Rapid, sensitive detection of mutant alleles in codon 12 of K-ras by REMS-PCR

BioTechniques

Volumn 27, Issue 3, 1999, Pages 418-422

  Roberts, N J ^a   Impey, H L ^a   Applegate, T L ^a   Fuery, C J ^a   Ward, R L ^b   Todd, Alison V ^a  

^a JOHNSON AND JOHNSON   (United States)

^b ST VINCENT S HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CODON; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; GENE MUTATION; HUMAN; ONCOGENE K RAS; POINT MUTATION; POLYMERASE CHAIN REACTION;

EID: 0032875520     PISSN: 07366205     EISSN: None     Source Type: Journal    
DOI: 10.2144/99273bm04     Document Type: Article

References (3)

1. Al-Mulla, F., J.J. Going, E.T.H.H. Sowden, A. Winter, I.R. Pickford and G.D. Birnie. 1998. Heterogeneity of mutant versus wildtype Ki-ras in primary and metastatic colorectal carcinomas, and association of codon-12 valine with early mortality. J. Pathol. 185:130-138.
2. De Gregorio, L., G. Manenti, M. Incarbone, S. Pilotti, U. Pastorino, M.A. Pierotti and T.A. Dragani. 1998. Prognostic value of loss of heterozygosity and KRAS2 mutations in lung adenocarcinoma. Int. J. Cancer 79:269-272.
3. Ward, R., N. Hawkins, R. O'Grady, C. Sheehan, T. O'Conner, H. Impey, N. Roberts, C. Fuery and A. Todd. 1998. Restriction endonuclease-mediated selective polymerase chain reaction: a novel assay for the detection of K-ras mutations in clinical samples. Am. J. Pathol. 153:373-379.