Developmental effects of plasticizer butyl benzyl phthalate after a single administration in rats

Journal of Applied Toxicology

Volumn 19, Issue 5, 1999, Pages 357-365

  Ema, Makoto ^a   Miyawaki, Emiko ^a   Kawashima, Kunio ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

Butyl benzyl phthalate; Developmental toxicity; Embryolethality; Foetal malformation; Phthalic acid ester; Rat; Teratogenicity

Indexed keywords

PHTHALIC ACID ESTER; PLASTICIZER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MALFORMATION; CERVICAL SPINE; CLEFT PALATE; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; EMBRYO; EMBRYOTOXICITY; FEMALE; FETUS; INTRAGASTRIC DRUG ADMINISTRATION; NONHUMAN; ORGANOGENESIS; PRIORITY JOURNAL; RAT; TERATOGENICITY;

ANIMALS; BODY WEIGHT; EMBRYO LOSS; EMBRYONIC AND FETAL DEVELOPMENT; FEMALE; FETUS; GESTATIONAL AGE; INTUBATION, GASTROINTESTINAL; MALE; PHTHALIC ACIDS; PLASTICIZERS; PREGNANCY; RATS; RATS, WISTAR; TIME FACTORS;

ANIMALIA;

EID: 0032873344     PISSN: 0260437X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1263(199909/10)19:5<357::AID-JAT589>3.0.CO;2-X     Document Type: Article

References (32)

1. J. Autian, Toxicity and health threats of phthalate esters: review of the literature. Environ. Health Perspect. 4, 3-26 (1973).
2. CIRC (Cosmetic Ingredient Review Committee), Final report on the safety assessment of butyl benzyl phthalate. J. Am. Coll. Toxicol. 11, 1-23 (1992).
3. F. L. Mayer, Jr., D. L. Stalling and J. L. Johnson, Phthalate esters as environmental contaminants. Nature 238, 411-413 (1972).
4. C. S. Giam, H. S. Chan, G. S. Neff and E. L. Atlas, Phthalate ester plasticizers: a new class of marine pollutant. Science 199, 419-421 (1978).
5. D. T. Williams, Dibutyl- and di-(2-ethylhexyl)phthalate in fish. J. Agric. Food Chem. 21, 1128-1129 (1973).
6. G. H. Tan, Residue levels of phthalate esters in water and sediment samples from the Klang River basin. Bull. Environ. Contam. Toxicol. 54, 171-176 (1995).
7. S. Jobling, T. Reynolds, R. White, M. G. Parker and J. P. Sumpter, A variety of environmentally persistent chemicals, including some phthalate plasticizers, are weakly estrogenic. Environ. Health Perspect. 103, 582-587 (1995).
8. C. Sonnenschein, A. M. Soto, M. F. Fernandez, N. Olea, F. Olea-Serrano and M. D. Ruiz-Lopez, Development of a marker of estrogenic exposure in human serum. Clin. Chem. 41, 1888-1895 (1995).
9. A. M. Soto, C. Sonnenschein, K. L. Chung, M. F. Fernandez, N. Olea and F. O. Serrano, The E-screen assay as a tool to identify estrogens: an update on estrogenic environmental pollutants. Environ. Health Perspect. 103, 113-122 (1995).
10. C. A. Harris, P. Hunt, M. G. Parker and J. P. Sumpter, The estrogenic activity of phthalate esters in vitro. Environ. Health Perspect. 105, 802-811 (1997).
11. N. G. Coldham, M. Dave, S. Sivapathasundaram, D. P. McDonnell, C. Connor and M. J. Sauer, Evaluation of a recombinant yeast cell estrogen screening assay. Environ. Health Perspect. 105, 734-742 (1997).
12. C. J. Price, E. A. Field, M. C. Marr, C. B. Myers and R. E. Morrissey, Final report on the developmental toxicity of butyl benzyl phthalate (CAS No. 85-68-7) in CD-1 Swiss mice. NTP Report 90-114 (1990).
13. E. A. Field, C. J. Price, M. C. Marr, C. B. Myers, R. E. Morrissey and B. A. Schwetz, Developmental toxicity evaluation of butyl benzyl phthalate (CAS No. 85-68-7) administered in feed to CD rats on gestational days 6 to 15. Final Study Report: NTP/NIES Contact No. N01-ES-9-5255 (1989).
14. M. Ema, T. Murai, T. Itami and H. Kawasaki, Evaluation of the teratogenic potential of the plasticizer butyl benzyl phthalate in rats. J. Appl. Toxicol. 10, 339-343 (1990).
15. M. Ema, T. Itami and H. Kawasaki, Effect of period of exposure on the developmental toxicity of butyl benzyl phthalate in rats. J. Appl. Toxicol. 12, 57-61 (1992).
16. M. Ema, T. Itami and H. Kawasaki, Teratogenic evaluation of butyl benzyl phthalate in rats by gastric intubation. Toxicol. Lett. 61, 1-7 (1992).
17. M. Ema, T. Itami and H. Kawasaki, Teratogenic phase specificity of butyl benzyl phthalate in rats. Toxicology 79, 11-19 (1993).
18. M. Ema, R. Kurosaka, H. Amano and Y. Ogawa, Comparative developmental toxicity of n-butyl benzyl phthalate and di-n-butyl phthalate in rats. Arch. Environ. Contam. Toxicol. 28, 223-228 (1995).
19. A. H. Piersma, A. Verhoef and P. M. Dortant, Evaluation of the OECD 421 reproductive toxicity screening test protocol using butyl benzyl phthalate. Toxicology 99, 191-197 (1995).
20. S. Kawamura, A. Hirohashi, T. Kato and M. Yasuda, Bone-staining technique for fetal rat specimens without skinning and removing adipose tissue. Congenital Anomalies (Senten ljo) 30, 93-95 (1990).
21. J. G. Wilson, Methods for administering agents and detecting malformations in experimental animals. In Teratology - Principles and Techniques, ed. by J. G. Wilson and J. Warkany, pp. 262-277. University of Chicago Press, Chicago, IL (1965).
22. D. A. Eigenberg, H. P. Bozigian, D. E. Carter and I. G. Sipes, Distribution, excretion, and metabolism of butylbenzyl phthalate in the rat. J. Toxicol. Environ. Health 17, 445-456 (1986).
23. H. Mikuriya, I. Ikemoto and A. Tanaka, Urinary metabolites contributing to testicular damage induced by butylbenzyl phthalate. Jikeikai Med. J. 35, 403-409 (1988).
24. P. W. Albro and B. Moore, Identification of the metabolites of simple phthalate diesters in rat urine. J. Chromatogr. 94, 209-218 (1974).
25. 14C in the rat. J. Agric. Food Chem. 23, 854-858 (1975).
26. A. Tanaka, A. Matsumoto and T. Yamaha, Biochemical studies on phthalic esters. III. Metabolism of dibutyl phthalate (DBP) in animals. Toxicology 9, 109-123 (1978).
27. M. Ema, R. Kurosaka, H. Amano and Y. Ogawa, Developmental toxicity evaluation of mono-n-butyl phthalate in rats. Toxicol. Lett. 78, 101-106 (1995).
28. M. Ema, A. Harazono, E. Miyawaki and Y. Ogawa, Developmental toxicity of mono-n-benzyl phthalate, one of the major metabolites of the plasticizer n-butyl benzyl phthalate, in rats. Toxicol. Lett. 86, 19-25 (1996).
29. M. Ema, R. Kurosaka, A. Harazono, H. Amano and Y. Ogawa, Phase specificity of developmental toxicity after oral administration of mono-n-butyl phthalate in rats. Arch. Environ. Contam. Toxicol. 31, 170-176 (1996).
30. M. Ema, H. Amano and Y. Ogawa, Characterization of the developmental toxicity of di-n-butyl phthalate in rats. Toxicology 86, 163-174 (1994).
31. M. Ema, A. Harazono, E. Miyawaki and Y. Ogawa, Characterization of developmental toxicity of mono-n-benzyl phthalate in rats. Reprod. Toxicol. 10, 365-372 (1996).
32. M. Ema, A. Harazono, E. Miyawaki and Y. Ogawa, Developmental effects of di-n-butyl phthalate after a single administration in rats. J. Appl. Toxicol. 17, 223-229 (1997).