Nasal nitric oxide in man

Thorax

Volumn 54, Issue 10, 1999, Pages 947-952

  Lundberg, J O N ^a   Weitzberg, E ^b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; ANTIBIOTIC AGENT; ARGININE; CAPSAICIN; CIGARETTE SMOKE; GLUCOCORTICOID; HISTAMINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR;

AIRWAY; EXERCISE; HUMAN; NONHUMAN; NOSE; PRIORITY JOURNAL; REVIEW;

EID: 0032872838     PISSN: 00406376     EISSN: None     Source Type: Journal    
DOI: 10.1136/thx.54.10.947     Document Type: Review

References (69)

1. Moncada S, Higgs A The t.-arginine-nitric oxide pathway. N Engl J Med 1993;329:2002-12.
2. Nathan C, Xie Q-W. Nitric oxide synthases: roles, tolls, and controls. Cell 1994;78:915-8.
3. Archer S. Measurement of nitric oxide in biological models. FASEB J 1993;7:349-60.
4. Gustafsson LE, Leone AM, Person MG, et al. Endogenous nitric oxide is present in the exhaled air of rabbits, guinea pigs and humans. Biochem Biophys Res Commun 1991;181:852-7.
5. Alving K, Weitzberg E, Lundberg JM. Increased amounts of nitric oxide in exhaled air of asthmatics. Eur Respir J 1993;6:1368-70.
6. Lundberg JON, Weitzberg E, Nordvall SL, et al. Primarily nasal origin of exhaled nitric oxide and absence in Kartagener's syndrome Eur Respir J 1994;7:1501-4.
7. Gerlach H, Rossaint R, Pappert D, et al Autoinhalation of nitric oxide after endogenous synthesis in nasopharynx. Lancet 1994;343:518-9.
8. Lundberg JON. Airborne nitric oxide: inflammatory marker and aerocrine messenger in man. Acta Physiol Scand 1996;157:1-27.
9. Lundberg JON, Farkas-Szallasi T, Weitzberg E, et al. High nitric oxide production in human paranasal sinuses. Nature Med 1995;1:370-3.
10. Lundberg JON, Rinder J, Weitzberg E, et al. Nasally exhaled nitric oxide in humans originates mainly in the paranasal sinuses. Acta Physiol Scand 1994:152:431-2.
11. Lundberg JON, Nordvall SL, Weitzberg E, et al. Exhaled NO in pediatric asthma and cystic fibrosis. Arch Dis Child 1996;75:323-6.
12. Baraldi E, Azzolin N, Biban P, et al, Effect of antibiotic therapy on nasal nitric oxide concentration in children with acute sinusitis Am J Respir Crit Care Med 1997;155:1680-3.
13. Schedin U, Roken B, Nyman G, et al. Endogenous nitric oxide in the airways of different animal species. Acta Anaesthesiol Scand 1997;41:1133-41.
14. Lewandowski K, Busch T, Lohbrunner H, et al. Low nitric oxide concentrations in exhaled gas and nasal airways of mammals without paranasal sinuses. J Appl Physiol 1998;85:405-10.
15. Geller DA, Lowenstein CJ, Shapiro RA, et al Molecular cloning and expression of inducible nitric oxide synthase from hepatocytes. Proc Natl Acad Sci USA 1993;90:3491-5.
16. Lundberg JON, Weitzberg E, Rinder J, et al. Calcium-independent and steroid-resistant nitric oxide synthase activity in human paranasal sinus mucosa. Eur Respir J 1996;9:1344-7.
17. Ramis I, Lorente J, Roselló-Catafau J, et al. Differential activity of nitric oxide synthase in human nasal mucosa and polyps. Eur Respir J 1996;9:202-6.
18. Watkins D, Lewis R, Basclain K, et al. Expression and localization of the inducible isoform of nitric oxide synthase in nasal polyp epithelium. Clin Exp Allergy 1998;28:211-9.
19. Fontijin A, Sabadell A, Ronco R. Homogenous chemiluminescent measurement of nitric oxide with ozone: implications for continuous selective monitoring of gaseous air pollutants. Anal Chem 1970;42:575-9.
20. Leone AM, Gustavsson LE, Francis PL, et al. Nitric oxide is present in exhaled breath in humans: direct GC-MS confirmation, Biochem Biophys Res Commun 1994;201:883-7.
21. Lundberg JON, Weitzberg E, Lundberg JM, et al. Nitric oxide in exhaled air. Eur Respir J 1996;9:2671-80.
22. Kharitonov S, Alving K, Barnes PJ. Exhaled and nasal nitric oxide measurements: recommendations. Eur Respir J 1997;10:1683-93.
23. Kimberly B, Nejadnik B, Giraud G, et al. Nasal contribution to exhaled nitric oxide at rest and during breathholding. Am J Respir Crit Care Med 1996;153:829-36.
24. Silkoff P, McClean P, Slutsky A, et al. Marked flow-dependence of exhaled nitric oxide using a new technique to exclude nasal nitric oxide. Am J Respir Crit Care Med 1997;155:260-7.
25. Dubois A, Douglas J, Stìu J, et al Production and absorption of nitric oxide in the nose. J Appl Physiol 1998;84:1217-24.
26. Schedin U, Gustafsson LE, Herin P, et al. Endogenous nitric oxide in the upper airways of healthy new-born infants. Pediatr Res 1996;40:148-51.
27. Lundberg JON, Rinder J, Weitzberg E, et al. Heavy physical exercise acutely decreases nitric oxide levels in the nasal airways in man. Acta Physiol Scand 1996;159:51-7.
28. Imada M, Iwamoto J, Nonaka S, et al. Measurement of nitric oxide in human nasal airway. Eur Respir J 1996;9:556-9.
29. Phillips C, Giraud G, Holden W. Exhaled nitric oxide during exercise: site of release and modulation by ventilation and flow J Appl Physiol 1996;80:1865-71.
30. Yasuda Y, Itoh T, Miyamura M, et al. Comparisons of exhaled nitric oxide and cardiorespiratory indices between nasal and oral breathing during submaximal exercise in humans. Japanese J Physiol 1997;47:465-70.
31. Balfour-Lynn I, Laverty A, Dinwiddle R. Reduced upper airway nitric oxide in cystic fibrosis. Arch Dis Child 1996;75:319-22.
32. Dotsch J, Demirakca S, Terbrack H, et al. Airway nitric oxide in asthmatic children and patients with cystic fibrosis. Eur Respir J 1996;9:2537-40.
33. Lindberg S, Cervin A, Runer T. Nitric oxide (NO) production in the upper airways is decreased in chronic sinusitis. Acta Oto-Laryngol 1997;117:113-7.
34. Martin U, Bryden K, Devoy M, et al. Increased levels of exhaled nitric oxide during nasal and oral breathing in subjects with seasonal rhinitis. J Allergy Clin Immunol 1996;97:768-72.
35. Kharitonov S, Rajakulasingam K, O'Connor B, el al. Nasal nitric oxide is increased in patients with asthma and allergic rhinitis and may be modulated by nasal glucocorticosteroids. J Allergy Clin Immunol 1997;99:58-64.
36. Sato M, Fukuyama N, Sakai M, et al. Increased nitric oxide in nasal lavage fluid and nitrotyrosine formation in nasal mucosa indices for severe perennial nasal allergy Clin Exp Allergy 1998;28:597-605.
37. Arnal J, Didier A, Rami J, et al. Nasal nitric oxide is increased in allergic rhinitis. Clin Exp Allergy 1997;27:347-50.
38. Adisesh L, Kharitonov S, Yates D, et al. Exhaled and nasal nitric oxide is increased in laboratory animal allergy. Clin Exp Allergy 1998;28:876-80.
39. Kirsten A, Jorres R, Kirsten D, et al. Effect of a nasal challenge with endotoxin-containing swine confinement dust on nasal nitric oxide production. Eur J Med Res 1997;2:335-9.
40. Furukawa K, Harrison DG, Saleh D, et al. Expression of nitric oxide synthase in the human nasal mucosa. Am J Respir Crit Care Med 1996;153:847-50.
41. Hamid Q, Springall DR, Riveros-Moreno V, et al. Induction of nitric oxide synthase in asthma. Lancet 1993;342:1510-3.
42. Ferguson E, Eccles R. Changes in nasal nitric oxide concentration associated with symptoms of common cold and treatment with a topical nasal decongestant. Acta Oto-Laryngol 1997;117:614-7.
43. Murphy A, Plattmills T, Lobo M, et al. Respiratory nitric oxide levels in experimental human influenza. Chest 1998;114:452-6.
44. Grunewald C, Carlström K, Kumelin G, et al. Exhaled oral and nasal nitric oxide during t.-arginine infusion in preeclampsia. Gynecol Obstet Invest 1998;46:232-7.
45. Rinder J, Lundberg JON, Änggård A, et al. Effects of topical nasal decongestants, t.-arginine and nitric oxide synthase inhibition on nasal cavity nitric oxide levels and nasal cavity volume in man. Am J Rhinol 1996;10:399-408.
46. Albert J., Schedin U., Lindqvist M., et al. Blockade of endogenous nitric oxide production results in moderate hypertension, reducing sympathetic activity and shortening bleeding time in healthy volunteers. Acta Anaesthesiol Scand 1997;41:1104-13.
47. Robbins R, Millatmal T, Lassi K, et al. Smoking cessation is associated with an increase in exhaled nitric oxide. Chest 1997;112:313-8.
48. Sanders S, Siekierski E, Porter J, et al. Nitric oxide inhibits rhinovirus-induced cytokine production and viral replication in a human respiratory epithelial cell line. J Virol 1998;72:934-42.
49. Mancinelli RL, McKay CP. Effects of nitric oxide and nitrogen dioxide on bacterial growth. Appl Environ Microbiol 1983;46:198-202.
50. Xie Q-W, Nathan C. The high output nitric oxide pathway: role and regulation. J Leucocyte Biol 1994;56:576-82.
51. Jain B, Rubenstein I, Robbins RA, et al. Modulation of airway epithelial cell ciliary beat frequency by nitric oxide. Biochem Biophys Res Commun 1993;191:83-8.
52. Runer T, Cervin A, Lindberg S, et al. Nitric oxide is a regulator of mucociliary activity in the upper respiratory tract. Otolaryngol Head Neck Surg 1998;119:278-87.
53. Lindberg S, Cervin A, Runer T. Low levels of nasal nitric oxide (NO) correlate to impaired mucociliary function in the upper airways. Acta Oto-Laryngol 1997;117:728-34.
54. Lundberg JON, Lundberg JM, Alving K, et al. Nitric oxide and inflammation: the answer is blowing in the wind. Nature Med 1997;3:30-1.
55. Lundberg JON, Hellström PM, Lundberg JM, et al Nitric oxide in ulcerative colitis. Lancet 1995;345:449.
56. Lundberg JON, Hellström PM, Lundberg JM, et al. Greatly increased luminal nitric oxide in ulcerative colitis. Lancet 1994;344:1673-74.
57. Lundberg JON, Adofsson J, Jansson O, et al. Elevated nitric oxide in the urinary bladder in infectious and non-infectious cystitis. Urology 1996;48:700-2.
58. Beckman JS, Beckman TW, Chen J, et al. Apparent hydroxyl radical production by peroxinitrite: implications for endothelial cell injury from nitric oxide. Proc. Natl Acad Sci USA 1990;87:1620-4.
59. McCafferty DM, Mudgett JS, Swain MG, et al. Inducible nitric oxide synthase plays a critical role in resolving intestinal inflammation, Gastroenterology 1997;112:1022-7.
60. Davidson D, Barefield E, Kattwinkel J, et al. Inhaled nitric oxide for the early treatment of persistent pulmonary hypertension of the term new-born: a randomized, double-masked, placebo-controlled, dose-response, multicenter study. The I-NO/PPHN Study Group. Pediatrics 1998;101:325-34.
61. Puybasset L, Rouby J, Mourgeon E, et al. Inhaled nitric oxide in acute respiratory failure: dose-response curves. Intensive Care Med 1994;20:319-27
62. Gerlach H, Rossaint R, Pappert D, et al. Time-course and dose-response of nitric oxide inhalation for systemic oxygenation and pulmonary hypertension in patients with adult respiratory distress syndrome. Eur J Clin Invest 1993;23:499-502.
63. Lundberg JON, Settergren G, Gelinder S, et al. Inhalation of nasally derived nitric oxide modulates pulmonary function in humans. Acta Physiol Scand 1996;158:343-7.
64. Settergren G, Angelin B, Liska J, et al. Lower pulmonary vascular resistance during nasal breathing: modulation by nitric oxide from the paranasal sinuses. Acta Physiol Scand 1998;163:235-9.
65. Lundberg JON, Lundberg JM, Settergren G, et al. Nitric oxide, produced in the upper airways, may act in an aerocrine fashion to enhance pulmonary oxygen uptake in humans. Acta Physiol Scand 1995;155:467-8.
66. Lee K, Tan P, Rico P, et al. Low levels of nitric oxide as contaminant in hospital compressed air: physiologic significance? Crit Care Med 1997;25:1143-6.
67. Pinsky M, Gene F, Lee K, et al. Contamination of hospital compressed air with nitric oxide: unwitting replacement therapy. Chest 1997;111:1759-63.
68. Herulf M, Lundberg JON, Weitzberg E. Nostril widening and arterial oxygenation. Respir Med 1999;93:134-5.
69. Loukides S, Kharitonov S, Wodebouse T, et al. Effect of arginine on mucociliary function in primary ciliary dyskinesia. Lancet 1998;352:371-2.