메뉴 건너뛰기




Volumn 15, Issue 6, 1996, Pages 497-503

Method for the simultaneous quantification of n-hexane metabolites: Application to n-hexane metabolism determination

Author keywords

2,5 hexanodione; bio marker; metabolism; n hexane; urine

Indexed keywords

2 HEXANOL; 2 HEXANONE; 2,5 DIMETHYLFURANE; 5 HEXANEDIOL; ACETONYLACETONE; GAMMA VALEROLACTONE; HEXANE; UNCLASSIFIED DRUG;

EID: 0029891564     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1177/096032719601500607     Document Type: Article
Times cited : (11)

References (32)
  • 1
    • 85007912770 scopus 로고
    • Experimental studies of the effects of n-hexane to albino rats. Japanese Journal of Industrial
    • Kurita H. Experimental studies of the effects of n-hexane to albino rats. Japanese Journal of Industrial Health 1967; 9: 672-677.
    • (1967) Health , vol.9 , pp. 672-677
    • Kurita, H.1
  • 2
    • 85007927065 scopus 로고
    • Electrophysiological studies on the peripheral neurotoxicity of n-hexane. Japanese Journal Industrial
    • Miyagaki H. Electrophysiological studies on the peripheral neurotoxicity of n-hexane. Japanese Journal Industrial Health 1967; 9: 660-671.
    • (1967) Health , vol.9 , pp. 660-671
    • Miyagaki, H.1
  • 3
    • 0016379951 scopus 로고
    • Influence of inducers and inhibitors on the hydroxylation pattern of n-hexane in rat liver microsomes
    • Fromer U., Ullirich V., Orrenius S. Influence of inducers and inhibitors on the hydroxylation pattern of n-hexane in rat liver microsomes. Febs Letters 1974; 41: 14-16.
    • (1974) Febs Letters , vol.41 , pp. 14-16
    • Fromer, U.1    Ullirich, V.2    Orrenius, S.3
  • 4
    • 0017072068 scopus 로고
    • Characterization of the metabolites of methyl-n-butylketone, methyl-iso-butylketone and methylethylketone in guinea pig serum and their clearance
    • Di Vincenzo GD, Kaplan CJ, Dedinas J. Characterization of the metabolites of methyl-n-butylketone, methyl-iso-butylketone and methylethylketone in guinea pig serum and their clearance. Toxicology and Applied Pharmacology 1976; 36: 511-522.
    • (1976) Toxicology and Applied Pharmacology , vol.36 , pp. 511-522
    • Di, V.G.1    Kaplan, C.J.2    Dedinas, J.3
  • 6
    • 0023598176 scopus 로고
    • The relevance of 4, 5-dihydroxy-2-hexanone in the excretion of n-hexane metabolites in rat and man
    • Fedtke N., Bolt MH The relevance of 4, 5-dihydroxy-2-hexanone in the excretion of n-hexane metabolites in rat and man. Archives of Toxicology 1987; 61: 131-137.
    • (1987) Archives of Toxicology , vol.61 , pp. 131-137
    • Fedtke, N.1    Bolt, M.H.2
  • 9
    • 0020362564 scopus 로고
    • An experimental study on the neurotoxicity of 2-octanone and 2-hexanol, a metabolite of n-hexane
    • Misumi J., Nagano M., Nomura S. An experimental study on the neurotoxicity of 2-octanone and 2-hexanol, a metabolite of n-hexane. Japanese Journal of Industrial Health 1982; 24: 475-484.
    • (1982) Japanese Journal of Industrial Health , vol.24 , pp. 475-484
    • Misumi, J.1    Nagano, M.2    Nomura, S.3
  • 10
    • 0021749272 scopus 로고
    • Neurophysiological studies on the relation between the structural properties and neurotoxicity of aliphatic hydrocarbon compounds in rats
    • Misumi J., Nagano M. Neurophysiological studies on the relation between the structural properties and neurotoxicity of aliphatic hydrocarbon compounds in rats. British Journal of Industrial Medicine 1984; 41: (4), 526-532.
    • (1984) British Journal of Industrial Medicine , vol.41 , Issue.4 , pp. 526-532
    • Misumi, J.1    Nagano, M.2
  • 11
    • 0021749113 scopus 로고
    • An electrophysiological study of 2-hexanone and 2, 5-hexanedione neurotoxicity in rats
    • Nachtman JP, Couri D. An electrophysiological study of 2-hexanone and 2, 5-hexanedione neurotoxicity in rats. Toxicology Letters 1984; 23: 141-145.
    • (1984) Toxicology Letters , vol.23 , pp. 141-145
    • Nachtman, J.P.1    Couri, D.2
  • 12
    • 0022404726 scopus 로고
    • Hexacarbon neuropathy: Tracking a toxin
    • Couri D., Milks MM Hexacarbon neuropathy: Tracking a toxin. Neurotoxicology 1985; 6: 65-72.
    • (1985) Neurotoxicology , vol.6 , pp. 65-72
    • Couri, D.1    Milks, M.M.2
  • 14
    • 0019454756 scopus 로고
    • Urinary excretion of the metabolites of n-hexane and its isomers during occupational exposure
    • Perbellini L., Brugnone F., Faggionato G. Urinary excretion of the metabolites of n-hexane and its isomers during occupational exposure. British Journal of Industrial Medicine 1981b; 38: 20-26.
    • (1981) British Journal of Industrial Medicine , vol.38 , pp. 20-26
    • Perbellini, L.1    Brugnone, F.2    Faggionato, G.3
  • 17
    • 0018773401 scopus 로고
    • Toxicological and metabolic studies of methyl n-butylketone, 2, 5-hexanedione, and 2, 5-hexanediol in male rats
    • Eben A. et al. Toxicological and metabolic studies of methyl n-butylketone, 2, 5-hexanedione, and 2, 5-hexanediol in male rats. Ecotoxicology and Environmental Safety 1979; 3: 204-217.
    • (1979) Ecotoxicology and Environmental Safety , vol.3 , pp. 204-217
    • Eben, A.1
  • 20
    • 0021678504 scopus 로고
    • n-Hexane metabolism in occupationally exposed workers
    • Mutti A. et al. n-Hexane metabolism in occupationally exposed workers. British Journal of Industrial Medicine 1984; 41: 533-538.
    • (1984) British Journal of Industrial Medicine , vol.41 , pp. 533-538
    • Mutti, A.1
  • 21
    • 0024214808 scopus 로고
    • Environmental and biological monitoring of exposure to toluene, styrene, and n-hexane
    • De Rosa E. et al. Environmental and biological monitoring of exposure to toluene, styrene, and n-hexane. Applied Industrial Hygiene 1988; 3: 332-337.
    • (1988) Applied Industrial Hygiene , vol.3 , pp. 332-337
    • De, R.E.1
  • 22
    • 0023832233 scopus 로고
    • 2, 5-Hexanedione extraction after occupational exposure to n-hexane
    • Ahonen I., Schimberg RW 2, 5-Hexanedione extraction after occupational exposure to n-hexane. British Journal of Industrial Medicine 1988; 45: 133-136.
    • (1988) British Journal of Industrial Medicine , vol.45 , pp. 133-136
    • Ahonen, I.1    Schimberg, R.W.2
  • 24
    • 0021285942 scopus 로고
    • Head-space sampling and GC analysis of volatile urinary metabolites. Journal of Chromatographic
    • Cert A., Bahima J. Head-space sampling and GC analysis of volatile urinary metabolites. Journal of Chromatographic Science 1984; 22: 7-11.
    • (1984) Science , vol.22 , pp. 7-11
    • Cert, A.1    Bahima, J.2
  • 25
    • 0019833155 scopus 로고
    • Dose-dependent uptake, distribution and elimination of inhalated n-hexane in the Fischer-344 rat
    • Baker TS, Rickert DE Dose-dependent uptake, distribution and elimination of inhalated n-hexane in the Fischer-344 rat. Toxicology and Applied Pharmacology 1981; 61: 414-422.
    • (1981) Toxicology and Applied Pharmacology , vol.61 , pp. 414-422
    • Baker, T.S.1    Rickert, D.E.2
  • 26
    • 0019979180 scopus 로고
    • Urinary excretion of n-hexane metabolites. A comparative study in rat, rabbit and monkey
    • Perabellini L., Amantini ML, Brugnone F., Frontali M. Urinary excretion of n-hexane metabolites. A comparative study in rat, rabbit and monkey. Archives of Toxicology 1982; 50: 203-215.
    • (1982) Archives of Toxicology , vol.50 , pp. 203-215
    • Perabellini, L.1    Amantini, M.L.2    Brugnone, F.3    Frontali, M.4
  • 27
    • 0019309090 scopus 로고
    • Identification of the metabolites of n-hexane, cyclohexane, and their isomers in men's urine
    • Perbellini L., Brugnone F., Pavan I. Identification of the metabolites of n-hexane, cyclohexane, and their isomers in men's urine. Toxicology and Applied Pharmacology 1980; 53: 220-229.
    • (1980) Toxicology and Applied Pharmacology , vol.53 , pp. 220-229
    • Perbellini, L.1    Brugnone, F.2    Pavan, I.3
  • 28
    • 0020384150 scopus 로고
    • Covalent binding of a neurotoxic n-hexane metabolite: conversion of primary amines to substituted pyrrole adducts by 2, 5-hexanedione
    • De Carpio AP, Olajos EJ, Weber P. Covalent binding of a neurotoxic n-hexane metabolite: conversion of primary amines to substituted pyrrole adducts by 2, 5-hexanedione. Toxicology and Applied Pharmacology 1982; 65: 440-450.
    • (1982) Toxicology and Applied Pharmacology , vol.65 , pp. 440-450
    • De, C.A.1    Olajos, E.J.2    Weber, P.3
  • 29
    • 0023873976 scopus 로고
    • Comparative neurotoxicity and pyrrole-forming potential of 2, 5-hexanedione and predeuterio-2, 5-hexanedione in rat
    • De Carpio AP, Briggs RG, Jackowski SJ, Kim JC Comparative neurotoxicity and pyrrole-forming potential of 2, 5-hexanedione and predeuterio-2, 5-hexanedione in rat. Toxicology and Applied Pharmacology 1988; 92: 75-85.
    • (1988) Toxicology and Applied Pharmacology , vol.92 , pp. 75-85
    • De, C.A.1    Briggs, R.G.2    Jackowski, S.J.3    Kim, J.C.4
  • 30
    • 0023103401 scopus 로고
    • Evidence that pyrrole formation is a pathogenetic step in γ-diketone neuropathy
    • Genter MB et al. Evidence that pyrrole formation is a pathogenetic step in γ-diketone neuropathy. Toxicology and Applied Pharmacology 1987; 87: 351-362.
    • (1987) Toxicology and Applied Pharmacology , vol.87 , pp. 351-362
    • Genter, M.B.1
  • 31
    • 0021821585 scopus 로고
    • O'Neil EA. Alterations in rat axonal cyto-skeletal proteins induced by in vitro and in vivo 2, 5-hexanedione exposure
    • De Carpio AP, O'Neil EA. Alterations in rat axonal cyto-skeletal proteins induced by in vitro and in vivo 2, 5-hexanedione exposure. Toxicology and Applied Pharmacology 1985; 78: 235-247.
    • (1985) Toxicology and Applied Pharmacology , vol.78 , pp. 235-247
    • De, C.A.1
  • 32
    • 0025866506 scopus 로고
    • Determination of urinary 2, 5-hexanedione concentration by an improved analytical method as an index of exposure to n-hexane
    • Saito I. et al. Determination of urinary 2, 5-hexanedione concentration by an improved analytical method as an index of exposure to n-hexane. British Journal of Industrial Medicine 1991; 48: 568-574.
    • (1991) British Journal of Industrial Medicine , vol.48 , pp. 568-574
    • Saito, I.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.