Nitric oxide in exhaled air

European Respiratory Journal

Volumn 9, Issue 12, 1996, Pages 2671-2680

  Lundberg, J O N ^a   Weitzberg, E ^b   Lundberg, J M ^a   Alving, K ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

asthma; inflammation; inhaled nitric oxide; Kartegener's syndrome; nitric oxide synthase; paranasal sinuses

Indexed keywords

NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ASTHMA; DIAGNOSTIC VALUE; EXHALATION; GAS ANALYSIS; GAS EXCHANGE; HUMAN; PATIENT MONITORING; PNEUMONIA; PRIORITY JOURNAL; REVIEW;

EID: 0029905086     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.96.09122671     Document Type: Review

References (71)

1. Archer S. Measurement of nitric oxide in biological models. FASEB J 1993; 7: 349-360.
2. Gustafsson LE, Leone AM, Persson MG, Wiklund NP, Moncada S. Endogenous nitric oxide is present in the exhaled air of rabbits, guinea-pigs and humans. Biochem Biophys Res Commun 1991; 181: 852-857.
3. Alving K, Weitzberg E, Lundberg JM. Increased amounts of nitric oxide in exhaled air of asthmatics. Eur Respir J 1993; 6: 1368-1370.
4. Lundberg JON, Weitzberg E, Nordvall SL, Kuylenstierna R, Lundberg JM, Alving K. Primarily nasal origin of exhaled nitric oxide and absence in Kartagener's syndrome. Eur Respir J 1994; 7: 1501-1504.
5. Leone AM, Gustavsson LE, Francis PL, Persson MO, Wiklund NP, Moncada S. Nitric oxide is present in exhaled breath in humans: direct GC-MS confirmation. Biochem Biophys Res Commun 1994; 201: 883-887.
6. Borland CDR, Higenbottam TW. A simultaneous single breath measurement of pulmonary diffusing capacity with nitric oxide and carbon monoxide. Eur Respir J 1989; 2: 56-63.
7. Persson MG, Wiklund NP, Gustavsson LE. Endogenous nitric oxide in single exhalations and the change during exercise. Am Rev Respir Dis 1993; 148: 1210-1214.
8. Kimberly B, Nejadnik B, Giraud G, Holden W. Nasal contribution to exhaled nitric oxide at rest and during breathholding. Am J Respir Crit Care Med 1996; 153: 829-836.
9. Rinder J, Lundberg JON, Änggård A, Alving K, Lundberg JM. Effects of topical nasal decongestants, L-arginine and nitric oxide synthase inhibition on nasal cavity nitric oxide levels and nasal cavity volume in man. Am J Rhinology 1996; (in press).
10. Lundberg JON, Rinder J, Weitzberg E, Alving K, Lundberg JM. Heavy physical exercise acutely decreases nitric oxide levels in the nasal airways in man. Acta Physiol Scand 1996; (in press).
11. Borland CDR, Cox Y, Higenbottam TW. Measurement of exhaled nitric oxide in man. Thorax 1993; 48: 1160-1162.
12. Gerlach H, Rossaint R, Pappert D, Knorr M, Falke KJ. Autoinhalation of nitric oxide after endogenous synthesis in nasopharynx. Lancet 1994; 343: 518-519.
13. Lundberg JON, Farkas-Szallasi T, Weitzberg E, et al. High nitric oxide production in human paranasal sinuses. Nature Med 1995; 1: 370-373.
14. Lundberg JON, Rinder J, Weitzberg E, Lundberg JM, Alving K. Nasally-exhaled nitric oxide in humans originates mainly in the paranasal sinuses. Acta Physiol Scand 1994; 152: 431-432.
15. Kharitonov SA, Yates D, Robbins RA, Logan-Sinclair R, Shinebourne EA, Barnes PJ. Increased nitric oxide in exhaled air of asthmatic patients. Lancet 1994; 343: 133-135.
16. Ji X, Hollocher TC. Nitrate reductase of Escherichia coli as a NO-producing nitrite reductase. Biochem Arch 1989; 5: 61-66.
17. Duncan C, Douglas H, Johnston P, et al. Chemical generation of nitric oxide in the mouth from the enterosalivary circulation of dietary nitrate. Nature Med 1995; 1: 546-551.
18. Shaul PW, North AJ, Wu LC, et al. Endothelial nitric oxide synthase is expressed in human bronchial epithelium. J Clin Invest 1994; 94: 2231-2236.
19. Asano K, Chee CBE, Gaston B, et al. Constitutive and inducible nitric oxide synthase gene expression regulation and activity in human lung epithelial cells. Proc Natl Acad Sci USA 1994; 91: 10089-10093.
20. Hamid Q, Springall DR, Riveros-Moreno V, et al. Induction of nitric oxide synthase in asthma. Lancet 1993; 342: 1510-1513.
21. Guo FH, Raeve HRD, Rice TW, Stuehr DJ, Thunnissen FB, Erzurum SC. Continuous nitric oxide synthesis by inducible nitric oxide synthase in normal human airway epithelium in vivo. Proc Natl Acad Sci USA 1995; 92: 7809-7813.
22. Geller DA, Lowenstein CJ, Shapiro RA, et al. Molecular cloning and expression of inducible nitric oxide synthase from hepatocytes. Proc Natl Acad Sci USA 1993; 90: 3491-3495.
23. Lundberg JON, Weitzberg E, Rinder J, et al. Calcium-independent and steroid-resistant nitric oxide synthase activity in human paranasal sinus mucosa. Eur Respir J 1996; 9: 1344-1347.
24. Lundberg JON. Airborne nitric oxide: inflammatory marker and aerocrine messenger in man. Acta Physiol Scand 1996; 157: 1-27.
25. Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEB J 1992; 6: 3051-3064.
26. Xu W, Charles IG, Liu L, Koni PA, Moncada S, Emson P. Molecular genetic analysis of the duplication of human inducible nitric oxide synthase (NOS-2) sequences. Biochem Biophys Res Commun 1995; 212: 466-472.
27. Trolin G, Anden T, Hedenstierna G. Nitric oxide in expired air at rest and during exercise. Acta Physiol Scand 1594; 151: 159-163.
28. Persson MG, Zetterström O, Agrenius V, Ihre E, Gustafsson LE. Single-breath nitric oxide measurements in asthmatic patients and smokers. Lancet 1994; 343: 146-147.
29. Massaro AF, Gaston B, Kita D, Fanta C, Stamler JS, Drazen JM. Expired nitric oxide levels during treatment of acute asthma. Am J Respir Crit Care Med 1995; 152: 800-803.
30. Lundberg JON, Nordvall SL, Weitzberg E, Kollberg H, Alving K. Exhaled NO in pediatric asthma and cystic fibrosis. Arch Dis Childhood 1996; 75: 323-326.
31. Martin U, Bryden K, Devoy M, Howarth P. Increased levels of exhaled nitric oxide during nasal and oral breathing in subjects with seasonal rhinitis. J Allergy Clin Immunol 1996; 97: 768-772.
32. Kharitonov SA, Wells AU, O'Connor BJ, et al. Elevated levels of nitric oxide in bronchiectasis. Am J Respir Crit Care Med 1995; 151: 1889-1893.
33. Alving K, Lundberg JON, Lundberg JM, Nordvall SL, Rak S, Weitzberg E. Nitric oxide in exhaled air: influence of inflammatory airway disease and smoking. Am J Respir Crit Care Med 1994; 149: A199.
34. Kharitonov SA, Yates D, Barnes PJ. Increased nitric oxide in exhaled air of normal human subjects with upper respiratory tract infections. Eur Respir J 1995; 8: 295-297.
35. Aust R, Drettner B. The patency of the maxillary ostium in relation to body posture. Acta Otolaryngol 1975; 80: 443-446.
36. Shechtman FG, Kraus WM, Shaefer SD. Inflammatory diseases of the sinuses. Otolaryngol Clin North Am 1993; 26: 509-516.
37. Kharitonov SA, Logan-Sinclair RB, Busset CM, Shinebourne EA. Peak expiratory nitric oxide difference in men and women: relation to menstrual cycle. Br Heart J 1994; 72: 243-245.
38. Rosselli M, Imthurm B, Macas E, Keller PJ, Dubey RK. Circulating nitrite/nitrate levels increase with follicular development: indirect evidence for estradiol-mediated NO release. Biochem Biophys Res Commun 1994; 202: 1543-1552.
39. Morris NH, Carroll S, Nicolaides KH, Steer PJ, Warren JB. Exhaled nitric oxide concentration and amniotic fluid nitrite concentrations during pregnancy. Eur J Clin Invest 1995; 25: 138-141.
40. Iwamoto J, Pendergast DR, Suzuki H, Krasney JA. Effect of graded exercise on nitric oxide in expired air in humans. Respir Physiol 1994; 97: 333-345.
41. Kharitonov SA, Yates DH, Barnes PJ. Inhaled glucocorticoids decreases nitric oxide in the exhaled air of asthmatic patients. Am J Respir Crit Care Med 1996; 153: 454-457.
42. Kharitonov SA, Lubec G, Lubec B, Hjelm M, Barnes PJ. L-arginine increases exhaled nitric oxide in normal human subjects. Clin Sci 1995; 88: 135-139.
43. Yates DH, Kharitonov SA, Robbins RA, Thomas PS, Barnes PJ. Effect of a nitric oxide synthase inhibitor and a glucocorticosteroid on exhaled nitric oxide. Am J Respir Crit Care Med 1995; 152: 892-896.
44. Persson MG, Cederqvist B, Wiklund CU, Gustafsson LE. Ethanol causes decrements in airway excretion of endogenous nitric oxide in humans. Eur J Pharmacol 1994; 270: 273-278.
45. Persson MG, Agvald P, Gustafsson LE. Detection of nitric oxide in exhaled air during administration of nitroglycerine in vivo. Br J Pharmacol 1994; 111: 825-828.
46. Ohki M, Hasegawa M, Kurita N, Watanabe I. Effects of exercise on nasal resistance and nasal blood flow. Acta Otolaryngol 1987; 104: 328-333.
47. Norman V, Keith CH. Nitrogen oxides in tobacco smoke. Nature 1965; 205: 915-916.
48. Alving K, Fornhem C, Lundberg JM. Pulmonary effects of endogenous and exogenous nitric oxide in the pig: relation to cigarette smoke inhalation. Br J Pharmacol 1993; 110: 739-746.
49. Schedin U, Frostell C, Gustafsson LE. Nitric oxide occurs in high concentrations in monkey upper airways. Acta Physiol Scand 1995; 155: 473-474.
50. Nussler AK, Billiar TR. Inflammation, immunoregulation, and inducible nitric oxide synthase. J Leukocyte Biol 1993; 54: 171-178.
51. Massaro AF, Mehta S, Lilly CM, Kobzic L, Reilly JJ, Drazen JM. Elevated nitric oxide concentrations in isolated lower airway gas of asthmatic subjects. Am J Respir Crit Care Med 1996; 153: 1510-1514.
52. Nathan C, Xie Q-W. Nitric oxide synthases: roles, tolls, and controls. Cell 1994; 78: 915-918.
53. Kharitonov S, O'Connor BJ, Evans DJ, Barnes PJ. Allergen-induced late asthmatic reactions are associated with elevation of exhaled nitric oxide. Am J Respir Crit Care Med 1995; 151: 1894-1899.
54. Lenfant C, Khaltaev N. Global strategy for asthma management and prevention. National Heart, Lung and Blood Institute/World Health Organization work shop report. 1995; pp. 1-8.
55. Schilling J, Holtzer P, Guggenbach M, Gyurech D, Marathia K, Geroulanos S. Reduced endogenous nitric oxide in the exhaled air of smokers and hypertensives. Eur Respir J 1994; 7: 467-471.
56. Lundberg JON, Weitzberg E. Lundberg JM, Alving K. Intragastric nitric oxide production in humans: measurements in expelled air. Gut 1994; 35: 1543-1546.
57. Benjamin N, O'Driscoll F, Dougall H, Duncan C, Smith L, Golden M. Stomach NO synthesis. Nature 1994; 368: 502.
58. Lundberg JON, Hellström PM, Lundberg JM, Alving K. Greatly increased luminal nitric oxide in ulcerative colitis. Lancet 1994; 344: 1673-1674.
59. Lundberg JON, Hellström PM, Lundberg JM, Alving K. Nitric oxide in ulcerative colitis. Lancet 1995; 345: 449.
60. Middleton SJ, Shorthouse M, Hunter JO. Increased nitric oxide synthesis in ulcerative colitis. Lancet 1993; 341: 465-466.
61. Lundberg JON, Adofsson J, Jansson O, et al. Elevated nitric oxide in the urinary bladder in infectious and non-infectious cystitis. Urology 1996; (in press).
62. Mancinelli RL, McKay CP. Effects of nitric oxide and nitrogen dioxide on bacterial growth. Appl Environ Microbiol 1983; 46: 198-202.
63. Jain B, Rubenstein I, Robbins RA, Leishe KL, Sisson JH. Modulation of airway epithelial cell ciliary beat frequency by nitric oxide. Biochem Biophys Res Commun 1993; 191: 83-88.
64. Runer T. Studies of mucociliary activity and blood flow in the upper airways, with special reference to endothelins and nitric oxide. Thesis, University of Lund, Sweden, 1996.
65. Salvemini D, Misko TP, Masferrer JL, Seibert K, Currie MG, Needleman P. Nitric oxide activates cyclo-oxygenase enzymes. Proc Natl Acad Sci USA 1993; 90: 7240-7244.
66. Murell GAC, Jang D, Williams RJ. Nitric oxide activates metalloprotease enzymes in articular cartilage. Biochem Biophys Res Commun 1995; 206: 15-21.
67. Beckman JS, Beckman TW, Chen J, Marshall P, Freeman BA. Apparent hydroxyl radical production by peroxy-nitrite: implications for endothelial cell injury from nitric oxide. Proc Natl Acad Sci USA 1990; 87: 1620-1624.
68. Heiss LN, Lancaster JR Jr, Corbetti JA, Goldman WE. Epithelial autotoxicity of nitric oxide: role in respiratory cytopathology of pertussis. Proc Natl Acad Sci USA 1994; 91: 267-270.
69. Gaston B, Drazen JM, Loscalzo J, Stamler JS. The biology of nitrogen oxides in the airways. Am J Respir Crit Care Med 1994; 149: 538-551.
70. Puybasset L, Rouby J, Mourgeon E, et al. Inhaled nitric oxide in acute respiratory failure: dose-response curves. Intensive Care Med 1994; 20: 319-327.
71. Lundberg JON, Lundberg JM, Settergren G, Alving K, Weitzberg E. Nitric oxide, produced in the upper airways, may act in an aerocrine fashion to enhance pulmonary oxygen uptake in humans. Acta Physiol Scand 1995; 155: 467-468.