N-Nitrosodi-n-propylamine induces organ specific mutagenesis with specific expression times in lacZ transgenic mice

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 444, Issue 2, 1999, Pages 309-319

  Itoh, Satoru ^a   Miura, Miki ^a   Itoh, Toshiaki ^b   Miyauchi, Yoshiteru ^c   Suga, Miho ^c   Takahashi, Yukimi ^c   Kasahara, Yoshinori ^c   Yamamura, Eiji ^d   Hirono, Haruyoshi ^d   Shimada, Hiroyasu ^a  

^a Drug Safety Research Laboratory   (Japan)

^b Drug Safety Research Center   (Japan)

^c Teijin 4 3 2 Asahigaoka T   (Japan)

^d Toxicology Laboratories   (Japan)

Author keywords

lacZ; Muta(TM)Mouse; Mutagenicity; N Nitrosodi n propylamine; Transgenic mouse

Indexed keywords

DIPROPYLNITROSAMINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE MUTATION; GENOTOXICITY; MALE; MICRONUCLEUS TEST; MOUSE; MUTAGENICITY; NONHUMAN; PRIORITY JOURNAL; RETICULOCYTE; TISSUE SPECIFICITY; TRANSGENIC MOUSE;

ANIMALS; CARCINOGENS; LAC OPERON; MALE; MICE; MICE, TRANSGENIC; MICRONUCLEUS TESTS; MUTAGENESIS; MUTAGENS; NITROSAMINES; ORGAN SPECIFICITY;

EID: 0032884961     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(99)00062-5     Document Type: Article

References (26)

1. Gossen J.A., de Leeuw W.J.F., Tan C.H.T., Zwarthoff E.C., Berends F., Lohman P.H.M., Knook D.L., Vijg J. Efficient rescue of integrated shuttle vectors from transgenic mice: a model for studying mutations in vivo. Proc. Natl. Acad. Sci. U.S.A. 86:1989;7971-7975.
2. CSGTM (The collaborative study group for the transgenic mouse mutation assay/JEMS-MMS) Organ variation in the mutagenicity of ethylnitrosourea in Muta™Mouse: results of the collaborative study on the transgenic mutation assay by JEMS-MMS. Environ. Mol. Mutagen. 28:1996;363-375.
3. Suzuki T., Itoh S., Nakajima M., Hachiya N., Hara T. Target organ and time-course in the mutagenicity of five carcinogens in MutaMouse; a summary report of the second collaborative study on the transgenic mutation assay by JEMS/MMS. Mutat. Res. (this issue). 444:1999;259-268.
4. IARC, IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, Vol. 17, Some N-Nitroso Compounds, World Health Organization, Lyon, 1978, pp. 177-189.
5. Gold L.S., Slone T.H., Stern B.R., Bernstein L. Comparison of target organs for mutagenic and non-mutagenic chemicals. Mutat. Res. 286:1993;75-100.
6. Noguchi T., Asakura M., Sugiyama T., Matsushima T. N-Nitroso-di-n-propylamine induces micronuclei in partially hepatectomized rat liver but not in mouse bone marrow cells. MMS Commun. 2:1994;79-82.
7. - phages based on galactose sensitivity. Transgenic Res. 3:1994;67-69.
8. - phage. Mutagenesis. 9:1994;183-185.
9. Mientjes E.J., Steenwinkel M.-J.S.T., van Delft J.H.M., Lohman P.H.M., Baan R.A. Comparison of the X-gal- and P-gal-based systems for screening of mutant λlacZ phages originating from the transgenic mouse strain 40.6. Mutat. Res. 360:1996;101-106.
10. Jiao J., Douglas G.R., Gingerich J.D., Soper L.M. Comparison of the molecular characteristics of lacZ transgenic mouse mutations detected by visual and positive selection. Mutat. Res. 372:1996;141-145.
11. Hayashi M., Morita T., Kodama Y., Sofuni T., Ishidate M. Jr. The micronucleus assay with mouse peripheral blood reticulocytes using acridine orange-coated slides. Mutat. Res. 245:1990;245-249.
12. CSGMT (The collaborative study group for the micronucleus test) Micronucleus test with mouse peripheral blood erythrocytes by acridine orange supravital staining: the summary report of the 5th collaborative study by CSGMT/JEMS-MMS. Mutat. Res. 278:1992;83-98.
13. Suzuki T., Itoh T., Hayashi M., Nishikawa Y., Ikezaki S., Furukawa F., Takahashi M., Sofuni T. Organ variation in the mutagenicity of dimethylnitrosamine in Big Blue® mice. Environ. Mol. Mutagen. 28:1996;348-353.
14. - plasmids. Nucleic Acids Res. 20:1992;3254.
15. - phage using a galactose-sensitive E. coli host. BioTechniques. 14:1993;128-130.
16. Ashby J. Transgenic germ cell mutation assays: a small collaborative study. Environ. Mol. Mutagen. 25:1995;1-3.
17. Ashby J., Gorelick N.J., Shelby M.D. Mutation assays in male germ cells from transgenic mice: overview of study and conclusions. Mutat. Res. 388:1997;111-122.
18. Douglas G.R., Jiao J., Gingerich J.D., Soper L.M., Gossen J.A. Temporal and molecular characteristics of lacZ mutations in somatic tissues of transgenic mice. Environ. Mol. Mutagen. 28:1996;317-324.
19. Itoh S., Shimada H. Bone marrow and liver mutagenesis in lacZ transgenic mice treated with hexavalent chromium. Mutat. Res. 412:1998;63-67.
20. Suzuki T., Hayashi M., Sofuni T. Initial experiences and future directions for transgenic mouse mutation assays. Mutat. Res. 307:1994;489-494.
21. Jiao J., Douglas G.R., Gingerich J.D., Soper L.M. Analysis of tissue-specific lacZ mutations induced by N-nitrosodibenzylamine in transgenic mice. Carcinogenesis. 18:1997;2239-2245.
22. Heddle J.A., Shaver-Walker P., Tao K.S., Zhang X.B. Treatment protocols for transgenic mutation assays in vivo. Mutagenesis. 10:1995;467-470.
23. Suzuki T., Hayashi M., Ochiai M., Wakabayashi K., Ushijima T., Sugimura T., Nagao M., Sofuni T. Organ variation in the mutagenicity of MeIQ in Big Blue® lacI transgenic mice. Mutat. Res. 369:1996;45-49.
24. Nishikawa A., Furukawa F., Kasahara K., Lee I.-S., Suzuki T., Hayashi M., Sofuni T., Takahashi M. Comparative study on organ-specificity of tumorigenicity, mutagenicity and cell proliferative activity induced by dimethylnitrosamine in Big Blue® mice. Cancer Lett. 117:1997;143-147.
25. Hakura A., Tsutsui Y., Sonoda J., Kai J., Imade T., Shimada M., Sugihara Y., Mikami T. Comparison between in vivo mutagenicity and carcinogenicity in multiple organs by benzo[a]pyrene in the lacZ transgenic mouse (Muta™Mouse). Mutat. Res. 398:1998;123-130.
26. Suzuki E., Okada M. Metabolic fate of N,N-dipropylnitrosamine and N,N-diamylnitrosamine in the rat, in relation to their lack of carcinogenic effect on the urinary bladder. Gann. 72:1981;552-561.