Threshold concentrations of endothelin-1: The effects on contractions induced by 5-hydroxytryptamine in isolated rat cerebral and mesenteric arteries

Pharmacology and Toxicology

Volumn 85, Issue 5, 1999, Pages 115-122

  Hempelmann, Ralf G ^a   Pradel, Rainer H E ^a   Mehdorn, H Maximilian ^a   Ziegler, Albrecht ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ENDOTHELIN 1; ENDOTHELIN RECEPTOR; SEROTONIN; VAPIPROST;

ANIMAL EXPERIMENT; ARTERY CONSTRICTION; ARTICLE; BASILAR ARTERY; DOSE RESPONSE; MALE; MAXIMUM ALLOWABLE CONCENTRATION; MESENTERIC ARTERY; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION; SMOOTH MUSCLE CONTRACTILITY; VASCULAR SMOOTH MUSCLE;

ANIMALIA;

EID: 0032885806     PISSN: 09019928     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0773.1999.tb00077.x     Document Type: Article

References (37)

1. Consigny, P. M.: Endothelin-1 increases arterial sensitivity to 5-hydroxytryptamine. Eur. J. Pharmacol. 1990, 186, 239-245.
2. 2/prostaglandin endoperoxid receptor blockade combined in one molecule - I. Biochemical profile in vitro. Thromb. Haemost. 1989, 61, 35-42.
3. De Nucci, G., R. Thomas, P. D'Orléans-Juste, E. Antunes, C. Walder, T. D. Warner & J. R. Vane: Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release or prostacyclin and endothelium-derived relaxing factor. Proc. Natl. Acad. Sci. U.S.A. 1988, 85, 9797-9800.
4. Deng, L. Y., J. S. Li & E. L. Schiffrin: Endothelin receptor subtypes in resistance arteries from humans and rats. Cardiovasc. Res. 1995, 29, 532-535.
5. A-dependent pressor effects and release of prostacyclin induced by endothelins in pulmonary and renal vasculature. J. Cardiovasc. Pharmacol. 1993, 22(Suppl. 8), S235-S238.
6. Feger, G. I., L. Schilling, H. Ehrenreich & M. Wahl: Endothelin-induced contraction and relaxation of rat isolated basilar artery: effect of BQ-123. J. Cereb. Blood Flow Metab. 1994, 14, 845-852.
7. H receptor activation. Res. Exp. Med. 1997, 196, 327-337.
8. Ferro, C.J. & D. J. Webb: The clinical potential of endothelin receptor antagonists in cardiovascular medicine. Drugs 1996, 51, 12-27.
9. Fujitani, Y., H. Ueda, T. Okada, Y. Urade & H. Karaki: A selective agonist of endothelin type B receptor, IRL 1620, stimulates cyclic GMP increase via nitric oxide formation in rat aorta. J. Pharmacol. Exp. Therap. 1993, 267, 683-689.
10. Gray, G. A. & D. J. Webb: The endothelin system and its potential as a therapeutic target in cardiovascular disease. Pharmacol. Therap. 1996, 72, 109-148.
11. Hempelmann, R. G. & A. Ziegler: Endothelium-dependent nor-adrenalinc-induced relaxation of rat isolated cerebral arteries: pharmacological characterization of receptor subtypes involved. Brit. J. Pharmacol. 1993, 110, 1321-1328.
12. Hempelmann, R. G., R. H. E. Pradel, H. L. Barth, H. M. Mehdorn & A. Ziegler: Interactions between vasoconstrictors in isolated human cerebral arteries. Acta Neurochir. 1997, 139, 474-582.
13. Ihara, M., K. Noguchi, T. Saeki, T. Fukuroda, S. Tsuchida, S. Kimura, T. Fukami, K. Ishikawa, M. Nishikibe & M. Yano: Biological profiles of highly potent novel endothelium antagonists selective for the ETA receptor. Life Sci. 1992, 50, 247-255.
14. Itoh, H., N. Hiraoko, H. Higuchi, M. Ito, T. Konishi & T. Nakano: Contractile actions of endothelin-1 in isolated helical strips from rat pulmonary artery: potentiation of serotonin-induced contraction. J. Cardiovasc. Pharmacol. 1992, 20, 1-6.
15. Jackson, W. F., A. König, T. Dambacher & R. Busse: Prostacyclin-induced vasodilation in rabbit heart is mediated by ATP-sensitive potassium channels. Amer. J. Physiol. 1993, 264, H238-H243.
16. B receptor. Brit. J. Pharmacol 1993, 109, 486-490.
17. B receptor antagonist, RES-701-1: effects on isolated blood vessels and small intestine. Eur. J. Pharmacol. 1994, 262, 255-259.
18. Kitazono, T., D. D. Heistad & F. M. Faraci: Dilatation of the basilar artery in response to selective activation of endothelin B-receptors in vivo. J. Pharmacol. Exp. Therap. 1995a, 273, 1-6.
19. Kitazono, T., D. D. Heistad & F. M. Faraci: Enhanced responses of the basilar artery to activation of endothelin-B receptors in stroke-prone spontaneously hypertensive rats. Hypertension 1995b, 25, 490-494.
20. 2 receptor blocking drug on platelets and vascular and airways smooth muscle in vitro. Brit. J. Pharmacol. 1989, 97, 783-794.
21. McPherson, G. A.: Assessing vascular reactivity of arteries in the small vessel myograph. Clin. Exp. Pharmacol. Physiol. 1992, 19, 815-825.
22. B receptors in rat isolated small mesenteric arteries. Brit. J. Pharmacol. 1997, 120, 1376-1382.
23. Moritoki, H., H. Miyano, S. Takeuchi, M. Yamaguchi, T. Hisayama & W. Kondoh: Endothelin-3-induced relaxation of rat thoracic aorta: a role for nitric oxide formation. Brit. J. Pharmacol. 1993, 108, 1125-1130.
24. Mulvany, M.J. & W. Halpern: Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. Circ. Res. 1977, 41, 19-26.
25. Okatani, Y., K. Taniguchi & Y. Sagara: Amplifying effect of endothelin-1 on serotonin-induced vasoconstriction of human umbilical artery. Amer. J. Obst. Gyn. 1995, 172, 1240-1245.
26. Pöch, G., R. J. Reiffenstein, P. Köck & S. N. Pancheva: Uniform characterisation of potentiation in simple and complex situations when agents bind to different molecular sites. Can. J. Physiol Pharmacol 1995, 73, 1574-1581.
27. Rae, G. A., M. Trybulec, G. De Nucci & J. R. Vane: Endothelin-1 releases eicosanoids from rabbit isolated perfused kidney and spleen. J. Cardiovasc. Pharmacol. 1989, 13(Suppl. 5), S89-S92.
28. 2 by endothelin in cultured vascular smooth muscle cells. Biochem. Biophys. Res. Comm. 1989, 158, 279-286.
29. Rubanyi, G. M. & M. A. Polokoff: Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology. Pharmacol. Rev. 1994, 46, 325-415.
30. B-type endothelin receptor. J. Cereb. Blood Flow Metab. 1995, 15, 699-705.
31. Schilling, L., G. I. Feger, H. Ehrenreich & M. Wahl: Cerebrovascular effects of endothelin-3: Modulation of contraction by nitric oxide is independent of endothelin B receptor activation. Neurol. Res. 1996, 18, 281-285.
32. Sharifi, A. M. & E. L. Schiffrin: Endothelin receptors mediating vasoconstriction in rat pressurized small arteries. Can. J. Physiol. Pharmacol. 1996, 74, 934-939.
33. Takase, H., P. Moreau & T. F. Lüscher: Endothelin receptor sub-types in small arteries. Studies with FR139317 and bosentan. Hypertension 1995, 25, 739-743.
34. Wong-Dusting, H.K., M. La & M. J. Rand: Effect of endothelin-1 on responses of isolated blood vessels to vasoconstrictor agonists. J. Cardiovasc. Pharmacol. 1991, 17 (Suppl.), S236-S238.
35. Yanagisawa, M.: The endothelin system. A new target for therapeutic intervention, Circulation 1994, 89, 1320-1323.
36. Yanagisawa, M., H. Kurihara, S. Kimura, Y. Tomobe, M. Kobayashi, Y. Mitsui, Y. Yazaki, K. Goto & T. Masaki: A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 1988, 332, 411-415.
37. Yang, Z., V. Richard, L. von Segesser, E. Bauer, P. Stulz, M. Turina & T. F. Lüscher: Threshold concentrations of endothelin-1 potentiate contractions to norepinephrine and serotonin in human arteries a new mechanism of vasospasm? Circulation 1990, 82, 188-195.