Cerebrovascular effects of endothelin-3: Modulation of contraction by nitric oxide is independent of endothelin B receptor activation

Neurological Research

Volumn 18, Issue 3, 1996, Pages 281-285

  Schilling, Lothar ^a   Feger, Gabriele I ^b   Ehrenreich, Hannelore ^c   Wahl, Michael ^a,c  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

^c UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

basilar artery; Endothelin; endothelium denuded segments; ET(A) blocker; ET(B) blocker; nitric oxide synthase inhibitor

Indexed keywords

ENDOTHELIN 3; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ANIMAL TISSUE; ARTERY CONSTRICTION; ARTERY DILATATION; BASILAR ARTERY; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME INHIBITION; MALE; NONHUMAN; RAT; RECEPTOR BINDING; RECEPTOR BLOCKING;

EID: 0030036732     PISSN: 01616412     EISSN: None     Source Type: Journal    
DOI: 10.1080/01616412.1996.11740421     Document Type: Conference Paper

References (24)

1. Lee M-E, de la Monte SM, Ng S-C, Bloch KD, Quertermous T. Expression of the potent vasoconstrictor endothelin in the human central nervous system. J Clin Invest 1990; 86: 141-147
2. Ehrenreich H, Anderson RW, Ogino Y, Rieckmann P, Costa T, Wood GP, Coligan JE, Kehrl JH, Fauci AS. Selective autoregulation of endothelins in primary astrocyte cultures: endothelin receptor-mediated potentiation of endothelin-1 secretion. New Biol 1991; 3: 135-141
3. Ehrenreich H, Kehrl JH, Anderson RW, Rieckmann P, Vitkovic L, Coligan JE, Fauci AS. A vasoactive peptide, endothelin-3, is produced by and specifically binds to primary astrocytes. Brain Res 1991; 538: 54-58
4. Ehrenreich H, Schilling L. New developments in understanding cerebral vasoregulation and vasospasm. The endothelin-nitric oxide network. Cleveland Clin J Med 1995; 62: 105-116
5. Feger CI, Schilling L, Ehrenreich H, Wahl M. Endothelin induced contraction and relaxation of rat isolated basilar artery: effect of BQ-123. J Cereb Blood Flow Metab 1994; 14: 845-852
6. B-type endothelin receptor. J Cereb Blood Flow Metab 1995; 15: 699-705
7. Feger GI, Schilling L, Ehrenreich H, Wahl M. Opposing effects of endothelin-1 in the isolated rat basilar artery: dominance of the contractile endothelin A receptor subtype. Vasc Res 1996; (submitted)
8. Osol G, Cipolla M, Knutson S. A new method for mechanically denuding the endothelium of small (50-150 μm) arteries with a human hair. Blood Vessels 1989; 26: 320-324
9. Ihara M, Noguchi K, Saeki T, Fukuroda T, Tsuchida S, Kimura S, Fukami T, Ishikawa K, Nishikibe M, Yano M. Biological profiles of highly potent novel endothelium antagonists selective for the ETA receptor. Life Sci 1992; 50: 247-255
10. Urade Y, Fujitani Y, Oda K, Watakabe T, Umemura I, Takai M, Okada T, Sakata K, Karaki H. An endothelin B receptor-selective antagonist: IRL 1038, [Cys11-Cys15]-endothelin 1(11-21). FEBS Lett 1992; 311: 12-16
11. Ishikawa K, Ihara M, Noguchi K, Mase T, Mino N, Saeki T, Fukuroda T, Fukami T, Ozaki S, Nagase T, Nishikibe M, Yano M. Biochemical and pharmacological profile of a potent and selective endothelin B-receptor antagonist, BQ-788. Proc Natl Acad Sci USA 1994;91:4892-4896
12. Mulsch A, Busse R. NG-nitro-L-arginine (N5-[imino(nitroamino) methyl]-L-ornithine) impairs endothelium-dependent dilations by inhibiting cytosolic nitric oxide synthesis from L-arginine. Naunyn-Schmiedeberg's Arch Pharmacol 1990; 341: 143-147
13. Schilling L, Parson AA, Mackert JRL, Wahl M. Effect of L-arginine on haemoglobin-induced inhibition of endothelium-dependent relaxation of isolated cerebral arteries. Acta Neurochir 1990; Suppl. 51: 341-343
14. Mayhan WG. Impairment of endothehum-dependent dilatation of basilar artery during chronic hypertension. Am J Physiol 1990; 259: H1455-HM62
15. Furchgott RF, Vanhoutte PM. Endothelium-derived relaxing and contracting factors. Faseb J 1989; 3: 2007-2018
16. Saijonmaa O, Nyman T, Fyhrquist F. Endothelin-1 stimulates its own synthesis in human endothelial cells. Biochem Biophys Res Commun 1992; 188: 286-291
17. Kanse SM, Takahashi K, Lam H-C, Rees A, Warren JB, Porta M, Molinatti P, Chatei M, Bloom SR. Cytokine stimulated endothelin release from endothelial cells. Life Sci 1991; 48: 1379-1384
18. Cocks TM, Malta E, King SJ, Woods RL, Angus JA. Oxyhaemoglobin increases the production of endothelin-1 by endothelial cells in culture. Eur J Pharmacol 1991; 196: 177-182
19. Bacic F, Uematsu S, McCarron RM, Spatz M. Secretion of immunoreactive endothelin-1 by capillary and microvascular endothelium of human brain. Neurochem Res 1992; 17: 699-702
20. Ehrenreich H, Costa T, Clouse KA, Pluta RM, Ogino Y, Coligan JE, Burd PR. Thrombin is a regulator of astrocytic endothelin-1. Brain Res 1993; 600: 201-207
21. Kraus GE, Bucholz RD, Yoon K-W, Knuepfer MM, Smith KR. Cerebrospinal fluid endothelin-1 and endothelin-3 levels in normal and neurosurgical patients: a clinical study and literature review. Surg Neurol 1991; 35: 20-29
22. Suzuki R, Masaoka H, Hirata Y, Marumo F, Isotani E, Hirakawa K. The role of endothelin-1 in the origin of cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage. J Neurosurg 1992; 77: 96-100
23. Ehrenreich H, Lange M, Near KA, Anneser F, Schoeller LAC, Schmid R, Winkler PA, Kehrl JH, Schmiedek P, Coebel F-D. Long term monitoring of immunoreactive endothelin-1 and endothelin-3 in ventricular cerebrospinal fluid, plasma, and 24-h urine of patients with subarachnoid hemorrhage. Res Exp Med 1992; 192: 257-268
24. Bian L-C, Zhang T-X, Zhao W-G, Shen J-K, Yang G-Y. Increased endothelin-1 in the rabbit model of middle cerebral artery occlusion. Neurosci Lett 1994; 174: 47-50