A gene promotes anxiety in mice - And also in scientists

Nature Medicine

Volumn 5, Issue 10, 1999, Pages 1131-1132

  Mcnaughton, Neil ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; ANXIOLYTIC AGENT; BARBITURIC ACID DERIVATIVE; BENZODIAZEPINE; MEPROBAMATE; RECEPTOR SUBUNIT;

AMYGDALOID NUCLEUS; ANXIETY NEUROSIS; AVOIDANCE BEHAVIOR; GENE CONTROL; GENETIC ANALYSIS; GENETIC PREDISPOSITION; HIPPOCAMPUS; HUMAN; MESENCEPHALON; MOUSE; NONHUMAN; PERIAQUEDUCTAL GRAY MATTER; PHOBIA; PRIORITY JOURNAL; SHORT SURVEY; THREAT;

ANIMALS; ANXIETY DISORDERS; DIAZEPAM; DISEASE MODELS, ANIMAL; MICE; MICE, MUTANT STRAINS; MODELS, PSYCHOLOGICAL; PERSONALITY DISORDERS; RECEPTORS, GABA-A;

EID: 0032874489     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/13455     Document Type: Short Survey

References (10)

1. A-receptor clustering results in enhanced anxiety and a bias for threat cues. Nature Neurosci. 2, 833-839 (1999).
2. Blanchard, R. J., Griebel, G., Henrie, J. A. & Blanchard, D. C. Differentiation of anxiolytic and panicolytic drugs by effects on rat and mouse defense test batteries. Neurosci. Biobehav. Rev. 21, 783-789 (1997).
3. Gray, J. A. & McNaughton, N. in Perspectives on Anxiety, Panic and Fear (ed. Hope, D.A.) 61-134 (University of Nebraska Press, Nebraska, 1998).
4. Gray, J.A. & McNaughton, N. in The neuropsychology of anxiety: an enquiry into the functions of the septohippocampal system 2nd edition (Oxford University Press, Oxford, in the press).
5. Graeff, F.G. Neuroanatomy and neurotransmitter regulation of defensive behaviors and related emotions in mammals. Braz. J. Med. Biol. Res. 27, 811-829 (1994).
6. Davis, M. The role of the amygdala in fear-potentiated startle: implications for animal models of anxiety. Trends in Pharmacological Science 13 35-41, (1992).
7. Andrews, G., Stewart, G., Morris-Yates, A., Holt, P. & Henderson, S. Evidence for a general neurotic syndrome. Br. J. Psychiatr. 157, 6-12 (1990).
8. Anagnostaras, S. G., Craske, M. G. & Fanselow, M. S. Anxiety: at the intersection of genes and experience. Nature Neurosci. 2, 780-782 (1999).
9. McNaughton, N. Cognitive dysfunction resulting from hippocampal hyperactivity - a possible cause of anxiety disorder? Pharmacol. Biochem. Behav. 56, 603-611 (1997).
10. Pan, W. X. & McNaughton, N. The medial supra-mammillary nucleus, spatial learning and the frequency of hippocampal theta activity. Brain Res. 764, 101-108 (1997).