HLA-DRB1 leprogenic motifs in Nigerian population groups

Clinical and Experimental Immunology

Volumn 118, Issue 1, 1999, Pages 56-62

  Uko, G P ^a,c   Lu, L Y ^b   Asuquo, M A ^a   Fici, D ^c   Maman, S ^c   Awdeh, Z ^c   Udim, E R ^a   Ding, W ^c   Umana, U ^a   Adewole, T ^a   Fraser, Patricia A ^c  

^a NIGERIAN INSTITUTE OF MEDICAL RESEARCH   (Nigeria)

^b KAOHSIUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

HLA DRB1; Leprogenic motif; Leprosy; Net charge; Shared epitope

Indexed keywords

HLA DR ANTIGEN;

ALLELE; ARTICLE; CELLULAR IMMUNITY; COMPLEX FORMATION; ETHNIC GROUP; GENETIC PREDISPOSITION; HLA SYSTEM; HUMAN; HUMAN CELL; LEPROSY; MYCOBACTERIUM LEPRAE; NIGERIA; POPULATION RESEARCH; PRIORITY JOURNAL; PROTECTION; RECEPTOR BINDING;

ADOLESCENT; ADULT; AGED; ALLELES; AMINO ACID MOTIFS; BINDING SITES; EPITOPES; FEMALE; GENE FREQUENCY; HISTOCOMPATIBILITY TESTING; HLA-DR ANTIGENS; HUMANS; LEPROSY; MALE; MIDDLE AGED; NIGERIA;

EID: 0032884556     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1999.01034.x     Document Type: Article

References (35)

1. 1 Nordeen SK, Lopez-Bravo L, Sundaresan TK. Estimated number of leprosy cases in the world. WHO Bull 1992; 70:707-10.
2. 2 Schurr E, Morgan K, Gros P, Skamene E. Genetics of leprosy. Am J Trop Med Hyg 1991; 44 (Suppl.):4-11.
3. 3 National tuberculosis & leprosy control programme. Annual report. Lagos, Nigeria: Federal Ministry of Health, 1995.
4. 4 Abel L, Sanchez FO, Orberti J, Thuc NV, Hoa LV, Lap VD. Susceptibility to leprosy is linked to the human NRAMP1 gene. J Infect Dis 1998; 177:133-45.
5. 5 Dessoukey MW, Sallam T, el-Shiemy S. HLA and leprosy: segregation and linkage study. Int J Dermatol 1996; 35:257-64.
6. 6 De Vries RR. Genetic control of immunopathology induced by Mycobacterium leprae. Am J Trop Med Hyg 1991; 44 (Suppl.):12-16.
7. 7 Mehra NK, Giphart MJ, Taneja V, Mitra DK, Rajalingam R. Variants of HLA-DR2/DR51 group haplotypes and susceptibility to tuberculoid leprosy and pulmonary tuberculosis in Asian Indians. Int J Lepro Other Mycobact Dis 1995; 63:241-8.
8. 8 Van Eden W, de Vries RRP, Mehra NK, Vaidja MC, D'Amaro J, Van Rood JJ. HLA segregation of tuberculoid leprosy: conformation of the DR2 marker. J Infect Dis 1980; 141:693-701.
9. 9 Todd JR, West BC, McDonald JC. Human leukocyte antigen and leprosy: study in northern Louisiana and review. Rev Infect Dis 1990; 12:63-74.
10. 10 Klaster P, de Vries RRP, Soebono H, Bos C, Burher S, Thole JE, Janson AM. Humoral and cellular immune reactivity to recombinant M. leprae antigens in HLA-typed leprosy patients and healthy controls. Int J Lepro Other Mycobact Dis 1997; 65:178-89.
11. 11 Adams E, Britton W, Morgan A, Sergeantson S, Basten A. Individuals from different populations identify multiple and diverse T-cell determinants on mycobacterial HSP70. Scand J Immunol 1994; 39:588-96.
12. 12 Gregersen PK, Silver J, Winchester RJ. The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum 1987; 30:1205-13.
13. 13 Ridley J, Jopling W. Classification of leprosy according to immunity: a five group system. Int J Lepr 1996; 34:255-73.
14. 14 Uko GP, Asuquo MA, Dawkins RL, Udim ER, Banjoko SO, Jaja O. HLA class I phenotype and gene frequencies in parts of southern Nigeria. Dis Markers 1997; 13:123-9.
15. 15 Kimura A, Sasazuki T. Eleventh International Histocompatibility Workshop reference protocol for the HLA DNA-typing technique. In: Tsuji K, Aizawa M, Sasazuki T, eds. Proceedings of the 11th International Histocompatibility Workshop and Conference. New York: Oxford University Press, 1992:397-419.
16. 16 Everitt BS. The analysis of contingency tables. (Monographs on applied probability and statistics). New York: Chapman & Hall Ltd, Halsted Press, 1980:38-66.
17. 17 Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 1959; 22:719-48.
18. 18 Stern LJ, Brown JH, Jardetzky TS, Gorga JC, Urban RG, Strominger JL, Wiley DC. Crystal structure of the human class II MHC protein HLA-DR1 completed with an influenza virus peptide. Nature (Lond) 1996; 368:215-21.
19. 19 Fu XT, Bono CP, Woulfe SL et al. Pocket 4 of the HLA DR (α, β1*0401) molecule is a major determinant of T cell recognition of peptide. J Exp Med 1995; 181:915-26.
20. 20 O'Sullivan D, Arrhenius T, Sidney J et al. On the interaction of promiscuous antigenic peptides with different DR alleles. Identification of common structural motives. J Immunol 1991; 147:2663-9.
21. 21 Alberts B, Bray D, Julian L, Raff M, Roberts K, Watson JD. The chemical components of a cell. In: Molecular biology of the cell, 3rd edn. New York: Garland Publishing Inc., 1994:41.
22. 22 Zerva L, Cizman B, Mehra NK, Alahari SK, Murali R, Smijewski CM, Kamoun M, Monos DS. Arginine at positions 13 or 70-71 in pocket 4 of HLA-DRBI alleles is associated with susceptibility to tuberculoid leprosy. J Exp Med 1996; 183:829-6.
23. 23 Ou D, Mitchell LA, Tingle AJ. A new categorization of HLA DR alleles on a functional basis. Hum Immunol 1998; 59:665-76.
24. 24 Kreiger JI, Karr RW, Grey HM et al. Single amino acid changes in DR and antigen define residues critical for peptide-MHC binding and T cell recognition. J Immunol 1991; 146:2331-40.
25. 25 Soebono H, de Vries RR, Klatser PR, Schreuda GM, Giphart MJ. Associations between HLA-DRB1 alleles and leprosy in an Indonesian population. Int J Lepro Other Mycobact Dis 1997; 65:190-6.
26. 86 HLA-DRB dimorphism in autoantigen presentation to human T cells. Proc Natl Acad Sci USA 1991; 88:7343-7.
27. 27 Demotz S, Barbey C, Corradin G, Amoroso A, Lanzavecchia A. The set of naturally processed peptides displayed by DR molecules is timed by polymorphism of residue 86. Eur J Immunol 1993; 23:425-32.
28. 28 Busch R, Hill CM, Hayhall JD, Lamb JR, Rothbard JB. Effect of natural polymorphisms at residue 86 of the HLA DR8 chain on peptide binding. J Immunol 1991; 147:1292-8.
29. 29 Struyk L, Hawes GE, Haanen JB, de Vries RRP, van den Elsen PJ. Clonal dominance and selection for similar Complementarity Determining Region 3 motifs among T lymphocytes responding to the HLA-DR3 associated Mycobacterium leprae heat shock protein 65-kd peptide 3-13. Hum Immunol 1995; 44:220-7.
30. 30 Wang X, Golkar L, Uyemura K et al. T cells bearing Vβ6 T cell receptors in the cell-mediated immune response to Mycobacterium leprae. J Immunol 1993; 151:7105-16.
31. 31 Mutis T, Cornelisse YE, Datema G, van den Elsen PJ, Ottenhoff TH, de Vries RR. Definition of a human suppressor T-cell epitope. Proc Natl Acad Sci USA 1994; 91:9456-60.
32. + T cells. Clin Immunol Immunopathol 1997; 82:60-67.
33. 33 de Vries RRP, Serjeantson SW, Layrisse Z. Leprosy. In: Albert ED, Baur MP, Mayr WR, eds. Histocompatibility testing. Report on the Ninth International Histocompatibility Workshop and Conference. Berlin: Springer-Verlag, 1984:362-7.
34. 34 Roy S, McGuire W, Mascie-Taylor CGN, Saha B, Hazra SK, Hill AVS, Kwiatkowski D. Tumor necrosis factor promoter polymorphism and susceptibility to lepromatous leprosy. J Infect Dis 1997; 176:530-2.
35. 35 Godal T, Mykestad B, Samuel DR, Myrvang B. Characterization of the cellular immune defect in lepromatous leprosy: a specific lack of circulating Mycobacterium leprae reactive lymphocytes. Clin Exp Immunol 1971; 9:821-31.