Prognostic significance of allelic imbalances on chromosome 9p in stage I non-small cell lung carcinoma

Clinical Cancer Research

Volumn 5, Issue 5, 1999, Pages 1139-1146

  Tomizawa, Yoshio ^a,b   Adachi, Jun Ichi ^a   Kohno, Takashi ^a   Hamada, Kunihiro ^a   Saito, Ryusei ^b   Noguchi, Masayuki ^a   Matsuno, Yoshihiro ^a   Hirohashi, Setsuo ^a   Yamaguchi, Naohito ^a   Yokota, Jun ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b GUNMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

ADULT; AGED; ALLELE; ARTICLE; CANCER STAGING; CANCER SURVIVAL; CHROMOSOME 9P; FEMALE; GENE MUTATION; HETEROZYGOSITY LOSS; HUMAN; LUNG CANCER; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGNOSIS; SINGLE STRAND CONFORMATION POLYMORPHISM; TUMOR SUPPRESSOR GENE;

ADULT; AGED; ALLELES; CARCINOMA, NON-SMALL-CELL LUNG; CHROMOSOMES, HUMAN, PAIR 18; CHROMOSOMES, HUMAN, PAIR 2; CHROMOSOMES, HUMAN, PAIR 22; CHROMOSOMES, HUMAN, PAIR 9; DNA, NEOPLASM; FEMALE; GENES, P53; HUMANS; LIFE TABLES; LOSS OF HETEROZYGOSITY; LUNG NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM STAGING; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RETROSPECTIVE STUDIES; SEX FACTORS; SMOKING; SURVIVAL ANALYSIS;

EID: 0032900873     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Moore, D. F., and Lee, J. S. Staging and prognostic factor: non-small cell lung cancer. In: H. I. Pass, J. B. Mitchell, D. H. Johnson, and A. T. Turrisi (eds.), Lung Cancer: Principles and Practice, pp.481-494. Philadelphia: Lippincott-Raven Publishers, 1996.
2. Minna, J. D. Neoplasms of the lung. In: J. D. Wilson, E. Braunwald, K. J. Isselbacher, R. G. Petersdorf, J. B. Martin, A. S. Fauci, and R. K. Root (eds.), Harrison's Principles of Internal Medicine (ed. 12), pp. 1102-1110. New York: McGraw-Hill, 1991.
3. Yokota, J., and Sugimura, T. Multiple steps in carcinogenesis involving alterations of multiple tumor suppressor genes. FASEB J., 7: 920-925, 1993.
4. Yokota, J., Wada, M., Shimosato, Y., Terada, M., and Sugimura, T. Loss of heterozygosity on chromosomes 3, 13, and 17 in small-cell carcinoma and on chromosome 3 in adenocarcinorna of the lung. Proc. Natl. Acad. Sci. USA, 84: 9252-9256, 1987.
5. Harbour, J. W., Lai, S. L., Whang-Peng, J., Gazdar, A. F., Minna, J. D., and Kaye, F. J. Abnormalities in structure and expression of the human retinoblastoma gene in SCLC. Science (Washington DC), 241: 353-357, 1988.
6. Nigro, J. M., Baker, S. J., Preisinger, A. C., Jessup, J. M., Hostetter, R., Cleary, K., Bigner, S. H., Davidson, N., Baylin, S., Devilee, P., Glover, T., Collins, F. S., Weston, A., Modali, R., Harris, C. C., and Vogelstein, B. Mutations in the p53 gene occur in diverse human tumor types. Nature (Lond.), 342: 705-708, 1989.
7. Sameshima, Y., Matsuno, Y., Hirohashi, S., Shimosato, Y., Mizoguchi, H., Sugimura, T., Terada, M., and Yokota, J. Alterations of the p53 gene are common and critical events for the maintenance of malignant phenotypes in small-cell lung carcinoma. Oncogene, 7: 451-457, 1992.
8. Takahashi, T., Nau, M. M., Chiba, I., Birrer, M. J., Rosenberg, R. K., Vinocour, M., Levitt, M., Pass, H., Gazdar, A. F., and Minna, J. D. p53: a frequent target for genetic abnormalities in lung cancer. Science (Washington DC), 246: 491-494, 1989.
9. Chiba, I., Takahashi, T., Nau, M. M., D'Amico, D., Curiel, D. T., Mitsudomi, T., Buchhagen, D. L., Carbone, D., Piantadosi, S., Koga, H., Reissman, P. T., Slamon, D. J., Holmes, E. C., and Minna, J. D. Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer. Oncogene, 5: 1603-1610, 1990.
10. Shimizu, E., Coxon, A., Otterson, G. A., Steinberg, S. M., Kratzke, R. A., Kim, Y. W., Fedorko, J., Oie, H., Johnson, B. E., Mulshine, J. L., Minna, J. D., Gazdar, A. F., and Kaye, F. J. RB protein status and clinical correlation from 171 cell lines representing lung cancer, extrapulmonary small cell carcinoma, and mesothelioma. Oncogene, 9: 2441-2448, 1994.
11. INK4 protein is restricted to the subset of lung cancer lines that retains wildtype RB. Oncogene, 9: 3375-3378, 1994.
12. INK4 expression in primary lung cancers and cell lines. Cancer Res., 55: 505-509, 1995.
13. Shiseki, M., Kohno, T., Adachi, J., Okazaki, T., Otsuka, T., Mizoguchi, H., Noguchi, M., Hirohashi, S., and Yokota, J. Comparative allelotype of early and advanced stage non-small cell lung carcinomas. Genes Chromosomes Cancer, 17: 71-77, 1996.
14. Shiseki, M., Kohno, T., Nishikawa, R., Sameshima, Y., Mizoguchi, H., and Yokota, J. Frequent allelic losses on chromosomes 2q, 18q, and 22q in advanced non-small cell lung carcinoma. Cancer Res., 54: 5643-5648, 1994.
15. WHO. Histological Typing of Lung Tumors, No. 1, Ed. 2. Geneva: WHO, 1981.
16. Otsuka, T., Kohno, T., Mori, M., Noguchi, M., Hirohashi, S., and Yokota, J. Deletion mapping of chromosome 2 in human lung carcinoma. Genes Chromosomes Cancer, 16: 113-119, 1996.
17. Mountain, C. F. Revisions in the international system for staging lung cancer. Chest, 111: 1710-1717, 1997.
18. Isobe, T., Hiyama, K., Yoshida, Y., Fujiwara, Y., and Yamakido, M. Prognostic significance of p53 and ras gene abnormalities in lung adenocarcinoma patients with stage I disease after curative resection. Jpn. J. Cancer Res., 85: 1240-1246, 1994.
19. Harpole, D. H., Jr., Herndon, J. E., II, Wolfe, W. G., Iglehart, J. D., and Marks, J. R. A prognostic model of recurrence and death in stage I non-small cell lung cancer utilizing presentation, histopathology, and oncoprotein expression. Cancer Res., 55: 51-56, 1995.
20. Williams, D. E., Pairolero, P. C., Davis, C. S., Bernatz, P. E., Payne, W. S., Taylor, W. F., Uhlenhopp, M. A., and Fontana, R. S. Survival of patients surgically treated for stage I lung cancer. J. Thorac. Cardiovasc. Surg., 82: 70-76, 1981.
21. Ichinose, Y., Hara, N., Ohta, M., Yano, T., Maeda, K., Asoh, H., and Katsuda, Y. Is T factor of the TNM staging system a predominant prognostic factor in pathologic stage I non-small-cell lung cancer? J. Thorac. Cardiovasc. Surg., 106: 90-94, 1993.
22. Takita, J., Hayashi, Y., Kohno, T., Shiseki, M., Yamaguchi, N., Hanada, R., Yamamoto, K., and Yokota, J. Allelotype of neuroblastoma. Oncogene, 11: 1829-1834, 1995.
23. Moch, H., Presti, J. C., Sauter, G., Buchholz, N., Jordan, P., Mihatsch, M. J., and Waldman, F. M. Genetic aberrations detected by comparative genomic hybridization are associated with clinical outcome in renal cell carcinoma. Cancer Res., 56: 27-30, 1996.
24. Eiriksdottir, G., Sigurdsson, A., Jonasson, J. G., Agnarsson, B. A., Sigurdsson, H., Gudmundsson, J., Bergthorsson, J. T., Barkardottir, R. B., and Egilsson, V. Loss of heterozygosity on chromosome 9 in human breast cancer: association with clinical variables and genetic changes at other chromosome regions. Int. J. Cancer, 64: 378-382, 1995.
25. Field, J. K., Kiaris, H., Risk, J. M., Tsiriyotis, C., Adamson, R., Zoumpourlis, V., Rowley, H., Taylor, K., Whittaker, J., Howard, P., Beirne, J. C., Gosney, J. R., Woolgar, J., Vaughan, E. D., Spandidos, D. A., and Jones, A. S. Allelotype of squamous cell carcinoma of the head and neck: fractional allele loss correlates with survival. Br. J. Cancer, 72: 1180-1188, 1995.
26. Kishimoto, Y., Sugio, K., Mitsudomi, T., Oyama, T., Virmani, A. K., McIntire, D. D., and Gazdar, A. F. Frequent loss of the short arm of chromosome 9 in resected non-small cell lung cancers from Japanese patients and its association with squamous cell carcinoma. J. Cancer Res. Clin. Oncol., 121: 291-296, 1995.
27. Kishimoto, Y., Sugio, K., Hung, J. Y., Virmani, A. K., McIntire, D. D., Minna, J. D., and Gazdar, A. F. Allele-specific loss in chromosome 9p loci in preneoplastic lesions accompanying non-small-cell lung cancers. J. Natl. Cancer Inst., 87: 1224-1229, 1995.
28. Thiberville, L., Payne, P., Vielkinds, J., LeRiche, J., Horsman, D., Nouvet, G., Palcic, B., and Lam, S. Evidence of cumulative gene losses with progression of premalignant epithelial lesions to carcinoma of the bronchus. Cancer Res., 55: 5133-5139, 1995.
29. Petersen, I., Bujard, M., Petersen, S., Wolf, G., Goeze, A., Schwendel, A., Langreck, H., Gellert, K., Reichel, M., Just, M., Manoir, S., Cremer, T., Dietel, M., and Ried, T. Patterns of chromosomal imbalances in adenocarcinoma and squamous cell carcinoma of the lung. Cancer Res., 57: 2331-2335, 1997.
30. Kamb, A., Gruis, N. A., Weaver-Feldhaus, J., Liu, Q., Harshman, K., Tavtigian, S. V., Stockert, E., Day, R. S., III, Johnson, B. E., and Skolnick, M. H. A cell cycle regulator potentially involved in genesis of many tumor types. Science (Washington DC), 264: 436-440, 1994.
31. Nakagawa, K., Conrad, N. K., Williams, J. P., Johnson, B. E., and Kelley, M. J. Mechanism of inactivation of CDKN2 and MTS2 in non-small cell lung cancer and association with advanced stage. Oncogene, 11: 1843-1851, 1995.
32. INK4a expression in resected non-small cell lung tumors. Cancer Res., 56: 3415-3420, 1996.
33. INK4A inactivation in non-small cell lung cancer cell lines. Cancer Res., 55: 6200-6209, 1995.
34. INK4 and retinoblastoma protein status in non-small cell lung cancer: potential synergistic effect with altered p53 protein on proliferative activity. Cancer Res., 56: 5557-5562, 1996.
35. Kim, S. K., Ro, J. Y., Kemp, B. L., Lee, J. S., Kwon, T. J., Fong, K. M., Sekido, Y., Minna, J. D., Hong, W. K., and Mao, L. Identification of three distinct tumor suppressor loci on short arm of chromosome 9 in small cell lung cancer. Cancer Res., 57: 400-403, 1997.
36. Neville, E. M., Stewart, M., Myskow, M., Donnelly, R. J., and Field, J. K. Loss of heterozygosity at 9p23 defines a novel locus in non-small cell lung cancer. Oncogene, 11: 581-585, 1995.
37. Mead, L. J., Gillespie, M. T., Irving, L. B., and Campbell, L. J. Homozygous and hemizygous deletions of 9p centromeric to the interferon genes in lung cancer. Cancer Res., 54: 2307-2309, 1994.
38. Wiest, J. S., Franklin, W. A., Otstot, J. T., Forbey, K., Varella-Garcia, M., Rao, K., Drabkin, H., Gemmill, R., Ahrent, S., Sidransky, D., Saccomanno, G., Fountain, J. W., and Anderson, M. W. Identification of a novel region of homozygous deletion on chromosome 9p in squamous cell carcinoma of the lung: the location of a putative tumor suppressor gene. Cancer Res., 57: 1-6, 1997.
39. Hamada, K., Kohno, T., Kawanishi, M., Ohwada, S., and Yokota, J. Association of CDKN2A (p16)/CDKN2B (p15) alterations and homozygons chromosome arm 9p deletions in human lung carcinoma. Genes Chromosomes Cancer, 22: 232-240, 1998.
40. Tomizawa, Y., Kohno, T., Fujita, T., Kiyama, M., Saito, R., Noguchi, M., Matsuno, Y., Hirohashi, S., Yamaguchi, N., Nakajima, T., and Yokota J. Correlation between the status of the p53 gene and survival in patients stage I non-small cell lung carcinoma. Oncogene, 18: 1007-1014, 1999.
41. Mao, L., Lee, J. S., Kurie, J. M., Fan, Y. H., Lippman, S. M., Lee, J. J., Ro, J. Y., Broxson, A., Yu, R., Morice, R. C., Kemp, B. L., Khuri, F. R., Walsh, G. L., Hittelman, W. N., and Hong, W, K. Clonal genetic alteration in the lungs of current and former smoker. J. Natl. Cancer Inst., 89: 857-862, 1997.