelated rhesus monkeys
32. Benzodiazepines as appetite-enhancing compounds
33. Behavioral pharmacology of food, water and salt intake in relation to drug actions at benzodiazepine receptors
34. Spontaneous activity and brain 5-hydroxyindole levels measured in rats tested in two designs of elevated X-maze
35. The determinants of exploration and neophobia
36. Actions of sulpiride and tiapride in a simple model of anxiety in mice
37. Neuropharmacological specificity of a simple animal model for the benavioral actions of benzodiazepines
38. Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines
39. Absence of intrinsic antagonist actions of benzodiazepine antagonists on an exploratory model of anxiety in the mouse
40. Effects in the X-maze anxiety model of agents acting at 5-HT1 and 5-HT2 receptors
41. Evaluation of psychotropic drugs with a modified open field test
42. Etude des effets du diazepam sur le compartement explorateur du porc
43. Acute and chronic effects of three benzodiazepines in the social interaction anxiety test in mice
44. Hereditary determinants of fears and phobias
45. Open field behavior in the rat: what does it mean?
46. Symposium on pharmacology of emotive behavior—closing remarks
47. 3H-TVX Q 7821: identification of 5-HT binding sites as target for a novel putative anxiolytic
48. Severe anxiety induced by FG 7142, a β-carboline ligand for benzodiazepine receptors
49. An anxiogenic benzodiazepine receptor ligand induces learned helplessness
50. Does directed exploration influence locomotor activity in a holeboard test?
51. Behavioral effects of alpha-2 adrenoceptor antagonists and their interactions with ethanol in tests of locomotion, exploration and anxiety in mice
52. Experiments with animals: introduction
53. An analysis of sex differences in the open field and tests of exploration and anxiety
54. Potentiation of the effects of chlorpromazine on exploration in the rat by prior experience
55. A comparison of the effects of ethanol and chlordiazepoxide on exploration and on its habituation
56. Effects of parachlorophenylalanine and amphetamine on habituation of exploration
57. The use of social interaction as a method of detecting anxiolytic activity of chlordiazepoxide-like drugs
58. Rapid development of tolerance to the sedative effects of lorazepam and triazolam in the rat
59. Behavioural pharmacology of benzodiazepines. Prog. Neuropsychopharmacol.
60. The neurochemistry of anxiety
61. Behavioral effects of penthylenetetrazole reversed by chlordazepoxide and enhance by Ro 15-1788
62. What can be learned from the effects of benzodiazepines on exploratory behavior?
63. Animal models for predicting clinical efficacy of anxiolytic drugs: social behaviour
64. The contribution of behavioral studies to the neuropharmacology of anxiety
65. Effects of time of day and food deprivation on exploratory activity in the rat
66. Can social interaction be used to measure anxiety?
67. A test of anxiety that distinguishes between the actions of benzodiazepines and those of other minor tranquilisers and of stimulants
68. Chronic treatment with imipramine does not reverse the effects of 3 anxiogenic compounds in a test of anxiety in the rat
69. β-CCE and chlordiazepoxide reduce exploratory head-dipping and rearing: no mutual antagonism
70. The sensitivity of the rat corticosterone response to environmental manipulations and to chronic chlordiazepoxide
71. No cross-tolerance between the stimulatory and depressant actions of benzodiazepines in mice
72. Do the intrinsic actions of benzodiazepine receptor antagonists imply the existence of an endogenous ligand for benzodiazepine receptors?
73. Studies on the role of ACTH and of 5-HT in anxiety, using an animal model
74. Validity of head-dipping as a measure of exploration in a modified hole-board
75. Anxiogenic actions of benzodiazepine antagonists
76. Intrinsic actions of benzodiazepine antagonists
77. Intrinsic behavioural actions of n-propyl β-carboline-3-carboxylate
78. The sedative effects of CL 218872, like those of chlordiazepoxide are reversed by benzodiazepine antagonists
79. Effects of the β-carboline, FG 7142, in the social interaction test of anxietty and the holeboard; corelations between behavior and plasma concentrations
80. Behavioral effects of acute and chronic administration of caffeine in the rat
81. A randomized clinical trial of phenelzine and imipramine for posttraumatic stress disorder
82. Inhibition of ultrasonic distress vocalizations in rat pups by chlordiazepoxide and diazepam
83. Distress vocalization in rat pups. A simple screening method for anxiolytic drugs
84. Effects of agents which interact with central benzodiazepine binding sites on stresss-induced ultrasounds in rat pups
85. Buspirone. A preliminary review of its pharmacological properties and therapeutic efficacy as an anxiolytic
86. Culture and anxiety: cross-cultural evidence for the patterning of anxiety disorders
87. Emotionality in male and female rodents: a reply to Archer
88. Biological basis of the therapeutic effects of benzodiazepines
89. Exposure in vivo of agoraphobics: contributions of diazepam, group exposure and anxiety evocation
90. Emotional behaviour in the rat. I Defaecation and urination as measures of individual differences in emotionality
91. The inheritance of emotionality
92. Exploratory behaviour in elevated and enclosed mazes
93. Effects of alpha-adrenoceptor agonists and antagonists in a maze-exploration model of ‘fear’-motivated behaviour
94. Effects of morphine and naloxone on separation distress and approach attachment: evidence for opiate mediation of social affect
95. Ro 15-4513 and Fg 7142 reverse the reduction in social behavior caused by ethanol in mice
96. Effects of caffeine on social behavior, exploration and locomotor activity: interactions with ethanol.
97. Effects of clonidine on anxiety disorders
98. Isolation distress in two-week-old rats: influence of home-cage, social companions, and prior experience with littermates
99. Anxiogenic-like properties of benzodiazepine antagonists
100. Treatment of traumatic war neurosis with phenelzine
101. Behavioral ‘properties’ of drugs
102. Obsessive-compulsive disorder; a neuropethological perspective
103. Central administartion of corticotropin releasing factor alters rat pup isolation calls
104. Infant separation distress in genetically fearful rats
105. Rat pup ultrasonic isolation calls: possible mediation by the benzodiazepine receptor complex
106. The ontogeny of brain receptors for corticotropin-releasing factor and the development of their functional association with adenylate cyclase
107. Comparison of buspirone and diazepam in generalized anxiety disorder
108. Control of their environment reduces emotionality in rats
109. Can animal tests of anxiety detect panic-promoting agents?
110. Profiles of the antipanic compounds, triazolobenzodiazepines and phenelzine, in two animal tests of anxiety
111. Comparison of the effects of clonidine, rilmenidine, and guanfacine in the holeboard and elevated plus-maze
112. Arousal levels and attribution effects in diazepam-assisted flooding
113. The potential anxiolytic activity of GR38032F, a 5HT3-receptor antagonist
114. Imipramine and chlordiazepoxide in depressive and anxiety disorders: II. Efficacy in anxious outpatients
115. Opioid-mediation of separation distres in 10-day-old rats: reversal of stress with maternal stimuli
116. Conditions of fear and anxiety
117. Can social and agonistic interactions be used to detect anxiolytic activity of drugs?
118. Enhanced relief of phobias by flooding during waning diazepam effect
119. An anlysis of drug effects in mice exposed to a simple novel environment
120. An analysis of the influence of alcohol on experimental neuroses in cats
121. Preparedness and phobias: a review
122. Pituitary-adrenal response to separation in mother and infant squirrel monkeys
123. Abnormal behavior in zoo animals
124. The psychopharmacology of aggression
125. Animal models of anxiety-based disorders: their usefulness and limitations
126. Unpredictable and uncontrollable aversive events
127. Control and early socioemotional development infant rhesus monkeys reared in controllable versus uncontrollable environments
128. Interaction of Ro 15-4513 and ethanol on the behaviour of mice: antagonistic or additive effects
129. The relation between fear induced by novel stimulation and exploratory behaviour
130. Benzodiazepine receptor-mediated experimental ‘anxiety’ in primates
131. Ultrasounds and maternal behavior in small rodents
132. The effects of benzodiazepines on the behavior of mice on a hole board
133. Beta adrenergic blockers
134. Animal and social phobias: Biological constraints on learned fear responses
135. The ultrasonic responses of albino mouse pups to tactile stimulation
136. Factors affecting ultrasound production in infant rodents
137. Animal models of human psychopathology
138. The neurochemical control of crying
139. An example of an experimentally produced neurosis and its treatment in the weak type of nervous system
140. Can drug effects on anxiety and convulsions be separated?
141. Multiple sites of action for anxiogenic drugs: behavioural, electrophysiological and biochemical correlations
142. Can anti-panic drugs antagonise the anxiety produced in the rat by drugs acting at the GABA-benzodiazepine receptor complex?
143. Validation of open: closed arm entries in an elevated plus-maze as a measure of anxiety in the rat
144. Selective agonists and antagonists for 5-hydroxytryptamine receptor subtypes, and interactions with yohimbine and FG 7142 using the elevated plus-maze test in the rat
145. Effects of two benzodiazepines, phenobarbitone and baclofen on synpatic transmission in the rat cuneate nucleus
146. The staircase test: some evidence of nonspecificity for anxiolytics
147. Patterns of phobic neurosis: a retrospective study
148. A critique of the methods available for the measurement of spontaneous motor activity
149. Differences in benzodiazepine receptor binding in Maudsley reactive and Maudsley non-reactive rats
150. Metrazol tolerance in a ‘normal’ volunteer population
151. On the construct validity of open-field measures
152. Equivalence and persistence of the effects of psychoactive drugs and past experience
153. Relationships between exploratory behaviour and fear: a review
154. Psychological studies of exploration in animals: a reappraisal
155. Cognitive, social, and physiological determinants of emotional state
156. Phobias and preparedness
157. The treatment of endogenous anxiety with phobic, hystericala and hypochondriacal symptoms
158. Exploratory behaviour the inadequacy of activity measures
159. Screening hallucinogenic drugs: systematic study of three behavioral tests
160. The staircase test in mice: a simple and efficient procedure for primary screening of anxiolytic agents
161. A novel chemically induced animal model of human anxiety
162. Sound production by infant Peromyscus maniculatus (Rodentia Myomorphia)
163. Innate recognition of coral snake pattern by a possible avian predator
164. Coral-snake recognition and stimulus generalization by naive great kiskadees (Aves: Tyrannidae)
165. Traumatic avoidance learning: several extinction procedures with dogs
166. Open-field chez le rat: inter-relations entre locomotion, exploration et emotivité
167. Preselection of animals in studies of anti-anxiety drugs
168. Buspirone—an anxioselective drug with dopaminergic action
169. Anxiety-like disorders in young nonhuman primates
170. Inherited and experimental factors associated with individual differences in anxious behavior displayed by rhesus monkeys
171. ‘Peripheral’ and ‘central’ type benzodiazepine receptors in Maudsley rats
172. Transcultural aspects of anxiety
173. Stimulus change and complexity in exploratory behavior
174. Learning models of obsessional-compulsive disorder
175. Tricyclic antidepressants
176. Dissociation de deux composantes du compartement chez le rat sous l'effet de psychotropes. Application a l'étude des anxiolytiques
177. Anxiogenic properties of beta-CCE and FG 7142: a review of promises and pitfalls
178. Convulsant/depressant site of action at the allosteric benzodiazepine-GABA receptor-ionophore complex
179. Genetics
180. 5-HT1A receptor-related anxiolytics
181. Animal models for the study of anti-anxiety agents: a review
182. Classification of anxiety disorders: a critique of DSM-III
183. The risk of pharmacological dependence with Buspirone
184. Effects of caffeine on anxiety and depression
185. The open-field test: a critical review
186. Pharmacologic models
187. Nicotine as a resource
188. Some traps and pontifications
189. Effects of morphine on learned adaptive responses and experimental neurosis in cats
190. Alcohol and anxiety
191. Buspirone: a potential atypical neuroleptic
192. Pharmacology of benzodiazepines: laboratory and clinical correlations