Lymphoid hyperplasia in transgenic mice over-expressing a secreted form of the human interleukin-1β gene product

Immunology

Volumn 96, Issue 1, 1999, Pages 128-137

  Bjorkdahl O ^a,c   Akerblad P ^a   Gjorloff Wingren A ^a   Leanderson, T ^a   Dohlsten, M ^a,b  

^a LUND UNIVERSITY   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

^c Immunology Group   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GENE PRODUCT; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; MONOCLONAL ANTIBODY;

ANIMAL CELL; ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE OVEREXPRESSION; LYMPHOID HYPERPLASIA; LYMPHOID TISSUE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, CD44; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; CD4-POSITIVE T-LYMPHOCYTES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMANS; HYPERPLASIA; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; INTERLEUKIN-1; INTERLEUKIN-2; INTERLEUKIN-4; L-SELECTIN; LYMPH NODES; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PROTEIN ISOFORMS; SPLEEN;

EID: 0032891514     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.1999.00655.x     Document Type: Article

References (34)

1. 1. DINARELLO C.A. (1991) Interleukin-1 and interleukin-1 antagonism. Blood 77, 1627.
2. 2. AREND W.P. (1993) Interleukin-1 receptor antagonist. Adv Immunol 54, 167.
3. 3. COLOTTA F., DOWER S.K., SIMS J.E. & MANTOVANI A. (1994) The type II 'decoy' receptor: a novel regulatory pathway for interleukin 1. Immunol-Today 15, 562.
4. 4. HOGQUIST K.A., UNANUE E.R. & CHAPLIN D.D. (1991) Release of IL-1 from mononuclear phagocytes. J-Immunol 147, 2181.
5. 5. HOGQUIST K.A., NETT M.A., UNANUE E.R. & CHAPLIN D.D. (1991) Interleukin 1 is processed and released during apoptosis. Proc Natl Acad Sci USA 88, 8485.
6. 6. MIURA M., ZHU H., ROTELLO R., HARTWIEG E.A. & YUAN J. (1993) Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3. Cell 75, 653.
7. 7. YUAN J., SHAHAM S., LEDOUX S., ELLIS H.M. & HORVITZ H.R. (1993) The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme. Cell 75, 641.
8. 8. KYRIAKIS J.M., BANERJEE P., NIKOLAKAKI E. et al. (1994) The stress-activated protein kinase subfamily of c-Jun kinases. Nature 369, 156.
9. 9. FRESHNEY N.W., RAWLINSON L., GUESDON F. et al. (1994) Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27. Cell 78, 1039.
10. 10. LANE T.A., LAMKIN G.E. & WANCEWICZ E.V. (1990) Protein kinase C inhibitors block the enhanced expression of intercellular adhesion molecule-1 on endothelial cells activated by interleukin-1, lipopolysaccharide and tumor necrosis factor. Biochem Biophys Res Commun 172, 1273.
11. 11. ALIMZHANOV M.B., KUPRASH D.V., KOSCO-VILBOIS M.H. et al. (1997) Abnormal development of secondary lymphoid tissues in lymphotoxin beta-deficient mice. Proc Natl Acad Sci USA 94, 9302.
12. 12. ETTINGER R., BROWNING J.L., MICHIE S.A., VAN EWIJK W. & MCDEVITT H.O. (1996) Disrupted splenic architecture, but normal lymph node development in mice expressing a soluble lymphotoxin-beta receptor-IgG1 fusion protein. Proc Natl Acad Sci USA 93, 13102.
13. 13. MATSUMOTO M., FU Y.X., MOLINA H. & CHAPLIN D.D. (1997) Lymphotoxin-α-deficient and TNF receptor-I-deficient mice define developmental and functional characteristics of germinal centers. Immunol Rev 156, 137.
14. 14. RENNERT P.D., BROWNING J.L., MEBIUS R., MACKAY F. & HOCHMAN P.S. (1996) Surface lymphotoxin alpha/beta complex is required for the development of peripheral lymphoid organs. J Exp Med 184, 1999.
15. 15. WINGREN A.G., BJORKDAHL O., LABUDA T. et al. (1996) Fusion of a signal sequence to the interleukin-1 beta gene directs the protein from cytoplasmic accumulation to extracellular release. Cell Immunol 169, 226.
16. 16. BJORKDAHL O., GJÖRLOFF-WINGREN A., HEDLUND G., OHLSSON L. & DOHLSTEN M. (1997) Gene transfer of a hybrid interleukin-1β gene to B16 mouse melanoma recruits leukocyte subsets and reduces tumour growth In Vivo Canc Immunol Immunother 44, 273.
17. 17. KILLAR L.M., HATFIELD C.A., CARDING S.R., PAN M., WINTERROWD G.E. & BOTTOMLY K. (1989) In vivo administration of interleukin 1 elicits increased la antigen expression on B cells through the induction of interleukin 4. Eur J Immunol 19, 2205.
18. 18. KENNEY J.S., MASADA M.P., EUGUI E.M., DELUSTRO B.M., MULKINS M.A. & ALLISON A.C. (1987) Monoclonal antibodies to human recombinant interleukin 1 (IL 1)β: quantitation of IL 1β and inhibition of biological activity. J Immunol 138, 4236 issn: 0022.
19. 19. AKERBLAD P., SIGVARDSSON M. & LEANDERSON T. (1996) Early B-cell factor (EBF) down-regulates immunoglobulin heavy chain intron enhancer function in a plasmacytoma cell line. Scand J Immunol 44, 89.
20. 20. DINARELLO C.A. (1996) Biologic basis for interleukin-1 in disease. Blood 87, 2095.
21. 21. REED S.G., PIHL D.L., CONLON P.J. & GRABSTEIN K.H. (1989) IL-1 as adjuvant. Role of T cells in the augmentation of specific antibody production by recombinant human IL-1α. J Immunol 142, 3129.
22. 22. LOWENTHAL J.W., CEROTTINI J.C. & MACDONALD H.R. (1986) Interleukin 1-dependent induction of both interleukin 2 secretion and interleukin 2 receptor expression by thymoma cells. J Immunol 137, 1226.
23. 23. HO S.N., ABRAHAM R.T., NILSON A., HANDWERGER B.S. & MCKEAN D.J. (1987) Interleukin 1-mediated activation of interleukin 4 (IL 4)-producing T lymphocytes. Proliferation by IL 4-dependent and IL 4-independent mechanisms. J Immunol 139, 1532.
24. 24. HUNNINGHAKE G.W., GLAZIER A.J., MONICK M.M. & DINARELLO C.A. (1987) Interleukin-1 is a chemotactic factor for human T-lymphocytes. Am Rev Respir Dis 135, 66.
25. 25. LOWENTHAL J.W. & MACDONALD H.R. (1987) Expression of interleukin-1 receptors is restricted to the L3T4+ subset of mature T-lymphocytes. J Immunol 138, 1.
26. 26. DE TOGNI P., GOELLNER J., RUDDLE N.H. et al. (1994) Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science 264, 703.
27. 27. MATSUMOTO M., MARIATHASAN S., NAHM M.H., BARANYAY F., PESCHON J.J. & CHAPLIN D.D. (1996) Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers. Science 271, 1289.
28. 28. PASPARAKIS M., ALEXOPOULOU L., EPISKOPOU V. & KOLLIAS G. (1996) Immune and inflammatory responses in TNF α-deficient mice: a critical requirement for TNF α in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response. J Exp Med 184, 1397.
29. 29. MIZOGUCHI E., MIZOGUCHI A. & BHAN A.K. (1997) Role of cytokines in the early stages of chronic colitis in TCR α-mutant mice. Lab Invest 76, 385.
30. 30. REED S.G., PIHL D.L. & GRABSTEIN K.H. (1989) Immune deficiency in chronic Trypanosoma cruzi infection. Recombinant IL-1 restores Th function for antibody production. J Immunol 142, 2067.
31. 31. SUEMATSU S., MATSUDA T., AOZASA K. et al. (1989) IgGl plasmacytosis in interleukin 6 transgenic mice. Proc Natl Acad Sci USA 86, 7547.
32. 32. LEMAY S., MAO C. & SINGH A.K. (1996) Cytokine gene expression in the MRL/Ipr model of lupus nephritis. Kidney Int 50, 85.
33. 33. GEIGER T., TOWBIN H., COSENTI-VARGAS A. et al. (1993) Neutralization of interleukin-1 beta activity in vivo with a monoclonal antibody alleviates collagen-induced arthritis in DBA/1 mice and prevents the associated acute-phase response. Clin Exp Rheumatol 11, 515.
34. 34. VAN DEN BERG W.B., JOOSTEN L.A., HELSEN M. & VAN DE LOO F.A. (1994) Amelioration of established murine collagen-induced arthritis with anti-IL-1 treatment. Clin Exp Immunol 95, 237.