Poisoning of topoisomerase I by an antitumor indolocarbazole drug: Stabilization of topoisomerase I-DNA covalent complexes and specific inhibition of the protein kinase activity

Cancer Research

Volumn 59, Issue 1, 1999, Pages 52-55

  Labourier, Emmanuel ^a   Riou, Jean François ^b   Prudhomme, Michelle ^c   Carrasco, Carolina ^d   Bailly, Christian ^d   Tazi, Jamal ^a  

^a INSTITUT DE GÉNÉTIQUE MOLÉCULAIRE DE MONTPELLIER   (France)

^b SANOFI   (France)

^c UNIVERSITÉ CLERMONT AUVERGNE   (France)

^d CENTRE OSCAR LAMBRET   (France)

Author keywords

[No Author keywords available]

Indexed keywords

6 FORMYLAMINO 12,13 DIHYDRO 1,11 DIHYDROXY 5H INDOLO[2,3 A][PYRROLO[3,4 C]CARBAZOLE 5,7(6H) DIONE 13 GLUCOSIDE; CAMPTOTHECIN; CARBAZOLE DERIVATIVE; DNA TOPOISOMERASE; INDOLOCARBAZOLE; PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GROWTH; COMPLEX FORMATION; CONCENTRATION RESPONSE; DNA CLEAVAGE; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG SPECIFICITY; ENZYME INHIBITION; LEUKEMIA CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN PHOSPHORYLATION;

ANIMALS; ANTINEOPLASTIC AGENTS; CARBAZOLES; DNA; DNA TOPOISOMERASES, TYPE I; INDOLES; MICE; PROTEIN KINASE INHIBITORS; TUMOR CELLS, CULTURED;

EID: 0032893999     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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