Recommendations for the immunohistochemical evaluation of hormone receptors on paraffin sections of breast carcinomas. Update 1999;Recommandations pour l'evaluation immunohistochimique des recepteurs hormonaux sur coupes en paraffine dans les carcinomes mammaires. Mise a jour 1999

Annales de Pathologie

Volumn 19, Issue 4, 1999, Pages 336-343

  Balaton, A J ^a   Le Doussal, V ^b   Arnould, L ^c   Barlier, C ^d   Bellocq, J P ^e   Ettore, F ^f   Fiche, M ^g   Jacquemier, J ^h   Mac Grogan, G ⁱ   Mathieu, M C ^j   Migeon, C ^k   Penault Llorca, F ^l   Pignodel, C ^m   Roger, P ⁿ   Simony Lafontaine, J ^o   Treilleux, I ^p   Verrielle, V ^q   Vilain, M O ^r   Voigt, J J ^s   Zafrani, B ^t  

^a Centre de Pathologie   (France)

^b CENTRE RENÉ HUGUENIN   (France)

^c CENTRE GEORGES FRANÇOIS LECLERC   (France)

^d CENTRE PAUL STRAUSS   (France)

^e HÔPITAL DE HAUTEPIERRE   (France)

^f CENTRE ANTOINE LACASSAGNE   (France)

^g NANTES UNIVERSITY HOSPITAL   (France)

^h INSTITUT PAOLI CALMETTES   (France)

ⁱ INSTITUT BERGONIÉ   (France)

^j INSTITUT GUSTAVE ROUSSY   (France)

^k CENTRE ALEXIS VAUTRIN   (France)

^l CENTRE JEAN PERRIN   (France)

^m DEPARTMENT OF NEUROLOGY   (France)

ⁿ MONTPELLIER UNIVERSITY HOSPITAL   (France)

^o CENTRE VAL D AURELLE   (France)

^p CENTRE LÉON BÉRARD   (France)

^q CENTRE PAUL PAPIN   (France)

^r CENTRE OSCAR LAMBRET   (France)

^s INSTITUT CLAUDIUS REGAUD   (France)

^t INSTITUT CURIE   (France)

more..

Author keywords

Breast cancer; Estrogen receptor; Immunohistochemistry; Progesterone receptor; Quality assurance

Indexed keywords

ESTROGEN RECEPTOR; PARAFFIN; PROGESTERONE RECEPTOR;

ARTICLE; BREAST CARCINOMA; HUMAN; IMMUNOHISTOCHEMISTRY; PRACTICE GUIDELINE; QUALITY CONTROL; SAMPLING; STANDARDIZATION; TISSUE FIXATION;

EID: 0032870556     PISSN: 02426498     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (65)

1. GROUPE D'ÉTUDE DES RÉCEPTEURS HORMONAUX PAR IMMUNOHISTOCHIMIE. FNCLCC/AFAQAP. Recommandations pour l'évaluation immunohistochimique des récepteurs hormonaux sur coupes en paraffine dans les carcinomes mammaires. Ann Pathol 1996 ; 16 : 144-8.
2. JACOBS TW, SIZIOPIKOU KP, PRIOLEAU JE, RAZA S, BAUM JK, HAYES DF, SCHNITT SJ. Do prognostic marker studies on breast core needle biopsy specimens accurately reflect the marker status of the tumor? Lab Invest 1997 ; 76 : 20A.
3. ZIDAN A, BROWN JSC, PESTON D, SHOUSHA S. Oestrogen and progesterone receptor assessment in core biopsy specimens of breast carcinoma. J Clin Pathol 1997 ; 50 : 27-9.
4. JENSEN V, LAKEDARL M. Immunohistochemical quantitation of oestrogen receptors and proliferative activity in oestrogen receptor positive breast cancer. J Clin Pathol 1995 ; 48 : 429-32.
5. LAYFIELD LJ, SARIA E, MOONEY EE, LIU K, DODGE RR. Tissue heterogeneity of immunohistochemically detected estrogen receptor. Implications for image analysis quantification. Am J Clin Pathol 1998 ; 110 : 758-64.
6. VON WASIELEWSKI R, MENGEL M, NOLTE M, WERNER M. Influence of fixation, antibody clones, and signal amplification on steroid receptor analysis. Breast J 1998 ; 4 : 33-40.
7. GRABAU DA, NIELSEN O, HANSEN S, NIELSEN MN, LAENKHOLM AV, KNOOP A, PFEIFFER P. Influence of storage temperature and high-temperature antigen retrieval buffers on results of immunohistochemical staining in sections stored for long periods. Appl Immunohistochem 1998 ; 6 : 209-13.
8. WAKINS J, KELLOCK D, GILLET C, EGAN M, PONTIN JE, MILLIS RR, LEVINSON DA. Enhancement of immunostaining (correspondence). Histopathology 1990 ; 17 : 185-9.
9. WILLIAMS JH, MEPHAM BL, WRIGHT DH. Tissue preparation for immunocytochemistry. J Clin Pathol 1997 ; 50 : 422-8.
10. MOTE PA, LEARY JA, CLARKE CL. Immunohistochemical detection of progesterone receptors in archival breast cancer. Biotech Histochem 1998; 73 : 117-27.
11. AL SAATI T, CLAMENS S, COHEN-KNAFO E. FAYE JC, PRATS H, COINDRE JM, WAFFLART J, CAVERIVIERE P. BAYARD F, DELSOL G. Production of monoclonal antibodies to human oestrogen receptor protein (ER) using recombinant ER (RER). Int J Cancer 1993 ; 55 : 651-4.
12. GOWN AM, DEWEVER N, BATTIFORA H. Microwave-based antigen unmasking : a revolutionary new technique for routine immunohistochimistry. Appl Immunohistochem 1993 ; 1 : 256-66.
13. LEONG ASL, MILLIOS J. Comparison of antibodies to estrogen and progesterone receptors and the influence of microwave-antigen retrieval. Appl Immunohistochem 1993 ; 1 : 282-8.
14. BEVITT DJ, MILTON ID, PIGGOT N, HENRY L, CARTER MJ, TOMS GL, LENNARD TWJ, WESTLEY B, ANGUS B. HORNE CHW. New monoclonal antibodies to oestrogen and progesterone receptors effective for paraffin sections immunohistochemistry. J Pathol 1997 ; 183 : 228-32.
15. NORTON AJ, JORDAN S, YEOMANS P. Brief, high-temperature heat denaturation (pressure cooking) : an effective method of antigen retrieval for routinely processed tissues. J Pathol 1994 ; 175 : 371-9.
16. BIER B, BANKFALVI A, GROTE L, BLASIUS S, OFNER D, BOCKER W, JASANI B, SCHMID KW. Wet autoclave pretreatment for immunohistochemical demonstration of oestrogen receptors in routinely processed breast carcinoma tissue. Histochem J 1995 ; 27 : 148-154.
17. MAN YG, TAVASSOLI FA. A simple epitope retrieval method without the use of microwave oven or enzyme digestion. Appl Immunohistochem 1996 ; 4 : 139-41.
18. ELIAS JM, MARGIOTTA M. Low temperature antigen restoration of steroid hormone receptor proteins in routine paraffin sections. J Histotechnol 1997 ; 20 : 155-8.
19. SHI S-R, COTE R, YOUNG LL, TAYLOR CR. Antigen retrieval immunohistochemistry practice and development. J Histotechnol 1997 ; 20 : 145-54.
20. MILLER K, AULD J, JESSUP E, RHODES A, ASHTON-KEY M. Antigen unmasking in formalin-fixed paraffin-embedded sections by pressure cooking : a comparison with microwave heating and traditional methods. Adv Anat Pathol 1995 ; 2 : 60-4.
21. MOTE PA, LEARY JA, CLARKE CL. Immunohistochemical detection of progesterone receptors in archival breast cancer. Biotech Histochem 1998 ; 73 : 117-27.
22. BALATON AJ, MATHIEU MC, LE DOUSSAL V. Optimization of heat-induced epitope retrieval for estrogen receptor determination by immunohistochemistry on paraffin-sections : results of a multicentric study. Appl Immunohistochem 1996 ; 4 : 259-63.
23. KOOPAL SA, IGLESIAS COMA M, TIEBOSCH ATMG, SURMEIJER AJH. Low-temperature heating overnight in Tris-HC1 buffer pH 9 is a good alternative for antigen retrieval in formalin-fixed paraffin-embedded tissue. Appl Immunohistochem 1998 ; 6 : 228-33.
24. PESTON D, SHOUSHA S. Low temperature heat mediated antigen retrieval for demonstration of oestrogen and progesterone receptors in formalin-fixed paraffin sections. J Cell Pathol 1998 ; 3 : 91-7.
25. HENDRICKS JB, WILKINSON EJ. Comparison of two antibodies for evaluation of estrogen receptors in paraffin-embedded tumors. Mod Pathol 1993 ; 6 : 765-70.
26. KELL DL, KAMEL OW, ROUSE RV. Immunohistochemical analysis of breast carcinoma estrogen and progesterone receptors in paraffin-embedded tissue. Correlation of clone ER1D5 and 1A6 with cytosol-based hormone receptor assay. Appl Immunohistochem 1993 ; 1 : 275-81.
27. ESTEBAN JM, AHN C, BATTIFORA H, FELDER B. Quantitative immunohistochemical assay for hormonal receptors : technical aspects and biological signifiance. J Cell Biochem (Suppl) 1994 ; 19 : 138-45.
28. GOULDING H, PINDER SE, SNEAD D, CANNON P, BELL J, ELSTON W, BLAMEY RW, ELLIS EO. A new immunohistochemical antibody for the assessment of oestrogen status on routine formalin fixed tissue samples. Hum Pathol 1994 ; 26 : 292-4.
29. GRAY DJ, PACE GE, DEEGS CS. Immunohistochemical detection of steroid receptors in paraffin-embedded tissues comparison with biochemical method and rationale for a changeover in a community hospital. Am J Clin Pathol 1994 ; 102 : 257.
30. PELLICER EM, SUNDBLAD A. Evaluation of antibodies to oestrogen receptors. Appl Immunohistochem 1994 ; 2 : 141.
31. SACCANI JOTTI G, JOHNSTON SRD, SALTER J, DETRE S, DOWSETT M. Comparison of new immunohistochemical assay for oestrogen receptor in paraffin wax embedded breast carcinoma with quantitative immunoassay. J Clin Pathol 1994 ; 47 : 900-5.
32. SANNINO P, SHOUSHA S. Demonstration of oestrogen receptors in paraffin wax sections of breast carcinoma using the monoclonal antibody 1D5 and microwave oven processing. J Clin Pathol 1994 ; 47 : 90-2.
33. VERONESE SM, BARBARESCHI M, MORELLI L, ALDOVINI D, MAURI FA, CAFFO O, GAMBACORTA M, DALLA PALMA P. Predictive value of ER1D5 antibody immunostaining in breast cancer. A paraffin-based retrospective study of 257 cases. Appl Immunohistochem 1995 ; 3 : 85-90.
34. DE MASCAREL I, SOUBEYRAN I, MAC GROGAN G, WAFFLART J, BONICHON F, DURAND M, AVRIL A, MAURIAC L, TROJANI M, COINDRE JM. Immunohistochemical analysis of estrogen receptors in 938 breast carcinomas. Concordance with biochemical assay and prognostic signifiance. Appl Immunohistochem 1995 ; 3 : 222-31.
35. HAPPERFIELD LC, ECHEZARRETA G, GILLETT CE, HANBY AM, BARNES DM, BOBROW LG. Assessment of oestrogen and progesterone receptor antibodies in formalin-fixed routinely processed paraffin-wax embedded tissue. J Cell Pathol 1996 ; 1 : 170-1.
36. BARNES D, MILLIS RR. Oestrogen receptors : the history, the relevance and the methods of evaluation. Progr Pathol 1996 ; 2 : 89-114.
37. NEDERGAARD L, CHRISTENSEN L, RASMUSSEN BB, JACOBSEN GK. Comparison of two monoclonal antibodies for the detection of estrogen receptors in primary breast carcinomas. Path Res Pract 1996 ; 192 : 983-8.
38. PERTSCHUK LP, FELDMAN JG, KIM Y-D, BRAITWAITE L, SCHNEIDER F, BRAVERMAN AS, AXIOTIS C. Estrogen receptor immunocytochemistry in paraffin embedded tissues with ER1D5 predicts breast cancer endocrine response more accurately than H222Spg in frozen sections or cytosol-based ligandbinding assays. Cancer 1996 ; 77 : 2514-9.
39. SOUBEYRAN I, QUENEL N, COINDRE J-M, BONICHON F, DURAND M, WAFFLART J, MAURIAC L. PS2 : a marker improving prediction of response to neoadjuvant tamoxifen in post-menopausal breast cancer patients. Br J Cancer 1996 ; 1445-51.
40. JENSEN V, ANDERSEN J. Value of immunohistochemical-determined oestrogen receptor status and proliferative activity in breast cancer : a retrospective study including patients treated by endocrine therapy at the time of recurrence. Breast 1996 ; 5 : 127-34.
41. FERNÖ M, ANDERSSON C, GIITA F, IDVALL I. Oestrogen receptor analysis of paraffin sections and cytosol samples of primary breast cancer in relation to outcome to adjuvant tamoxifen therapy. Acta Oncol 1996 ; 35 : 17-22.
42. YOUNES M, LAUCIRICA R, MILLER CC, BROWN RW. The prognostic value of estrogen receptor immunocytochemistry (ERICA) in breast cancer does not depend on the staining intensity. Breast Dis 1996 ; 9 : 157-70.
43. ALBERTS SR, INGLES JN, ROCHE PR, CHA SS, WOLD LE, FARR Jr GA, KROOK JE, WIEAND SH. Comparison of estrogen receptor determinations by a biochemical ligand-binding assay and immunohistochemical staining with monoclonal antibody ER1D5 in females with lymph node positive breast carcinoma entered on two prospective clinical trials. Cancer 1996 ; 78 : 764-72.
44. GOLOUH R, VROHEC I, BRACKO M. FRKOVIC-GRAZIO S. Comparison of standardized immunohistochemical and biochemical assays for estrogen and progesterone receptors in breast carcinoma. Pathol Res Prac 1997 ; 193 : 543-9.
45. VILAIN M.O, DELOBELLE-DEROIDE A, BLOGET F, CABARET V, PEYRAT JP, FOURNIER C, HECQUET B, FOURNIER J, VENNIN P, BONNETERRE J. Détection immunohistochimique des récepteurs de l'œstradiol et de la progestérone sur coupes en paraffine après traitement au micro-ondes. Comparaison au dosage biochimique des récepteurs sur une série de 123 carcinomes mammaires avec détermination du seuil de positivité optimal. Ann Pathol 1997 ; 17 : 82-8.
46. SNEAD DRJ, GOULDING H, BELL JA, ELSTON CW, ELLIS EO, BLAMEY RW, ROBERTSON JFR, PINDER SE. Combined progesterone and oestrogen receptor (ER and PR) status in predicting hormone sensitive breast cancer : better than ER alone ? J Pathol 1997 ; 81 (suppl) : 5A.
47. KATOH AK, STEMLER N, SPECHT S, D'AMICO F. Immunoperoxidase staining for estrogen and progesterone receptors in archival formalin fixed, paraffin embedded breast carcinomas after microwave antigen retrieval. Biotech Histochem 1998 ; 72 : 291-8.
48. CLAHSEN PC, VELDE CJH VAN DE, DUVAL C, PALLUD C, MANDARD A-M, DELOBELLE-DEROIDE A, BROEK L VAN DEN, SAHMOUD TM, VIJVER M VAN DE. P53 accumulation and response to adjuvant chemotherapy in premenopausal women with node-negative early breast cancer. J Clin Oncol 1998 ; 16 : 470-9.
49. BIENSTERFELD S, SCHRODER W, STEINHAGEN G, KOCH R, VEUSKENS U, SCHMITZ FJ, HANDT S, BOCKING A. Simultaneous immunohistochemical and biochemical hormone receptor assessment in breast cancer provides complementary prognostic information. Anticancer Res 1997 ; 17 : 4723-30.
50. CRAIG ALLRED D, HARVEY JM, BERARDO M, CLARK GM. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod Pathol 1998 ; 11 : 155-68.
51. SOOMRO S, SHOUSHA S. Demonstration of progesterone receptors in paraffin wax sections of breast carcinomas. J Clin Pathol 1990 ; 43 : 671-4.
52. KADJIAN EP, JIN L, DAVENPORT RD, LLOYD RV. Immunohistochemical analysis of hormone receptors, tumor vascularity and proliferative activity in paraffin-embedded sections of breast carcinoma tissues. Appl Immunohistochem 1993 ; 1 : 31-8.
53. MÜLLER-HOLZNER E, ZEIMET AG, DAXENBICHLER G, MARTH C, MULLER LC, DAPUNT O. Progesterone receptors in routinely paraffin-embedded primary breast carcinomas and lymph node metastases. Breast Cancer Res Treat 1993 ; 25 : 47-55.
54. GOLDBERG DE, STUART J, KOERNER FC. Progesterone receptor detection in paraffin sections of human breast cancers by an immunoperoxidase technique incorporating microwave heating. Mod Pathol 1994 ; 7 : 401-6.
55. MAC GROGAN G, SOUBEYRAN I, DE MASCAREL I, WAFFLART J, BONICHON F, DURAND M, AVRIL A, MAURIAC L, TROJANI M, COINDRE JM. The immunohistochemical detection of progesterone receptors in breast invasive ductal carcinomas. A correlative study on 942 cases. Appl Immunohistochem 1996 ; 4 : 219-27.
56. COHEN C, LAWSON D. Progesterone-receptor expression : comparison of two antibodies with three detection kits. Appl Immunohistochem 1998 ; 6 : 158-63.
57. HOWARD S, BOBROW LG, TOTTY BA. Effect of surfactants on immunohistochemical demonstration of estrogen receptors. J Pathol 1998 ; 184 (Suppl) : 24A.
58. LOPEZ-PRESAS E, BAUNOCH DA. A comparison of ER Clones 1D5, CC4-5 and 6F11 Using manual and automated methods in paraffin-embedded tissue. Mod Pathol 1998 ; 11 : 186A.
59. BALATON AJ, BAVIERA EE, GALET B, VAURY P, VUONG, PN. Évaluation immunohistochimique des récepteurs aux estrogènes et à la progestérone sur coupes en paraffine de carcinomes. Réflexions pratiques suscitées par l'étude de 368 cas. Arch Anat Cytol Pathol 1995 ; 43 : 93-100.
60. JACOBS TW, PRIOLEAU JE, STILLMAN IE, SCHNITT SJ. Loss of tumor marker immunostaining intensity on stored paraffin sections of breast cancer. J Ntl Cancer Inst 1996 ; 15 : 1054-9.
61. HENDRICKS JB, STEPHEN CA, WILKINSON EJ, SZEKERES G. Estrogen receptor specific (ER1D5) epitope stability in paraffin sections. J Histotechnol 1996 ; 19 : 1-3.
62. BERTHEAU P, CAZALS-HATEM D, MEIGNIN V, DE ROQUANCOURT A, VEROLA O, LESOURD A, SENE C, BROCHERIOU C, JANIN A. Variability of immunohistochemical reactivity on stored paraffin slides. J Clin Pathol 1998 ; 51 : 370-4.
63. REMMELE W, SCHICKETANZ KH. Immunohistochemical determination of estrogen and progesterone receptor content in human breast cancer. Computer-assisted image analysis (QIC Score) vs subjective grading (IRS). Pathol Res Pract 1993 ; 189 : 862-6.
64. BARNES DM, HARRIS WH, SMITH P, MILLIS RR, RUBENS RD. Immunohistochemical determination of oestrogen receptor : comparison of different methods of assessment of staining and correlation with clinical outcome of breast cancer patients. Brit Med J 1996 ; 73 : 1445-51.
65. BALATON AJ. Approche systématique de la qualité technique en immunohistochimic. Ann Pathol 1999 ; 19 : 299-308.