Role of the serotonergic system in the forced swimming test

Neuroscience and Biobehavioral Reviews

Volumn 19, Issue 3, 1995, Pages 377-395

  Borsini, Franco ^a  

^a Boehringer Ingelheim Italia SpA   (Italy)

Author keywords

Antidepressants; Behaviour; Forced swimming test; Mouse; Rat; Serotonergic drugs; Serotonin

Indexed keywords

1 (2 METHOXYPHENYL) 4 (4 PHTHALIMIDOBUTYL)PIPERAZINE; 2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 2,3 DIHYDRO 2 OXO 1 BENZIMIDAZOLECARBOXYLIC ACID 6 METHOXY 3ALPHA TROPANYL ESTER; 8 [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] 8 AZASPIRO[4.5]DECANE 7,9 DIONE; ADATANSERIN; ANTIDEPRESSANT AGENT; BACLOFEN; BUSPIRONE; CITALOPRAM; FENCLONINE; FLUOXETINE; FLUVOXAMINE; GEPIRONE; INDALPINE; ITASETRON; MESULERGINE; METERGOLINE; METHYSERGIDE; METITEPINE; ONDANSETRON; PINDOLOL; PIZOTIFEN; PROPRANOLOL; SEROTONIN; SEROTONIN AGONIST; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; TRAZODONE; UNINDEXED DRUG; ZIMELDINE;

ANHEDONIA; ANIMAL BEHAVIOR; ANIMAL MODEL; CONTROLLED STUDY; DEPRESSION; IMMOBILIZATION; INTRACEREBRAL DRUG ADMINISTRATION; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; REVIEW; SEROTONIN UPTAKE; SEROTONINERGIC SYSTEM; SUBCUTANEOUS DRUG ADMINISTRATION; SWIMMING;

ANIMAL; ANTIDEPRESSIVE AGENTS; DEPRESSION; MALE; MICE; RATS; SEROTONIN; SEROTONIN AGONISTS; SEROTONIN UPTAKE INHIBITORS; SWIMMING;

EID: 0029067853     PISSN: 01497634     EISSN: None     Source Type: Journal    
DOI: 10.1016/0149-7634(94)00050-B     Document Type: Article

References (178)

1. Paternal alcohol exposure: Paradoxical effect in mice and rats
2. Differential effects of clomipramine given locally or systemically on extracellular 5-hydroxytryptamine in raphe nuclei and frontal cortex
3. In vivo brain dialysis study of the somatodendritic release of serotonin in the raphe nuclei of the rat: Effects of 8-hydroxy-2-(di-n-propylamino) tetralin
4. Serotonergic and nonserotonergic neurons of the dorsal raphe: Reciprocal changes in firing induced by peripheral nerve stimulation
5. 1A binding site in the rat striatum
6. B-agonist, on forced swimming-induced immobility in mice
7. Involvement of amygdaloid catecholaminergic mechanism in suppressive effect of desipramine and imipramine on duration of immobility in rats forced to swim
8. Forced swimming test in rats: Effect of desipramine administration and the period of exposure to the test on struggling behavior, swimming, immobility and defecation rate
9. Influence of various acute stressors on the activity of adult male rats in a holeboard and in the forced swim test
10. 5-HT and antidepressants: New views from microdialysis studies
11. Quantified regional and laminar distribution of the serotonin innervation of the anterior half of adult rat cerebral cortex
12. 3H)Desipramine binding to rat brain tissue: Binding to both noradrenaline uptake sites and sites not related to noradrenaline neurons
13. Pharmacologic profile of fezolamine fumarate: A nontricyclic antidepressant in animal models
14. Fluvoxamine preferentially increases extracellular 5-hydroxytryptamine in the raphe nuclei: An in vivo microdialysis study
15. 8-Hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) elicits eating in free-feeding rats by acting on central serotonin neurons
16. Antidepressant-like effect of LY228729 as measured in the rodent forced swim paradigm
17. Further characterization of the behavioral despair test in mice: Positive effect of convulsants
18. Direct evidence for important species difference in the mechanism of 8-OH-DPAT-induced hypothermia
19. Minaprine, a new drug with antidepressant properties
20. 1A agonist gepirone: Electrophysiological studies in the rat brain
21. 1A receptors without altering 5-HT autoreceptor sensitivity: An electrophysiological study in the rat brain
22. Electrophysiological assessment of putative antagonists of 5-hydroxytryptamine receptors: A single-cell study in the rat dorsal raphe nucleus
23. 2 receptors and serotonergic axons in rat neocortex
24. Immobility test: Effects of 5-hydroxytryptaminergic drugs and role of catecholamines in the activity of some antidepressants
25. Evidence that dopaminergic mechanisms are mainly involved in the antiimmobility (“despair test”) effect of a repeated treatment with antidepressants in rats
26. Is the forced swimming test a suitable model for revealing antidepressants activity?
27. The forced swimming test: Its contribution to the understanding of the mechanisms of action of antidepressants
28. 1C receptor function
29. Potential antidepressant activity and enhancement of serotonin uptake of a new dibenzothiadizepine derivative
30. BIMT 17 activates the serotonin inhibitory response at cortical level
31. Behavioural despair test
32. Effects of antidepressants and anticholinergics in a mouse “behavioral despair” test
33. Different synaptic location of mianserin and imipramine binding sites
34. Anomalous “depressants” activity of trazodone and related halogenated phenylpiperazines in a putative model of depression
35. The Pharmacology of sibutramine hydrochloride (BTS 54 524), a new antidepressant which induces rapid noradrenergic downregulation
36. Cortical modulation of spontaneous activity during hunger and thirst
37. 1A receptors causes amnesia and anxiolytic-like but not antidepressant-like effects in the rat
38. Selective enhancement of dopamine utilization in the rat prefrontal cortex by food deprivation
39. Effects of fluoxetine on the spontaneous electrical activity of fronto-cortical neurons
40. The inhibitory effect of 8-OH-DPAT on firing activity of dorsal raphe serotonergic neurons in rats is attenuated by lesion of the frontal cortex
41. 1A receptor agonist
42. Different effects of intracerebral and systemic administration of buspirone in the forced swimming test: Involvement of a metabolite
43. 1A receptor agonist, reduces the immobility of rats in the forced swimming test by acting on the nucleus raphe dorsalis
44. 1-(3-trifluoromethylphenyl)piperazine (TFMPP) in the ventral tegmental area reduces the effect of desipramine in the forced swimming test in rats: Possible role of serotonin receptors
45. Role of central serotonergic neurons in the effect of sertraline in rats in the forced swimming test
46. Effect of chronic treatment with 8-OH-DPAT in the forced swimming test requires the integrity of presynaptic serotonergic mechanisms
47. The role of serotonin and dopamine in brain in the antidepressant-like effect of clonidine in the forced swimming test
48. 1A receptors
49. Mesulergine antagonism towards the fluoxetine anti-immobility effect in the forced swimming test in mice
50. 1A receptors in the antidepressant-like activity of gepirone in the forced swimming test in rats
51. Pharmacological studies on stress-induced increase in frontal cortical dopamine metabolism in the rat
52. Action of antidepressants on the septal nuclei of the rat
53. 1A agonists
54. Stressful environmental stimuli increase extracellular DOPAC levels in the prefrontal cortex of hypoemotional (Roman high-avoidance) but not hyperemotional (Roman low-avoidance) rats. An in vivo voltammetric study
55. Comparison of desipramine, amitriptyline, zimelidine and alaproclate in six animal models used to investigate antidepressant drugs
56. Are ascending noradrenergic and serotonergic pathways necessary for effects of electroconvulsive treatment, clonidine hypothermia and forced swimming study?
57. 2-adrenolytic activity
58. Antidepressant action of imipramine and iprindole in mice is enhanced by inhibitors of enkephaline-degrading peptidases
59. A set of behavioural test predicting antidepressant activity
60. Naloxone inhibits clomipramine in mouse forced swimming test
61. Influence of naloxone on antidepressant drug effects in the forced swimming test in mice
62. 1A receptor ligands 8-OH-DPAT and ipsapirone in animal models of anxiety and depression
63. Low doses of the putative serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) elicit feeding in the rat
64. Para-chlorophenylalanine prevents feeding induced by serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin
65. Neuroanatomical circuits in depression: Implications for treatment mechanisms
66. 1A receptors which inhibit cAMP production in hippocampal and cortical neurons in primary culture
67. 1B binding sites
68. Further evidence that noradrenaline is not involved in the anti-immobility activity of chronic desipramine in the rat
69. Species differences in the mechanism through which the serotonergic agonists indorenate and ipsapirone produce their anxiolytic action
70. 3H)Opipramol labels a novel binding site and sigma receptors in rat brain membranes
71. 2 receptors throughout the rat central nervous system using quantitative autoradiography
72. A Pharmacological analysis of the eating response induced by 8-OH-DPAT injected into the dorsal raphé nucleus reveals the involvement of a dopaminergic mechanism
73. Antidepressant and anxiolytic effects of alprazolam vs. the conventional antidepressant desipramine and the anxiolytic diazepam in the forced swim test in rats
74. Psychopharmacological profile of 1-(m-(trifluoromethyl) phenyl) piperazine (TFMPP)
75. 2 receptors
76. Presynaptic serotonin receptor-mediated response in mice attenuated by antidepressant drugs and electroconvulsive shock
77. The pharmacology of the hypothermic response in mice to 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT)
78. 1 receptor ligand ipsapirone (TVX Q 7821) on 5-HT synthesis and the behavioural effects of 5-HT agonists in mice and rats
79. The pharmacology of the behavioural and hypothermic responses of rats to 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT)
80. Action of serotonin mimetics in the behavioural despair test in rats
81. The effect of antidepressants on behavioral despair in rats
82. Effect of bilateral olfactory bulbectomy in the rat, alone or in combination with antidepressants, on the learned immobility model of depression
83. Biochemical and Pharmacological evaluation of the novel antidepressant and serotonin uptake inhibitor 2-(3,4-dichlorobenzyl)-2-dimethylamino-1-propanol hydrochloride
84. 3H-PAT
85. 3H)8-Hydroxy-2-(di-n-propylamino) tetralin binding to pre and postsynaptic 5-hydroxytryptamine sites in various regions of the rat brain
86. Biochemical evidence for the 5-HT agonist properties of PAT (8-hydroxy-2-(di-n-propylamino) tetralin) in the rat brain
87. 2 receptors
88. Effects of cholinomimetics, cholinolytics and atypical antidepressants in the behavioural despair test in the rat
89. Serotonin axon terminals in the ventral tegmental area of the rat: Fine structure and synaptic input to dopaminergic neurons
90. Effect of tryptophan on the behaviour of nonstressed and stressed mice in Porsolt's swim test
91. Effects of tryptophan and serotonin uptake inhibitors on behavior in male transgenic transforming growth factor alpha mice
92. 8-Hydroxy-2-(di-n-propylamino) tetralin, 8-OH-DPAT, a potent and selective simplified ergot congener with central 5-HT-receptor stimulating activity
93. IA autoreceptor agonists
94. 1A autoreceptor blockade potentiates the ability of the 5-HT reuptake inhibitor citalopram to increase nerve terminal output of 5-HT in vivo: A microdialysis study
95. Swimming immobility of REM sleep deprived rats reared in different environments
96. Prefrontal cortical lesions and timidity in rats. I. Reactivity to aversive stimuli
97. Administration of 8-hydroxy-2-(di-n-propylamino) tetralin in raphe nuclei dorsalis and medianus reduces serotonin synthesis in the rat brain: Differences in potency and regional sensitivity
98. An increase of extracellular serotonin in the dorsal raphe masks the effect of sertraline in the frontal cortex
99. Citalopram's ability to increase the extracellular concentrations of serotonin in the dorsal raphe prevents the drug's effect in the frontal cortex
100. The effect of prefrontal lesions and food deprivation on response to stimulus change
101. Amygdaloid catecholaminergic mechanisms involved in suppressive effects of electroconvulsive shock on duration of immobility in rats forced to swim
102. 1A presynaptic, but not postsynaptic receptor-mediated responses: Relationship to antidepressant-like action
103. 1- adrenergic mechanisms in the immobility-reducing action of desipramine in the forced swimming test
104. Sertraline, 1S, 4-n-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine, a new uptake inhibitor with selectivity for serotonin
105. Studies on the locus coeruleus system in an animal model for antidepressive activity
106. Possible interactionship of the locus coeruleus-hippocampal noradrenergic neurons to depression and mode of action of antidepressant drugs
107. 1A receptor agonists in animal models of depression and anxiety
108. Purine nucleoside—Mediated immobility in mice: Reversal by antidepressants
109. Influences of stress on phosphoinositide hydrolysis in rat cerebral cortex slices
110. 7) implicated in the regulation of mammalian circadian rhythms
111. 1A receptors and behavioural responses
112. 1A receptors
113. The effect of serotonin antagonists in a behavioural despair procedure in mice
114. Fluvoxamine, a new antidepressant drug, fails to show antiserotonin activity
115. Some central effects of repeated treatment with fluvoxamine
116. Effects of MK-801 and antidepressant drugs in the forced swimming test in rats
117. Additive effects of clonidine and antidepressants drugs in the forced swimming test
118. 2 antagonists have antidepressant-like effect on differential-reinforcement-of-low-rate 72-second schedule
119. Psychopharmacology of ritanserine: Comparison with chlordiazepoxide
120. 1A agonists
121. 1C receptor mRNA in the rodent brain examined by in situ hybridization histochemistry. Comparison with receptor binding distribution
122. Acute tryptophan depletion: A method of studying antidepressant action
123. Stress preferentially increases extraneuronal levels of excitatory amino acids in the prefrontal cortex: Comparison to hippocampus and basal ganglia
124. Dihydropyridine calcium channel antagonists reduce immobility in the mouse behavioural despair test; antidepressants facilitate nifedipine action
125. BAY K 8644 enhances immobility in the mouse behavioural despair test, an effect blocked by nifedipine
126. Characteristics of central 5-HT receptors and their adaptive changes following intracerebral 5,7-dihydroxytryptamine administration in the rat
127. Atypical anxiolitytic profile of buspirone and a related drug, SM-3997, in a modified forced swim test employing straw suspension
128. Swimming mice: In search of an animal model of depression for human depression
129. A new behavioural test for antidepressant drugs
130. Neural adaptation in imipramine-treated rats processed in forced swimming test: Assessment of time course, handling, rat strain and amine uptake
131. 5-Hydroxytryptamine receptors
132. A stimulatory effect of intraaccumbens injections of noradrenaline on the behavior of rats in the forced swimming test
133. Mesolimbic noradrenaline but not dopamine is responsible for organization of rat behavior in the forced swiming test and an anti-immobilizing effect of desipramine
134. Modification of behavioral response to intra-hippocampal injections of noradrenaline and adrenoceptor agonists by chronic treatment with desipramine and citalopram: Functional aspects of adaptive receptor changes
135. The effects of antidepressants an electroconvulsive shocks on the functioning of the mesolimbic dopaminergic system: A behavioral study
136. The effect of 5,7-DHT-induced lesions of the median raphe nucleus and chronic desipramine administration upon motor behaviour of rats given intrahippocampal clonidine injection
137. Brain neurotransmitter systems mediating behavioral deficits produced by inescapable shock treatment in rats
138. Etude Pharmacologique d'un nouvel antidepresseur: la tineptine
139. Behavioural despair test in mice: A primary screening test for antidepressants
140. Behavioural despair in rats: A new model sensitive to antidepressant treatments
141. Immobility induced by forced swimming in rats: Effects of agents which modify central catecholamine and serotonin activity
142. Behavioral despair test
143. The central action of pizotifen
144. Antidepressant-like activity of ipsapirone, buspirone and gepirone in the forced swimming test in rats pretreated with prodifen
145. Potentation by TRH of the effect of imipramine on the forced-swimming test
146. 1C receptors
147. Acute uptake inhibition increases extracellular serotonin in the rat forebrain
148. Further studies on the mechanism of serotonin-dependent anorexia in rats
149. Effect of zimelidine, a new antidepressant, on the forced swimming test in rats
150. 1A agonist with anxiolytic and antidepressant effects in animals
151. Neuro-anatomical correlate of the antidepressant-like effects of ipsapirone and 8-OH-DPAT in the rat forced swimming test
152. 1A receptor ligands 8-OH-DPAT, ipsapirone and buspirone in the rat
153. 1A receptor ligands in animal models of anxiety, impulsivity and depression: Multiple mechanisms of action
154. 1A receptor agonists 8-OH-DPAT and ipsapirone in the rat forced swimming test
155. Ultrastructural relationships of serotonin axon terminals in the cerebral cortex of the adult rat
156. Effect of monoamine precursors on the forced-swimming test in mice
157. 1A receptor agonists on 5-HT release in rat brain in vivo
158. Use of synthesis inhibitors in defining a role for biogenic amines during imipramine treatment in depressed patients
159. Parachlorophenylalanine reversal of tranylcypromine effects in depressed patients
160. 1A receptors
161. 1A receptors
162. 1 receptor
163. The role of brain serotonin in the electroconvulsive shock-induced changes in behavioural effects of intra-hippocampally injected clonidine
164. Effects of 8-OH-DPAT and ipsapirone in the tests used for evaluation of the antidepressant action
165. 1 receptor and of catecholaminergic systems in the behavioural response to 8-hydroxy-2-(di-n-propyl-amino)-tetralin in the rat
166. Functional antagonists at the NMDA receptor complex exhibit antidepressant actions
167. The behavioural despair models as a predictor of antidepressant activity: Effects of serotonergic drugs
168. Electrophysiological characterization of serotonergic dorsal raphe neurons recorded extracellularly and intracellularly in rat brain slices
169. Benzodiazepines reverse the anti-immobility effect of antidepressants in the forced swimming test in mice
170. Quantitative autoradiography of multiple 5-HT receptor subtypes in the brain of control or 5,7-dihydroxytryptamine-treated rats
171. 1A agonists measured with the forced swim test
172. The validity of animal models of depression
173. The 5-HT transporter is an additional site of action for the 5-HT agonists RU 24969 and TFMPP
174. 8-OH-DPAT labels two sites in the raphe nucleus area of rat brains
175. Alteration in raphe and frontal cortex serotonin overflow following focal and systemic administration of fluoxetine
176. Behavioural Pharmacological properties of the novel antidepressant paroxetine, a selective 5-HT uptake inhibitor
177. Tryptophan depletion causes a rapid lowering of mood in normal males