메뉴 건너뛰기




Volumn 108, Issue 2-3, 1999, Pages 225-231

Determination of free and glucuronated hexane metabolites without prior hydrolysis by liquid- and gas-chromatography coupled with mass spectrometry

Author keywords

Liquid chromatography mass spectrometry; n Hexane; Phase I and Phase II metabolites

Indexed keywords

ACETONYLACETONE; ALKANONE; DICHLOROMETHANE; GLUCURONIDE; HEXANE; HEXANOL; LACTONE;

EID: 0032871029     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(99)00093-4     Document Type: Article
Times cited : (32)

References (16)
  • 1
    • 0031709780 scopus 로고    scopus 로고
    • Determination of n-hexane metabolites by liquid chromatography/mass spectrometry 1. 2,5-Hexanedione and other phase I metabolites in untreated and hydrolyzed urine samples by atmospheric pressure chemical ionization
    • Andreoli R., Manini P., Mutti A., Bergamaschi E., Niessen W.M.A. Determination of n-hexane metabolites by liquid chromatography/mass spectrometry 1. 2,5-Hexanedione and other phase I metabolites in untreated and hydrolyzed urine samples by atmospheric pressure chemical ionization. Rapid Commun. Mass Spectrom. 12:1998;1410-1416.
    • (1998) Rapid Commun. Mass Spectrom. , vol.12 , pp. 1410-1416
    • Andreoli, R.1    Manini, P.2    Mutti, A.3    Bergamaschi, E.4    Niessen, W.M.A.5
  • 3
    • 0017072068 scopus 로고
    • Characterization of the metabolites of methyl n-butyl ketone, methyl iso-butyl ketone, and methyl ethyl ketone in guinea pig serum and their clearance
    • Di Vincenzo G.D., Kaplan C.J., Dedinas J. Characterization of the metabolites of methyl n-butyl ketone, methyl iso-butyl ketone, and methyl ethyl ketone in guinea pig serum and their clearance. Toxicol. Appl. Pharmacol. 36:1976;511-522.
    • (1976) Toxicol. Appl. Pharmacol. , vol.36 , pp. 511-522
    • Di Vincenzo, G.D.1    Kaplan, C.J.2    Dedinas, J.3
  • 4
    • 0023635286 scopus 로고
    • 4,5-Dihydroxy-2-hexanone: A new metabolite of n-hexane and of 2,5-hexanedione in rat urine
    • Fedtke N., Bolt H.M. 4,5-Dihydroxy-2-hexanone: a new metabolite of n-hexane and of 2,5-hexanedione in rat urine. Biomed. Environ. Mass Spectrom. 14:1987;563-572.
    • (1987) Biomed. Environ. Mass Spectrom. , vol.14 , pp. 563-572
    • Fedtke, N.1    Bolt, H.M.2
  • 5
    • 0023598176 scopus 로고
    • The relevance of 4,5-dihydroxy-2-hexanone in the excretion kinetics of n-hexane metabolites in rat and man
    • Fedtke N., Bolt H.M. The relevance of 4,5-dihydroxy-2-hexanone in the excretion kinetics of n-hexane metabolites in rat and man. Arch. Toxicol. 61:1987;131-137.
    • (1987) Arch. Toxicol. , vol.61 , pp. 131-137
    • Fedtke, N.1    Bolt, H.M.2
  • 7
    • 0025039711 scopus 로고
    • The method of choice for the determination of 2,5-hexanedione as an indicator of occupational exposure to n-hexane
    • Kawai T., Mizunuma K., Yasugy T., Uchida Y., Ikeda M. The method of choice for the determination of 2,5-hexanedione as an indicator of occupational exposure to n-hexane. Int. Arch. Occup. Environ. Health. 62:1990;403-408.
    • (1990) Int. Arch. Occup. Environ. Health , vol.62 , pp. 403-408
    • Kawai, T.1    Mizunuma, K.2    Yasugy, T.3    Uchida, Y.4    Ikeda, M.5
  • 9
    • 0031728768 scopus 로고    scopus 로고
    • Determination of n-hexane metabolites by liquid chromatography/mass spectrometry 2. Glucuronide-conjugates metabolites in untreated urine samples by electrospray ionization. Rapid Commun
    • Manini P., Andreoli R., Mutti A., Bergamaschi E., Niessen W.M.A. Determination of n-hexane metabolites by liquid chromatography/mass spectrometry 2. Glucuronide-conjugates metabolites in untreated urine samples by electrospray ionization. Rapid Commun. Mass Spectrom. 12:1998;1615-1624.
    • (1998) Mass Spectrom. , vol.12 , pp. 1615-1624
    • Manini, P.1    Andreoli, R.2    Mutti, A.3    Bergamaschi, E.4    Niessen, W.M.A.5
  • 13
    • 0019450385 scopus 로고
    • Measurement of the urinary metabolites of n-hexane, cyclohexane and their isomers by gas chromatography
    • Perbellini L., Brugnone F., Silvestri R., Gaffuri E. Measurement of the urinary metabolites of n-hexane, cyclohexane and their isomers by gas chromatography. Int. Arch. Occup. Environ. Health. 48:1981;99-106.
    • (1981) Int. Arch. Occup. Environ. Health , vol.48 , pp. 99-106
    • Perbellini, L.1    Brugnone, F.2    Silvestri, R.3    Gaffuri, E.4
  • 15
    • 0027441003 scopus 로고
    • Biochemical and physiological aspects of 2,5-hexanedione: Endogenous or exogenous product?
    • Perbellini L., Pezzoli G., Brugnone F., Canesi M. Biochemical and physiological aspects of 2,5-hexanedione: endogenous or exogenous product? Int. Arch. Occup. Environ. Health. 65:1993;49-52.
    • (1993) Int. Arch. Occup. Environ. Health , vol.65 , pp. 49-52
    • Perbellini, L.1    Pezzoli, G.2    Brugnone, F.3    Canesi, M.4
  • 16
    • 0029891564 scopus 로고    scopus 로고
    • Method for the simultaneous quantification of n-hexane metabolites: Application to n-hexane metabolism determination
    • Soriano T., Menendez M., Sanz P., Repetto M. Method for the simultaneous quantification of n-hexane metabolites: application to n-hexane metabolism determination. Hum. Exp. Toxicol. 15:1996;497-503.
    • (1996) Hum. Exp. Toxicol. , vol.15 , pp. 497-503
    • Soriano, T.1    Menendez, M.2    Sanz, P.3    Repetto, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.