The N-end rule pathway is required for import of histidine in yeast lacking the kinesin-like protein Cin8p

Current Genetics

Volumn 36, Issue 3, 1999, Pages 113-123

  Xie, Youming ^a   Varshavsky, Alexander ^a  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

CIN8; HIP1; Histidine import; Kinesin; Proteolysis; Ubiquitin; UBR1

Indexed keywords

CARRIER PROTEIN; HISTIDINE; KINESIN; UBIQUITIN;

AMINO ACID TRANSPORT; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; FUNGAL GENETICS; FUNGUS MUTANT; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; SACCHAROMYCES CEREVISIAE;

EID: 0032872581     PISSN: 01728083     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002940050480     Document Type: Article

References (61)

1. Alagramam K, Naider F, Becker JM (1995) A recognition component of the ubiquitin system is required for peptide transport in Saccharomyces cerevisiae. Mol Microbiol 15:225-234
2. Ausubel FM, Brent R, Kingston RE, Moore DD, Smith JA, Seidman JG, Struhl K (eds) (1996) Current protocols in molecular biology. Wiley-Interscience, New York
3. Baker RT, Varshavsky A (1995) Yeast N-terminal amidase. A new enzyme and component of the N-end rule pathway. J Biol Chem 270:12065-12074
4. Bachmair A, Finley D, Varshavsky A (1986) In vivo half-life of a protein is a function of its amino-terminal residue. Science 234:179-186
5. Bachmair A, Varshavsky A (1989) The degradation signal in a short-lived protein. Cell 56:1019-1032
6. Balzi E, Choder M, Chen W, Varshavsky A, Goffeau A (1990) Cloning and functional analysis of the arginyl-tRNA-protein transferase gene ATEI of Saccharomvces cerevisiae. J Biol Chem 265:7464-7471
7. Bartel B, Wünning I, Varshavsky A (1990) The recognition component of the N-end rule pathway. EMBO J 9:3179-3189
8. Baudin A, Ozier-Kalogeropolous O, Denoel A, Lacroute A, Cullin C (1993) A simple and efficient method for direct gene deletion in Saccharomyces cerevisiae. Nucleic Acids Res 21:3329-3330
9. Baumeister W, Walz J, Zühl F, Seemüller E (1998) The proteasome: paradigm of a self-compartmentalizing protease. Cell 92:367-380
10. Byrd C, Turner GC, Varshavsky A (1998) The N-end rule pathway controls the import of peptides through degradation of a transcriptional repressor. EMBO J 17:269-277
11. Chau V, Tobias JW, Bachmair A, Marriott D, Ecker DJ, Gonda DK, Varshavsky A (1989) A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein. Science 243:1576-1583
12. Chen D-C, Yang B-C, Kuo T-T (1992) One-step transformation of yeast in stationary phase. Curr Genet 21:83-84
13. Coux O, Tanaka K, Goldberg AL (1996) Structure and functions of the 20S and 26S proteasomes. Annu Rev Biochem 65:801-817
14. deGroot RJ, Rümenapf T, Kuhn RJ, Strauss JH (1991) Sindbis virus RNA polymerase is degraded by the N-end rule pathway. Proc Natl Acad Sci USA 88:8967-8971
15. Didion T, Regenberg B, Jørgesen MU, Kielland-Brandt MC, Andersen HA (1998) The permease homologue Ssylp controls the expression of amino-acid and peptide transporter genes in Saccharomyces cerevisiae. Mol Microbiol 27:643-650
16. Dohmen RJ, Wu P, Varshavsky A (1994) Heat-inducible degron: a method for constructing temperature-sensitive mutants. Science 263:1273-1276
17. Galan JM, Moreau V, Andre B, Volland C, Haguenauer-Tsapis R (1996) Ubiquitination mediated by the Npi1p/Rsp5b ubiquitin-protein ligase is required for endocytosis of the yeast uracil permease. J Biol Chem 271:10946-10952
18. Geiser JR, Schott EJ, Kingsbury TJ, Cole NB, Totis LJ, Bhattacharyya G, He L, Hoyt MA (1997) Saccharomyces cerevisiae genes required in the absence of the CIN8-encoded spindle motor act in functionally diverse mitotic pathways. Mol Cell Biol 8:1035-1050
19. Ghislain M, Dohmen RJ, Levy F, Varshavsky A (1996) Cdc48p interacts with Ufd3p, a WD repeat protein required for ubiquitin-mediated proteolysis in Saccharomyces cerevisiae. EMBO J 15:4884-4899
20. Glickman MH, Rubin DM, Fried VA, Finley D (1998) The regulatory particle of the Saccharomyces cerevisiae proteasome. Mol Cell Biol 18:3149-3162
21. Gonda DK, Bachmair A, Wünning I, Tobias JW, Lane WS, Varshavsky A (1989) Universality and structure of the N-end rule. J Biol Chem 264:16700-16712
22. Gonen H, Schwartz AL, Ciechanover A (1991) Purification and characterization of a novel protein that is required for degradation of N-alpha-acetylated proteins by the ubiquitin system. J Biol Chem 266:19221-19231
23. Grauslund M, Didion T, Kielland-Brandt MC, Andersen HA (1995) BAP2, a gene encoding a permease for branched-chain amino acids in Saccharomyces cerevisiae. Biochim Biophys Acta 1269:275-280
24. Hein C, Springael J-Y, Christiane V, Haguenauer-Tsapis R, Andre B (1995) NPI1, an essential yeast gene involved in induced degradation of Gap1 and Fur4 permeases, encodes the Ras5 ubiquitin-protein ligase. Mol Microbiol 18:77-87
25. Hershko A (1991) The ubiquitin pathway for protein degradation. Trends Biochem Sci 16:265-268
26. Hershko A (1997) Roles of ubiquitin-mediated proteolysis in cell cycle control. Curr Opin Cell Biol 9:788-799
27. Herskowitz I, Jensen RE (1991) Putting the HO gene to work: practical uses for mating-type switching. Methods Enzymol 194:132-146
28. Hicke L, Riezman H (1996) Ubiquitination of a yeast plasma membrane receptor signals its ligand-stimulated endocytosis. Cell 84:277-287
29. Hill CP, Johnston NL, Cohen RE (1993) Crystal structure of a ubiquitin-dependent degradation substrate: a three-disulfide form of lysozyme. Proc Natl Acad Sci USA 90:4136-4140
30. Ho AK, Raczniak GA, Ives EB, Wente SR (1998) The integral membrane protein sn11p is genetically linked to yeast nuclear pore complex function. Mol Biol Cell 9:355-373
31. Hochstrasser M (1996) Ubiquitin-dependent protein degradation. Annu Rev Genet 30:405-439
32. Hondermarck H, Sy J, Bradshaw RA, Arfin SM (1992) Dipeptide inhibitors of ubiquitin-mediated protein turnover prevent growth factor-induced neurite outgrowth in rat pheochromocytoma PC12 cells. Biochem Biophys Res Commun 30:280-288
33. Hoyt MA, He L, Loo KK, Saunders WS (1992) Two Saccharomyces cerevisiae kinesin-related gene products required for mitotic spindle assembly. J Cell Biol 118:109-120
34. Jauniaux J-C, Grenson M (1990) GAP1, the general amino-acid permease gene of Saccharomyces cerevisiae: nucleotide sequence, protein similarity with the other bakers yeast amino-acid permeases, and nitrogen catabolite repression. Eur J Biochem 190:39-44
35. Johnson ES, Ma PC, Ota IM, Varshavsky A (1995) A proteolytic pathway that recognizes ubiquitin as a degradation signal. J Biol Chem 270:17442-17456
36. Kwon YT, Reiss Y, Fried VA, Hershko A, Yoon JK, Gonda DK, Sangan P, Copeland NG, Jenkins NA, Varshavsky A (1998) The mouse and human genes encoding the recognition component of the N-end rule pathway. Proc Natl Acad Sci USA 95:7898-7903
37. Madura K, Varshavsky A (1994) Degradation of G-alpha by the N-end rule pathway. Science 265:1454-1458
38. Merrill BJ, Holm C (1998) The RAD52 recombinational repair pathway is essential in po130 (PCNA) mutants that accumulate small single-stranded DNA fragments during DNA synthesis. Genetics 148:611-624
39. Mumberg D, Muller R, Funk M (1994) Regulatable promoters of Saccharomyces cerevisiae - comparison of transcriptional activity and their use for heterologous expression. Nucleic Acids Res 22:5767-5768
40. Ota IM, Varshavsky A (1993) A yeast protein similar to bacterial two-component regulators. Science 262:566-569
41. Peters J-M, King RW, Deshaies RJ (1998) Cell cycle control by ubiquitin-dependent proteolysis. Ubiquitin and the biology of the cell. Plenum Press, New York, pp 345-387
42. Pickart CM (1997) Targeting of substrates to the 26S proteasome. FASEB J 11:1055-1066
43. Posas F, Wurgler-Murphy SM, Maeda T, Witten EA, Thai TC, Saito H (1996) Yeast HOG1 MAP kinase cascade is regulated by a multistep phosphorelay mechanism in the SLN1-YPD1-SSK1 "two-component" osmosensor. Cell 86:865-875
44. Rechsteiner M, Hoffman L, Dubiel W (1993) The multicatalytic and 26S proteases. J Biol Chem 268:6065-6068
45. Roof DM, Meluh PB, Rose MD (1992) Kinesin-related proteins required for assembly of the mitotic spindle. J Cell Biol 118:95-108
46. Rothstein R (1991) Targeting, disruption, replacement, and allele rescue: integrative DNA transformation in yeast. Methods Enzymol 194:281-301
47. Schaffner M, Smith S, Jentsch S (1998) The ubiquitin conjugation system. In: Peters J-M, Harris JR, Finley D (eds) Ubiquitin and the biology of the cell. Plenum Press, New York, pp 65-98
48. Schmitt ME, Brown TA, Trumpower BL (1990) A rapid and simple method for preparation of RNA from Saccharomyces cerevisiae. Nucleic Acids Res 18:3091-3092
49. Sherman F, Fink GR, Hicks JB (1986) Methods in yeast genetics. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York
50. Sijts AJ, Pilip I, Pamer EG (1997) The Listeria monocytogenes-secreted p60 protein is an N-end rule substrate in the cytosol of infected cells. Implications for major histocompatibility complex class-I antigen processing of bacterial proteins. J Biol Chem 272:19261-19268
51. Sikorski RS, Hieter P (1989) A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in S. cerevisiae. Genetics 122:19-27
52. Singer-Kruger B, Ferro-Novick S (1997) Use of a synthetic lethal screen to identify yeast mutants impaired in endocytosis, vacuolar protein sorting and the organization of the cytoskeleton. Eur J Cell Biol 74:365-375
53. Solomon V, Baracos V, Sarraf P, Goldberg A (1998 a) Rates of ubiquitin conjugation increase when muscles atrophy, largely through activation of the N-end rule pathway. Proc Natl Acad Sci USA 95:12602-12607
54. Solomon V, Lecker SH, Goldberg AL (1998 b) The N-end rule pathway catalyzes a major fraction of the protein degradation in skeletal muscle. J Biol Chem 273:25216-25222
55. Taban CH, Hondermarck H, Bradshaw RA, Boilly B (1996) Effect of a dipeptide inhibiting ubiquitin-mediated protein degradation on nerve-dependent limb regeneration in the newt. Experientia 52:865-870
56. Tanaka J, Fink GR (1985) The histidine permease gene (HIP1) of Saccharomyces cerevisiae. Gene 38:205-214
57. Tobias JW, Shrader TE, Rocap G, Varshavsky A (1991) The N-end rule in bacteria. Science 254:1374-1377
58. Varshavsky A (1996) The N-end rule: functions, mysteries, uses. Proc Natl Acad Sci USA 93:12142-12149
59. Varshavsky A (1997) The ubiquitin system. Trends Biochem Sci 22:383-387
60. Varshavsky A, Byrd C, Davydov IV, Dohmen RJ, Du F, Ghislain M, Gonzalez M, Grigoryev S, Johnson ES, Johnsson N, Johnston JA, Kwon YT, Lévy F, Lomovskaya O, Madura K, Ota I, Rümenapf T, Shrader TE, Suzuki T, Turner G, Waller PRH, Webster A (1998) The N-end rule pathway. In: Peters J-M, Harris JR, Finley D (eds) Ubiquitin and the biology of the cell. Plenum Press, New York, pp 223-278
61. Worley CK, Ling R, Callis J (1998) Engineering in vivo instability of firefly luciferase and Escherichia coli beta-glucuronidase in higher plants using recognition elements from the ubiquitin pathway. Plant Mol Biol 37:337-347