Epileptiform discharges to extracellular stimuli in rat neocortical slices after photothrombotic infarction

Journal of the Neurological Sciences

Volumn 156, Issue 2, 1998, Pages 133-137

  Buchkremer Ratzmann, Irmgard ^a   August, Matthias ^a   Hagemann, Georg ^a   Witte, Otto W ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Electrophysiology; Epilepsy; Infarction; Photothrombotic; Stroke

Indexed keywords

DIZOCILPINE; LUBELUZOLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN INFARCTION; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EPILEPSY; EPILEPTIC DISCHARGE; MALE; NEOCORTEX; NEUROPATHOLOGY; NONHUMAN; OCCLUSIVE CEREBROVASCULAR DISEASE; PRIORITY JOURNAL; RAT; SEIZURE;

ANIMALS; CEREBRAL INFARCTION; DIZOCILPINE MALEATE; ELECTRIC STIMULATION; ELECTROPHYSIOLOGY; EPILEPSY; INTRACRANIAL EMBOLISM AND THROMBOSIS; LIGHT; MALE; NEOCORTEX; NEUROPROTECTIVE AGENTS; PIPERIDINES; RATS; RATS, WISTAR; REACTION TIME; THIAZOLES;

EID: 0032054356     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-510X(98)00034-3     Document Type: Article

References (23)

1. Albertson T.E., Walby W.F., Stark L.G., Joy R.M. The effect of propofol on ca1 pyramidal cell excitability and GABA(a)-mediated inhibition in the rat hippocampal slice. Life Sci. 58:1996;2397-2407.
2. Asconape J.J., Penry J.K. Poststroke seizures in the elderly. Clin. Geriatr. Med. 7:1991;483-492.
3. Buchkremer-Ratzmann I., August M., Hagemann G., Witte O.W. Electrophysiological transcortical diaschisis after cortical thrombosis in the rat brain. Stroke. 27:1996;1105-1111.
4. Buchkremer-Ratzmann I., Witte O.W. Pharmacological reduction of electrophysiological diaschisis after photothrombotic ischemia in rat neocortex. Eur. J. Pharm. 320:1997;103-109.
5. De Ryck M., Keersmaekers R., Duytschaever H., Claes C., Clincke G., Van Reet G. Lubeluzole protects sensorimotor function and reduces infarct size in a photochemical stroke model in rats. J. Pharmacol. Exp. Ther. 279:1996;748-758.
6. Domann R., Hagemann G., Kraemer M., Freund H.-J., Witte O.W. Electrophysiological changes in the surrounding brain tissue of photochemically induced cortical infarcts in the rat. Neurosci. Lett. 155:1993;69-72.
7. Gill R. The pharmacology of α-amino-3-hydroxy-5-methyl-4-isoxazole propianate (AMPA)/kainate antagonists and their role in cerebral ischaemia. Cerebrovasc. Brain Metab. Rev. 6:1994;225-256.
8. Horne A.L., Harrison N.L., Turner J.P., Simmonds M.A. Spontaneous paroxysmal activity induced by zero magnesium and bicuculline: suppression by NMDA antagonists and GABA mimetics. Eur. J. Pharmacol. 122:1986;231-238.
9. Kapur J., Strinter J.L., Lothman E.W. Evidence that repetitive seizures in the hippocampus cause a lasting reduction of GABAergic inhibiton. J. Neurophysiol. 61:1989;417-426.
10. Kotila M., Waltimo O. Epilepsy after stroke. Epilepsia. 33:1992;495-498.
11. Lesage A.S., Peeters L., Leysen J.E. Lubeluzole, a novel long-term neuroprotectant, inhibits the glutamate-activated nitric oxide synthase pathway. J. Pharmacol. Exp. Ther. 279:1996;759-766.
12. Luhmann H.J. Ischemia and lesion induced imbalances in cortical function. Prog. Neurobiol. 48:1996;131-166.
13. Matsumoto H., Ajmone-Marsan C. Cortical cellular phenomena in experimental epilepsy: Interictal manifestations. Exp. Neurol. 9:1964;286-304.
14. Metherate R., Ashe J.H. GABAergic suppression prevents the appearance and subsequent fatigue of an NMDA receptor-mediated potential in neocortex. Brain Res. 699:1995;221-230.
15. Neumann-Haefelin T., Hagemann G., Witte O.W. Cellular correlates of neuronal hyperexcitability in the vicinity of photochemically induced cortical infarcts in rats in vitro. Neurosci. Lett. 193:1995;101-104.
16. O'Shaughnessy C.T., Aram J.A., Lodge D. A1 adenosine receptor-mediated block of epileptiform activity induced in zero magnesium in rat neocortex in vitro. Epilepsy Res. 2:1988;294-301.
17. Paxinos, G., Watson, C., The Rat Brain in Sterotyxoc Coordinates, Academic Press, London, 1986.
18. Pohlmann Eden B., Hoch D.B., Cochius J.I., Hennerici M.G. Stroke and epilepsy - critical review of the literature. 1. Epidemiology and risk factors (review). Cerebrovasc. Dis. 6:1996;332-338.
19. Roberts E. GABA-related phenomena, models of nervous system function, and seizures. Ann. Neurol. 16(Suppl.):1984;S77-S89.
20. Sae Monn Oh., Betz A.L. Interaction between free radicals and excitatory amino acids in the formation of ischemic brain edema in rats. Stroke. 22:1991;915-921.
21. Schiene K., Bruehl C., Zilles K., Qu M.S., Hagemann G., Kraemer M., Witte O.W. Neuronal hyperexcitability and reduction of GABA(a)-receptor expression in the surround of cerebral photothrombosis. J. Cereb. Blood Flow Metab. 16:1996;906-914.
22. So E.L., Annegers J.F., Hauser W.A., Obrien P.C., Whisnant J.P. Population-based study of seizure disorders after cerebral infarction. Neurology. 46:1996;350-355.
23. Wang X., Robinson P.J. Cyclic GMP-dependent protein kinase and cellular signaling in the nervous system. J. Neurochem. 68:1997;443-456.