Heavy physical exercise decreases nitric oxide levels in the nasal airways in humans

Acta Physiologica Scandinavica

Volumn 159, Issue 1, 1997, Pages 51-57

  Lundberg, J O N ^a   Rinder, J ^a,b   Weitzberg, E ^b   Alving, K ^c   Lundberg, J M ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c NONE

Author keywords

Acoustic rhinometry; Exercise; Nitric oxide; Upper airways

Indexed keywords

NITRIC OXIDE;

ARTICLE; CHEMOLUMINESCENCE; CONTROLLED STUDY; EXERCISE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; NOSE CAVITY; PARANASAL SINUS; PRIORITY JOURNAL; RHINOMETRY; TISSUE LEVEL; VOLUNTEER;

EID: 0031012335     PISSN: 00016772     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-201X.1997.68339000.x     Document Type: Article

References (19)

1. Alving, K., Weitzberg, E. & Lundberg, J.M. 1993. Increased amounts of nitric oxide in exhaled air of asthmatics. Eur Resp J 6, 1368-1370.
2. Brenner, I.K.M., Shek, P.N. & Shepard, R.J. 1994. Infection in athletes. Sports Med 17, 86-107.
3. Falck, B., Aust, R., Svanholm, H. & Bäcklund, L. 1989. The effect of physical work on the mucosal blood flow and gas exchange in the human maxillary sinus. Rhinology 27, 241-250.
4. Gerlach, H., Rossaint, R., Pappert, D., Knorr, M. & Falke, K.J. 1994. Autoinhalation of nitric oxide after endogenous synthesis in nasopharynx. Lancet 343, 518-519.
5. Gustafsson, L.E., Leone, A.M., Persson, M.G., Witlund, N.P. & Moncada, S. 1991. Endogenous nitric oxide is present in the exhaled air of rabbits, guinea pigs and humans. Biochem Biophys Res Comm 181, 852-857.
6. Hilberg, O., Jackson, A.C., Swift, D.L. & Pedersen, O.F. 1989. Acoustic rhinometry: evaluation of nasal geometry by acoustic reflection. J Appl Physiol 66 (1), 295-303.
7. Iwamoto, J., Pendergast, D.R., Suzuki, H., Krasney, J.A. 1994. Effect of graded exercise on nitric oxide in expired air in humans. Respir Physiol 97, 333-345.
8. Leaf, C.D., Wishnok, J.S. & Tannenbaum, S.R. 1990. Nitric oxide: the dark side. In: S. Moncada & E.A. Higgs (eds), Nitric Oxide from L-Arginine: a Bioregulatory System, pp. 291-299. Elsevier, Amsterdam.
9. Lundberg, J.O.N., Weitzberg, E., Nordvall, S.L., Kuylenstierna, R., Lundberg, J.M. & Alving, K. 1994a. Primarily nasal origin of exhaled nitric oxide and absence in Kartagener's syndrome. Eur Resp J 7, 1501-1504.
10. Lundberg, J.O.N., Rinder, J., Weitzberg, E., Lundberg, J.M. & Alving, K. 1994b. Nasally exhaled nitric oxide in humans originates mainly in the paranasal sinuses. Acta Physiol Scand 152, 431-432.
11. Lundberg, J.O.N., Farkas-Szallasi, T., Weitzberg, E., Rinder, J., Lidholm, J., Änggård, A., Hökfelt, T., Lundberg, J.M. & Alving, K. 1995. High nitric oxide production in human paranasal sinuses. Nature Med 1, 370-373.
12. Lundberg, J.O.N., Weitzberg, E., Rinder, J., Rudehill, A., Jansson, O., Wiklund, N.P., Lundberg, J.M. & Alving, K. 1996. Calcium-independent and steroid resistant nitric oxide synthase activity in human paranasal sinus mucosa. Eur Resp J 9, 1344-1347.
13. Ohki, M., Hasegawa, M., Kurita, N. & Watanabe, I. 1987. Effects of exercise on nasal resistance and nasal blood flow. Acta Oto-Laryngol 104, 328-333.
14. Persson, M.G., Wiklund, N.P. & Gustafsson, L.E. 1993. Endogenous nitric oxide in single exhalations and the change during exercise. Am Rev Respir Dis 148, 1210-1214.
15. Persson, M.G., Agvald, P. & Gustafsson, L.E. 1994. Detection of nitric oxide in exhaled air during administration of nitroglycerine in vivo. Br J Pharmacol 111, 825-828.
16. Rinder, J. & Lundberg, J.M. 1996 a. Nasal vasoconstriction and decongestant effects of nitric oxide synthase inhibition in the pig. Acta Physiol Scand 157, 233-244.
17. 1-receptor antagonist SR 140.333 on capsaicin-evoked vasodilation in the pig nasal mucosa in vivo. Acta Physiol Scand 156, 115-122.
18. Rinder, J., Lundberg, J.O.N., Änggård, A., Alving, K. & Lundberg, J.M. 1996. Effects of topical nasal decongestants, L-arginine and nitric oxide synthase inhbition on nasal cavity nitric oxide levels and nasal cavity volume in man. Am J Rhinology (in press).
19. Rinder, J., Lundberg, J.O.N., Weitzberg, E., Lundberg, J.M. & Alving, K. 1995. Nitric oxide in human nasal airways decreases during exercise. Endothelium 3, 82.