Effects of NNC 711, a GABA uptake inhibitor, on pentylenetetrazol-induced seizures in developing and adult rats

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 358, Issue 3, 1998, Pages 334-341

  Kubová, Hanna ^a   Haugvicová, Renata ^a   Mareš, Parel ^a  

^a INSTITUTE OF PHYSIOLOGY   (Czech Republic)

Author keywords

GABA transporter; NNC 711; Ontogeny; Pentylenetetrazol; Rats; Seizures

Indexed keywords

1 [2 (BENZHYDRYLIDENEAMINOOXY)ETHYL] 1,2,5,6 TETRAHYDRO 3 PYRIDINECARBOXYLIC ACID; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID CARRIER; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; PENTETRAZOLE; UNCLASSIFIED DRUG;

4 AMINOBUTYRIC ACID UPTAKE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CLONIC SEIZURE; CONTROLLED STUDY; DEVELOPMENTAL, AGE AND GROWTH PARAMETERS; DRUG EFFECT; ELECTROCORTICOGRAPHY; ELECTROENCEPHALOGRAM; GRAND MAL SEIZURE; NONHUMAN; ONTOGENY; RAT; SEIZURE;

AGING; ANIMALS; ANTICONVULSANTS; CONVULSANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROENCEPHALOGRAPHY; GABA ANTAGONISTS; INJECTIONS, INTRAPERITONEAL; NIPECOTIC ACIDS; OXIMES; PENTYLENETETRAZOLE; RATS; RATS, WISTAR; SEIZURES;

EID: 0031718318     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00005262     Document Type: Article

References (42)

1. Balcar VJ, Johnston GAR (1987) Ontogeny of GABAergic systems in the brain. In: Redburn DA, Schousboe A (eds) Neurotrophic activity of GABA during development. Liss, New York, pp 96-117
2. Borden LA, Murali Dhar TG, Smith KE, Weinshank RL, Branchek TA, Gluchowski C (1994) Tiagabine, SK&F 89976A, CT-966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur J Pharmacol 269:219-224
3. Browning RA (1985) Role of the brain stem reticular formation in tonic-clonic seizures: lesion and pharmacological studies. Fed Proc 44:2425-2431
4. Browning RA, Nelson DK (1986) Modification of electroshock and pentylenetetrazol seizure pattern in rats after precollicular transections. Exp Neurol 93:546-556
5. Draguhn A, Heinemann U (1996) Different mechanisms regulate IPSC kinetics in early postnatal and juvenile hippocampal cells. J Neurophysiol 76:3983-3993
6. Fariello RG, Varasi M, Smith MC (1995) Valproic acid. Mechanisms of action. In: Levy RH, Mattson RH, Meldrum BS (eds) Antiepileptic drugs, 4th edn. Raven Press, New York, pp 581-588
7. Jursky F, Nelson N (1996) Developmental expression of GABA transporters GAT1 and GAT4 suggests involvement in brain maturation. J Neurochem 67:857-867
8. Krogsgaard-Larsen P, Falch E, Larsson OM, Schousboe A (1987) GABA uptake inhibitors: relevance to antiepileptic drug research. Epilepsy Res 1:77-93
9. Kruger HP, Lehmacher W, Wall KD (1981) The fourfold table. Fischer, Stuttgart
10. Kubová H, Mareš P (1989) Time course of the anticonvulsant action of clonazepam in developing rats. Arch Int Pharmacodyn 298:15-24
11. Kubová H, Mareš P (1991) Anticonvulsant effects of phenobarbital and primidone during ontogenesis in rats. Epilepsy Res 10:148-155
12. Kubová H, Mareš P (1992) The effect of ontogenetic development on the anticonvulsant activity of midazolam. Life Sci 50:1665-1672
13. Kubová H, Mareš P (1993) Anticonvulsant action of oxycarbazepine, hydroxycarbamazepine, and carbamazepine against metrazol-induced motor seizures in developing rats. Epilepsia 34:188-192
14. Kubová H, Mareš P, Vorlíček J (1993) Stable anticonvulsant action of benzodiazepines during development in rats. J Pharm Pharmacol 45:807-810
15. Kubová H, Haugvicová R, Mareš P (1997) Anticonvulsant effect of SL 75 102 in adult and immature rats. Physiol Res 46:73-76
16. Lehmann EL, D'Abrera HJM (1975) Non-parametrics. McGraw Hill, San Francisco
17. Löscher W, Schmidt D (1988) Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations. Epilepsy Res 2:145-181
18. Macdonald RL (1995) Benzodiazepines. Mechanisms of action. In: Levy RH, Mattson RH, Meldrum BS (eds) Antiepileptic drugs, 4th edn. Raven Press, New York, pp 695-703
19. Mareš P (1991) Epileptic phenomena in the immature brain. Physiol Res 40:577-548
20. Mareš P, Haugvicová R (1997) Anticonvulsant action of gabapentin during postnatal development in rats. Epilepsia 38:893-896
21. Mareš P, Marešová D, Schickerová R (1981) Effect of antiepileptic drugs on metrazol convulsions during ontogenesis in the rat. Physiol Bohemoslov 30:113-121
22. Meldrum BS (1975) Epilepsy and gamma-aminobutyric acid mediated inhibition. Int Rev Neurobiol 17:1-36
23. Meldrum BS (1989) GABAergic mechanisms in the pathogenesis and treatment of epilepsy. Br J Clin Pharmacol 27 [Suppl 1]:3S-11S
24. Miller RG (1981) Simultaneous statistical inference. Springer, Berlin Heidelberg New York
25. Minelli A, Brecha NC, Karschin C, DeBiasi S, Conti F (1995) GAT-1, a high affinity GABA plasma membrane transporter, is localized to neurons and astroglia in the cerebral cortex. J Neurosci 15:7734-7746
26. Morselli PL, Bartholini G, Lloyd KG (1986) Progabide. In: Meldrum BS, Porter RJ (eds) New anticonvulsant drugs, John Libbey, London, pp 237-253
27. Mumford JP, Lewis PJ (1991) Vigabatrin. Epilepsy Res [Suppl 3]:161-168
28. Mutani R, Cantello R, Gianelli M, Bettucci D (1991) Rational basis for the development of new antiepileptic drugs. Epilepsy Res [Suppl 3]:23-28
29. Pierce MW, Suzdak PD, Gustavson LE, Mengel HB, McKelvy JF, Mant T (1991) Tiagabine. Epilepsy Res Suppl 3:157-160
30. Pohl M, Mareš P (1987) Flunarizine influences metrazol-induced seizures in developing rats. Epilepsy Res 1:302-305
31. Polášek R, Kubová H, Šlamberová R, Mareš P, Vorlíček J (1996) Suppression of cortical epileptic afterdischarges in developing rats by anticonvulsants increasing GABAergic inhibition. Epilepsy Res 25:177-184
32. Prichard JW, Ransom BR (1995) Phenobarbital. Mechanisms of action. In: Levy RH, Mattson RH, Meldrum BS (eds) Antiepileptic drugs, 4th edn. Raven Press, New York, pp 359-369
33. Rogawski MA, Porter RJ (1990) Antiepileptic drugs: pharmacological mechanisms and clinical efficacy with consideration of promising developmental stage compounds. Pharmacol Rev 42:223-286
34. Schickerová R, Mareš P, Trojan S (1984) Correlation between electrocorticographic and motor phenomena induced by metrazol during ontogenesis in rats. Exp Neurol 84:153-164
35. Staňková L, Kubová H, Mareš P (1992) Anticonvulsant action of lamotrigine during ontogenesis in rats. Epilepsy Res 13:17-22
36. Staňková L, Koźuchová A, Mareš P (1997) Anticonvulsant effect of progabide in rats during ontogenesis. Physiol Res 46:47-52
37. Suzdak PD, Frederiksen K, Andersen KE, Sorensen PO, Knutsen LJS, Nielsen EB (1992) NNC-711, a novel potent and selective GABA uptake inhibitor. Pharmacological characterization. Eur J Pharmacol 223:189-198
38. Swinyard EA (1973) Assay of antiepileptic drug activity in experimental animals. In: Mercier J (ed) International encyclopedia of pharmacology and therapeutics, vol 1. Pergamon, Oxford pp 47-65
39. Velíšek L, Kubová H, Pohl M, Staňková L, Mareš P, Schickerová R (1992) Pentylenetetrazol-induced seizures in rats: an ontogenetic study. Naunyn Schmiedebergs Arch Pharmacol 346:588-591
40. Vergnes M, Marescaux C, Micheletti G, Depaulis A, Rumbach L, Warter JM (1984) Enhancement of spike and wave discharges by GABAmimetic drugs in rats with spontaneous petit-mal-like epilepsy. Neurosci Lett 44:91-94
41. Wong PT, McGeer EG (1981) Postnatal changes of GABAergic and glutamatergic parameters. Dev Brain Res 1:519-530
42. Yan X-X, Cariaga WA, Ribak CE (1997) Immunoreactivity for GABA plasma membrane transporter, GAT-1, in the developing rat cerebral cortex: transient presence in the somata of neocortical and hippocampal neurons. Dev Brain Res 99:1-19