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Volumn 40, Issue 9, 1999, Pages 1184-1189

GABA uptake blocker NNC-711 exhibits marked anticonvulsant action in two cortical epileptic models in immature rats

Author keywords

Anticonvulsant; Cerebral cortex; GABA uptake blocker; Ontogeny; Rat

Indexed keywords

1 [2 (BENZHYDRYLIDENEAMINOOXY)ETHYL] 1,2,5,6 TETRAHYDRO 3 PYRIDINECARBOXYLIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; ANTICONVULSIVE AGENT; UNCLASSIFIED DRUG;

EID: 0032880368     PISSN: 00139580     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1528-1157.1999.tb00846.x     Document Type: Article
Times cited : (12)

References (30)
  • 1
    • 0019454782 scopus 로고
    • GABA receptor - Functional considerations and pharmacology
    • Enna SJ. GABA receptor - functional considerations and pharmacology. Biochem Pharmacol 1991;30:907-14.
    • (1991) Biochem Pharmacol , vol.30 , pp. 907-914
    • Enna, S.J.1
  • 2
    • 0024410491 scopus 로고
    • GABAergic mechanisms in the pathogenesis and treatment of epilepsy
    • Meldrum B. GABAergic mechanisms in the pathogenesis and treatment of epilepsy. B J Pharmacol 1989;27(suppl 1):3S-11S.
    • (1989) B J Pharmacol , vol.27 , Issue.SUPPL. 1
    • Meldrum, B.1
  • 3
    • 0026287884 scopus 로고
    • Rational basis for the development of new antiepileptic drugs
    • Mutani R, Cantello R, Gianelli M, Bettucci D. Rational basis for the development of new antiepileptic drugs. Epilepsy Res 1991;suppl 3:23-8.
    • (1991) Epilepsy Res , Issue.SUPPL. 3 , pp. 23-28
    • Mutani, R.1    Cantello, R.2    Gianelli, M.3    Bettucci, D.4
  • 4
    • 0028181832 scopus 로고
    • Effect of a gamma-aminobutyric acid uptake inhibitor, NNC-711, on spontaneous postsynaptic currents in cultured rat hippocampal neurons: Implications for antiepileptic drug development
    • Oh DJ, Dichter MA. Effect of a gamma-aminobutyric acid uptake inhibitor, NNC-711, on spontaneous postsynaptic currents in cultured rat hippocampal neurons: implications for antiepileptic drug development. Epilepsia 1994;35:426-30.
    • (1994) Epilepsia , vol.35 , pp. 426-430
    • Oh, D.J.1    Dichter, M.A.2
  • 5
    • 0030272426 scopus 로고    scopus 로고
    • GABA transporter heterogeneity: Pharmacological and cellular localization
    • Borden LA. GABA transporter heterogeneity: pharmacological and cellular localization. Neurochem Int 1996;29:335-56.
    • (1996) Neurochem Int , vol.29 , pp. 335-356
    • Borden, L.A.1
  • 6
    • 0030055881 scopus 로고    scopus 로고
    • Developmental expression of GABA transporters GAT1 and GAT4 suggests involvement in brain maturation
    • Jursky F, Nelson N. Developmental expression of GABA transporters GAT1 and GAT4 suggests involvement in brain maturation. J Neurochem 1996;67:857-67.
    • (1996) J Neurochem , vol.67 , pp. 857-867
    • Jursky, F.1    Nelson, N.2
  • 7
    • 0028849688 scopus 로고
    • GAT-1, a high-affinity GABA plasma membrane transporter, is localized to neurons and astroglia in the cerebral cortex
    • Minelli A, Brecha NC, Karschin C, DeBiasi S, Conti F. GAT-1, a high-affinity GABA plasma membrane transporter, is localized to neurons and astroglia in the cerebral cortex. J Neurosci 1995;15: 7734-46.
    • (1995) J Neurosci , vol.15 , pp. 7734-7746
    • Minelli, A.1    Brecha, N.C.2    Karschin, C.3    DeBiasi, S.4    Conti, F.5
  • 8
    • 0029836285 scopus 로고    scopus 로고
    • Effects of gamma-aminobutyric acid (GABA) agonists and GABA uptake inhibitors on pharmacosensitive and pharmacoresistant epileptiform activity in vitro
    • Pfeiffer M, Draguhn A, Meierkord H, Heinemann U. Effects of gamma-aminobutyric acid (GABA) agonists and GABA uptake inhibitors on pharmacosensitive and pharmacoresistant epileptiform activity in vitro. Br J Pharmacol 1996;119:569-77.
    • (1996) Br J Pharmacol , vol.119 , pp. 569-577
    • Pfeiffer, M.1    Draguhn, A.2    Meierkord, H.3    Heinemann, U.4
  • 11
    • 0028999957 scopus 로고
    • A review of the preclinical pharmacology of tiagabine: A potent and selective anticonvulsant GABA uptake inhibitor
    • Suzdak PD, Jansen JA. A review of the preclinical pharmacology of tiagabine: a potent and selective anticonvulsant GABA uptake inhibitor. Epilepsia 1995;36:612-26.
    • (1995) Epilepsia , vol.36 , pp. 612-626
    • Suzdak, P.D.1    Jansen, J.A.2
  • 12
    • 0000353470 scopus 로고
    • Tiagabine
    • Levy RH, Mattson RH, Meldrum BS, eds. New York: Raven Press
    • Ostergaard LH, Gram L, Dam M. Tiagabine. In: Levy RH, Mattson RH, Meldrum BS, eds. Antiepileptic drugs. 4th ed. New York: Raven Press, 1995:1057-61.
    • (1995) Antiepileptic Drugs. 4th Ed. , pp. 1057-1061
    • Ostergaard, L.H.1    Gram, L.2    Dam, M.3
  • 14
    • 0026539825 scopus 로고
    • NNC-711, a novel potent and selective gamma-aminobutyric acid uptake inhibitor: Pharmacological characterization
    • Suzdak PD, Frederiksen K, Andersen KE, Sorensen PO, Knutsen L, Nielsen EB. NNC-711, a novel potent and selective gamma-aminobutyric acid uptake inhibitor: pharmacological characterization. Eur J Pharmacol 1992;224:189-98.
    • (1992) Eur J Pharmacol , vol.224 , pp. 189-198
    • Suzdak, P.D.1    Frederiksen, K.2    Andersen, K.E.3    Sorensen, P.O.4    Knutsen, L.5    Nielsen, E.B.6
  • 15
    • 0029127939 scopus 로고
    • Re-evaluation of GABA transport in neuronal and glial cell cultures: Correlation of pharmacology and mRNA localization
    • Borden LA, Smith KE, Vaysse PJ, Gustafson EL, Weinshank RL, Branchek TA. Re-evaluation of GABA transport in neuronal and glial cell cultures: correlation of pharmacology and mRNA localization. Receptors Channels 1995;3:129-46.
    • (1995) Receptors Channels , vol.3 , pp. 129-146
    • Borden, L.A.1    Smith, K.E.2    Vaysse, P.J.3    Gustafson, E.L.4    Weinshank, R.L.5    Branchek, T.A.6
  • 16
    • 0031718318 scopus 로고    scopus 로고
    • Effects of NNC 711, a GABA uptake inhibitor, on pentylenetetrazol-induced seizures in developing and adult rats
    • Kubová H, Haugvicová R, Mareš P. Effects of NNC 711, a GABA uptake inhibitor, on pentylenetetrazol-induced seizures in developing and adult rats. Naunyn Schmiedebergs Arch Pharmacol 1998; 358:334-41.
    • (1998) Naunyn Schmiedebergs Arch Pharmacol , vol.358 , pp. 334-341
    • Kubová, H.1    Haugvicová, R.2    Mareš, P.3
  • 17
    • 0027311213 scopus 로고
    • New model of cortical epileptic foci in freely moving developing rats
    • Soukupová S, Mikolášová R, Kubová H, Mareš P. New model of cortical epileptic foci in freely moving developing rats. Epilepsy Res 1993;15:27-33.
    • (1993) Epilepsy Res , vol.15 , pp. 27-33
    • Soukupová, S.1    Mikolášová, R.2    Kubová, H.3    Mareš, P.4
  • 18
    • 0027346447 scopus 로고
    • Developmental changes of thresholds for cortical epileptic afterdischarges
    • Makal V, Miňová M, Kubová H, Mareš P. Developmental changes of thresholds for cortical epileptic afterdischarges. Physiol Res 1993;42:49-52.
    • (1993) Physiol Res , vol.42 , pp. 49-52
    • Makal, V.1    Miňová, M.2    Kubová, H.3    Mareš, P.4
  • 19
    • 0027180364 scopus 로고
    • Stable anticonvulsant action of benzodiazepines during development in rats
    • Kubová H, Mareš P, Vorlíček J. Stable anticonvulsant action of benzodiazepines during development in rats. J Pharm Pharmacol 1993;45:807-10.
    • (1993) J Pharm Pharmacol , vol.45 , pp. 807-810
    • Kubová, H.1    Mareš, P.2    Vorlíček, J.3
  • 20
    • 0343182988 scopus 로고    scopus 로고
    • Suppression of cortical epileptic afterdischarges in developing rats by anticonvulsants increasing GABAergic inhibition
    • Polášek R, Kubová H, Šlamberová R, Mareš P, Vorlíček J. Suppression of cortical epileptic afterdischarges in developing rats by anticonvulsants increasing GABAergic inhibition. Epilepsy Res 1996;25:177-84.
    • (1996) Epilepsy Res , vol.25 , pp. 177-184
    • Polášek, R.1    Kubová, H.2    Šlamberová, R.3    Mareš, P.4    Vorlíček, J.5
  • 22
    • 0030321511 scopus 로고    scopus 로고
    • Transition between two types of epileptic seizures in developing rats as a sign of progressive epileptogenesis
    • Mareš P, Kubová H, Haugvicová R. Transition between two types of epileptic seizures in developing rats as a sign of progressive epileptogenesis. Epilepsy Res 1996;suppl 12:75-8.
    • (1996) Epilepsy Res , Issue.SUPPL. 12 , pp. 75-78
    • Mareš, P.1    Kubová, H.2    Haugvicová, R.3
  • 23
    • 0015306389 scopus 로고
    • Modification of seizure activity by electrical stimulation: II. Motor seizures
    • Racine RJ. Modification of seizure activity by electrical stimulation: II. Motor seizures. Electroencephalogy Clin Neurophysiol 1972;32:269-79.
    • (1972) Electroencephalogy Clin Neurophysiol , vol.32 , pp. 269-279
    • Racine, R.J.1
  • 24
    • 0017161111 scopus 로고
    • Neurochemical aspects of the ontogenesis of GABAergic neurons in the rat brain
    • Coyle JT, Enna SJ. Neurochemical aspects of the ontogenesis of GABAergic neurons in the rat brain. Brain Res 1976;111:119-33.
    • (1976) Brain Res , vol.111 , pp. 119-133
    • Coyle, J.T.1    Enna, S.J.2
  • 25
    • 0019590060 scopus 로고
    • Postnatal changes of GABAergic and glutamatergic parameters
    • Wong PT, McGeer EG. Postnatal changes of GABAergic and glutamatergic parameters. Dev Brain Res 1981;1:519-30.
    • (1981) Dev Brain Res , vol.1 , pp. 519-530
    • Wong, P.T.1    McGeer, E.G.2
  • 26
    • 0024437301 scopus 로고
    • Ontogeny of high affinity uptake of GABA studied in "minislices" (tissue prisms) of rat cerebral cortex
    • Balcar VJ, Johnston GAR. Ontogeny of high affinity uptake of GABA studied in "minislices" (tissue prisms) of rat cerebral cortex. Dev Brain Res 1989;49:295-9.
    • (1989) Dev Brain Res , vol.49 , pp. 295-299
    • Balcar, V.J.1    Johnston, G.A.R.2
  • 27
    • 0031058314 scopus 로고    scopus 로고
    • Immunoreactivity for GABA plasma membrane transporter, GAT-1, in the developing rat cerebral cortex: Transient presence in the somata of neocortical and hippocampal neurons
    • Yan X-X, Cariaga WA, Ribak CE. Immunoreactivity for GABA plasma membrane transporter, GAT-1, in the developing rat cerebral cortex: transient presence in the somata of neocortical and hippocampal neurons. Dev Brain Res 1997;99:1-19.
    • (1997) Dev Brain Res , vol.99 , pp. 1-19
    • Yan, X.-X.1    Cariaga, W.A.2    Ribak, C.E.3
  • 28
    • 0021885199 scopus 로고
    • Role of the brain stem reticular formation in tonic-clonic seizures: Lesion and pharmacological studies
    • Browning RA. Role of the brain stem reticular formation in tonic-clonic seizures: lesion and pharmacological studies. Fed Proc 1985;44:2425-31.
    • (1985) Fed Proc , vol.44 , pp. 2425-2431
    • Browning, R.A.1
  • 29
    • 0031672046 scopus 로고    scopus 로고
    • Clobazam exerts an anticonvulsant action in immature rats
    • Šlamberová R, Mareš P, Vorlíček J. Clobazam exerts an anticonvulsant action in immature rats. Physiol Res 1998;47:301-5.
    • (1998) Physiol Res , vol.47 , pp. 301-305
    • Šlamberová, R.1    Mareš, P.2    Vorlíček, J.3
  • 30
    • 0030949379 scopus 로고    scopus 로고
    • Anticonvulsant effect of progabide in rats during ontogenesis
    • Staňková L, Kožuchová A, Mareš P. Anticonvulsant effect of progabide in rats during ontogenesis. Physiol Res 1997;46:47-52.
    • (1997) Physiol Res , vol.46 , pp. 47-52
    • Staňková, L.1    Kožuchová, A.2    Mareš, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.