Antagonism of the aconitine-induced inexcitability by the structurally related Aconitum alkaloids, lappaconitine and ajacine

Brain Research

Volumn 842, Issue 2, 1999, Pages 332-341

  Ameri, Angela ^a   Simmet, Thomas ^a  

^a UNIVERSITY OF ULM   (Germany)

Author keywords

Aconitum alkaloid; Electrophysiology; Epileptiform activity; Hippocampus

Indexed keywords

ACONITINE; ALKALOID; LAPPACONITINE; MAGNESIUM ION; POTASSIUM ION; SODIUM CHANNEL; SODIUM ION;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; EPILEPTIC DISCHARGE; EXCITABILITY; EXCITATORY POSTSYNAPTIC POTENTIAL; HIPPOCAMPUS; MALE; NERVE CELL; NEUROTRANSMISSION; NONHUMAN; PRESYNAPTIC NERVE; PRIORITY JOURNAL; RAT;

ACONITINE; ALKALOIDS; ANALGESICS, NON-NARCOTIC; ANIMALS; EVOKED POTENTIALS; EXCITATORY POSTSYNAPTIC POTENTIALS; HIPPOCAMPUS; MALE; MOLECULAR STRUCTURE; NEURONS; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS;

EID: 0032875318     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(99)01838-7     Document Type: Article

References (24)

1. Ameri A. Structure-dependent differences in the effects of the Aconitum alkaloids lappaconitine, N-deacetyllappaconitine and lappaconidine in rat hippocampal slices. Brain Res. 769:1997;36-43.
2. Ameri A. The effects of Aconitum alkaloids on the central nervous system. Prog. Neurobiol. 56:1998;211-235.
3. Ameri A., Metzmeier P., Peters T. Frequency-dependent inhibition of neuronal activity by lappaconitine in normal and epileptic hippocampal slices. Br. J. Pharmacol. 118:1996;577-584.
4. Ameri A., Shi Q., Aschhoff J., Peters T. Electrophysiological effects of aconitine in rat hippocampal slices. Neuropharmacology. 35:1996;13-22.
5. 2+ currents in apical dendrites. Hippocampus. 6:1996;79-95.
6. Apland J.P., Cann F. Anticonvulsant effects of memantine and MK-801 in guinea pig hippocampal slices. Brain Res. Bull. 37:1995;311-316.
7. Catterall W.A. Neurotoxins that act on the voltage-sensitive sodium channels in excitable membranes. Annu. Rev. Pharmacol. Toxicol. 20:1980;15-43.
8. + channels: local anesthetics, antiarrhythmics and anticonvulsants. Trends Pharmacol. Sci. 8:1987;57-65.
9. Catterall W.A. Cellular and molecular biology of voltage-gated sodium channels. Physiol. Rev. 72:1992;15-48.
10. Jung H.Y., Mickus T., Spruston N. Prolonged sodium channel inactivation contributes to dendritic action potential attenuation in hippocampal pyramidal neurons. J. Neurosci. 17:1997;6639-6646.
11. Ono M., Satoh T. Pharmacological studies of lappaconitine. Arzneim.-Forsch./Drug Res. 38:1988;892-895.
12. Ono M., Satoh T. Pharmacological studies of lappaconitine: occurrence of analgesic effect without opioid receptor. Res. Commun. Chem. Pathol. Pharmacol. 12:1989;13-25.
13. Ono M., Satoh T. Pharmacological studies of lappaconitine. Analgesia produced by intacerebroventricular, intracisternal and intrathecal injections. J. Pharmacobio.-Dyn. 13:1990;374-377.
14. Ono M., Satoh T. Pharmacological studies of lappaconitine: supraspinal interaction in antinociception. Arch. int. Pharmacodyn. 309:1991;32-41.
15. Ono M., Satoh T. Pharmacological studies of lappaconitine: antinociception and inhibition of the spinal action of substance P and somatostatin. Jpn. J. Pharmacol. 55:1991;523-530.
16. Ono M., Satoh T. Pharmacological studies of lappaconitine: possible interaction with the endogenous noradrenergic and serotonergic pathways to induce antinociception. Jpn. J. Pharmacol. 58:1992;251-257.
17. Rogawski M.A., Porter R.J. Antiepileptic drugs: pharmacological mechanisms and clinical efficacy with consideration of promising developmental stage compounds. Pharmacol. Rev. 42:1990;223-286.
18. 3H ] noradrenaline uptake of the Aconitum alkaloids 3-acetylaconitine, lappaconitine, and N-deacetyllappaconitine in rat hippocampus Biochem. Pharmacol. 55:1998;883-888.
19. Shimidzu T., Itoh Y., Tatsumi S., Hayashi S., Ukai Y., Yoshikuni Y., Kimura K. Blockade of voltage-sensitive sodium channels by NS-7, a novel neuroprotective compound, in the rat brain. Naunyn-Schmiedeberg's Arch. Pharmacol. 355:1997;601-608.
20. Stuart G.J., Sakmann B. Active propagation of somatic action potentials into neocortical pyramidal cell dendrites. Nature. 367:1994;69-72.
21. Stuart G.J., Sakmann B. Amplification of EPSPs by axosomatic sodium channels in neocortical pyramidal neurons. Neuron. 15:1995;1065-1076.
22. Ulbricht W. Effects of veratridine on sodium currents and fluxes. Rev. Physiol. Biochem. Pharmacol. 133:1998;1-54.
23. Valeev A.E., Verkhratskii A.N., Dzhakhangirov F.N. Effects of allapanine on sodium currents in neurons isolated from the rat trigeminal ganglion and cardiomyocytes. Neirofiziologiya. 22:1990;201-206.
24. 3H ] batrachotoxinin A 20-a benzoate to sodium channels by the anticonvulsant drugs diphenylhydantoin and carbamazepine Mol. Pharmacol. 22:1982;627-635.