Induction of VEGF and VEGF receptor gene expression by hypoxia: Divergent regulation in vivo and in vitro

Kidney International

Volumn 51, Issue 2, 1997, Pages 448-453

  Sandner, Peter ^a   Wolf, Konrad ^a   Bergmaier, Ulrike ^a   Gess, Bernhard ^a   Kurtz, Armin ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; CONFERENCE PAPER; CONTROLLED STUDY; GENE CONTROL; GENE EXPRESSION; HORMONE RELEASE; HYPOXIA; LIVER CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0031030706     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1038/ki.1997.60     Document Type: Conference Paper

References (35)

1. JELKMANN W: Erythropoietin: Structure, control of production, and function. Physiol Rev 72:449-489, 1992
2. FERRARA N, BUNTING S: Vascular endothelial growth factor, a specific regulator of angiogenesis. Curr Opin Nephrol Hypertens 5:35-44, 1995
3. SHWEIKI D, ITIN A, SCFFER D, KESHET E: Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359:843-845, 1992
4. WEBSTER KA: Regulation of glycolytic enzyme RNA transcriptonal rates by oxygen availability in skeletal muscle cells. Mol Cell Biochem 77:19-28, 1987
5. GRAVEN KK, TROXLER RF, KORNFELD H, PANCHENKO MV, FARBER HW: Regulation of endothelial cell glyceraldehyde-3-phosphate dehydrogenase expression by hypoxia. J Biol Client 269:2446-24453, 1994
6. WANG GL, SEMENZA GL: General involvement of hypoxia-inducible factor 1 in transcriptional response to hyopxia. Proc Natl Acad Sci USA 90:4304-4308, 1993
7. WEBSTER KA, DISHER DJ, BISHOPRIC NH: Induction and nuclear accumulation of fos and jun proto-oncogenes in hypoxic cardiac myocytes. J Biol Chem 286:16852-16858, 1993
8. SHIMA DT, DEUTSCH U, D'AMORE PA: Hypoxic induction of vascular endothelial growth factor (VEGF) in human epithelial cells is mediated by increases in mRNA stability. FEBS 370:203-208, 1995
9. GOLDBERG MA, SCHNEIDER TJ: Similarities between the oxygensensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin. J Biol Chem 269:4355-4359, 1994
10. LEVY AP, LEVY NS, LOSCALZO J, CALDERONE A, TAKAHASHI N, KIANG-TECK Y, KOREN G, COLUCCI WS, GOLDBERG MA: Regulation of vascular endothelial growth factor in cardiac myocytes. Circ Res 76:758-766, 1995
11. IKEDA E, ACHEN MG, BREIER G, RISAU W: Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells. J Biol Chem 270:19761-19766, 1995
12. BROGI E, Wu T, NAMIKI A, ISNER JM: Indirect angiogenic cytokines upregulate VEGF and bFGF gene expression in vascular smooth muscle cells, whereas hypoxia upregulates VEGF expression only. Circulation 90:649-652, 1994
13. MINCHENKO A, BAUEK T, SALCEDA S, CARO J: Hypoxic stimulation of vascular endothelial growth factor expression in vitro and in vivo. Lab Invest 71:374-379, 1994
14. SANDNER P, GESS B, WOLF K, KURTZ A: Divergent regulation of vascular endothelial growth factor and of erythropoietin gene expression in vivo. Pflügers Arch 431:905-912, 1996
15. TUDER RM, FLOOK BE, VOELKL NF: Increased gene expression for VEGF and the VEGF receptors KDR/Flk and Fit in lungs exposed to acute o to chronic hypoxia. J Clin Invest 95:1798-1807, 1995
16. ULLRICH A, SCHLESSINGER J: Signal transduction by receptors with tyrosine kinase activity. Cell 61:203-212, 1990
17. TERMAN BI, VERMAZEN MD, CARRION ME, DIMITROV D, ARMELLINO DC, GOSPODAROWICZ D, BOHLEN P: Identification of the KDR tyrosine kinase as a receptor for vascular endothelial growth factor. Biochem Biophys Res Commun 187:1579-1586, 1992
18. DEVRIES C, ESCOBEDO JA, UENO H, HOUCK KA, FERRARA N, WILLIAMS LT: The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science 255:989-991, 1992
19. QUINN T, PETERS KG, DEVRIES C, FERRARA N, WILLIAMS LT: Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium. Proc Natl Acad Sci USA 90:7533-7537, 1993
20. PAJUSOLA K, APRELIKOVA O, KORHONEN J, KAIPAINEN A, PERTOVAARA L, ALITALO R, ALITALO K: Flt-4 receptor tyrosine kinase contains seven immunglobulin-like loops and is expressed in multiple human tissues and cell lines. Cancer Res 52:5738-5743, 1992
21. ROSNET O, MARCHETTO S, DE LAPEYRIERE O, BIRNBAUM D: Murine Flt-3, a gene encoding a novel tyrosine kinase receptor of the PDGFR/CSF-1R familiy. Oncogene 6:1641-1650, 1991
22. KAIPAINEN A, JORHONEN J, PAJUSOLA K, APRELIKOVA O, PERSIC MG, TERMAN BI, ALITALO K: The related flt4, flt1 and KDR receptor tyrosine kinases show distinct expression pattern in human fetal endothelia cells. J Expr Med 178:2077-2088, 1993
23. TISCHER E, MITCHELL R, HARTMANN T, SILVA M, GOSPODAROWICZ D, FIDDES JC, ABRAHAM JA: The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon spicing. J Biol Chem 266:11947-11954, 1991
24. WALTENBERGER J, CLAESSON-WELSH L, SIEGBAHN A, SHIBUYA M, HELDIN CH: Different signal transduction properties of KDR and Fit1, two receptors for vascular endothelial growth factor. J Biol Chem 269:26988-26995, 1994
25. PARK JE, CHEN HH, WINER J, HOUCK KA FERRARA N: Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Fit-1 but not Flk-1/KDR. J Biol Chem 269:26646-25654, 1994
26. KENDALL RL, WANG G, DISALVO J, THOMAS KA: Specifity of vascular endothelial cell growth factor receptor ligand binding domains. Biochem Biophys Res Commun 201:326-330, 1994
27. LEE J, GRAY A, YUAN J, LUOH SM, ABRAHAM H, WOOD WI: Vascular endothelial growth factor-related protein: A ligand and specific activator of the tyrosine kinase receptor Flt-4. Proc Natl Acad Sci USA 93:1988-1992, 1996
28. ECKARDT KU, PUGH CW, RATCLIFFE PJ, KURTZ A: Oxygen dependent expression of the erythropoietin gene in rat hepatocytes in vitro. Pflügers Arch 423:356-364, 1993
29. SHIBUYA M, YAMAGUCHI S, YAMANE A, IKEDA T, TOJO A, MATSUSHIME H, SATO M: Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (fit) closely related to the fms family. Oncogene 5:519-524, 1990
30. FINNERTY H, KELLEHER K, MORRIS GE, BEAN K, MERBERG DM, KRIZ R, MORRIS JC, SOOKDEO H, TURNER KJ, WOOD CR: Molecular cloning of murine FLT and FLT4. Oncogene 8:2293-2298, 1993
31. LETWIN K, YEE SP, PAWSON T: Novel protein-tyrosine kinase cDNAs related to fps/fes and eph cloned using anti phosphotyrosine antibody. Oncogene 3:621-627, 1988
32. GESS B, SANDNER P, KURTZ A: Differential effects of kinase inhibitors on erythropoietin and vascular endothelial growth factor gene expression in rat hepatocytes. Pflügers Arch 432:426-432, 1996
33. MILLAUER B, WIZIGMANN-VOOS S, SCHNURCH H, MARTINEZ R, MOLLER NP, RISAU W, ULLRICH A: High affinity binding and developmental expression suggest flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell 72:835-846, 1993
34. HU Z, EVARTS RP, FUJIO K, MARSDEN ER, THORGEIRSSON SS: Expression of fibroblast growth factor receptors flg and bek during hepatic ontogenesis and regeneration in the rat. Cell Growth Differ 6:1019-1025, 1995
35. MAXWELL PH, FERGUSON DJ, OSMOND MK, PUGH CW, HERYET A, DOE BG, JOHNSON MH, RATCLIFFE PJ: Expression of a homologously recombined erythropoietin-SV40 T antigen fusion gene in mouse liver: Evidence for erythropoietin production by Ito cells. Blood 84:1823-1830, 1994