메뉴 건너뛰기




Volumn 45, Issue 4, 1996, Pages 421-430

Co-integration of β-lactoglobulin/human serum albumin hybrid genes with the entire β-lactoglobulin gene or the matrix attachment region element: Repression of human serum albumin and β-lactoglobulin expression in the mammary gland and dual regulation of the transgenes

Author keywords

Co injection; Gene expression; Milk proteins

Indexed keywords

ALBUMIN; BETA LACTOGLOBULIN;

EID: 0029959646     PISSN: 1040452X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2795(199612)45:4<421::AID-MRD3>3.0.CO;2-T     Document Type: Article
Times cited : (12)

References (44)
  • 1
    • 0025285392 scopus 로고
    • High-level expression of biologically active human α1-antitrypsin in the milk of transgenic mice
    • Archibald AL, McClenaghan M, Hornsey V, Simons JP, Clark AJ (1990): High-level expression of biologically active human α1-antitrypsin in the milk of transgenic mice. Proc Natl Acad Sci USA 87:5178-5182.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 5178-5182
    • Archibald, A.L.1    McClenaghan, M.2    Hornsey, V.3    Simons, J.P.4    Clark, A.J.5
  • 2
    • 0019023345 scopus 로고
    • Purification of mouse immunoglobulin heavy chain messenger RNAs from total myeloma tumor RNA
    • Auffray C, Rougeon F (1980): Purification of mouse immunoglobulin heavy chain messenger RNAs from total myeloma tumor RNA. Eur J Biochem 107:303-314.
    • (1980) Eur J Biochem , vol.107 , pp. 303-314
    • Auffray, C.1    Rougeon, F.2
  • 3
    • 0027132817 scopus 로고
    • HSA production by mammary explants of virgin transgenic mice: A reliable tool for predicting levels of secretion into milk
    • Barash I, Baruch A, Nathan M, Shani M, Hurwitz DR (1993): HSA production by mammary explants of virgin transgenic mice: A reliable tool for predicting levels of secretion into milk. Anim Biotech 4:203-215.
    • (1993) Anim Biotech , vol.4 , pp. 203-215
    • Barash, I.1    Baruch, A.2    Nathan, M.3    Shani, M.4    Hurwitz, D.R.5
  • 4
    • 0028429098 scopus 로고
    • Ectopic expression of β-lactoglobulin/human serum albumin fusion genes in transgenic mice: Hormonal regulation and in situ localization
    • Barash I, Faerman A, Ratovitsky T, Puzis R, Nathan M, Hurwitz DR, Shani M (1994): Ectopic expression of β-lactoglobulin/human serum albumin fusion genes in transgenic mice: hormonal regulation and in situ localization. Transgenic Res 3:141-151.
    • (1994) Transgenic Res , vol.3 , pp. 141-151
    • Barash, I.1    Faerman, A.2    Ratovitsky, T.3    Puzis, R.4    Nathan, M.5    Hurwitz, D.R.6    Shani, M.7
  • 5
    • 0029670090 scopus 로고    scopus 로고
    • Elements within the β-lactoglobulin gene inhibit expression of human serum albumin cDNA and minigenes in transfected cells but rescue their expression in the mammary gland of transgenic mice
    • Barash I, Nathan M, Kari R, Ilan N, Shani M, Hurwitz DR (1996): Elements within the β-lactoglobulin gene inhibit expression of human serum albumin cDNA and minigenes in transfected cells but rescue their expression in the mammary gland of transgenic mice. Nucleic Acids Res 24:602-610.
    • (1996) Nucleic Acids Res , vol.24 , pp. 602-610
    • Barash, I.1    Nathan, M.2    Kari, R.3    Ilan, N.4    Shani, M.5    Hurwitz, D.R.6
  • 6
    • 0029022892 scopus 로고
    • Developmental regulation of the ovine β-lactoglobulin/human serum albumin transgene is distinct from that of the β-lactoglobulin and the endogenous β-casein genes in the mammary gland of transgenic mice
    • Baruch A, Shani M, Hurwitz DR, Barash I (1995): Developmental regulation of the ovine β-lactoglobulin/human serum albumin transgene is distinct from that of the β-lactoglobulin and the endogenous β-casein genes in the mammary gland of transgenic mice. Dev Genet 16:241-252.
    • (1995) Dev Genet , vol.16 , pp. 241-252
    • Baruch, A.1    Shani, M.2    Hurwitz, D.R.3    Barash, I.4
  • 7
    • 0028718295 scopus 로고
    • The gene encoding the major milk-specific proteins and their use in transgenic studies and protein engineering
    • Bawden WS, Passey RJ, Mackinlay AG (1994): The gene encoding the major milk-specific proteins and their use in transgenic studies and protein engineering. Biotechnol Genet Eng Rev 12:89-137.
    • (1994) Biotechnol Genet Eng Rev , vol.12 , pp. 89-137
    • Bawden, W.S.1    Passey, R.J.2    Mackinlay, A.G.3
  • 8
    • 0016302398 scopus 로고
    • Identification of a nuclear protein matrix
    • Berezney R, Coffey D (1974): Identification of a nuclear protein matrix. Biochem Biophys Res Commun 60:1410-1419.
    • (1974) Biochem Biophys Res Commun , vol.60 , pp. 1410-1419
    • Berezney, R.1    Coffey, D.2
  • 9
    • 0026725682 scopus 로고
    • A 17.6 kbp region located upstream of the rabbit WAP gene directs high level expression of a functional human protein variant in transgenic mouse milk
    • Bischoff R, Degryse E, Perraud F, Dalemans W, Ali-Hadji D, Thepot D, Devinoy E, Houdebine LM, Pavirani A (1992): A 17.6 kbp region located upstream of the rabbit WAP gene directs high level expression of a functional human protein variant in transgenic mouse milk. FEBS Lett 305:265-268.
    • (1992) FEBS Lett , vol.305 , pp. 265-268
    • Bischoff, R.1    Degryse, E.2    Perraud, F.3    Dalemans, W.4    Ali-Hadji, D.5    Thepot, D.6    Devinoy, E.7    Houdebine, L.M.8    Pavirani, A.9
  • 11
    • 0028138645 scopus 로고
    • Dissection of the locus control function located on the chicken lysozyme gene domain in transgenic mice
    • Bonifer C, Yannoutsos N, Kruger G, Grosveld F, Sippel AE (1994): Dissection of the locus control function located on the chicken lysozyme gene domain in transgenic mice. Nucleic Acids Res 20: 4202-4210.
    • (1994) Nucleic Acids Res , vol.20 , pp. 4202-4210
    • Bonifer, C.1    Yannoutsos, N.2    Kruger, G.3    Grosveld, F.4    Sippel, A.E.5
  • 12
    • 0023497799 scopus 로고
    • Regulatory elements in the first intron contribute to transcriptional control of the human α1(I) collagen gene
    • Bornstein P, McKay J, Morishima JK, Devarayalu S, Gelinas RE (1987): Regulatory elements in the first intron contribute to transcriptional control of the human α1(I) collagen gene. Proc Natl Acad Sci USA 84:8869-8873.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 8869-8873
    • Bornstein, P.1    McKay, J.2    Morishima, J.K.3    Devarayalu, S.4    Gelinas, R.E.5
  • 14
    • 0025906388 scopus 로고
    • A generic intron increases gene expression in transgenic mice
    • Choi T, Huang M, Gorman C, Jaenisch R (1991): A generic intron increases gene expression in transgenic mice. Mol Cell Biol 11: 3070-3074.
    • (1991) Mol Cell Biol , vol.11 , pp. 3070-3074
    • Choi, T.1    Huang, M.2    Gorman, C.3    Jaenisch, R.4
  • 15
    • 0027254748 scopus 로고
    • A 5′ element of the chicken β-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila
    • Chung JH, Whiteley M, Felsenfeld G (1993): A 5′ element of the chicken β-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila. Cell 74:505-514.
    • (1993) Cell , vol.74 , pp. 505-514
    • Chung, J.H.1    Whiteley, M.2    Felsenfeld, G.3
  • 17
    • 0022553738 scopus 로고
    • Chromosomal loop anchorage of the kappa immunoglobulin gene occurs next to the enhancer in a region containing toopoisomerase II sites
    • Cockerill PN, Garrard WT (1986): Chromosomal loop anchorage of the kappa immunoglobulin gene occurs next to the enhancer in a region containing toopoisomerase II sites. Cell 44:273-282.
    • (1986) Cell , vol.44 , pp. 273-282
    • Cockerill, P.N.1    Garrard, W.T.2
  • 18
    • 0027260427 scopus 로고
    • Identification and analysis of a matrix-attachment region 5′ of the rat glutamate-dehydrogenase-encoding gene
    • Das AT, Luderus ME, Lamers WH (1993): Identification and analysis of a matrix-attachment region 5′ of the rat glutamate-dehydrogenase-encoding gene. Eur J Biochem 215:777-785.
    • (1993) Eur J Biochem , vol.215 , pp. 777-785
    • Das, A.T.1    Luderus, M.E.2    Lamers, W.H.3
  • 20
    • 0025162591 scopus 로고
    • Mapping of structural and transcription-related matrix attachment sites in the α-globin gene domain of avian erythroblasts and erythrocytes
    • Farache G, Razin SV, Rzeszowska-Wolny J, Moreau J, Recillas Targa F, Scherrer K (1990): Mapping of structural and transcription-related matrix attachment sites in the α-globin gene domain of avian erythroblasts and erythrocytes. Mol Cell Biol 10:5349-5358.
    • (1990) Mol Cell Biol , vol.10 , pp. 5349-5358
    • Farache, G.1    Razin, S.V.2    Rzeszowska-Wolny, J.3    Moreau, J.4    Recillas Targa, F.5    Scherrer, K.6
  • 21
    • 0023550898 scopus 로고
    • Evidence for a locus activation region: The formation of developmentally stable hypersensitive sites in globin-expressing hybrids
    • Forrester WC, Takegawa S, Papayannopoulow T, Stamatoyannopoulos G, Groudine M (1987): Evidence for a locus activation region: The formation of developmentally stable hypersensitive sites in globin-expressing hybrids. Nucleic Acids Res 85:10159-10177.
    • (1987) Nucleic Acids Res , vol.85 , pp. 10159-10177
    • Forrester, W.C.1    Takegawa, S.2    Papayannopoulow, T.3    Stamatoyannopoulos, G.4    Groudine, M.5
  • 22
    • 0024542052 scopus 로고
    • Mouse embrionic stem cells and reporter constructs to detect developmentally regulated genes
    • Gossler A, Joyner AL, Rossant J, Skarnes WC (1989): Mouse embrionic stem cells and reporter constructs to detect developmentally regulated genes. Science 244:463-465.
    • (1989) Science , vol.244 , pp. 463-465
    • Gossler, A.1    Joyner, A.L.2    Rossant, J.3    Skarnes, W.C.4
  • 23
    • 0025486920 scopus 로고
    • The mammary gland as a bioreactor: Production of foreign proteins in milk
    • Hennighausen L (1990): The mammary gland as a bioreactor: production of foreign proteins in milk. Protein Exp Purif 1:3-8.
    • (1990) Protein Exp Purif , vol.1 , pp. 3-8
    • Hennighausen, L.1
  • 24
    • 0028235475 scopus 로고
    • Production of pharmaceutical proteins from transgenic animals
    • Houdebine LM (1994): Production of pharmaceutical proteins from transgenic animals. J Biotechnol 34:269-287.
    • (1994) J Biotechnol , vol.34 , pp. 269-287
    • Houdebine, L.M.1
  • 25
    • 0028535450 scopus 로고
    • Specific combinations of human serum albumin introns direct high level expression of albumin in transgected COS cells and in the milk of transgenic mice
    • Hurwitz DR, Nathan M, Barash I, Ilan N, Shani M (1994): Specific combinations of human serum albumin introns direct high level expression of albumin in transgected COS cells and in the milk of transgenic mice. Transgenic Res 3:365-375.
    • (1994) Transgenic Res , vol.3 , pp. 365-375
    • Hurwitz, D.R.1    Nathan, M.2    Barash, I.3    Ilan, N.4    Shani, M.5
  • 27
    • 0025869479 scopus 로고
    • Scaffold-attached regions from three human interferon b domains can be used to enhance the stable expression of gene under the control of various promoters
    • Klehr D, Maass K, Bode J (1991): Scaffold-attached regions from three human interferon b domains can be used to enhance the stable expression of gene under the control of various promoters. Biochemistry 30:1264-1270.
    • (1991) Biochemistry , vol.30 , pp. 1264-1270
    • Klehr, D.1    Maass, K.2    Bode, J.3
  • 28
    • 0024841323 scopus 로고
    • The limits of the DNasel-sensitive domain of the human apolipoprotein B gene coincide with the location of chromosomal anchorage loops and define the 5′ and 3′ boundaries of the gene
    • Levy-Wilson B, Fortier C (1989): The limits of the DNasel-sensitive domain of the human apolipoprotein B gene coincide with the location of chromosomal anchorage loops and define the 5′ and 3′ boundaries of the gene. J Biol Chem 264:21196-21204.
    • (1989) J Biol Chem , vol.264 , pp. 21196-21204
    • Levy-Wilson, B.1    Fortier, C.2
  • 29
    • 0026651977 scopus 로고
    • Matrix-attachment region can impart position-independent regulation of a tissue-specific gene in transgenic mice
    • McKnight RA, Shamay A, Sankaran L, Wall RJ, Hennighausen L (1992): Matrix-attachment region can impart position-independent regulation of a tissue-specific gene in transgenic mice. Proc Natl Acad Sci USA 89:6943-6947.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 6943-6947
    • McKnight, R.A.1    Shamay, A.2    Sankaran, L.3    Wall, R.J.4    Hennighausen, L.5
  • 30
    • 0029169597 scopus 로고
    • Expression of genomic and cDNA transgenes after co-integration in transgenic mice
    • McKnight RA, Wall RJ, Hennighausen L (1995): Expression of genomic and cDNA transgenes after co-integration in transgenic mice. Trangenic Res 4:39-43.
    • (1995) Trangenic Res , vol.4 , pp. 39-43
    • McKnight, R.A.1    Wall, R.J.2    Hennighausen, L.3
  • 31
    • 0023488840 scopus 로고
    • Detection in situ of genomic regulatory elements in Drosophila
    • O'Kane CL, Gehring WJ (1987): Detection in situ of genomic regulatory elements in Drosophila. Proc Natl Acad Sci USA 85:9123-9127.
    • (1987) Proc Natl Acad Sci USA , vol.85 , pp. 9123-9127
    • O'Kane, C.L.1    Gehring, W.J.2
  • 35
    • 0023969306 scopus 로고
    • The matrix attachment regions of the chicken lysozyme gene co-map with the boundaries of the chromatin domain
    • Phi-Van L, Stratling WH (1988): The matrix attachment regions of the chicken lysozyme gene co-map with the boundaries of the chromatin domain. EMBO J 7:655-664.
    • (1988) EMBO J , vol.7 , pp. 655-664
    • Phi-Van, L.1    Stratling, W.H.2
  • 36
    • 0028345440 scopus 로고
    • Characterization of two intronic nuclear-matrix-attachment regions in the human DNA topoisomerase I gene
    • Romig H, Ruff J, Fackelmayer FO, Patil MS, Richter A (1994): Characterization of two intronic nuclear-matrix-attachment regions in the human DNA topoisomerase I gene. Eur J Biochem 221:411-419.
    • (1994) Eur J Biochem , vol.221 , pp. 411-419
    • Romig, H.1    Ruff, J.2    Fackelmayer, F.O.3    Patil, M.S.4    Richter, A.5
  • 38
    • 0023646640 scopus 로고
    • Alteration of the quality of milk by expression of sheep beta-lactoglobulin in transgenic mice
    • Simons JP, McClenaghan M, Clark AJ (1987): Alteration of the quality of milk by expression of sheep beta-lactoglobulin in transgenic mice. Nature 328:530-532.
    • (1987) Nature , vol.328 , pp. 530-532
    • Simons, J.P.1    McClenaghan, M.2    Clark, A.J.3
  • 39
    • 0024948946 scopus 로고
    • A nuclear DNA attachment element mediates elevated and position independent gene activity
    • Stief A, Winter DM, Startling WH, Sippel AE (1989): A nuclear DNA attachment element mediates elevated and position independent gene activity. Nature 341:343-345.
    • (1989) Nature , vol.341 , pp. 343-345
    • Stief, A.1    Winter, D.M.2    Startling, W.H.3    Sippel, A.E.4
  • 40
    • 0025174655 scopus 로고
    • The structure and assembly of active chromatin
    • Svaren J, Chalkley R (1990): The structure and assembly of active chromatin. Trends Genet 6:52-56.
    • (1990) Trends Genet , vol.6 , pp. 52-56
    • Svaren, J.1    Chalkley, R.2
  • 41
    • 0026637569 scopus 로고
    • Making transgenic livestock: Genetic engineering on a large scale
    • Wall RJ, Hawk HW, Nel N (1992): Making transgenic livestock: genetic engineering on a large scale. J Cell Biochem 49:113-120.
    • (1992) J Cell Biochem , vol.49 , pp. 113-120
    • Wall, R.J.1    Hawk, H.W.2    Nel, N.3
  • 44
    • 0024790860 scopus 로고
    • Immunoglobulin kappa gene expression after stable integration. 2. Role of intronic MAR and enhancer in transgenic mice
    • Xu M, Hammer E, Blasquez VC, Jones SL, Gerrard WT (1989): Immunoglobulin kappa gene expression after stable integration. 2. Role of intronic MAR and enhancer in transgenic mice. J Biol Chem 264:21190-21195.
    • (1989) J Biol Chem , vol.264 , pp. 21190-21195
    • Xu, M.1    Hammer, E.2    Blasquez, V.C.3    Jones, S.L.4    Gerrard, W.T.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.