Immunohistochemical and mutational analysis of p53 tumor suppressor gene in gestational trophoblastic disease: Correlation with mdm2, proliferation index, and clinicopathologic parameters

International Journal of Gynecological Cancer

Volumn 9, Issue 2, 1999, Pages 123-130

  Cheung, A N Y ^a   Shen, D H ^b   Khoo, U S ^a   Chiu, M P M ^a   Tin, V P C ^a   Chung, L P ^a   Ngan, H Y S ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Gestational trophoblastic disease; Ki67; mdm2; p53

Indexed keywords

PROTEIN MDM2; PROTEIN P53;

ARTICLE; CELL PROLIFERATION; CHROMOSOME 17; CLINICAL ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; FEMALE; GENE OVEREXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDATIDIFORM MOLE; IMMUNOREACTIVITY; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; TROPHOBLASTIC DISEASE; TUMOR SUPPRESSOR GENE;

EID: 0032896883     PISSN: 1048891X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1525-1438.1999.09904.x     Document Type: Article

References (42)

1. Mazur MT, Kurman RJ. Gestational trophoblastic disease. In: Kurman RJ (ed): Blaustein's Pathology of Female Genital Tract. 4th edn. New York: Springer-Verlag 1994; pp. 1049-93.
2. Elston CW. Gestational trophoblastic disease. In Fox H (ed): Obstetrical and Gynaecological Pathology. 4th edn. Edinburgh: Churchill Livingstone 1995; pp. 1597-640.
3. Cheung ANY, Ngan HYS, Chen WZ, Collins RJ. The significance of proliferating cell nuclear antigen in human trophoblastic disease-an immunohistochemical study. Histopathol 1993;22:565-8.
4. Cheung ANY, Ngan HYS, Collins RJ, Wong YL. Assessment of cell proliferation in hydatidiform mole using monoclonal antibody MIB1 to Ki-67 antigen. J Clin Pathol 1994;47:601-4.
5. Cheung ANY, Srivastava G, Pittaluga S, Man TK, Ngan H, Collins RJ. Expression of c-myc and c-fms oncogenes in trophoblastic cells in hydatidiform mole and normal human placenta. J Clin Pathol 1993;46:204-7.
6. Cheung ANY, Srivastava G, Chung LP, et al. Expression of the p53 gene in trophoblastic cells in hydatidiform moles and normal human placentas. J Reprod Med 1994; 39:223-7.
7. Shi YF, Xie X, Zhao CL, et al. Lack of mutation in tumour-suppressor gene p53 in gestational trophoblastic tumours. Br J Cancer 1996;73:1216-9.
8. Chen CA, Chen YH, Chen TM, et al. Infrequent mutation in tumor suppressor gene p53 in gestational trophoblastic neoplasia. Carcinogenesis 1994;15:221-3.
9. Fakharzadeh SS, Trusko SP, George DL. Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line. EMBO J 1991;10:1565-9.
10. Momand J, Zambetti GP, Olson DC, George D, Levine AJ. The mdm2 oncogene product forms a complex with the p53 protein and inhibits p53 mediated transactivation. Cell 1992;69:1237-45.
11. Chen J, Wu X, Lin J, Levine AJ. mdm2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein. Mol Cell Biol 1996;16:2445-52.
12. Jenkins JR, Rudge K, Currie GA. Cellular immortalization by cDNA clone encoding the transformation-associated phosphoprotein p53. Nature 1984;312:651-4.
13. Finlay CA, Hinds PW, Levine AJ. The p53 proto-oncogene can act as a suppressor of transformation. Cell 1989;57: 1083-93.
14. Ullrich SJ, Anderson CW, Mercer WE, Appella E. The p53 tumour suppressor protein, a modulator of cell proliferation. J Biol Chem 1992;267:15259-62.
15. Levine AJ, Momand J, Finlay CA. The p53 tumour suppressor gene. Nature 1991;351:453-6.
16. Vogelstein B. Cancer: a deadly inheritance. Nature 1990; 348:681-2.
17. Hollstein M, Sidransky D, Vogelstein B, Harris CC. p53 mutations in human cancers. Science 1991;253:49-53.
18. Fulop V, Mok SC, Genest DR, Gati I, Doszpod J, Berkowitz RS. p53, p21, RB, and mdm2 oncoproteins. Expression in normal placenta, partial and complete mole, and choriocarcinoma. J Reprod Med 1998;43:119-27.
19. Roncalli M, Bulfamante G, Viale G, et al. C-myc and tumour suppressor gene product expression in developing and term human trophoblast. Placenta 1994;15:399-409.
20. Marzusch K, Ruck P, Horny HP, Dietl J, Kaiserling E. Expression of the p53 tumour suppressor gene in human placenta: an immunohistochemical study. Placenta 1995; 16:101-4.
21. Persaud V, Ganjei P, Nadji M. Cell proliferative activity and mutation of p53 suppressor gene in human gestational trophoblastic disease. West Indian Med J 1993;42: 142-3.
22. Haidacher S, Blaschitz A, Desoye G, Dohr G. Immunohistochemical evidence of p53 protein in human placenta and choriocarcinoma cell lines. Hum Reprod 1995;10: 983-8.
23. Lee YS. p53 expression in gestational trophoblastic disease. Int J Gynecol Pathol 1995;14:119-24.
24. Piette J, Neel H, Marechal V. mdm2: keeping p53 under control. Oncogene 1997;15:1001-10.
25. Olson DC, Marechal V, Momand J, Chen J, Romocki C, Levine AJ. Identification and characterization of multiple mdm2 proteins and mdm 2 p53 protein complexes. Oncogene 1993;8:2353-60.
26. Save V, Nylander K, Hall PA. Why is p53 protein stabilized in neoplasia? Some answers but many more questions. J Pathol 1998;184:348-350.
27. Marchetti A, Buttitta F, Pellegrini S, et al. mdm2 gene amplification and overexpression in non small cell lung carcinomas with accumulation of the p53 protein in the absence of p53 gene mutations. Diagn Mol Pathol 1995; 4:93-7.
28. Landers JE, Haines DS, Strauss JF III, George DL. Enhanced translation: a novel mechanism of mdm2 oncogene overexpression identified in human tumor cells. Oncogene 1994;9: 2745-50.
29. Bosari S, Roncalli M, Viale G, Bossi P, Coggi G. p53 immunoreactivity in inflammatory and neoplastic diseases of the uterine cervix. J Pathol 1993;169:425-30.
30. Ogden GR, Chisholm DM, Kiddie RA, Lane DP. p53 protein on odontogenic cysts: Increased expression in some odontogenic keratocysts. J Clin Pathol 1992;45:1007-10.
31. Dietzmann K, von Bossanyi P, Sallaba J, Kirches E, Synowitz HJ, Warich Kirches M. Immunohistochemically detectable p53 and mdm-2 oncoprotein expression in astrocytic gliomas and their correlation to cell proliferation. Gen Diagn Pathol 1996;141:339-44.
32. Matsuno A, Nagashima T, Matsuura R, et al. Correlation between MIB-1 staining index and the immunoreactivity of p53 protein in recurrent and non-recurrent meningiomas. Am J Clin Pathol 1996; 106:776-81.
33. Querzoli P, Albonico G, Ferretti S, et al. MIB-1 proliferative activity in invasive breast cancer measured by image analysis. J Clin Pathol 1996;49:926-30.
34. Nawa G, Ueda T, Mori S, et al. Prognostic significance of Ki67 (MIB1) proliferation index and p53 over-expression in chondrosarcomas. Int J Cancer 1996;69:86-91.
35. Costa MJ, Walls J, Ames P, Roth LM. Transformation in recurrent ovarian granulosa cell tumors: Ki67 (MIB-1) and p53 immunohistochemistry demonstrates a possible molecular basis for the poor histopathologic prediction of clinical behaviour. Hum Pathol 1996;27:274-81.
36. Harloziska A, Bar JK, Sedlaczek P, Gerber J. Expression of p53 protein and Ki-67 reactivity in ovarian neoplasms. Correlation with histopathology. Am J Clin Pathol 1996; 105:334-40.
37. Sun XF, Carstensen JM, Stal O, Zhang H, Nordenskjold B. Proliferating cell nuclear antigen (PCNA) in relation to ras, c-erbB-2, p53, clinico-pathological variables and prognosis in colorectal carcinoma. Int J Cancer 1996;69: 5-8.
38. Fisher SJ, Damsky CH. Human cytotrophoblast invasion. Semin Cell Biol 1993;4:183-8.
39. Pritsche M, Haessler C, Brandner G. Induction of nuclear accumulation of the tumour suppressor protein p53 by DNA-damaging agents. Oncogene 1993;8:307-18.
40. Merritt AJ, Potten CS, Kemp CJ, et al. The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice. Cancer Res 1994;54:614-7.
41. Shaw P, Bovey R, Tardy S, Sahly R, Sordat B, Costa J. Induction of apoptosis by wild-type p53 in a human colon tumour-derived cell line. Proc Natl Acad Sci USA 1992;89:4495-9.
42. Kastan MB, Onyekwere O, Sidransky D, Vogelstein B, Craig RW. Participation of p53 protein in the cellular response to DNA damage. Cancer Res 1991;51:6304-11.